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Clinical Care - Transplantation Regimen Toxicities and Engraftment Poster III

Monday, December 8, 2008: 5:30 PM-7:30 PM
Hall A (Moscone Center)
Optimal Thalassemia Free Survival and Minimal Regimen Related Toxicity in 50 Consecutive Transplants of High Risk Beta Thalassemia Pediatric Patients Using Myelablative Therapy with Intravenous Busulphan

Sarah Marktel, MD*, Robert Chiesa, MD*, Barbara Cappelli, MD*, Tito Roccia, MD*, Ilaria Frugnoli, MD*, Anna Noè, MD*, Erika Biral, MD*, Roberto Crocchiolo, MD*, Costanza Evangelio, MD*, Marco Fossati, MD*, Sara Napolitano, MD*, Clara Soliman*, Laura Cursi, MD*, Federica Cattaneo, MD*, Laura Zito, PD*, Rossana Fiori, MD*, Katharina Fleischhauer, MD*, Roberto Miniero, MD, Prof.*, Fabio Ciceri, MD* and Maria Grazia Roncarolo, MD, Prof.*

Pediatric Immunohematology and Bone Marrow Transplantation Unit, Scientific Institute H S Raffaele, Milano, Italy

Prediction of VOD Using Biomarkers of Endothelial Injury

Corey Cutler, MD, MPH1, J. Aldridge2*, H. T. Kim2*, S. Ayanian3*, G. Bradwin3*, C. Revta1*, G. Murga1*, V. Ho1*, E. Alyea1*, J. Koreth1*, P. Armand1*, P. G. Richardson1*, R. J. Soiffer1*, J. Ritz1* and J. H. Antin1*

1Medical Oncology, Dana-Farber Cancer Inst., Boston, MA
2Computational Biology and Biostatistics, Dana-Farber Cancer Inst., Boston, MA
3Laboratory Medicine, Children's Hospital Boston, Boston, MA

Transfusion Requirements in Allogeneic Hematopoietic Cell Transplantation (HCT) Recipients Given Either Myeloablative or Nonmyeloablative Conditioning, and Effect of ABO Incompatibility on HCT Outcomes

Zejing Wang, MD, PhD1*, Mohamed L. Sorror, MD, MS2*, Wendy Leisenring, Sc.D.2*, Gary Schoch1*, David G. Malonely, MD, PhD2*, Brenda M. Sandmaier, MD2 and Rainer F. Storb, MD2

1Fred Hutchinson Cancer Research Center, Seattle, WA
2Fred Hutchinson Cancer Research Center/ University of Washington, Seattle, WA

Platelet Transfusion Requirement during ASCT for Lymphoma Is a Powerful Prognostic Variable

Hien Duong*, Lisa Rybicki*, John Sweetenham*, Brad Pohlman, Ronald Sobecks, Robert Dean, Edward Copelan, Steven Andresen*, Stephen Smith, Shawnda Sungren*, Josephine Chan* and Brian Bolwell

Cleveland Clinic Taussig Cancer Institute, Cleveland, OH

Evaluation of Toxicity and Tissue Radiation Doses Obtained in Mice with An Anti-CD45 Monoclonal Antibody (mAb) Labeled with the Alpha-Emitting Radionuclides, Astatine-211 or Bismuth-213

Hirohisa Nakamae, MD, PhD1*, D. Scott Wilbur, PhD2*, Donald K Hamlin2*, Monica S Thakar, MD3, Erlinda B Santos1*, Darrell R Fisher, PhD4*, Aimee L Kenoyer1*, John M. Pagel, MD, PhD3, Oliver W. Press, MD, PhD3, Rainer F. Storb, MD3 and Brenda M. Sandmaier, MD3

1Fred Hutchinson Cancer Research Center, Seattle, WA
2Department of Radiation Oncology, University of Washington, Seattle, WA
3Fred Hutchinson Cancer Research Center & University of Washington, Seattle, WA
4Pacific Northwest National Laboratory, Richland, WA

Adding  Total Marrow and Lymph Node Irradiation (TMLI) Using Helical Tomotherapy to Reduced Intensity Conditioning (RIC) Regimen of Fludarabine (FLU) and Melphalan (MEL) in Patients (pts) with Advanced Hematological Malignancies

Joseph Rosenthal, Jeffrey Y. Wong*, George Somlo*, David Snyder*, Margaret O'Donnell*, Anthony Stein*, Ayurporn Nademanee*, Maria Delioukina*, Leslie Popplewell*, Pablo Parker*, Ricardo Spielberger*, Firoozeh Sahebi*, Chatchada Karanes*, Debbie Hitt*, Hossameldin Naeem*, Andrew Dagis* and Stephen Forman*

City of Hope, Duarte, CA

Salvage Allogeneic Hematopoietic Cell Transplantation with Fludarabine and Total Body Irradiation (3 or 4 Gy) after Failure of First Allografts

Boglarka Gyurkocza, MD1, Thai M. Cao, MD2, Rainer F. Storb, MD1, Thoralf Lange, MD3*, Wendy Leisenring, Sc.D.1*, Georg Franke, MD3*, Mohamed L. Sorror, MD, MS1*, David G. Maloney, MD, PhD1, Judith Shizuru, MD, PhD4* and Brenda M. Sandmaier, MD1*

1Fred Hutchinson Cancer Research Center/University of Washington, Seattle, WA
2University of Utah, Salt Lake City, UT
3University of Leipzig, Leipzig, Germany
4Stanford University Medical Center, Palo Alto, CA

Pre-Transplant Conditioning Using Intravenous Busulfan Is a Feasible and Effective Option in Reduced-Intensity Cord Blood Transplantation

Naoyuki Uchida, MD1, Hisashi Yamamoto, MD1*, Naofumi Matsuno, MD1*, Kazuya Ishiwata, MD1*, Masanori Tsuji, MD1*, Shinsuke Takagi, MD1*, Hideki Araoka, MD2*, Daisuke Kato, MD1*, Mayumi Yoshimi, MD1*, Sachiko Seo, MD1*, Kazuhiro Masuoka, MD1*, Atsushi Wake, MD1*, Madoka Narita1*, Kimiko Sagawa1*, Akiko Yoneyama, MD2*, Shigeyoshi Makino, MD3* and Shuichi Taniguchi, MD, PhD1

1Department of Hematology, Toranomon Hospital, Tokyo, Japan
2Department of Infectious Diseases, Toranomon Hospital, Tokyo, Japan
3Department of Transfusion Medicine, Toranomon Hospital, Tokyo, Japan

Reduced Toxicity Conditioning with Treosulfan and Fludarabine in Allogeneic Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndromes: Results of an International Prospective Phase II Trial

Tapani Ruutu1, Liisa Volin1*, Dietrich W. Beelen2*, Rudolf Trenschel2*, Juergen Finke3, Marc Schnitzler3*, Jerzy Holowiecki4, Sebastian Giebel4*, Lutz Uharek5*, I. Wolfgang Blau5*, Matthias Stelljes6*, Joachim Kienast6*, Kajsa Larsson7*, Axel R. Zander8, Martin Gramatzki9, Roland Repp9*, Hermann Einsele10*, Gernot Stuhler10*, Mathias Freund11 and Jochen Casper11*

1Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
2Department of Bone Marrow Transplantation, University Hospital Essen, Germany
3Department of Medicine - Hematology, Oncology, University of Freiburg, Germany
4University Department of Hematology and BMT, Silesian Medical University, Katowice, Poland
5Medical Clinic III - Hematology and Oncology, Charité University Medicine Berlin, Germany
6Department of Hematology/Oncology, University of Muenster, Germany
7Centre for Allogeneic Stem Cell Transplantation & Department of Hematology, Karolinska University Hospital & Karolinska Institute, Stockholm, Sweden
8Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
9Division of Stem Cell Transplantation & Immunotherapy, 2nd Medical Department; University of Kiel, Germany
10Department of Hematology/Oncology, University of Wuerzburg, Germany
11Division of Hematology and Oncology, University of Rostock, Germany

Defibrotide in Prevention of Liver Toxicity in Patients at High Risk of VOD after HSC Transplantation

G. Milone, M. Poidomani*, S. Coppoletta*, E. Mauro*, E. Marturano*, F. Crispi*, A. Spadaro*, A. Di Marco* and S. Leotta*

Hematology, Bone Marrow Transplantation Unit, Catania, Italy

Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) Combined with Leukemic Risk Factors Predict Outcome of AML Patients after Allogeneic Stem Cell Transplantation Following Reduced Intensity Conditioning (RIC)

Philipp Hemmati1, Theis Terwey1*, Gero Massenkeil, MD2*, Philipp D. le Coutre, MD3, Stefan Neuburger1*, Lam G Vuong1*, Bernd Dörken1* and Renate Arnold, MD, PhD1*

1Department of Hematology and Oncology, Charité - University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany
2Department of Internal Medicine, Hematology and Oncology, Ruhr-University Bochum
3Department of Hematology and Oncology, Charité - Humboldt-Universitat, Campus Virchow, Berlin, Germany

Validation of Comorbidity Indexes in Reduced-Intensity Conditioning (RIC) Allogeneic Stem Cell Transplantation. the Hematopoietic Cell Transplantation Comorbidity Index Is the Best Predictor of NRM and Survival

Pere Barba1*, Jose Luis Piñana2*, Alex Amoros3*, David Valcárcel2*, Rodrigo Martino2*, Anna Sureda2*, Javier Briones2*, Julio Delgado2*, Miquel Granell2*, Salut Brunet2*, M.ª Rosa Suñol3* and J. Sierra, MD1

1Clinical Hematology, Hospital De Sant Pau, Barcelona, Spain
2Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
3Institut Universitari Fundació Avedis Donabedian, Barcelona, Spain

Reduced Intensity Conditioning (RIC) Prior to Allogeneic Stem Cell Transplantation in AML Patients with An Intermediate Risk Karyotype: No Difference in Outcome as Compared to Standard Myeloablative Conditioning (MAC)

Philipp Hemmati1, Gero Massenkeil, MD2*, Theis Terwey1*, Stefan Neuburger1*, Philipp D. le Coutre, MD3, Lam G Vuong1*, Bernd Dörken1* and Renate Arnold, MD, PhD1*

1Department of Hematology and Oncology, Charité - University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany
2Department of Internal Medicine, Hematology and Oncology, Ruhr-University Bochum
3Department of Hematology and Oncology, Charité - Humboldt-Universitat, Campus Virchow, Berlin, Germany

Impact on Pulmonary Function of Pre-Transplant Radiotherapy in Hodgkin Lymphoma Patients Undergoing Autologous Stem Cell Transplant (ASCT)

Christy Stotler, DO1, Paul Elson, ScD2*, Brian Bolwell, MD1, Matt Kalaycio, MD1, Brad Pohlman, MD1*, Ronald Sobecks, MD1, Robert Dean, MD1, Steven Andresen, DO1*, Edward Copelan, MD1*, Josephine Chan1* and John Sweetenham, MD1*

1Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
2Quantitative Health Sciences, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH

Frequency and Relevance of CD10+CD19+ Hematogones after Allogeneic Stem Cell Transplantation

Axel Nogai, Dr.1*, Eckhard Thiel, Prof., Dr., Dr.1, Thomas Burmeister, Dr.1*, Susanne Ganepola1*, Rita Lippoldt1*, Igor W. Blau, PD, Dr.1*, Olga O. Blau, MD, PhD1, Carola Tietze-Bürger1*, Lutz Uharek, Prof., Dr.2* and Stefan Schwartz, Dr.1*

1Medizinische Klinik III (Haematologie, Onkologie und Transfusionsmedizin), Charite Campus Benjamin Franklin (Charite Centrum 14), Berlin, Germany
2Medical Clinic III - Hematology and Oncology, Charité University Medicine Berlin, Germany

HLA Class I and HLA Class II Antibodies in Whole Blood Donors and a Lookback on Recipients of Their Blood Components

Fleur M Aung, MD1*, Aida Narvios, MD2 and Benjamin Lichtiger2*

1Laboratory Medicine, UT MD ANDERSON CANCER CENTER, Houston, TX
2Laboratory Medicine, UT MD Anderson Cancer Center, Houston, TX

Haploidentical Hematopoietic Stem Cell Transplantation in Children Leukemia and Lymphoma with G-CSF Mobilized Marrow Grafts without T Cell Depletion: A Single Center Report of 45 Cases

HengXiang Wang*, Hong-Min Yan*, Lian-Ning Duan*, Ling Zhu*, Mei Xue* and Jing Liu*

Department of Hematology, General Hospital of PLA, Beijing, China

Complete Donor Chimerism Predicts Molecular Remission in High Risk CLL Following Nonmyeloablative Transplantation

Carol Jones1*, Renee Letzinger2*, James L. Zehnder, MD3 and David Miklos, MD, PhD4

1Pathology, Stanford University, School of Medicine, Palo Alto, CA
2Medicine, Division of Bone Marrow Transplantation, Stanford University, Stanford, CA
3Hematology, Stanford Univ. Medical Center, Stanford, CA
4Stanford University School of Medicine, Stanford, CA

Cotransplantation of Mesenchymal Stem Cells Prompted Platelets Recovery in HLA-Haploidentical/Mismatched Blood and Marrow Transplantation: A Randomized Phase II Study

Kai yan Liu1*, Xiao Jun Huang1, Yu hong Chen1*, Huan Chen1*, Lan ping Xu1*, Xiao hui Zhao1*, Ting Zhao1*, Yu Wang1*, Jin Wang1*, Wei Han1* and Chun hua Zhao2*

1Institute of Hematology, Beijing, China
2ICenter of Excellence in Tissue Engineering, nstitute of BasicMedical Sciences, CAMS & PUMC,, Beijing, China

Reduced Intensity Conditioning with Thiotepa and Fludarabine for Allogeneic Transplantation: Evidence for Low Toxicity and Long-Lasting Disease Control in MDS with Low/Intermediate-1 IPSS Score and in AML from MDS in Complete Remission

Emilio Paolo Alessandrino1*, Luca Malcovati1*, Giorgio La Nasa2*, Paolo de Fabritiis3*, Massimo Bernardi4*, Paolo Di Bartolomeo5*, Paolo Bernasconi1, Anna A Colombo1*, Daniela Caldera1*, Cristiana Pascutto1*, Patrizio Mazza6*, Franco Narni7*, Rosanna Scime'8*, Attilio Olivieri9, Marco Casini10* and Andrea Bacigalupo for GITMO11*

1Division of Hematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
2Cagliari University
3Hematology, University Tor Vergata, Rome, Italy
4Hematology and Bone Marrow Transplantation Unit, IRCCS H San Raffaele, Milano, Italy
5Unità Terapia Intensiva Ematologica per il Trapianto Emopoietico, Ospedale Civile, Pescara, Italy
6Ematologia-Taranto, Italy
7Division of Hematology, Modena University Hospital, Modena, Italy
8Hematology, Ospedale Cervello, Palermo, Italy
9Ospedale San Carlo, Potenza, Italy
10Department of Hematology, Bolzano Central Hospital, Bolzano, Italy
11Ospedale S. Martino, Genova, Italy

Outcomes for Unrelated Donor Hematopoietic Cell Transplantation (URD-HCT) for Patients with Acute Lymphoblastic Leukemia (ALL) Using Fractionated Total Body Irradiation (FTBI) and Etoposide (VP16)

Margaret O'Donnell1, P Parker1*, A Dagis1*, ML Slovak1*, D Snyder1*, A Stein1*, R. Spielberger2*, A Pawlowska1*, J Rosenthal1*, J Palmer1*, N. Kogut2* and S. J Forman1*

1City of Hope, Duarte, CA
2Kaiser Permanente, Duarte, CA

Genetic Polymorphism of Cytochrome P450 1B1 (C432G) Is Associated with An Increased Treatment-Related Mortality and Lower Overall Survival in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Michael Koldehoff, MD*, Ahmet H. Elmaagacli* and Dietrich W. Beelen*

Dept. of Bone Marrow Transplantation, Univ. of Duisburg-Essen, Essen, Germany

High-Sensitivity Monitoring of Hematopoietic Chimerism after Double Umbilical Cord Blood Transplantation by Real-Time Quantitative Polymerase Chain Reaction

Sophie Marty-Grès1*, Marielle Moussiere1*, Odile Avinens1*, Monique Andary1*, Annie Ramounau-Pigot1*, Patrice Ceballos2*, Jean-Côme Meniane2*, Geneviève Margueritte3*, Nathalie Fegueux2*, Jean-Francois Rossi2 and Jean-François Eliaou1*

1Laboratory of Immunology, CHU Montpellier, Montpellier, France
2Hematology-Oncology, CHU Montpellier, Montpellier, France
3Pediatric Onco-Hematology, CHU Montpellier, Montpellier

Genetic Variations in CYP2B6 and Risk of Cyclophosphamide Toxicity in Patients Undergoing Myeloablative Stem Cell Transplantation

Stacy E Melanson, MD, PhD1*, Joseph H. Antin, MD2, Michael H. Court, PhD3*, Vincent Ho4*, Jerome Ritz, MD5, Haesook T. Kim6*, Frank C Kuo, MD, PhD1*, Janina A Longtine, MD1* and Petr Jarolim, MD, PhD7

1Pathology, Brigham and Women's Hospital, Boston, MA
2Brigham & Women's Hospital, Dana-Farber Cancer Inst., Boston, MA
3Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA
4Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
5Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA
6Dana Farber Cancer Institute, Boston, MA
7Harvard Medical School, Brigham and Women's Hosp., Boston, MA

Pharmacokinetics of Alemtuzumab Used as Conditioning Agent in Reduced Intensity Transplantation for Pediatric Non-Malignant Disorders

Julie Kanter, MD, Manasa Kanthamneni*, Shannon Witty*, Yvonne Barnes*, Robert Hayashi* and Shalini Shenoy*

Pediatric Hematology/Oncology, Washington University, St. Louis, MO

*signifies non-member of ASH