50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Platelet Disorders and VWD

Tuesday, December 9, 2008: 1:00 PM-2:30 PM

301 - South (Moscone Center)

Moderators:

Laura Noé and Soochong Kim, PhD

1:00 PM

Loss of Gs Activity in Platelets from Carriers with a Heterozygous Missense Mutation in the Regulator of G Protein Signaling 2 (RGS2)

Laura Noé¹^*, Kathleen Freson¹^*, Elke Giets¹^*, Chantal Thijs¹^*, Christine Wittevrongel¹^* and Christel Van Geet, MD, PhD²

¹Center for Molecular and Vascular Biology, KULeuven, Leuven, Belgium
²Dept. of Hematology, Pediatrics, UZ Gasthuisberg Leuven, Leuven, Belgium

1:15 PM

2854

Negative Regulation of Gq-Mediated Pathways in Platelets by G12/13 Pathways through Fyn Kinase

Soochong Kim, DVM, PhD^* and Satya P. Kunapuli, Ph.D.

Physiology, Temple University School of Medicine, Philadelphia, PA

1:30 PM

1831

RUNX1/CBFA2 Regulates Myosin Light Chain 9 (MYL9) in Megakaryocytic Cells: Decreased MYL9 Expression in Human RUNX1 Haplodeficiency

Gauthami S Jalagadugula, Ph.D¹^*, Gurpreet Kaur, Ph.D¹^*, Guangfen Mao, MD¹^*, Danny Dhanasekaran, Ph.D²^* and A. Koneti Rao, MD¹^*

¹Thrombosis Research Center and Department of Medicine, Temple University School of Medicine, Philadelphia, PA
²Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Phialdelphia, PA

1:45 PM

1832

High Mortality in Mice with Platelets Expressing Integrin αIIbβ3 Locked-in Its High Affinity State

David A. Wilcox, PhD¹, Juan Fang, MD¹^*, Paula North, MD, PhD²^*, Paquita Nurden, MD³, Alan T. Nurden, PhD³ and Nathalie Valentin, PhD⁴^*

¹Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
²Department of Pathology, Medical College of Wisconsin
³CRPP/PTIB, Pessac, France
⁴Laboratoire d'Immunologie, Laboratoire de thérapie génique, INSERM U649, Nantes, France

2:00 PM

2020

Recombinant Protein Infusion and Hydrodynamic Plasmid Delivery Strategies Provide Distinct and Complementary Approaches to the Characterization of Variant Forms of Von Willeband Factor (VWF) in VWF Knockout Mice

Cynthia M. Pruss, BSc^*, Carol A. Hegadorn^*, Andrea Labelle^*, Erin Burnett^*, Mia Golder^* and David Lillicrap, MD

Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada

2:15 PM

3394

Quebec Platelet Disorder Is Caused by a Cis-Acting Mutation near the Plasminogen Activator Gene (PLAU) That Increases PLAU Transcription by Megakaryocytes

Maria Diamandis¹^*, Andrew D Paterson, PhD²^*, Johanna M Rommens, PhD²^*, D. Kika Veljkovic, MD¹^*, Jessica Blavignac¹^*, John S Waye, PhD¹^*, Francine Derome³^*, Georges E. Rivard, MD³ and Catherine PM Hayward, MD, PhD¹

¹McMaster University, Hamilton, ON, Canada
²The Hospital for Sick Children and The University of Toronto, Toronto, ON, Canada
³Centre Hospitalier Universitaire Sainte Justine, Montreal, QC, Canada

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