50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Experimental Transplantation

Sunday, December 7, 2008: 6:00 PM-8:00 PM

Hall A (Moscone Center)

Graft-Versus-Host Tolerance in Dogs Following T-Cell Depleted Bone Marrow Transplantation with Absorbed ATG or CD6-Antibody

Julia Zorn¹^* and Hans Jochem Kolb, MD²

¹Institute of Molecular Immunology, Clinical Cooperation Group Hematopoietic Cell Transplantation, Helmholtz Zentrum Muenchen, Muenchen, Germany
²3. Medizinische Klinik, Transplantationseinheit, München, Germany

2339

UTY-Coded Minor Histocompatibility Antigens as Targets for a Graft-Versus-Host Reaction against Hematopoietic Cells in the Dog

Dagmar Bund¹^*, Raymund Buhmann²^*, Julia Zorn³^*, Helga Schmetzer Jr.⁴^* and Hans-Jochem Kolb⁵

¹Clinical Cooperation group Hematopoietic cell transplantation, Helmholtz Center Munich, Munich, Germany
²Medical Clinic III, Klinikum Großhadern Medical Center (KGMC), Klinikum Großhadern, Ludwig-Maximilians-University Munich, Munich, Germany
³Institute of Molecular Immunology, Clinical Cooperation Group Hematopoietic Cell Transplantation, Helmholtz Zentrum Muenchen, Muenchen, Germany
⁴Dept for Hematopoetic Transplantations, MED3, University of Munich,Germany, Munich, Germany
⁵Medical Clinic III, Klinikum GroÃŸhadern Medical Center (KGMC), Klinikum GroÃŸhadern, Ludwig-Maximilians-University Munich, Munich, Germany

2340

TCRbeta Gene Rearrangements for Detection and Monitoring of Minimal Residual Disease after Allogenic Stem-Cell Transplantation in Patients with Advanced Mycosis Fungoides and Sézary Syndrome

Laura Corti, MS¹^*, Giorgia Saporiti, MD²^*, Elisa Fermo, MS³^*, Emilio Berti, MD⁴^*, Luigia Venegoni, MS⁵^*, Giorgio Lambertenghi Deliliers, MD² and Francesco Onida, MD²

¹Department of Pharmacology, Chemotherapy and Medical Tossicology - University of Milan, Fondazione Matarelli, Milan, Italy
²Department of Medical Science - O.U. Hematology 1 - CTMO, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena and University of Milan, Milan, Italy
³O.U. Hematology 2, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy
⁴Department of Dermatology, University of Milan-Bicocca and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
⁵O.U. Dermatology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy

2341

Roscovitine Prevents Alloreactive T Cell Expansion and TNF-a-Mediated Proinflammatory Gene Expression and Protects against GvHD

Lequn Li, MD, PhD¹^*, Hui Wang, MD, PhD², Roderick Bronson, MD³^* and Vassiliki Boussiotis, MD, PhD⁴^*

¹Hematology Oncology and Cancer Biology, Harvard Institutes of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
²Massachusetts General Hospital, Boston, MA
³Department of Rodent Pathology, Harvard Medical School, Boston, MA
⁴Hematology-Oncology and Cancer Biology, Harvard Institutes of Medicine, Beth Israel Deaconess Medical Center, Boston, MA

2342

Donor T Cell Production of IL-21 Accelerates Graft-Versus-Host Disease Lethality

Christoph Bucher, MD¹, Christine Vogtenhuber, PhD¹^*, Lisa Jasperson¹^*, Angela Panoskaltsis-Mortari, PhD², Emily Goren³^*, Pallavur Sivakumar, PhD⁴^* and Bruce R. Blazar, MD³

¹Univ. of Minnesota, Minneapolis, MN
²Dept. of Pediatrics, University of Minnesota, Minneapolis, MN
³University of Minnesota, Minneapolis, MN
⁴Zymogenetics Inc., Seattle, WA

2343

Paradoxical Effects of Interferon-γ in Allogeneic Bone Marrow Transplant: Donor Dendritic Cells Regulate Graft-Versus-Leukemia and Graft-Versus-Host Disease Activities

Ying Lu, PhD^*, Jian-Ming Li, PhD, Wayne Harris, BS^* and Edmund Waller, MD, PhD

Emory University, Winship Cancer Inst., Atlanta, GA

2344

Large Scale Selective Ex Vivo Expansion of CD4⁺CD25⁺FOXP3⁺ Regulatory T Cells from Peripheral Blood

Tokiko Nagamura-Inoue, MD, PhD¹, Kazuo Ogami¹^*, Kazuaki Yokoyama²^*, Kiyoko Izawa²^*, Seiichiro Kobayashi²^*, Shin Nakayama¹^*, Ikuo Ishige¹^*, Yusuke Inoue³^*, Jun Ooi²^*, Kaoru Uchimaru²^*, Satoshi Takahashi²^* and Arinobu Tojo⁴^*

¹Dep. of Cell Processing and Transfusion, Research Hospital, Institute of Medical Sciece, Univ. of Tokyo, Tokyo, Japan
²Dep. of Hematology/Oncology, Research Hospital, Institute of Medical Sciece, Univ. of Tokyo, Tokyo, Japan
³Dep. of Radiology, Research Hospital, Institute of Medical Sciece, Univ. of Tokyo, Tokyo, Japan
⁴Dep. of Cell Processing and Transfusion, and Hematology/Oncology, Research Hospital, Institute of Medical Sciece, Univ. of Tokyo, Tokyo, Japan

2345

Donor Bone Marrow Derived IL-17 Expressing Cells Exacerbate Chronic Graft-Versus-Host Disease in a Murine Bone Marrow Transplantation

Rie Kuroda, MD¹^*, Ryosei Nishimura, MD, PhD¹^*, Katsuaki Sato, MD, PhD²^*, Hideaki Maeba, MD¹, Kazuhito Naka, PhD³^*, Yo Niida, MD, PhD¹^*, Raita Araki, MD¹^*, Yoichiro Iwakura, PhD⁴^*, Shoichi Koizumi, MD, PhD¹^* and Akihiro Yachie, MD, PhD¹^*

¹Pediatrics, Graduate School of Medical Science and School of Medicine, Kanazawa University, Kanazawa, Japan
²Pathophysiological and Experimental Pathology, Kanazawa Medical University, Kanazawa, Japan
³Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
⁴Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan

2346

Peripheral Alloantigen Drives Early Dysfunction and Eventual Exhaustion of CTL Following Delayed Donor Leukocyte Infusions

Barry R Flutter, PhD¹^*, Farnaz Fallah-Arani, PhD¹^*, Clare Bennett, PhD¹^*, Janani Sivakumaran¹^*, Gordon J Freeman, PhD²^*, Megan Sykes, MD, PhD³ and Ronjon Chakraverty, MD, PhD¹

¹Transplantation Immunology Group, University College London, London, United Kingdom
²Dana Faber Cancer Institute/Harvard Medical School, Boston, MA
³Transplant Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA

2347

GITR Ligand on Leukemic Myeloid Dendritic Cells Suppresses Induction of Leukemia-Associated Antigen-Specific CTLs from Naïve CD8⁺ T Cells

Yukio Kondo, MD, PhD^*, Takamasa Katagiri, PhD^*, Kinya Ohata, MD^* and Shinji Nakao, MD, PhD

Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan

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^*signifies non-member of ASH

Experimental Transplantation - GVHD and GVL Poster II