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Lymphoma: Chemotherapy and Clinical Trials Poster III

Monday, December 8, 2008: 5:30 PM-7:30 PM
Hall A (Moscone Center)
VNCOP-B (Etoposide, Mitoxantrone, Cyclophosphamide, Vincristine, Prednisolone, Bleomycin) Plus Rituximab Therapy in Elderly Patients with Aggressive B-Cell Non-Hodgkin Lymphoma: A Phase II Study of Efficacy and Safety

Kazuyoshi Ishii, MD1*, Masahiro Manabe, MD2*, Toshiya Yagi, MD2*, Hirofumi Teshima, MD2*, Yasuaki Nagare, MD3*, Hidetsugu Kimura, MD3*, Fumiaki Urase, MD3*, Kunio Hayashi, MD4, Masaru Shibano, MD5*, Machiko Tsukaguchi, MD5*, Tatsuya Katsurada, MD6*, Atsuko Mugitani, MD7*, Hitoshi Kitayama, MD8* and Shosaku Nomura, MD1*

1Hematology, Kishiwada City Hospital, Kishiwada, Japan
2Hematology, Osaka City General Hospital, Osaka, Japan
3Internal Medicine, Sakai Hospital, Kinki University School of Medicine, Sakai, Japan
4Hematology, Hirakata Kosai Hospital, Hirakata, Japan
5Hematology, Sakai Municipal Hospital, Sakai, Japan
6Hematology, Takeda General Hospital, Kyoto, Japan
7Hematology, Fuchu Hospital, Izumi, Japan
8Internal Medicine, Hoshigaoka Kosei Nenkin Hospital, Hirakata, Japan

Liposome-Encapsulated Doxorubicin Is Highly Active in Patients with B- as Well as T/ NK-Cell Lymphomas and Cardiac Comorbidity or Older Age

Cathrin C Skrabs1*, Alexander Hauswirth1*, Karin Eigenberger1*, Christine Einberger1*, Markus Raderer2*, Wolfgang R Sperr1*, Paul Knoebl1*, Leonhard Muellauer3*, Martin Uffmann4*, Karin Dieckmann5*, Alexander Gaiger1* and Ulrich Jaeger, MD1

1Dept. of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
2Dept. of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria
3Department of Pathology, Medical University of Vienna, Vienna, Austria
4Department of Radiology, Medical University of Vienna, Vienna, Austria
5Department of Radiotherapy, Medical University of Vienna, Vienna, Austria

The Baseline PET SUV Correlates Better with Clinical Outcome Than the Post-Therapy PET Scan in Previously Untreated Patients with Histologically Aggressive Non-Hodgkin Lymphoma (NHL)

Fernando Cabanillas, MD1, Jorge Toro2*, Jorge Perdomo3*, Orestes Pavia1*, Idalia Liboy1*, Clara Salgado1*, Viviana Freire1*, Ezequiel Rivera1* and Norman Maldonado4*

1Hospital Auxilio Mutuo, Cancer Center, San Juan, PR
2Sononuclear, San Juan, PR
3Hato Rey Hematology Oncology Group, San Juan, PR
4Hospital del Maestro, San Juan, PR

Poor Outcome for Children and Adolescents with Progressive Disease or Relapse of Lymphoblastic Lymphoma - a Report of the BFM Group

Birgit Burkhardt, MD, PhD1*, Alfred Reiter, MD2, Eva Landmann, MD2*, Peter J. Lang, MD3, Lisa Lassay, MD4*, Roswitha Dickerhoff, MD5, Max Lakomek, MD6*, Guenter Henze, MD7* and Arend von Stackelberg, MD7*

1Department of Pediatrics, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
2Dept. of Pediatric Hematology and Oncology, Children's University Hospital, Giessen, Germany
3Dept. of Hematology/Oncology, Children's University Hospital, Tubingen, Germany
4Dept. Pediatric Hematology/Oncology, Children's University Hospital, Aachen, Germany
5Children's Hospital, Saint Augustin, Germany
6Dept. Pediatric Hematology/Oncology, Children's University Hospital, Goettingen, Germany
7Ped. Oncology/Hematology, Charité, Med. Univ., Berlin, Berlin, Germany

Gray Zone Lymphomas: Clinical and Histological Characteristics and Treatment with Dose-Adjusted-EPOCH-R

Kieron Dunleavy, MD, Stefania Pittaluga, MD, PhD*, Nicole Grant, MPH*, Seth Steinberg, PhD*, Margaret Shovlin, RN*, Kevin Tay, MD*, John E. Janik, MD*, Elaine S. Jaffe, M.D.* and Wyndham H. Wilson, MD, PhD

Center for Cancer Research, National Cancer Institute, Bethesda, MD

Treatment of Primary CNS Lymphoma in the Elderly, a Multicenter Retrospective Analysis

Jacoline E.C. Bromberg1*, Jeanette Doorduyn2, Macha Schuurmans1*, Philip Poortmans3*, Martin J.B. Taphoorn4*, Tatjana Seute5*, Adriaan W. Dekker, MD6, Roelien H. Enting7*, Gustaaf van Imhoff8, Yvette van Norden9* and Martin van den Bent1*

1Neuro-Oncology, ErasmusMC, Daniel den Hoed Cancer center, Rotterdam, Netherlands
2Hematology, ErasmusMC, Daniel den Hoed Cancer center, Rotterdam, Netherlands
3Radiotherapy, Dr. Bernard Verbeeten Institute, Tilburg, Netherlands
4Neurology, Medisch Centrum Haaglanden, Den Haag, Netherlands
5Neurology, University Medical Center Utrecht, Utrecht, Netherlands
6University Hospital Ultrecht, B02.226, Utrecht, Netherlands
7Neuro-Oncology, University Medical Center Groningen, Groningen, Netherlands
8Hematology, Groningen University Medical Center, Groningen, Netherlands
9Trials and Statistics, ErasmusMC, Daniel den Hoed Cancer center, Rotterdam, Netherlands

Treatment of High Grade B-Cell Lymphoma with Chemotherapy Plus Rituximab: A Survival Benefit Can Be Demonstrated in the Routine Data of a Regional Cancer Registry

Stefan W Krause, MD1*, Reinhard Andreesen2, Ferdinand Hofstädter3* and Michael Gerken4*

1Medizinische Klinik 5, Universitätsklinikum, Erlangen, Germany
2Haematologie/Onkologie, Universitaetsklinik Regensburg, Regensburg, Germany
3Institut für Pathologie, Universitaet Regensburg, Regensburg, Germany
4Tumorzentrum Regensburg, Regensburg, Germany

Intensified CHOP (ICHOP) +/- Rituximab in Primary Mediastinal Diffuse Large B Cell Lymphoma (PMBCL): The Role of Doxorubicin/Cyclophosphamide Dose-Intensity

Rita Mazza, MD1*, Monica Demarco, MD1*, Michele Spina, MD2, Massimo Magagnoli, MD1*, Luca Castagna, MD1*, Licia Siracusano, MD1*, Laura Giordano, PhD1*, Umberto Tirelli, MD2*, Armando Santoro, MD1* and Monica Balzarotti, MD1*

1Oncology - Hematology, Istituto Clinico Humanitas, Rozzano, Italy
2Medical Oncology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano, Italy

High-Dose Chemotherapy and Autologous Stem-Cell Transplantation for Primary CNS Lymphoma: Updated Results from a Pilot and Phase II Study

Gerald Illerhaus1*, Fabian Müller2*, Friedrich Feuerhake3* and J.ürgen Finke4

1hematology / Oncology, University Hospital Freiburg, Medical Center, Freiburg, Germany
2Hematology / Oncology, University Hospital Freiburg, Medical Center, Freiburg, Germany
3Dept. of Neuropathology, University Hospital Freiburg, Medical Center, Freiburg, Germany
4Hematology/Oncology, University Medical Center Freiburg, Freiburg, Germany

Rituximab Added to CODOX-M/IVAC Is Highly Effective in HIV-Negative and hiv-Positive Burkitt Lymphoma

Jeremy S. Abramson, MD1, Jeffrey A. Barnes, M.D.1*, Christiana E. Toomey1*, Eric D. Jacobsen, MD2, Philippe Armand2*, Tak Takvorian, MD1*, David C. Fisher, MD2, Hazel Reynolds2*, Ephraim P. Hochberg1 and Ann S. LaCasce, MD2

1Center for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA
2Dana-Farber Cancer Inst., Boston, MA

The Addition of Systemic High-Dose Methotrexate (HD-MTX) to Intrathecal Chemotherapy (IT) for Central Nervous System (CNS) Prophylaxis Substantilly Reduces CNS Recurrence Rates in Patients with at-Risk Aggressive Lymphoma: A Historically Controlled Prospective Study

Kirsten Herbert, MBBS, FRACP, PhD1, Max Wolf, MBBS, FRACP, FRCPA2, Dennis Carney, MBBS, FRACP, FRCPA2*, David Alan Westerman, MBBS, FRACP, FRCPA3*, Henry Januszewicz, MBBS, FRACP, FRCPA3*, Simon Harrison, MBBS, PhD3*, David Ritchie, MBChB, FRACP, FRCPA, PhD3*, H. Miles Prince3 and John Francis Seymour, MBBS, FRACP, PhD4

1Dept. of Hematology, Peter MacCallum Cancer Center, East Melbourne, Australia
2Dept. of Hematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Australia
3Dept. of Haematology and Medical Oncology, Peter MacCallum Cancer Center, East Melbourne, Australia
4Dept. of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Australia

High Remission Rates and Prolonged Progression Free Survival in Newly Diagnosed Patients with Mantle Cell Lymphoma Treated with R-MACLO-IVAM-T

Peter J Hosein, MD, Daniel Morgensztern, MD*, Francine Coleman, MPH*, Gail Walker, PhD*, Maricer Escalon, MD, Joseph Rosenblatt, MD and Izidore S Lossos, MD

University of Miami Miller School of Medicine, Miami, FL

Effect of Adding Ibritumomab Tiuxetan (Zevalin) Radioimmunotherapy Consolidation to Three Cycles of CHOP Plus Involved-Field Radiotherapy for Limited-Stage Aggressive Diffuse B-Cell Lymphoma (SWOG 0313)

Thomas P. Miller, MD1, Joseph M Unger, MS2*, Catherine Spier, MD1*, Baldassarre Stea, MD, PhD1*, Oliver W. Press, MD, PhD2, Jonathan W. Friedberg, MD3, Michael LeBlanc, PhD2* and Richard I Fisher, MD4*

1Arizona Cancer Center, Tucson, AZ
2Fred Hutchinson Cancer Research Center, Seattle, WA
3James P. Wilmot Cancer Center, University of Rochester, Rochester, NY
4Wilmot Cancer Center, Rochester, NY

A Phase II Study of the Combination Chemotherapy Consisted of Rituximab and THP-COP Regimen as First-Line Treatment for Patients with Diffuse Large B-Cell Lymphoma

Hisashi Tsurumi, MD, PhD1, Naoe Goto2*, Takeshi Hara1, Senji Kasahara1, Nobuhiro Kanemura1, Junichi Kitagawa, MD1*, Takeshi Yoshikawa3*, Toshiki Yamada1*, Michio Sawada1*, Takeshi Takahashi3*, Tsuyoshi Takami2* and Hisataka Moriwaki1*

1First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
2Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan
3Division of Hematology, Gifu Municipal Hospital, Gifu, Japan

Long-Term Disease Control in Patients with Primary Central Nervous System Lymphoma

Ingo Schmidt-Wolf1, Hendrik Pels2*, Annika Jürgens2*, Sabine Rogowski2*, Axel Glasmacher, MD3, Ulrich Herrlinger1*, Holger Schulz4*, Andreas Engert, MD5, Michael Linnebank6*, Gabriele Schackert1*, Heinz Reichmann7*, Frank Kroschinsky7*, Marlies Vogt-Schaden1*, Gertlinde Egerer8*, Carlo Schaller9*, Monika Lamprecht1*, Peter Hau1*, Martina Deckert4*, Rolf Fimmers1*, Christoph Bangard4* and Uwe Schlegel2*

1CIO, Med. Klinik und Poliklinik III, University of Bonn, Bonn, Germany
2University of Bochum, Bochum, Germany
3Celgene GmbH, Muenchen, Germany
4CIO, Med. Klinik, University of Cologne, Cologne, Germany
5Cochrane Haematological Malignancies Group, Department of Internal Medicine I, University Hospital of Cologne, Cologne, Germany
6Klinik und Poliklinik für Neurologie, University of Bonn, Bonn, Germany
7University of Dresden, Dresden, Germany
8University of Heidelberg, Heidelberg, Germany
9University of Cologne, Department I Internal Medicine, Cologne

Treatment Outcome and Prognostic Factors in Patients with Precursor B and T Lymphoblastic Lymphoma

Myung Hee Chang1*, Seok Jin Kim, MD, PhD1, Won Seog Kim1*, Chul Won Choi, MD, PhD2*, Cheolwon Suh3, Sung Hyun Kim, MD, PhD4, Deok-Hwan Yang5*, Jong-Ho Won6 and Soon Il Lee7*

1Medicine, Samsung Med. Ctr., Seoul, South Korea
2Internal Medicine, Korea University Guro Hospital, Seoul, South Korea
3Asan Medical Center, Seoul
4Dept. of Hem.-Onc., Internal Med., Dong-A University Hospital, Pusan, South Korea
5Hematology-Oncolology, Chonnam National University Hwasun Hospital, Jeollanam-do, South Korea
6Soon Chun Hyang University Hospital, Seoul
7Internal Medicine,, Dankook University College of Medicine, Cheonan, South Korea

Relapse of Central Nervous System Lymphoma after systemic Lymphoma (SCNSL): Clinical Features and Outcome as compared to Primary CNS Lymphoma (PCNSL) Patients

Ingo Schmidt-Wolf1, Hendrik Pels2*, Annika Jürgens2*, Katrin Patrij1*, Luise Wätzel3*, Ulrich Herrlinger4*, Holger Schulz3*, Andreas Engert, MD5, Michael Linnebank4*, Gabriele Schackert6*, Heinz Reichmann7*, Frank Kroschinsky8*, Marlies Vogt-Schaden9*, Gertlinde Egerer9*, Carlo Schaller10*, Monika Lamprecht11*, Peter Hau12*, Martina Deckert13*, Rolf Fimmers14*, Christoph Bangard3* and Marcel Reiser15*

1CIO, Med. Klinik und Poliklinik III, University of Bonn, Bonn, Germany
2University of Bochum, Bochum, Germany
3CIO, Med. Klinik, University of Cologne, Cologne, Germany
4Klinik und Poliklinik für Neurologie, University of Bonn, Bonn, Germany
5Cochrane Haematological Malignancies Group, Department of Internal Medicine I, University Hospital of Cologne, Cologne, Germany
6Neurologische Klinik, University of Dresden, Dresden, Germany
7University of Dresden, Dresden, Germany
8Medizinische Klinik, University of Dresden, Dresden, Germany
9University of Heidelberg, Heidelberg, Germany
10University of Cologne, Department I Internal Medicine, Cologne
11University of Kiel, Kiel, Germany
12University of Regensburg, Regensburg, Germany
13University of Cologne, Cologne, Germany
14University of Bonn, Bonn, Germany
15Klinikum, Universität zu Köln, Köln, Germany

Treating Lymphoma with Curative Intent in HIV Positive Patients after the Advent of HAART: A Comparative Analysis with the HIV Negative Population

Alessandro Re1*, Alessandra Tucci1*, Salvatore Casari2*, Chiara Cattaneo1*, Graziella Cristini3*, Giampiero Carosi2* and Giuseppe Rossi1

1Department of Hematology, Spedali Civili, Brescia, Italy
2Department of Infectious Diseases, Univerity of Brescia, Brescia, Italy
3Infectious Diseases, Spedali Civili, Brescia, Italy

R-CHOEP-14 X 6 Followed by Systemic CNS Prophylaxis for Diffuse Large B-Cell Lymphoma (DLBCL)/Follicular Lymphoma (FL) Grade 3 with Age Adjusted IPI Score 2-3: Preliminary Results of a Nordic Lymphoma Group (NLG) Phase 2 Study Including 160 Patients Aged 18-64 Years

Harald Holte, MD, PhD1*, Sirpa M. Leppa, MD, PhD2, Magnus Bjorkholm, MD, PhD3, Oystein Fluge, MD, PhD4*, Sirkku Jyrkkio, MD, PhD5*, Jan Delabie, MD, PhD6*, Christer Sundstrom, MD, PhD7*, Marja-Liisa Karjalainen-Lindsberg, MD, PhD8*, Martin Erlanson, MD, PhD9*, Arne Kolstad, MD, PhD1*, Alexander Fossa, MD, PhD1*, Björn Östenstad, MD, PhD10*, Eva Lofvenberg, MD, PhD11, Marie Nordström, MD, PhD11*, Lars Möller-Pedersen, MD, PhD12*, Harald Anderson, PhD13*, Mats Jerkeman, MD, PhD14* and Mikael Eriksson, MD, PhD14*

1Oncology, Norwegian Radium Hospital, Oslo, Norway
2Oncology, Helsinki University Central Hosp., Helsinki, Finland
3Department of Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
4Oncology and Radiotherapy, Haukeland University Hospital, Bergen, Norway
5Oncology and Radiotherapy, Turku University Centre Hospital, Turku, Finland
6Pathology, Norwegian Radium Hospital, Oslo, Norway
7Pathology, Academic Hospital, Uppsala, Sweden
8Pathology, Helsinki University Central Hosp., Helsinki, Finland
9Oncology, Norrlands University Hospital, Umeå, Sweden
10Oncology, Ulleval University Hospital, Oslo, Norway
11Hematology, Karolinska University Hospital, Stockholm, Sweden
12Hematology, Odense University Hospital, Odense, Denmark
13Cancer Epidemiology, Lund University, Lund, Sweden
14Oncology, Lund University Hospital, Lund, Sweden

Importance of Relative Dose Intensity for Survival in Diffuse Large B-Cell Lymphoma Patients Treated with CHOP-Like Regimen

Tsuneaki Hirakawa1*, Hiroki Yamaguchi1, Seiji Gomi2*, Norio Yokose3*, Koiti Inokuchi1 and Kazuo Dan1

1Division of Hematology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
2Department of Hematology, Yokohama Minami Kyosai Hospital, Kanagawa, Japan
3Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan

Long-Term Outcome of AIDS-Related Lymphoma Treated with Abbreviated Cycles of EPOCH-RR: A Prospective Study of 40 Patients

Kieron Dunleavy, MD, Richard Little, MD*, Alan S. Wayne, MD*, Nicole Grant, MPH*, Stefania Pittaluga, MD, PhD*, Elaine S. Jaffe, MD*, Seth Steinberg, PhD*, Robert Yarchoan, MD, PhD*, Jorge A. Carrasquillo, MD*, John E. Janik, MD* and Wyndham H. Wilson, MD, PhD

Center for Cancer Research, National Cancer Institute, Bethesda, MD

Interim 18f[FDG] Positron Emission Tomography in Patients with Diffuse Large B-Cell Lymphoma

Federica Gigli1*, Luca Nassi1*, Mara Negri1*, Laura Travaini2*, Sara Steffanoni1*, Sarah Jane Liptrott1*, Patrizia Mancuso1*, Paola Bertazzoni1*, Simona Bassi, MD1*, Liliana Calabrese1*, Emilia Cocorocchio1* and Giovanni Martinelli1

1Hematology, European Institute of Oncology, Milan, Italy
2Nuclear Medicine, European Institute of Oncology, Milan, Italy

The Impact of Therapeutic Management and Prognostic Factors on the Outcome of Primary Cutaneous B-Cell Lymphomas (PCBCL) (IELSG 11 Study)

Sergio Cortelazzo, MD1*, Michael Mian, MD1*, Maria Cantonetti, MD2*, Andreas Sarris, MD3*, Andrea Rossi, MD4*, Alessandro Rambaldi, MD4, Giuseppe Lombardo, MD5*, Felice Pasini, MD6*, Achille Ambrosetti, MD7*, Liliana Devizzi, MD8*, Mario Busetto, MD9*, Osnat Bairey, MD10*, Emilio Berti, MD11*, Giovanni Martinelli, MD12, Richard Tsang, MD13*, Silvia Rudoy, MD14*, Robert Blum, MD15*, Andres JM Ferreri, MD16, Graziella Pinotti, MD17*, Enrico Pogliani, MD18* and Emanuele Zucca, MD19*

1Div. of Hematology and BMT, Bolzano, Italy
2Chair of Hematology, University of Rome
3Hematology, Hygeia
4Hematology, Ospedali Riuniti di Bergamo, Bergamo, Italy
5Istituto Dermatologico Italiano
6Chair of Oncology, University of Verona
7Chair of Hematology, University of Verona
8Istituto Nazionale Tumori, Milano, Italy
9Radiotherapy, Venice
10Institute of Hematology, Rabin Medical Center
11Dermatologia, University of Milan-Bicocca and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
12Hematology, European Institute of Oncology, Milan, Italy
13Radiation Oncology, Princess Margaret Hospital, Toronto, ON, Canada
14Hematology, Instituto Santojiani, Buenos Aires, Argentina
15Haematology, Melbourne, Australia
16Unit of Lymphoid Malignancies, Department of Oncology, Istituto Scientifico San Raffaele, Milano, Italy
17UO Oncologia Medica, Ospedale di Circolo Fondazione Macchi, Varese
18Chair of Hematology, University of Milan-Bicocca
19Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland

Gem-(R)CHOP Versus (R)CHOP: A Randomized Phase II Study of Gemcitabine Combined with (R)CHOP in Untreated Aggressive Non-Hodgkin’s Lymphoma - EORTC Lymphoma Group Protocol 20021

Igor Aurer1*, Houchingue Eghbali2, John M. Raemaekers3, Hussein M Khaled4*, Martine Van Glabbeke5*, Liliana Baila5* and Richard van der Maazen6*

1Division of Hematology, University Hospital Center Zagreb, Zagreb, Croatia
2Institut Bergonie, Bordeaux, France
3Dept. of Hematology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
4National Cancer Institute, Cairo, Egypt
5EORTC Data Center, Brussels, Belgium
6Dept. of Radiation Oncology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands

High-Dose Methotrexate and Early Intensification of Therapy Do Not Improve 3 Year EFS in Children and Adolescents with Disseminated Lymphoblastic Lymphoma.  Results of the Randomized Arms of COG A5971

Minnie Abromowitch, MD1, Amanda Termuhlen, MD2*, Myron Chang, PhD3*, Sherrie L. Perkins, MD, PhD4, Thomas Gross, MD, PhD5, Howard J. Weinstein, MD6 and Jonathan Finlay, MD7*

1Pediatric Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE
2Dept of Pediatric Hem-Oncology, Nationwide Childrens Hospital, Columbus, OH
3Data Center, Childrens Oncology Group, Gainesville, FL
4Pathology, University of Utah and ARUP Institute, Salt Lake City, UT
5Nationwide Children's Hospital, The Ohio State University, Columbus, OH
6Mass General Hosp. for Children, Boston, MA
7Peds Hematology/Oncology, Childrens Hospital Los Angeles, Los Angeles, CA

High-Dose Methotrexate and Cytarabine Chemotherapy May Be Effective and Safe in Solid Organ Transplant Recipients with Primary CNS Lymphomas (PCNSL)

Laura Moise, M.D.1*, Clemence Matta1*, Sylvain Pilorge1*, Marius Moldovan1*, Christophe Ferme, MD2*, Antoine Durrbach3* and Vincent Ribrag, MD4

1Medicine, Institut Gustave Roussy, Villejuif, France
2Dept. of Medicine, Institut Gustave Roussy, Villejuif, France
3Nephrology, CHU paris XI, Le Kremlin-Bicetre, France
4Dpt. of Medicine, Institut Gustave Roussy, Villejuif, France

Excellent Immune Recovery Following the Intensive Chemotherapy CODOX-M/IVAC, An Effective Therapy for HIV-Associated Burkitt’s Lymphoma (BL)

Silvia Montoto, MD1, Jamie Wilson2*, Kate Shaw3*, Maureen Heath4*, Andy Wilson1*, Chloe Orkin5*, Christopher McNamara2*, Margaret Johnson6*, Mark Bower3* and Kate Cwynarski2*

1CR-UK Medical Oncology Unit, St Bartholomew's Hospital, Barts and The London School of Medicine and Dentistry, London, United Kingdom
2Haematology, Royal Free Hospital, London, United Kingdom
3Medical Oncology, Chelsea & Westminster Hospital, London, United Kingdom
4Medical Oncology, St Bartholomew's Hospital, London, United Kingdom
5Infection and Immunity, St Bartholomew's Hospital, London, United Kingdom
6HIV Medicine, Royal Free Hospital, London, United Kingdom

Reduction of Immunosuppression and Subsequent Rituximab Monotherapy or CHOP-Based Chemotherapy +/- Rituximab as a Treatment for PTLD Does No Impair the Renal Graft Function: A Matched Pair Control Analysis in 55 Renal Transplant Recipients with PTLD and 1075 Renal Transplant Controls

Ulrike Appel1*, Carl Hinrichs2*, Petra Reinke2*, Nina Babel2*, Hans H Neumayer3*, Klemens Budde3*, Martin Dreyling4, Ulrich Dührsen5*, Volker Kliem6*, Silke Schüttrumpf7*, Ingeborg A Hauser8*, Hans G Mergenthaler9*, Bernd Dörken10, Ioannis Anagnostopoulos11*, Hanno Riess1* and Ralf Trappe1*

1Department of Hematology and Oncology, Campus Virchow Clinic, Charité - Universitätsmedizin Berlin, Berlin, Germany
2Department of Nephrology and Intesive Care, Campus Virchow Clinic, Charité-Universitätsmedizin Berlin, Berlin, Germany
3Department of Nephrology, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany
4Department of Internal Medicine III, University Hospital Grosshadern, University of Munich, Munich, Germany
5Clinic of Hematology, University Hospital, University of Duisburg-Essen, Essen, Germany
6Department of Internal Medicine/Nephrology, Nephrological Center, Hann. Muenden, Hann. Muenden, Germany
7Department of Hematology/Oncology, University of Göttingen, Göttingen, Germany
8Medical Clinic III, Clinic of the J.W. Goethe University, Frankfurt/Main, Germany
9Department of Hematology and Oncology, Section Internal Medicine, Klinikum Stuttgart - Katharinenhospital and Bürgerhospital, Stuttgart, Germany
10Department of Hematology and Oncology, Campus Virchow Clinic, Charité - Universitätsmedizin Berlin, Berlin, Germany
11Department of Pathology, Campus Benjamin Franklin, Charité - Universitätsmedizin, Berlin, Germany

Results of the Largest Study on Post-Transplant-Lymphoproliferations (PTLDs) of the Central Nervous System (CNS) in the Rituximab Era: A Surprising Overrepresentation of Kidney Transplantations, Key Importance of Methotrexate (Mtx), Cytarabine (AraC) and Radiotherapy (RX) for Long Term Survival and Low Impact of Rituximab (R)

Sylvain Choquet1*, Stefan Oertel2*, Ioannis Anagnostopoulos3*, Hanno Riess4*, Madalina Uzunov5*, V.éronique Leblond6* and Ralf Trappe7*

1Clinical Haematology, hôpital Pitié Salpêtrière, APHP, Paris, France
2Roche, Basel
3Department of Pathology, Campus Benjamin Franklin, Charité - Universitätsmedizin, Berlin, Germany
4Clinical Haematology, hôpital Pitié Salpêtrière, APHP, Berlin, Germany
5Service d'Hématologie Clinique, Hôpital Pitié-Salpêtrière, Paris, France
6Hopital Pitie-Salpetriere, Paris, France
7Medizinische Klinik m.S. Hämatologie & Oncologie, Campus Virchow, Charité, Berlin, Germany

No Benefit from Rituximab Containing Regimens in Patients with Primary Extranodal Diffuse Large B-Cell Lymphoma

Gonzalo Gutiérrez-García1*, Luis Colomo2*, Neus Villamor1*, Leonor Arenillas1*, Antonio Martínez2*, Mireia Camós1*, Marina Diaz-Beyá1*, Carlos Fernández de Larrea1*, Xavier Calvo1*, Eva Giné1*, Francesc Bosch1*, Elias Campo2*, Emili Montserrat1 and Armando López-Guillermo1

1Hematology, Hospital Clinic, Barcelona, Spain
2Pathology, Hospital Clinic, Barcelona, Spain

THP-COP Regimen for the Treatment of Peripheral T Cell Lymphoma and Adult T Cell Leukemia/Lymphoma: A Multicenter Phase II Study

Yasushi Takamatsu, MD, PhD1*, Junji Suzumiya, MD2, Atae Utsunomiya, MD3*, Koichi Maeda, MD4*, Hitoshi Matsuoka, MD5*, Hitoshi Suzushima, MD6*, Junichi Tsukada, MD, PhD7 and Kazuo Tamura, MD, PhD8*

1Division of Medical Oncology, Hematology, and Infectious Disease, Fukuoka University Hospital, Fukuoka, Japan
22nd Dept. of Internal Med., Fukuoka Univ. Chikushi Hosp., Chikushino, Japan
3Dept. of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan
4Department of Hematology, Miyakonojo National Hospital, Miyakonojo, Japan
5Department of Hematology, Koga General Hospital, Miyazaki, Japan
6Department of Hematology, NTT West Kyushu General Hospital, Kumamoto, Japan
7Cancer Chemotherapy Ctr., University of Occupational, Kitakyushu, Japan
8Division of Medical Oncology, Hematology, and Infectious Disease, Fukuoka University, Fukuoka, Japan

*signifies non-member of ASH