Mahadeo Sukhai, BSc, MSc, PhD^1*, Mariam Thomas, BSc^2*, Rashmi Goswami, MD, FRCPC^3*, Yali Xuan, B.Sc.^1*, Patricia Pintor dos Reis, Ph.D.^1* and Suzanne Kamel-Reid, Ph.D., FACMG¹

¹Applied Molecular Oncology, Ontario Cancer Institute, Toronto, ON, Canada
²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
³CIHR Training Program in Molecular Oncologic Pathology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, ON, Canada

Xiaoqing Li^1*, Jun Liu^2*, Rui Zhou^2*, Yanli He^1*, Shi Huang^3*, Shiang Huang, MD¹ and Xian-Ming Chen^2*

¹Institute of Hematology, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China
²Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE
³Burnham Institute for Medical Research, La Jolla, CA

Paola Ballerini^1*, Pierre-Yves Boelle^2*, Caroline Deswarte^3*, Anne Auvrignon^4*, Gabrielle Couchy^5*, Judith Landman-Parker⁶, Alain Robert^7*, Brigitte Nelken^8*, Mircea Adam^1*, Helene Lapillonne^3*, Eric Delabesse, PhD^9*, Christine Perot^10*, Jean Luc Lai^11*, Nicole Dastugue^12*, Claude Preudhomme^13*, Jessica Zucman-Rossi^5* and Guy Leverger^14*

¹Laboratoire d'hématologie,, Hôpital Trousseau APHP, Paris, France
²Inserm 707, UPMC, Paris6, Paris, France
³Umr-S 893, UPMC Paris6,, Paris, France
⁴Pediatric Hematology Oncology, Hopital Trousseau, Paris, France
⁵U 674, INSERM, Paris, France
⁶Pediatric Hematology Oncology, Hopital Trousseau/UPMC-Paris6/ UMR-S893, Paris, France
⁷CHU Toulouse, Toulouse, France
⁸Pediatrics Hematology, CHU Lille, Lille
⁹Laboratoire d'Hématologie, CHU Purpan, Toulouse, France
¹⁰Cytogenetics, Hôpital Saint Antoine, Paris, France
¹¹Cytogenetics, CHRU Lille, Lille, France
¹²Laboratoire d'Hématologie, Hôpital Purpan, Toulouse, France
¹³Laboratoire d'hematologie, CHRU Lille, Lille, France
¹⁴Pediatric Hematology Oncology, Hopital Trousseau APHP/UPMC-Paris6/UMR-S893, Paris, France

Linda Zane^1*, David Sibon^2*, Patrick Mehlen^3*, Rabih Murr^4*, Zdenko Herceg^4*, Franck Mortreux^1* and Eric Wattel^5*

¹Oncovirologie et Biotherapies, CENTRE LEON BERARD, FRE CNRS 3011, Université Lyon 1, LYON Cedex 08, France
²Service Hematologie-Oncologie, HOPITAL ST LOUIS, Paris
³Apoptose, Cancer ET Developpement , Umr Cnrs 5838, CENTRE LEON BERARD, Lyon Cedex 08
⁴IARC, Lyon
⁵Centre LéonBérard, Oncovirologie et Biothérapies, Lyon, France

Sina Koch^1*, Martin Ryser^2*, Angela Jacobi^2*, Sebastian Brenner², Martin Bornhaeuser^1*, Gerhard Ehninger¹ and Christian Thiede^1*

¹Medical Clinic I, University Hospital, Dresden, Germany
²Department of Pediatrics, University Hospital, Dresden, Germany

Anton Parker^1*, Shilu Amin^2*, Tricia Zwiefelhofer^3*, Ben Gregory^1*, Helen White, PhD^4*, Oliver Giles Best, PhD^5*, Nick Cross, PhD^4*, Jelena Mann, PhD^2*, Mathias Ehrich, MD^3* and David Graham Oscier, MD¹

¹Dept. of Hematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
²Dept. of Cell Signalling, University of Newcastle, Newcastle, United Kingdom
³Sequenom, Inc., San Diego, CA
⁴NGRL (Wessex), Salisbury, United Kingdom
⁵Royal North Shore Hospital, Northern Blood Research Centre, Sydney, Australia

Maika Almstedt^1*, Dietmar Pfeifer, PhD^2* and Michael Lubbert³

¹Medicine, University of Freiburg, Freiburg, Germany
²Hematology and Oncology, University of Freiburg, Freiburg, Germany
³University of Freiburg, Freiburg, Germany

Jan-Henning Klusmann, MD^1*, Frank Godinho^2*, Thanaseelan Pushpanathan^1*, Dirk Reinhardt, MD, PhD¹, Stuart H Orkin, MD^2* and Zhe Li, PhD^2*

¹Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany
²Division of Hematology/Oncology, Children's Hospital, Boston, MA

Elizabeth A. Griffiths, MD¹, Craig M. Hooker, MPH^2*, Michael A. McDevitt, MD, PhD³, Judith E. Karp, MD¹, James G. Herman, MD^1* and Hetty E. Carraway, MD¹

¹Department of Oncology, Johns Hopkins Hospital, Baltimore, MD
²School of Medicine, Johns Hopkins University, Baltimore, MD
³Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

Stephanie Halene, MD¹, Ee-chun Cheng, B.S.^2*, Vincent Schulz, Ph.D.^3*, David Tuck, M.D.^4* and Diane Krause, MD, PhD⁵

¹Internal Medicine, Yale Univ. School of Med., New Haven, CT
²Laboratory Medicine, Yale Univ. School of Med., New Haven, CT
³Pediatrics, Yale Univ. School of Med., New Haven, CT
⁴Pathology, Yale Univ. School of Med., New Haven, CT
⁵Yale University School of Medicine, New Haven, CT

Anne Novak¹, Takashi Akasaka^2*, Michelle Manske^1*, Mamta Gupta^1*, Thomas Witzig^1*, Martin JS Dyer^3*, Ahmet Dogan⁴, Ellen Remstein^4* and Stephen Ansell^1*

¹Division of Hematology, Mayo Clinic, Rochester, MN
²MRC Toxicology Unit, Leicester, United Kingdom
³MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom
⁴Divisions of Anatomic Pathology and Hematopathology, Mayo Clinic, Rochester, MN

Arati V Rao^1*, Sascha A Tuchman^1*, Anil Potti^2*, David A. Rizzieri, MD³, Hiroyuki Mano^4*, Ruud Delwel, PhD⁵, Peter Valk⁶ and B. Lowenberg, MD⁵

¹Medical Oncology, Duke University Medical Center, Durham, NC
²Medical Oncology, Duke Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC
³Cellular Therapy, Duke Univ. Med. Ctr., Durham, NC
⁴Division of Functional Genomics, Jichi Medical University, Shimotsuke-shi, Tochigi, Japan
⁵Erasmus University Medical Center, Rotterdam, Netherlands
⁶Hematology, Erasmus University Medical Center, Rotterdam, Netherlands

Elizabeth A. Griffiths, MD¹, Craig M. Hooker, MPH^2*, Michael A. McDevitt, MD, PhD³, Judith E. Karp, MD¹, James G. Herman, MD^1* and Hetty E. Carraway, MD¹

¹Department of Oncology, Johns Hopkins Hospital, Baltimore, MD
²School of Medicine, Johns Hopkins University, Baltimore, MD
³Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

Julia Gambone, B.A.^1*, Stephanie Dusaban^2* and Susan Shetzline, Ph.D.³

¹Medicine, University of South Carolina, SC
²Molecular Medicine, Cornell University, Ithaca, NY
³Medicine-Hematology/Oncology, University of Pennsylvania, Philadelphia, PA

Alena Y. Zhang, PharmD, PhD^1*, Blaine W. Robinson, PhD¹, Kajia Cao, PhD^2*, Kathryn Behling, MD, PhD^1*, Meenakshi Devidas, PhD^3*, Todd Alonzo, PhD^4*, Susana C. Raimondi, PhD⁵, Andrew Carroll, PhD^6*, Robert J. Arceci, MD, PhD⁷, Alan Gamis, MD⁸, Stephen P. Hunger, MD⁹, Gregory H. Reaman, MD¹⁰, Richard C. Harvey, PhD¹¹, Cheryl L. Willman, MD¹¹, Li-San Wang, PhD^2* and Carolyn A. Felix, MD¹²

¹Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA
³Department of Epidemiology & Health Policy Research, University of Florida College of Medicine, Gainesville, FL
⁴Department of Preventive Medicine, University of Southern California, Arcadia, CA
⁵Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁶Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
⁷Department of Pediatrics, Johns Hopkins University of School of Medicine, Baltimore, MD
⁸Division of Hematology/ Oncology/ Bone Marrow Transplantation, Children's Mercy Hospital & Clinics, Kansas City, MO
⁹University of Colorado Denver School of Medicine and The Children's Hospital, Aurora, CO
¹⁰Children's National Medical Center, Washington, DC
¹¹Department of Pathology, The Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM
¹²Division of Oncology and Department of Pediatrics, The Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA

Richard C. Harvey, PhD¹, I-Ming Chen, MS^2*, Kerem Ar, MS^1*, Stephen P. Hunger, MD³, Mignon Loh, MD³, Eric C. Larsen, MD^3*, Meenakshi Devidas, PhD^3*, Elizabeth Raetz, MD³, Gregory Reaman, MD³, William L. Carroll, MD³, Naomi Winick, MD³, Malcolm Smith, MD, PhD^4*, Kevin K Dobbin, PhD^4* and Cheryl L. Willman, MD¹

¹University of New Mexico Cancer Center, Albuquerque, NM
²Department of Pathology, The Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM
³Children's Oncology Group, Arcadia, CA
⁴National Cancer Institute, Bethesda, MD

Susumu Goyama^*, Eriko Nitta^*, Munetake Shimabe^*, Tetsuya Yoshino^*, Shinichi Kako^*, Motoshi Ichikawa^*, Yoichi Imai^*, Tsuyoshi Takahashi^*, Akira Hangaishi^* and Mineo Kurokawa, MD, PhD

Hematology and Oncology, University of Tokyo, Tokyo, Japan

Marianne Eyholzer^1*, Julian Schardt^2*, Deborah Shan^1*, Beatrice U Mueller^3* and Thomas Pabst⁴

¹Department of Clinical Research, University of Bern, Bern, Switzerland
²Department of Oncology and Clinical Research, University Hospital, Bern, Switzerland
³Department of Internal Medicine, University Hospital, Bern, Switzerland
⁴Institute of Medical Oncology, Berne, Switzerland

Tomoya Minami^*, Osamu Horie, Ph.D.^*, Kana Inoue^*, Sawako Toji^*, Norinaga Urahama, M.D., Ph.D.^* and Mitsuhiro Ito, M.D., Ph.D.

Laboratory of Hematology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan

Medhanie Assmelash Mulaw^*, Alexandre Krause^*, Alexander Riedel^*, Belay Tizazu^*, Hendrik Reuter^* and Stefan K. Bohlander^*

Department of Medicine III, CCG Leukemia, HelmholtzZetrum Muenchen, University of Munich, Germany, Munich, Germany

Asahito Hama, MD^1*, Hiroshi Yagasaki, MD, PhD^1*, Hideki Muramatsu, MD^1*, Nobuhiro Nishio, MD^1*, Akihiro Abe, MD, PhD², Yoshiyuki Takahashi, MD, PhD^1* and Seiji Kojima, MD, PhD^1*

¹Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
²Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Joost C. van Galen, MSc^1*, Roland P. Kuiper, PhD², Liesbeth van Emst, BSc^1*, Marloes R. Levers, BSc^1*, Simon V. van Reijmersdal, BSc^2*, Ad Geurts van Kessel, PhD^2*, Peter M. Hoogerbrugge, MD, PhD¹ and Frank N. van Leeuwen, PhD¹

¹Pediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
²Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

Weigang Tong, MD, PhD^*, Shao-Qing Kuang, MD, PhD^*, William Wierda, MD, PhD^*, Michael J. Keating, MD and Guillermo Garcia-Manero, MD

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Anmaar Abdul-Nabi, MD^1*, Enas R Yassin, MD^2*, Akiko Takeda, PhD³ and Nabeel R. Yaseen, MD, PhD⁴

¹Pathology and Immunology, Washington University in St.Louis, School of medicine, Saint Louis, MO
²Pathology and Immunology, Washington University in St. Louis, St. Louis, MO
³Washington University Sch of Medicine, Saint Louis, MO
⁴Pathology and Immunology, Washington University in St Louis, Saint Louis, MO

Erin K Hertlein, PhD¹, Derek A. West^1*, Ruth W Craig, PhD^2*, David M Lucas, PhD¹ and John C. Byrd, MD¹

¹Department of Internal Medicine, The Ohio State University, Columbus, OH
²Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH