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Platelet Structure and Biochemistry

Tuesday, December 9, 2008: 1:00 PM-2:30 PM
300 - South (Moscone Center)
Moderators:
Charles S. Abrams, MD and Subhashree Pradhan, Ph.D.
1:00 PM
1834
Impaired Actin Assembly and Lamellipodia Formation in ATE1 Knockout Platelets

Lurong Lian, M.D.1*, Anna S. Kashina, Ph.D.2*, Karen P. Fong, Ph.D.1*, Yanfeng Wang, M.D.1* and Charles S. Abrams, MD3

1University of Pennsylvania School of Medicine, Philadelphia, PA
2University of Pennsylvania School of Medicine
3School of Medicine, University of Pennsylvania, Philadelphia, PA
1:15 PM
2871
Cross Talk Between Serine/Threonine Protein Phosphatase 2A and Tyrosine Kinase Src Regulates αIIbβ3 Function

Subhashree Pradhan, Ph.D.1*, Vimal Patel, BS2* and K. Vinod Vijayan, PhD3

1Baylor College of Medicine, Houston, TX
2Medicine, Baylor College of Medicine, Houston, TX
3Thrombosis Research Center, Baylor College of Medicine, Houston, TX
1:30 PM
2870
Complex and Novel Associations of the Guanine Exchange Factors Cool-1 and Cool-2 with the Scaffolding Proteins GIT1 and GIT2 in Human Platelets

Daniel L. Greenberg, MD and Alex Spencer, BA, MBA*

Oregon Health Sciences Univ., Portland, OR
1:45 PM
1844
Functional Genomics of the Platelet ADP and Collagen Signalling Pathways

Stephen F Garner1*, Chris I Jones2*, Jonathan Stephens1*, Sarah L Bray3*, Will Angenent4*, Philippa Burns1*, Richard W Farndale5*, Catherine Rice4*, Frank Dudbridge3*, Nick Watkins6*, Bernard de Bono7*, Panos Deloukas4*, Alison H Goodall8* and Willem Ouwehand6*

1Dept. of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge, United Kingdom
2University of Reading, Reading, United Kingdom
3MRC Biostatistics Unit, Cambridge, United Kingdom
4Wellcome Trust Sanger Institute, Hinxton, United Kingdom
5Biochemistry, University of Cambridge, Cambridge, United Kingdom
6Haematology, University of Cambridge and NHS Blood and Transplant, Cambridge, United Kingdom
7European Bioinformatics Institute, Hinxton, United Kingdom
8Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
2:00 PM
1849
A Role for α-Actinin in Inside-out αIIbβ3 Signaling

Seiji Tadokoro1*, Masamichi Shiraga2*, Hirokazu Kashiwagi2*, Tsuyoshi Kamae2*, Masao Akiyama2*, Tsuyoshi Nakazawa2*, Yuzuru Kanakura2 and Yoshiaki Tomiyama3

1Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
2Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
3Department of Blood Transfusion, Osaka University Hospital, Osaka, Japan
2:15 PM
2858
A Conserved Transmembrane Domain Interface Regulates Integrin Function

Bryan W, Berger1*, Lisa M. Span1*, Daniel W, Kulp1*, Paul C. Billings1*, William F. DeGrado1* and Joel S. Bennett, MD2

1Biochemistry/Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA
2University of Pennsylvania, Philadelphia, PA
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