50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Blood Coagulation and Fibrinolytic Factors Poster II

Sunday, December 7, 2008: 6:00 PM-8:00 PM

Hall A (Moscone Center)

2012

The Regulatory Function of Amino Acid Region 659-663 of Factor Va on Prothrombinase during Thrombin Formation

Jamila Hirbawi^* and Michael Kalafatis^*

Cleveland State University, Cleveland, OH

2013

Assembly of the Prothrombinase Complex on Human Fibroblast Surface Is Enhanced by TSP1 and Leads to CTGF Upregulation by a Different Mechanism from the One Used by FXa and Thrombin

Mario C. Rico, M.D.¹, James J. Rough, M.D.²^*, Joanne M. Manns, Ph.D.³^*, Satya P. Kunapuli, Ph.D.¹ and Raul A. De La Cadena, M.D.¹

¹Physiology, Temple University School of Medicine, Philadelphia, PA
²Surgery, Temple University School of Medicine, Philadelphia, PA
³Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA

2014

Fluorescence Resonance Energy Transfer Studies of Prothrombin Recognition by Prothrombinase

Erin Zekas, B.S.^* and Sriram Krishnaswamy, PhD

Children's Hospital of Philadelphia, Philadelphia, PA

2015

The Role of the P1 Residue of Protease Nexin 2 and Basic Pancreatic Trypsin Inhibitor in the Mechanism of Factor XIa Inhibition

Duraiswamy Navaneetham, Ph.D.¹^*, Dipali Sinha, PhD²^* and Peter N. Walsh, MD, PhD³

¹Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA
²Oms 311, Temple University, Philadelphia, PA
³Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA

2016

Lysine-Binding Site-Dependent Interaction with Plasmin and Factor Va Responsible for Plasmin-Catalyzed Factor Va Inactivation

Katsumi Nishiya¹^*, Keiji Nogami¹^*, Kiyotaka Okada²^*, Osamu Matsuo²^*, Kenichi Ogiwara¹^* and Midori Shima¹

¹Department of Pediatrics, Nara Medical University, Kashihara , Nara, Japan
²Department of Physiology 2, Kinki University School of Medicine, Sayama City, Osaka, Japan

2017

Molecular weight-Dependent Mechanism of Heparin Neutralization by Platelet factor 4

Martine Marie Fiore, PhD^* and Ian J Mackie, Reader, in, Haemostasis, and, Th^*

Haematology, University College London, London, United Kingdom

2018

Mapping Interactions Between B2GPI and the Lipoprotein Receptors by Solution NMR Spectroscopy

Natalia Beglova, PhD and Chang-Jin Lee, PhD^*

Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

2019

Protease Activated Receptor-4 (PAR4) Uses Anionic Residues to Interact with α-Thrombin in the Absence or Presence of PAR1

Marvin T Nieman, PhD

Hematology-Oncology, Case Western Reserve University School of Medicine, Cleveland, OH

2020

Recombinant Protein Infusion and Hydrodynamic Plasmid Delivery Strategies Provide Distinct and Complementary Approaches to the Characterization of Variant Forms of Von Willeband Factor (VWF) in VWF Knockout Mice

Cynthia M. Pruss, BSc^*, Carol A. Hegadorn^*, Andrea Labelle^*, Erin Burnett^*, Mia Golder^* and David Lillicrap, MD

Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada

2021

Comparative Effects of the Direct Factor Xa Inhibitor, Apixaban, and the Direct Inhibitors of Factor VIIa, XIa and Thrombin on Tissue Factor-Induced Human Platelet Aggregation

Xiaosui Jiang¹^* and Pancras C. Wong, PhD, MBA²^*

¹Thrombosis Research, Bristol-Myers Squibb Company, Pennington, NJ
²Thrombosis Biology, Bristol-Myers Squibb Company, Pennington, NJ

2022

Effects of Substrate Geometry on Active Site Engagement Govern the Preferential Action of Prothrombinase on One of the Two Cleavage Sites in Prothrombin

Harlan N Bradford, B.S.^*, Joseph A Micucci, B.S.^* and Sriram Krishnaswamy, PhD

Children's Hospital of Philadelphia, Philadelphia, PA

2023

The Fibrinogen Elongated γ-Chain Inhibits Thrombin-Induced Platelet Response, Hindering the Interaction with Different Receptors

Stefano Lancellotti, BSc¹^*, Sergio Rutella, MD, PhD², Vincenzo De Filippis, PhD³^*, Nicola Pozzi, PhD³^*, Bianca C Rocca, MD, PhD⁴^* and Raimondo De Cristofaro, MD¹^*

¹Medicine, Catholic University Medical School, Rome, Italy
²Hematology, Catholic University Medical School, Rome, Italy
³Pharmaceutical Sciences, University of Padua, Padua, Italy
⁴Pharmacology, Catholic University Medical School, Rome, Italy

2024

Role of Mg²⁺ in Extrinsic and Intrinsic Coagulation Under Physiologic Conditions

Sayeh Agah¹^*, Amanda Sutton²^*, William H Velander²^* and S. Paul Bajaj³

¹Orthopaedic Surgery, UCLA/Orthopaedic Hospital, Los Angeles, CA
²Chemical and Biomolecular Engineering, University of Nebraska Lincoln, Lincoln, NE
³UCLA/Orthopedic Hospital, Los Angeles, CA

2025

Engineered Factor IX with Augmented Clotting Activities in a Hemophilia B Mouse Model

Chia-Ni Lin¹^*, Chung-Yang Kao¹^*, Chia-Lun Hong¹^*, Peiqing Ye²^*, Carol H. Miao, PhD³, Nobuko Hamaguchi⁴^*, Hua-Lin Wu⁵^*, Guey-Yueh Shi⁵^*, Yung-Li Yang⁶^*, I-Shing Yu¹^*, Mi-Hua Tao⁷^*, Cheng-Chieh Fang⁷^*, Yi-Lin Liu⁸^*, Katherine A. High, MD⁹ and Shu-Wha Lin¹^*

¹Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
²Seattle Children's Hospital Research Institute, Seattle, WA
³Seattle Children's Hospital Research Institute and Department of Pediatrics, University of Washington, Seattle, WA
⁴Department of Biochemistry, Brandeis University, Waltham, MA
⁵Department of Biochemistry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
⁶Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
⁷Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
⁸Department of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
⁹Howard Hughes Medical Institute, The Children's Hospital of Philadelphia, Philadelphia, PA

2026

Differential Anticoagulant Effects of Protein S on Vascular Cells and Platelets

Herm Jan Brinkman^*, Erica Sellink^*, Bas de Laat^* and Koen Mertens

Dept Plasma Proteins, Sanquin Blood Supply Foundation, Amsterdam, Netherlands

2027

Non-Classical Anti-Factor VIII C2 Domain Antibodies Are Pathogenic in a Murine in Vivo Bleeding Model

Shannon Meeks, MD, John F. Healey, BS^*, Ernest T. Parker, BS^*, Rachel T. Barrow, BS^* and John (Pete) Lollar, MD^*

Pediatrics, Emory University, Atlanta, GA

2028

A Unique Recombinant Plasmin Molecule Lacking Kringles 2-5 Possesses Equivalent Hemostatic Safety as Full-Length Human Plasmin

Victor J. Marder, MD¹, Valery Novokhatny²^*, Steve Manyak¹^*, Theresa Gruber¹^*, Jennifer Hunt³^*, John Bromirski²^*, Abha Goyal¹^*, Philip Scuderi²^* and Steve Petteway⁴^*

¹Division of Hematology/Medical Oncology, Los Angeles, CA
²Research & Preclinical Development, Talecris BioTherapeutics, Inc, Research Triangle Park, NC
³Preclinical Development, Talecris BioTherapeutics, Inc, Research Triangle Park, NC
⁴Research & Development, Talecris BioTherapeutics, Inc, Research Triangle Park, NC

2029

Structural and Functional Investigations of Active Site Binding Regions in Factor VIIa

S. Paul Bajaj¹, Amanda Sutton²^*, Sreejesh Shanker³^*, Amy E Schmidt³^*, Sayeh Agah³^*, William H Velander²^*, Kaillathe Padmanabhan⁴^* and Duilio Cascio⁵^*

¹UCLA/Orthopedic Hospital, Los Angeles, CA
²Chemical and Biomolecular Engineering, University of Nebraska Lincoln, Lincoln, NE
³Orthopaedic Surgery, UCLA/Orthopaedic Hospital, Los Angeles, CA
⁴Biochemistry, Michigan State University, East Lansing, MI
⁵Institute for Genomics and Proteomics, UCLA, Los Angeles, CA

2030

Structural and Functional Significance of Amino Acid Lysine192 (chymotrypsin numbering) in Factor XIa and Factor VIIa

Amy E Schmidt¹^*, Sayeh Agah¹^*, Mao-fu Sun²^*, Kaillathe Padmanabhan³^*, Duilio Cascio⁴^*, David Gailani⁵ and S. Paul Bajaj⁶

¹Orthopaedic Surgery, UCLA/Orthopaedic Hospital, Los Angeles, CA
²Pathology and Medicine, Vanderbilt University, Nashville, TN
³Biochemistry, Michigan State University, East Lansing, MI
⁴Institute for Genomics and Proteomics, UCLA, Los Angeles, CA
⁵Department of Pathology and Medicine, Vanderbilt University School of Medicine, Nashville, TN
⁶UCLA/Orthopedic Hospital, Los Angeles, CA

2031

Leslie R. Berry^* and Anthony K. C. Chan, MBBS

Pediatrics, Henderson Research Centre, McMaster University, Hamilton, ON, Canada

2032

Protein Z Dependent Protease Inhibitor Inhibition of Factor XIa Is Accelerated by Unfractionated Heparin in the Presence and Absence of Protein Z: Further Evidence of the Potential Significance of XIa Inhibitory Activity

Laura Young, FRACP, FRCPA¹^*, Neil Van de Water, PhD²^*, Paul L Harper, MD, FRCP, FRACP³^*, Paul A. Ockelford, FRACP, MD, FRCPA⁴, Anita Horvath, PhD⁵^*, Paul Coughlin, FRACP, PhD⁵^* and Peter Browett, MBChB, FRACP, FRCPA⁶

¹Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
²LabPlus, Auckland City Hospital, Auckland, New Zealand
³Clinical Haematology, Palmerston North Hospital, Palmerston North, New Zealand
⁴Diagnostic Med. Lab. Ltd., Auckland, New Zealand
⁵Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
⁶University of Auckland, Auckland, New Zealand

2033

Expression of Tissue Factor Is up-Regulated in U937/PR9 Cells by the PML/RARα Fusion Protein through Its Interaction with the Regulatory Region of Tissue Factor Promoter

Jingsong Yan^*, Hongchen Liu^*, Xiaoyu Su^*, Ping Wang^*, Zhen Ruan^*, Kankan Wang^*, Zhu Chen, Saijuan Chen^* and Xiaodong Xi^*

Shanghai Institute of Hematology and State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH