Before you can access ASH's online program, you must agree to the following:
Last updated January 16, 2009. Please note that this site represents the latest program changes
and differs from the print version in some details.

Bone Marrow Failure Poster III

Monday, December 8, 2008: 5:30 PM-7:30 PM
Hall A (Moscone Center)
Remission in Patients with Diamond Blackfan Anemia (DBA) Appears to Be Unrestricted by Phenotype or GenotypeClinically Relevant Abstract

Hun Lee, MD1, Charalampos Lyssikatos, MD2*, Eva Atsidaftos, MA3*, Ellen Muir, RN2*, Hanna Gazda, MD, PhD4, Alan H. Beggs, PhD4*, Jeffrey Michael Lipton, MD, PhD3 and Adrianna Vlachos, MD3

1Medicine, Long Island Jewish Medical Center, New Hyde Park, NY
2Hematology/Oncology and Stem Cell Transplantation, Schneider Children's Hospital, New Hyde Park, NY
3Hematology/Oncology and Stem Cell Transplantation, The Feinstein Institute for Medical Research, Schneider Children's Hospital, New Hyde Park, NY
4Genetics and Program in Genomics, Children's Hospital Boston, Harvard Medical School, Boston, MA

Embryoid Body Defect in Mouse Rps19-Haploinsufficient Embryonic Stem Cell Model of Diamond Blackfan Anemia

Sharon Singh, MD1*, Sehba Dsilva, MD1*, Jeffrey Michael Lipton, MD, PhD2, Steven Ellis, PhD3 and Johnson M. Liu, MD1

1Department of Pediatrics, The Feinstein Institute for Medical Research, Manhasset, NY
2Hematology/Oncology and Stem Cell Transplantation, Schneider Children's Hospital, New Hyde Park, NY
3Department of Biochemistry, University of Louisville, Louisville, KY

Copper Deficiency Remains An Underappreciated Cause of Ineffective HematopoiesisClinically Relevant Abstract

Amelia Langston, MD1, Jessica Neely, PA1*, Leonard Heffner1, D. Griffith2*, Martha Arellano, MD1, Gregory Esper, MD3*, Morgan L. McLemore, MD1, Thomas Ziegler, MD2*, Christine Kempton, MD4, Rajni Sinha, MD1*, H. Jean Khoury, MD1 and Elliott Winton1

1Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA
2Department of Medicine, Emory University School of Medicine, Atlanta, GA
3Department of Neurology, Emory University School of Medicine, Atlanta, GA
4Department of Hematology and Medical Oncology, and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA

Whole Genome Scanning in Aplastic Anemia Indicates That Polymorphisms in CD33 and Other Loci Can Constitute Predisposition Factors in This Disease

Bartlomiej P Przychodzen1*, Monika Jasek1*, Sandra P Smieszek1*, Anna Malgorzata Jankowska1*, Christine O'Keefe, PhD1*, Ronald Paquette, MD2 and Jaroslaw P. Maciejewski, MD, PhD1

1Experimental Hematology and Hematopoiesis Section, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH
2Dept. of Med., UCLA, Los Angeles, CA

TERT Mutations in Patients with Squamous Cell Carcinoma of the Tongue and Refractory Anemia

Geraldine Aubert, PhD1*, Mark Hills, PhD1*, Carol Cremin, MSc, CCGC2*, Irma Vulto1*, Barbara McGillivray, MD, FRCPC, FCCMG3* and Peter M. Lansdorp, MD, PhD1

1BC Cancer Research Centre, Terry Fox Laboratory, Vancouver, BC, Canada
2Hereditary Cancer Program, British Columbia Cancer Agency, Vancouver, Canada
3Department of Medical Genetics - Hereditary Cancer program - Room C234, BC Children's Hospital, Vancouver, BC, Canada

Combined Disruptions of the Ribosomal Protein s19 and Pim1 Kinase Genes Are Associated with Increased Myeloid/Erythroid Cellularity and Reduced Apoptosis

Anne-Sophie Fröjmark1*, Jitendra Badhai1*, Jens Schuster1*, Joakim Klar1*, Maria Thuvesson1*, Steven Ellis, PhD2 and Niklas Dahl1*

1Genetics and Pathology, Uppsala University, Uppsala, Sweden
2Department of Biochemistry, University of Louisville, Louisville, KY

Relapse of Children with Aplastic Anemia after Immunosuppressive TherapyClinically Relevant Abstract

Takuya Kamio, MD, PhD1*, Etsuro Ito, MD, PhD1, Akira Ohara, MD2, Yoshiyuki Kosaka, MD.PhD3*, Masahiro Tsuchida, MD4, Hideo Mugishima, MD, PhD5, Hiromasa Yabe, MD6*, Akira Morimoto, MD, PhD7*, Shouichi Ohga, MD, PhD8*, Hiroshi Yagasaki, MD.PhD9*, Fumio Bessho, MD, PhD10*, Tatsutoshi Nakahata, M.D., Ph.D.11 and Seiji Kojima, MD, PhD9*

1Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
2Department of Pediatrics, Toho University, Tokyo, Japan
3Department of Hematology and Oncology, Kobe Children's Hospital, Kobe, Japan
4Department of Pediatrics, Ibaraki Children's Hospital, Mito, Japan
5Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan
6Department of Cell Transplantation, Tokai University School of Medicine, Isehara, Japan
7Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
8Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
9Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
10Department of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan
11Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

BMI1 Interacts with FANCD2 at DNA Lesions and Prevents Chromosome Breaks

Jalila Chagraoui, PhD1, Josee Hebert, MD2, Simon Girard3* and Guy Sauvageau, MD, PhD4

1Laboratories of Molecular Genetics of Hematopoietic Stem Cells, Institute for Research in Immunology and Cancer (IRIC), Montreal, QC, Canada
22Department of Medicine and Division of Hematology and Leukemia Cell Bank of Quebec, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada
3Laboratories of Molecular Genetics of Hematopoietic Stem Cells, Institute for Reserch in Immunology and Cancer (IRIC), QC, Canada
4Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC, Canada

High Frequency of RPL11 Gene Mutation in Italian Patients with Diamond-Blackfan Anemia

Paola Quarello1*, Emanuela Garelli1*, Adriana Carando1*, Maria Francesca Campagnoli1*, Alfredo Brusco2*, Irma Dianzani3* and Ugo Ramenghi4

1Dipartimento di Scienze Pediatriche, Università di Torino, Torino, Italy
2Dipartimento di Genetica, Biologia e Chimica Medica, Università degli Studi di Torino, Torino, Italy
3Dipartimento di Scienze Mediche, Università del Piemonte Orientale, Novara, Italy
4Dipartimento di Scienze Pediatriche, Università degli Studi di Torino, Torino, Italy

Characterization of Novel Natural Mutations in Telomere Binding Protein Factor (TIN2) Identified in Patients with Bone-Marrow Failure Syndromes

Zhong-Tao Xin, PhD1*, Rodrigo Calado, MD, PhD2, Sharon A Savage, MD, FAAP3, Peter M Lansdorp4*, Neal S Young, MD5* and Hinh Ly, PhD1

1Department of Pathology, Emory University, Atlanta, GA
2National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD
3Division of Cancer Epidemiology and Gene, National Cancer Institute, Bethesda, MD
4Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
5National Institutes of Health, National Heart, Lung, and Blood Inst., Bethesda, MD

Age-Adjusted Telomere Length Is Not Associated with Variation in Hematological Parameters in Ageing Women

Isabelle Fleury, MD1, Sylvie Provost, M.Sc.1*, Claude Belisle, M.Sc.1* and Lambert Busque, MD2

1Hematology, Hôpital Maisonneuve-Rosemont and University of Montreal, Montreal, QC, Canada
2Hematology, Maisonneuve-Rosemont Hospital and University of Montreal, Montreal, QC, Canada

The Frequency and Characteristics of the Ribosomal Protein L5 (RPL5) and Ribosomal Protein L11 (RPL11) Gene Mutations in Patients with Diamond-Blackfan Anemia in the Czech National Registry

Dagmar Pospisilova, MD1*, Radek Cmejla, PhD2*, Jana Cmejlova, PhD2*, Helena Handrkova2*, Jan Stary, MD, PhD3* and Zdenka Cerna, MD4*

1Pediatrics, Palacky University and University Hospital Olomouc, Olomouc, Czech Republic
2Institute of Hematology and Blood Transfusion, Prague, Czech Republic
3Dept of Pediatric Hematology and Oncology, 2nd Medical School, Charles University Hospital Motol, Prague, Czech Republic
4Pediatrics, Charles University Hospital Plzen, Plzen, Czech Republic

Identification and Partial Characterization of a Novel Partner Protein for Fanconi Anemia Protein FANCM

Stacie Stone, Ph.D.1*, Alexandra Sobeck, Ph.D.1*, Igor Landais, Ph.D.1*, Weidong Wang, Ph.D.2* and Maureen Hoatlin, PhD1

1Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR
2Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore

*signifies non-member of ASH