50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Platelet Activation and Biochemistry Poster II

Sunday, December 7, 2008: 6:00 PM-8:00 PM

Hall A (Moscone Center)

Role of CalDAG-GEFI in Calcium-Dependent Thromboxane A2 Generation

Lucia Stefanini, PhD¹, R. Claire Roden²^* and Wolfgang Bergmeier, PhD²

¹Dept. of Medicine and Cardeza Foundation, Thomas Jefferson University, Philadelphia, PA
²Thomas Jefferson University, Philadelphia, PA

2853

The Role of Akt3 in Platelet Activation

Kelly A O'Brien¹^*, Aleksandra Stojanovic¹^*, Nissim Hay, PhD²^* and Xiaoping Du, MD, PhD¹

¹Pharmacology, University of Illinois at Chicago, Chicago, IL
²Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL

2854

Negative Regulation of Gq-Mediated Pathways in Platelets by G12/13 Pathways through Fyn Kinase

Soochong Kim, DVM, PhD^* and Satya P. Kunapuli, Ph.D.

Physiology, Temple University School of Medicine, Philadelphia, PA

2855

nPKC Epsilon Negatively Regulates Platelet Functional Responses

Yamini Saraswathy Bynagari, B-Tech.¹^*, Bela Nagy, M.D¹^*, Kamala Bhavaraju, MS¹^*, Donna Woulfe, PhD², Soochong Kim, PhD³^* and Satya P. Kunapuli, Ph.D.³

¹Physiology, Temple University School of medicine, Philadelphia, PA
²Medicine, Thomas Jefferson University, Philadelphia, PA
³Physiology, Temple University School of Medicine, Philadelphia, PA

2856

Characterization of the Weak Interaction of C-Src with the β3 Cytoplasmic Tail

David T. Moore¹^*, Anjali Ganjiwale¹^*, Hong Cheng²^*, Heinrich Roder²^*, William F. DeGrado¹^* and Joel S. Bennett, MD³

¹Biochemistry/Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA
²Biomolecular Structure and Function, Fox Chase Cancer Center, Philadelphia, PA
³University of Pennsylvania, Philadelphia, PA

2857

Mechanism of Thrombocytopenia Induced by Anti-CD40 Ligand Immune Complexes and the Prevalence of CD40 Ligand Autoantibodies in Patients with Thrombotic Autoimmune Disorders

Ali Amirkhosravi, Ph.D.¹^*, Todd V Meyer, Ph.D.¹^*, Liza Robles-Carillo, MS¹^*, Monica Davila, Ph.D.¹^*, Florian Langer, MD²^*, Hina Desai, MS¹^*, Patricia Weinstein, RN³^*, Mildred Amaya, MS¹^*, Eduardo Reyes, MS¹^* and John L Francis, Ph.D.¹

¹Center for Thrombosis Research, Florida Hospital, Orlando, FL
²Hematology and Oncology, University Hospital Eppendorf, Hamburg, Germany
³College of Nursing, University of Central Florida, Orlando, FL

2858

A Conserved Transmembrane Domain Interface Regulates Integrin Function

Bryan W, Berger¹^*, Lisa M. Span¹^*, Daniel W, Kulp¹^*, Paul C. Billings¹^*, William F. DeGrado¹^* and Joel S. Bennett, MD²

¹Biochemistry/Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA
²University of Pennsylvania, Philadelphia, PA

2859

NK Cell Anti-Tumor Reactivity Is Impaired by Platelet-Derived TGF-B through NKG2D Downregulation

Hans-Georg Kopp¹^*, Theresa Placke¹^*, Benjamin J Schmiedel¹^*, Lothar Kanz, MD¹, Matthias Krusch¹^* and Helmut R Salih, MD²

¹Hematology and Oncology, Eberhard Karls University, Tubingen, Germany
²Hematology and Oncology, Eberhard Karls University, Tuebingen, Germany

2860

Functional Genomics in Zebrafish Permits Rapid Characterization of Novel Platelet Membrane Proteins

Isabelle I Salles¹^*, Marie N O'Connor²^*, Nicholas A. Watkins²^*, Adam Walker³^*, Stephen F Garner²^*, Chris I Jones⁴^*, Iain Macauley²^*, Michael Steward³^*, Jaap Jan Zwaginga⁵, Sarah L Bray⁶^*, Ana Cvejic⁷^*, Frank Dudbridge⁶^*, Bernard de Bono⁸^*, Hans Deckmyn¹^*, Derek L. Stemple⁷^* and Willem Ouwehand, MD, PhD²^*

¹Laboratory for Thrombosis Research,IRC, Catholic University of Leuven (KUL), Kortrijk, Belgium
²Haematology, University of Cambridge and NHS Blood and Transplant, Cambridge, United Kingdom
³Domantis Limited, Cambridge, United Kingdom
⁴Cardiovascular science, University of Leicester, Leicester, United Kingdom
⁵Immunohem./Blood Transfusion, University Hospital Leiden, Leiden, Netherlands
⁶MRC Biostatistics Unit, Cambridge, United Kingdom
⁷Welcome Trust Sanger Institute, Hinxton, United Kingdom
⁸European Bioinformatics Institute, Hinxton, United Kingdom

2861

Loss of Gs Activity in Platelets from Carriers with a Heterozygous Missense Mutation in the Regulator of G Protein Signaling 2 (RGS2)

Laura Noé¹^*, Kathleen Freson¹^*, Elke Giets¹^*, Chantal Thijs¹^*, Christine Wittevrongel¹^* and Christel Van Geet, MD, PhD²

¹Center for Molecular and Vascular Biology, KULeuven, Leuven, Belgium
²Dept. of Hematology, Pediatrics, UZ Gasthuisberg Leuven, Leuven, Belgium

2862

Platelet Glycoprotein VI Contributes to Murine Experimental Metastasis

Shashank Jain^*, Susan Russell^* and Jerry Ware, PhD

Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR

2863

Proteomic Analysis of the alphaIIbbeta3 Interactome Reveals Novel Chaperone and Trafficking Proteins, Including An HSP40 Chaperone, DNAJC10, That Regulates alphaIIbbeta3 Surface Expression

Amanda Chen^*, Mahmoud Yazdani-Abyaneh^* and W. Beau Mitchell, MD

Platelet Biology, New York Blood Center, New York, NY

2864

Role of Sialic Acid for Platelet Lifespan and Function

Anne Louise Sørensen¹^*, Viktoria Rumjantseva²^*, Sara Nayeb-Hashemi²^*, Sunita Patel-Hett²^*, Jennifer Richardson²^*, Joseph Italiano Jr., PhD², Henrik Clausen¹^*, John H. Hartwig²^*, Hans H. Wandall¹^* and Karin M. Hoffmeister²^*

¹Department of Cellular and Molecular Medicine, Faculty of Health Sciences, Copenhagen N, Denmark
²Division of Translational Medicine, Brigham and Women's Hospital, Boston, MA

2865

Clearance Mechanisms for Chilled Platelets

Viktoria Rumjantseva¹^*, Emma C Josefsson, PhD²^*, Prabhjit K Grewal³^*, Hans H. Wandall⁴^*, Sara Neyeb-Hashemi¹^*, Goran Larson⁵^*, Jamey D Marth³^*, John H. Hartwig¹^* and Karin M. Hoffmeister, MD⁶

¹Division of Translational Medicine, Brigham and Women's Hospital, Boston, MA
²Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
³Cellular and Molecular Medicine, The Howard Hughes Medical Institute, San Diego, CA
⁴Department of Cellular and Molecular Medicine, Faculty of Health Sciences, copenhagen N, Denmark
⁵Clinical Chemistry and Tranfusion Medicine, Laboratory Medicine, Gothenburg, Sweden
⁶Brigham and Women's Hospital, Boston, MA

2866

NMR Structure of a Disulfide-Crosslinked αIIbβ3 Cytoplasmic Domain Heterodimer

Douglas G. Metcalf¹^*, Joseph M. Kielec¹^*, Kathleen G. Valentine¹^*, A. Joshua Wand¹^*, William F. DeGrado¹^* and Joel S. Bennett, MD²

¹Biochemistry/Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA
²University of Pennsylvania, Philadelphia, PA

2867

Mechanism of α-Thrombin Binding to Platelet Glycoprotein Ibα

Alessandro Zarpellon, PhD^*, Richard A. McClintock^*, James R. Roberts^* and Zaverio M. Ruggeri, MD

Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA

2868

Engagement of Fibrinogen and β3 Integrin Is Required for Maintenance of Platelet Intracellular and Cell Surface P-Selectin Expression

Hong Yang, MD¹^*, Sean Lang, BSc²^*, Zhimin Zhai, MD³^*, Christopher M. Spring, MSc⁴^*, Adili Reheman, MD⁵^*, Pingguo Chen, PhD⁴^*, Matthew J. Flick, PhD⁶, Jay L. Degen, PhD⁶, Ling Li, MSc⁷^*, Walter H.A. Kahr, MD, PhD⁸, John Freedman, MD⁹ and Heyu Ni, MD, PhD¹⁰^*

¹Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto and Canadian Blood Services, Toronto, ON, Canada
²Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto & Canadian Blood Services, Toronto, ON, Canada
³The Center Laboratory of Anhui Provincial Hospital, the Second Affiliated Hospital of Anhui Medical University, Hefei, China
⁴Department of Laboratory Medicine, St. Michael's Hospital and Canadian Blood Services, Toronto, ON, Canada
⁵Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital and University of Toronto, Toronto, ON, Canada
⁶Children's Hospital Research Foundation and University of Cincinnati, Cincinnati, OH
⁷Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
⁸Division of Haematology/Oncology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
⁹Departments of Laboratory Medicine and Pathobiology, Medicine, St. Michael's Hospital and University of Toronto, Toronto, ON, Canada
¹⁰Departments of Laboratory Medicine and Pathobiology, Medicine and Physiology, St. Michael's Hospital, University of Toronto &Canadian Blood Services, Toronto, ON, Canada

2870

Complex and Novel Associations of the Guanine Exchange Factors Cool-1 and Cool-2 with the Scaffolding Proteins GIT1 and GIT2 in Human Platelets

Daniel L. Greenberg, MD and Alex Spencer, BA, MBA^*

Oregon Health Sciences Univ., Portland, OR

2871

Cross Talk Between Serine/Threonine Protein Phosphatase 2A and Tyrosine Kinase Src Regulates αIIbβ3 Function

Subhashree Pradhan, Ph.D.¹^*, Vimal Patel, BS²^* and K. Vinod Vijayan, PhD³

¹Baylor College of Medicine, Houston, TX
²Medicine, Baylor College of Medicine, Houston, TX
³Thrombosis Research Center, Baylor College of Medicine, Houston, TX

2872

CIB1 Regulates Hemostasis through Integrin Outside-in Signaling

Meghna Ulhas Naik, MS¹^*, Padmini Manrai, BS¹^*, Kirk Czymmek, PhD¹^* and Ulhas Pandurang Naik, PhD²

¹Biological Sciences, University of Delaware, Newark, DE
²University of Delaware, Newark, DE

2873

CIB1 Is Required for FAK Activation during Outside-in Signaling through Platelet Integrin αIIbβ3

Ulhas Pandurang Naik, PhD¹ and Meghna Ulhas Naik, MS²^*

¹University of Delaware, Newark, DE
²Biological Sciences, University of Delaware, Newark, DE

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^*signifies non-member of ASH