50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Vascular Biology and Factor VII

Tuesday, December 9, 2008: 1:00 PM-2:30 PM

310 - South (Moscone Center)

Moderators:

Susan A. Maroney and S. Paul Bajaj, PhD

1:00 PM

Tissue Specific Expression of Alternatively Spliced Forms of Tissue Factor Pathway Inhibitor (TFPI) in Mice

Susan A. Maroney¹, Josephine P. Ferrel¹^*, Shuchong Pan²^*, Thomas A. White²^*, Robert D. Simari²^*, John H McVey³^* and Alan E Mast¹

¹Blood Center of Wisconsin, Milwaukee, WI
²Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN
³Experimental and Translational Research, Thrombosis Research Institute, London SW3 6LR, England

1:15 PM

2029

Structural and Functional Investigations of Active Site Binding Regions in Factor VIIa

S. Paul Bajaj¹, Amanda Sutton²^*, Sreejesh Shanker³^*, Amy E Schmidt³^*, Sayeh Agah³^*, William H Velander²^*, Kaillathe Padmanabhan⁴^* and Duilio Cascio⁵^*

¹UCLA/Orthopedic Hospital, Los Angeles, CA
²Chemical and Biomolecular Engineering, University of Nebraska Lincoln, Lincoln, NE
³Orthopaedic Surgery, UCLA/Orthopaedic Hospital, Los Angeles, CA
⁴Biochemistry, Michigan State University, East Lansing, MI
⁵Institute for Genomics and Proteomics, UCLA, Los Angeles, CA

1:30 PM

2030

Structural and Functional Significance of Amino Acid Lysine192 (chymotrypsin numbering) in Factor XIa and Factor VIIa

Amy E Schmidt¹^*, Sayeh Agah¹^*, Mao-fu Sun²^*, Kaillathe Padmanabhan³^*, Duilio Cascio⁴^*, David Gailani⁵ and S. Paul Bajaj⁶

¹Orthopaedic Surgery, UCLA/Orthopaedic Hospital, Los Angeles, CA
²Pathology and Medicine, Vanderbilt University, Nashville, TN
³Biochemistry, Michigan State University, East Lansing, MI
⁴Institute for Genomics and Proteomics, UCLA, Los Angeles, CA
⁵Department of Pathology and Medicine, Vanderbilt University School of Medicine, Nashville, TN
⁶UCLA/Orthopedic Hospital, Los Angeles, CA

1:45 PM

2032

Protein Z Dependent Protease Inhibitor Inhibition of Factor XIa Is Accelerated by Unfractionated Heparin in the Presence and Absence of Protein Z: Further Evidence of the Potential Significance of XIa Inhibitory Activity

Laura Young, FRACP, FRCPA¹^*, Neil Van de Water, PhD²^*, Paul L Harper, MD, FRCP, FRACP³^*, Paul A. Ockelford, FRACP, MD, FRCPA⁴, Anita Horvath, PhD⁵^*, Paul Coughlin, FRACP, PhD⁵^* and Peter Browett, MBChB, FRACP, FRCPA⁶

¹Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
²LabPlus, Auckland City Hospital, Auckland, New Zealand
³Clinical Haematology, Palmerston North Hospital, Palmerston North, New Zealand
⁴Diagnostic Med. Lab. Ltd., Auckland, New Zealand
⁵Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
⁶University of Auckland, Auckland, New Zealand

2:00 PM

3070

Conformational Activation of Zymogen-Like Thrombin Variants by Tight Binding Ligands

Anuja Khan, PhD¹^*, Peter Panizzi, PhD²^*, Heather K Kroh, PhD²^*, Paul E. Bock, PhD²^* and Sriram Krishnaswamy, PhD¹

¹Children's Hospital of Philadelphia, Philadelphia, PA
²Pathology, Vanderbilt University, Nashville, TN

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