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Animal Models

Tuesday, December 9, 2008: 1:00 PM-2:30 PM
302 - South (Moscone Center)
Moderators:
J. J. Hofstra, MD and Ted S Strom, MD, PhD
1:00 PM
Inhibition of Pulmonary Coagulopathy by Nebulized Natural Anticoagulants during Streptococcus Pneumoniae Pneumonia in Rats

J. J. Hofstra, MD1*, F. E. van den Boogaard, MD2*, A. D. Cornet, MD3*, A. P.J. Vlaar, MD2*, T. van der Poll, Prof, MD, PhD1*, M. Levi, Prof, MD, PhD1* and M. J. Schultz, MD, PhD4*

1Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
2Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
3Department of Intensive Care Medicine, VU Medical Center, Free University of Amsterdam, Amsterdam, Netherlands
4Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam

1:15 PM
Maternal Immune Response to Fetal Platelet GPIbα Causes More Frequent Miscarriage in An Animal Model: A Potential Explanation for Low Reported Incidence of Fetal and Neonatal Immune Thrombocytopenia Mediated by Anti-GPIbα Antibodies

Conglei Li, MD1*, Siavash Piran, MSc.1*, Pingguo Chen, PhD2*, Sean Lang, BSc.1*, Jerry Ware, PhD3, Zaverio M. Ruggeri, MD3, John Freedman, MD4 and Heyu Ni, MD, PhD5*

1Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital and University of Toronto, Toronto, ON, Canada
2Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital and Canadian Blood Services, Toronto, ON, Canada
3Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA
4Departments of Laboratory Medicine and Pathobiology, and Medicine, St. Michael's Hospital and University of Toronto, Toronto, ON, Canada
5Departments of Laboratory Medicine and Pathobiology, Medicine and Physiology, St. Michael's Hospital, University of Toronto and Canadian Blood Services, Toronto, ON, Canada

1:30 PM
Antiplatelet Antibodies in WASP(-) Mice Correlate with Accelerated in Vivo Platelet Consumption RatesClinically Relevant Abstract

Bindumadhav M Marathe1*, Amanda Prislovsky2*, Amira Hosni2* and Ted S Strom, MD, PhD2

1Pathology and Laboratory Medicine, University of Tennessee Health Sciences Center, Memphis, TN
2Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN

1:45 PM
Functional Genomics in Zebrafish Permits Rapid Characterization of Novel Platelet Membrane Proteins

Isabelle I Salles1*, Marie N O'Connor2*, Nicholas A. Watkins2*, Adam Walker3*, Stephen F Garner2*, Chris I Jones4*, Iain Macauley2*, Michael Steward3*, Jaap Jan Zwaginga5, Sarah L Bray6*, Ana Cvejic7*, Frank Dudbridge6*, Bernard de Bono8*, Hans Deckmyn1*, Derek L. Stemple7* and Willem Ouwehand, MD, PhD2*

1Laboratory for Thrombosis Research,IRC, Catholic University of Leuven (KUL), Kortrijk, Belgium
2Haematology, University of Cambridge and NHS Blood and Transplant, Cambridge, United Kingdom
3Domantis Limited, Cambridge, United Kingdom
4Cardiovascular science, University of Leicester, Leicester, United Kingdom
5Immunohem./Blood Transfusion, University Hospital Leiden, Leiden, Netherlands
6MRC Biostatistics Unit, Cambridge, United Kingdom
7Welcome Trust Sanger Institute, Hinxton, United Kingdom
8European Bioinformatics Institute, Hinxton, United Kingdom

2:00 PM
Unraveling the Danger Signal Necessary for the Immune Response to Therapeutic Factor VIII

Jonathan Skupsky, BS1*, Ai-Hong Zhang, MS, PhD2* and David W. Scott, PhD3

1Program in Molecular Medicine, MD/PhD Program, University of Maryland School of Medicine, Baltimore, MD
2Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimre, MD
3Depts. of Surgery & Microbiology-Immunology, University of Maryland School of Medicine, Baltimore, MD

2:15 PM
Recombinant PDGF-BB Enhances Platelet Recovery in Mice with Radiation Induced Thromobocytopenia

Jie Yu Ye1*, Godfrey ChiFung Chan, MD2, Shing Chan1*, Jue Cong Luo1* and Mo Yang1*

1Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
2Queen Mary Hospital, Hong Kong, Hong Kong