50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Lymphocytes and Lymphocyte Activation Poster II

Sunday, December 7, 2008: 6:00 PM-8:00 PM

Hall A (Moscone Center)

ER Stress and Inhibition of Key Apoptotic Caspases Regulate the Life-Span of Short-Lived Plasma Cells

Holger W Auner¹^*, Christine Beham-Schmid²^*, Niall Dillon¹^* and Pierangela Sabbattini¹^*

¹Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, London, United Kingdom
²Institute of Pathology, Medical University, Graz, Austria

2555

Naïve B Cells Differentiate into Highly Activated Granzyme B-Secreting B Cells in Response to Interleukin 21 and B Cell Receptor Stimulation

Elisabeth Schwesinger^*, Magdalena Hagn, MD^*, Thomas Simmet, MD^* and Bernd Jahrsdoerfer, MD

Department of Clinical Pharmacology, University of Ulm, Ulm, Germany

2556

Phenotypical and Functional Characterization of in Vitro Expanded Bone Marrow-Derived Mesenchymal Stromal Cells from Patients with Crohn’s Disease

Maria Ester Bernardo, MD¹, Maria Antonietta Avanzini¹^*, Rachele Ciccocioppo²^*, Cesare Perotti³^*, Angela Maria Cometa¹^*, Antonia Moretta¹^*, Monica Valli⁴^*, Francesca Novara⁵^*, Rita Maccario¹^*, Gino Roberto Corazza⁶^* and Franco Locatelli⁷^*

¹Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
²Struttura di Medicina Interna I, Fondazione IRCCS Policlinico San Matteo, Università di Pavia, Pavia, Italy
³3Servizio di Immuno-ematologia e Trasfusione, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁴Struttura di Medicina Interna I, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁵Biologia Generale e Genetica Medica, Università di Pavia., Pavia, Italy
⁶Struttura di Medicina Interna I, Fondazione IRCCS Policlinico San Matteo, Università di Pavia., Pavia, Italy
⁷Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Università di Pavia., Pavia, Italy

2557

Activated T Cells (ATC) Armed with Anti-CD3 X Anti-Her2/Neu Bispecific Antibody (Her2Bi) Is a Potent Immunomodulator

Oxana Norkina, MD^*, Archana Thakur, Ph.D.^*, Maxim Norkin, MD, PhD^*, Elyse Paul^*, Zaid Al-Kadhimi, MD^* and Lawrence G. Lum, MD, DSC

Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, MI

2558

IL-12 Stimulates Interferon-Gamma Mediated Inhibition of Tumor-Induced Regulatory T Cell Proliferation and Enhances Tumor Clearance

Xuefang Cao, PhD¹, Lynne I. Collins²^*, Sheng F. Cai¹^*, Joshua C. Mayer¹^*, Michael J. Walter, MD³^*, David Piwnica-Worms, MD, PhD²^*, Robert D. Schreiber, PhD⁴^* and Timothy J. Ley, MD⁵

¹Division of Oncology, Washington Univ., School of Medicine, Saint Louis, MO
²Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Molecular Biology and Pharmacology, Washington University School of Medicine
³Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine
⁴Department of Pathology and Immunology, Washington University School of Medicine
⁵for the “Genomics of AML” PPG, Washington University Medical School, Saint Louis, MO

2559

Exogenous Immunoglobulin Downregulates T Cell Receptor Signaling and Cytokine Production

Daniel S Tawfik, BS¹^*, Wendy S Hamilton, BS¹^*, Katelyn R Cowan, BS¹^* and Frederick D Goldman, MD²

¹Pediatrics, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA
²Pediatrics, University of Iowa Childrens Hospital, Iowa City, IA

2560

Statins Inhibit the Function of Human Antigen-Presenting Cells

Alexander Shimabukuro-Vornhagen, MD^*, Tanja Liebig^*, Shahram Zoghi^*, Clemens M Wendtner, MD^* and Michael S von Bergwelt-Baildon, MD^*

Department I of Internal Medicine, University Hospital Cologne, Cologne, Germany

2561

In Vitro Polarized Th17 CD4+ T Cells Home Primarily to Sites of Initial Antigen Encounter

Joseph H. Chewning, MD¹, Weiwei Zhang¹^*, Trenton Schoeb, PhD²^* and Casey Weaver, M.D.³^*

¹Pediatrics, University of Alabama at Birmingham, Birmingham, AL
²Genetics, University of Alabama at Birmingham, Birmingham, AL
³Pathology, University of Alabama at Birmingham, Birmingham

2562

Myeloid-Derived Suppressor Cell Regulation of PD-1 Expression on, and Longevity of, Human CD8⁺ T Cells

Young-June Kim, PhD, Adam T Aisen^* and Hal E. Broxmeyer^*

Indiana University School of Medicine, Indianapolis, IN

2563

Adoptively-Infused NK Cells Maintain Their Antitumor Effects in Vivo in the Presence of CyclosporineA (CSA)

Hisayuki Yokoyama¹, Andreas Lundqvist¹^*, Maria Berg¹^*, Muthalagu Ramanathan¹^*, Rebecca Lopez¹^*, Aleah Smith¹^*, Nicole Gormley¹^*, Su Su¹^*, J.Phillip McCoy²^* and Richard W. Childs, MD¹

¹Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
²Flow Cytometry Core, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD

2564

Combining Established and Novel Immunomodulators: Synergistic Inhibition of Major T Cell Effector Functions by Dexamethasone and Dasatinib

Ruth Seggewiss¹^*, Carolin Dix¹^* and Hermann Einsele, MD²

¹Medizinische Klinik and Poliklinik II, University of Wuerzburg, Wuerzburg, Germany
²Medizinische Klinik and Poliklinik II, Würzburg, Germany

2565

Identification of Novel Activities of Immunomodulatory Drugs: Cytoskeleton Reorganization through Modulation of Rho GTPases

Yibing Xu, PhD¹^*, JianWu Li, M.D.²^*, Greg Ferguson, Ph.D.¹^*, Frank Mercurio, Ph.D.³^*, Gody Khambatta⁴^*, Lisa Morrison, Ph.D.¹^*, Antonia Lopez-Girona²^*, Laura G Corral, Sr., Scientist², David Webb, Ph.D.⁵^*, Brydon L. Bennett, Ph.D.¹^* and Weilin Xie, Ph.D.¹^*

¹Inflammation Research, Celgene, San Diego, CA
²Discovery Biology, Celgene, San Diego, CA
³San Diego, CA
⁴Molecular and Medical Sciences, Celgene, San Diego
⁵Celgene, San Diego, CA

2566

Soluble CD14 Protects Human Lymphocytes from Apoptosis

Elizabeth Naparstek, M.D¹, Benjamin Sredni, PhD²^*, Eti Zigman¹^*, Gali Senyor¹^* and Boris Tartakovsky, PhD¹^*

¹Hematology and Bone Marrow Transplantation, Sourasky Medical Center, Tel-Aviv, Israel
²Safdie Institute for AIDS and Immunology Research, Ramat Gan, Israel

2567

Characterization of Gene p306 Expressed in Monocyte Derived Dendritic Cells

Anita Bringmann¹^*, Ingo Hilgendorf²^*, Silke Appel³^*, Stefanie Held¹^*, Karin von Schwarzenberg¹^*, Frank Grünebach⁴^* and Peter Brossart, MD¹

¹Hematology and Oncology, University Hospital Bonn, Bonn, Germany
²Cardiology and Angiology, University Hospital Freiburg, Freiburg, Germany
³Institute for Biomedicine, Bergen, Norway
⁴Hematology, Oncology, Immunology, Rheumatology, and Pneumology, University Hospital Tuebingen, Tuebingen, Germany

2568

APRIL Provides Springtime for Antibody-Producing Plasma-Cell Lifetime

Bertrand Huard, PhD¹^*, Elodie Belnoue²^*, Thomas Mc Kee²^*, Thomas Matthes, MD³, claire-Anne Siegrist²^* and Eddy Roosnek¹^*

¹Hematology, Med. Univ. Ctr., Geneva, Switzerland
²University Medical Center, Geneva, Switzerland
³Geneva University Hospital, Onex, Switzerland

2569

Complete Responses in Patients with Autoimmune Lymphoproliferative Syndrome (ALPS) Using the mTOR Inhibitor Sirolimus (rapamycin)

David T. Teachey, MD¹^*, Robert J Greiner, MD²^*, Dirk Schwabe, MD³^*, Jack Bleesing, MD, PhD⁴, Catherine Scott Manno, MD¹, Kathleen Sullivan, MD, PhD¹^*, Daniel S. Wechsler, MD, PhD²^* and Stephan A. Grupp, MD, PhD¹^*

¹Children's Hosp. of Philadelphia, Philadelphia, PA
²Duke University Medical Center, Durham, NC
³University Clinics Franfurt, Frankfurt, Germany
⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH

2570

A Head-to-Head Comparison Between Cyclophosphamide and Ontak in Reducing the Influence of Tregs on Self (Tumor) Peptide-Specific CTL Responses

Zhao Lu, MD¹ and David H Sherr, PhD²^*

¹Hematology-Oncology, Boston University School of Medicine, Boston, MA
²Environmental Health, Boston University School of Public Health, Boston, MA

2571

Activation and Effector Phenotype of CD8+ T Cells Crossprimed by a Minor Histocompatibility Antigen Expressed on Red Blood Cells

Maxime Desmarets, BS^* and James C. Zimring, MD, PhD

Pathology, Emory University School of Medicine, Atlanta, GA

2572

Human Cytomegalovirus: Degranulation Is a Prominent Feature of Functionally Impaired pp65- and IE-1-Specific T-Cells in Patients after Allogeneic Stem Cell Transplantation

Stephan Fuhrmann¹^*, Susanne Ganepola²^*, Lutz Uharek²^*, Eckhard Thiel²^*, Wolf-Dieter Ludwig¹^*, Hans-Dieter Volk³^* and Florian Kern⁴^*

¹Hematology, Oncology and Tumor Immunology, Robert-Rössle-Klinik im Helios Klinikum Berlin-Buch, Charité Berlin, Berlin, Germany
²Medizinische Klinik III (Haematologie, Onkologie und Transfusionsmedizin), Charite Campus Benjamin Franklin (Charite Centrum 14), Berlin, Germany
³Institut für Medizinische Immunologie, Charite Campus Mitte, Berlin, Germany
⁴Division of Medicine, Brighton and Sussex Medical School, Brighton, United Kingdom

2573

Suppression of Interferon Regulatory Factor 8 Modulates Toll Like Receptor 2 and Toll Like Receptor 7/8 Induced Dendritic Cell Activation

Daniela Werth¹^*, Anita Bringmann²^*, Katharina Brauer¹^*, Karin von Schwarzenberg²^*, Stefanie Held²^* and Peter Brossart, MD²

¹Hematology, Oncology, Immunology, Rheumatology, and Pneumology, University Hospital Tuebingen, Tuebingen, Germany
²Hematology and Oncology, University Hospital Bonn, Bonn, Germany

2574

The Role of Interleukin-15 on Natural Killer Cell Homeostasis and Activity in Patients with Acute Myeloid Leukemia

Miroslaw J Szczepanski, Malgorzata Czystowska^*, Marta E Szajnik^*, Magis Mandapathil^*, Benedict Hilldorfer^*, Ann Welsh^*, Kenneth Foon^*, Theresa L Whiteside^* and Michael Boyiadzis

University of Pittsburgh Cancer Institute, Univeristy of Pittsburgh School of Medicine, Pittsburgh, PA

2575

GATA-3 Requires C-Myb to Auto-Regulate Its Own Expression in Normal Human Peripheral Blood Lymphocytes Undergoing T Helper Type 2 (Th2) Cell Development

Yuji Nakata, MD¹^*, Shenghao Jin¹^*, Yuan Shen, MD²^* and Alan M. Gewirtz, MD³

¹Medicine, University of Pennsylvania, Philadelphia, PA
²Pathology, University of Pennsylvania, Philadelphia
³Univ. of PA School of Med., Philadelphia, PA

2576

Human Mesenchymal Stromal Cells (MSCs) Suppress Cytotoxicity of Natural Killer (NK) Cell Lines and Can Be Targets for NK-Mediated Cytolysis

Chia-Hsuan Donna Hu^*, Yoko Kosaka^* and Armand Keating, MD

Princess Margaret Hospital, Toronto, ON, Canada

2577

Demonstration of a Direct Immunomodulatory Role for Vitamin D in Human T Cells Using Flow Cytometry

Richard W. Joseph Jr., MD¹^*, Tae Kon Kim²^*, Lisa St. John³^*, Jahan Khalili⁴^*, Uday R Popat⁵^*, Richard E Champlin, MD⁶^*, Jeffrey J. Molldrem, M.D.³, Eric Wieder, Ph., D²^* and Krishna Komanduri, MD²^*

¹Department of Stem Cell Transplant and Cellular Therapy, MD Anderson Cancer Center, Houston, TX
²Stem Cell Transplant Program, Department of Medicine, University of Miami, Miami, FL
³Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX
⁴Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Houston, TX
⁵Stem Cell Transplantation and Cellular Therapy, U.T. M.D. Anderson Cancer Center, Houston, TX
⁶Stem Cell Transplantation and Cellular Therapy, The University of Texas M. D. Anderson Cancer Center, Houston, TX

2578

Enhanced B Cell Activation in the Absence of CD81

Mrinmoy Sanyal, PhD, Rosemary Fernandez^* and Shoshana Levy^*

Medicine, Division of Oncology, Stanford University, Stanford, CA

2579

Dipeptidyl Peptidase Inhibition Accelerates Dendritic Cell Cross Priming of Tumor-Reactive T Cells Resulting in Regression of Established Tumors

Meghaan Walsh¹^*, Aviva C Krauss, MD²^*, Jessica PE Davis³^*, Su Young Kim³^*, Martin Guimond, PhD⁴^*, Crystal L. Mackall, M.D.³ and Terry J Fry, M.D.⁵

¹Pediatric Oncology Branch, CCR, NCI, NIH, Bethesda, MD
²Pediatric Oncology Branch, CCR, NCI, NIH, Bethesda, MD USA,, Bethesda, MD
³Pediatric Oncology Branch, Center for Cancer Research/National Cancer Institute, Bethesda, MD
⁴Pediatric Oncology Branch, CCR, NCI, NIH, Bethesda, MD USA
⁵Pediatric Oncology Branch, CCR, NCI, NIH and Children's National Medical Center, Bethesda, MD

2580

Cyclin D3 Is Required for the Germinal Center Reaction

Jonathan U. Peled¹^*, J. Jessica Yu¹^*, Beibei Belinda Ding¹^*, Rita Shaknovich²^*, Piotr Sicinski³^*, Matthew D. Scharff¹^* and B. Hilda Ye¹

¹Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
²Departments of Medicine and Pathology, Cornell Medical Center, New York, NY
³Department of Cancer Biology, Dana Farber Cancer Institute, MA

2581

The Histone Deacetylase-8 (HDAC8) Selective Inhibitor PCI-34051 Decreases Interleukin-1 Beta Secretion in Vitro and Reduces Inflammation in Vivo

Sriram Balasubramanian, PhD¹, Susanne Steggerda, Ph.D.¹^*, Mint Sirisawad, M.S.¹^*, Marshall Schreeder²^*, Luke Doiron²^* and Joseph J Buggy, Ph.D.¹^*

¹Dept. of Cancer Biology, Pharmacyclics Inc., Sunnyvale, CA
²Conversant Healthcare Systems, Huntsville, AL

2582

Human CD4⁺CD25⁺regulatory T Cells Exhibit Dual Mechanisms of Action in Suppressing in Vitro Alloreactivity

Rachel E Protheroe, FRCPath¹^*, Graziella Mazza, PhD¹^*, Kirsty S Nicolson, PhD¹^*, Colin G Steward, PhD² and David C Wraith, PhD¹^*

¹Department of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
²BMT Unit, Royal Hospital for Children, Bristol

2583

A Phase II Study of the Purine Nucleoside Phosphorylase (PNP) Inhibitor RO5092888 (BCX-4208) in Patients with Moderate to Severe Chronic Plaque Psoriasis: Safety, Tolerability and Lymphocyte Effects

Joseph P Gomes, PharmD, MS, BCPS¹^*, Angela Georgy¹^*, Sharon Passe¹^*, Adrienne Farid¹^*, Shanta Bantia, PhD²^* and Gerhard Wolff¹^*

¹Inflammation CRED, Hoffmann-La Roche, Inc., Nutley, NJ
²BioCryst Pharmaceuticals Inc, Birmingham

2584

FTY720 Abrogates the Therapeutic Potential of Adoptively Transferred Treg Via Inhibition of IL-2 Induced in Vivo Expansion

Anna Maria Wolf¹^*, Kathrin Hochegger²^*, Robert Zeiser³^*, Christoph Duerr³^*, Michael Sixt⁴^*, Alexander Rosenkranz²^*, Gunther Gastl, Prof., Dr.⁵ and Dominik Wolf¹^*

¹Dpt. Haematology and Oncology, Medical University Innsbruck, Innsbruck, Austria
²Dpt. of Nephrology, Medical University Innsbruck, Innsbruck, Austria
³Haematology and Oncology, Medical University Freiburg, Freiburg, Germany
⁴Max Planck Institute for Biochemistry, Munich, Germany
⁵Internal Medicine V, Hematology & Oncology, Medical University, Innsbruck, Austria

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^*signifies non-member of ASH