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Acute Myeloid Leukemia - Therapy, Excluding Transplantation Poster II

Sunday, December 7, 2008: 6:00 PM-8:00 PM
Hall A (Moscone Center)
Minimizing Therapy for Patients with Acute Promyelocytic Leukemia: Efficacy of Single Cycle of Arsenic-Based Consolidation Therapy

Steven D. Gore, MD1, Lawrence Morris, MD2, Ivana Gojo, MD3, Marcel P. Devetten, MD4, Katarzyna Jamieson, MD5, Mikkael A. Sekeres, MD, MS6, Robert J. Arceci, MD, PhD7, Robert L. Redner, MD8, Tianna Dauses, BSN1*, Esther L Schachter-Tokarz9*, Ibitayo Owoeye, MD1* and Robert E. Gallagher, MD10

1The Sidney Kimmel Comprehensive Cancer Ctr. at Johns Hopkins, Baltimore, MD
2BMT Group of Georgia, Atlanta, GA
3University of Maryland Medical Center, Baltimore, MD
4Lied Transplant Center 8718, UNMC, Omaha, NE
5University of Florida, Gainesville, FL
6Hematologic Oncology and Blood Disorders R35, Cleveland Clinic, Cleveland, OH
7Bunting-Blaustein Cancer Research Building, Sidney Kimmel CCC at Johns Hopkins, Baltimore, MD
8Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA
9Oncology, Albert Einstein School of Medicine, Bronx, NY
10Montefiore Medical Center, Bronx, NY

CD4+ Regulatory T Cells Specific for the WT1 Antigen Are Present in Acute Myeloid Leukemia Patients: Implication for Immunotherapy

Said Dermime1*, Cynthia Lehe1*, Hazem Ghebeh1*, Abdullah Al-Sulaiman1*, Ghofran Al Qudaihi1*, Khaled Al-Hussein1*, Fahad Almohareb2*, Naeem A. Chaudhri, MD, FACP3, Fahad Z. Alsharif, MBChB, MD4, Hazza Al-Zahrani2*, Said Y Mohamed2*, Abdelghani Tbakhi2* and Mahmoud Aljurf, MD3

1Tumor immunology section, Research center, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
2Adult Hematology Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
3King Faisal Specialist, Riyadh, Saudi Arabia
4Kfcc, KFSHRC, MBC #64, Riyadh, Saudi Arabia

Intensive Consolidation with Clofarabine and Intermediate-Dose Cytarabine (CLARA) in Patients with High-Risk AML in First CR: The ALFA-0702 Pilot Study

Xavier Thomas1, Ida Lobe2*, Emmanuel Raffoux2*, Nicolas Boissel2*, Quoc-Hung Le1*, Franck Nicolini1, Adrienne de Labarthe2*, Sandrine Hayette3*, Jean-Michel Cayuela2* and Hervé Dombret2

1Department of Hematology, Hôpital Edouard Herriot, Lyon, France
2Department of Hematology, Hôpital Saint-Louis, AP-HP, Paris, France
3Hematology, Centre Hospitalier Lyon Sud, Pierre Bénite, France

Relapsed and Refractory Acute Myeloid Leukemia (AML) Treated with AS1411 and Cytarabine: A Randomized Phase II Trial

Robert Kenneth Stuart, MD1, Gary Acton2* and AS1411-201 Investigator Group2*

1Medical Univ. of S. Caroline, Charleston, SC
2Antisoma Research Ltd, London

High Dose Cytarabine and Clofarabine (HiDAC→CLOF) in Relapsed or Refractory Acute Myeloid Leukemia,  a Phase 2 Trial

Bayard Powell, Ralph D'Agostino Jr., PhD*, Denise Levitan, MD, Leslie Renee Ellis, MD, Susan Lyerly, PA-C*, Megan Skiles, PA-C*, Megan Manuel, NP*, Robin Harrelson, RN*, Claire Kimbrough* and David Duane Hurd, MD

Wake Forest Univ. School of Med., Winston Salem, NC

Molecular Response in Core Binding Factor Acute Myelogenous Leukemia with Fludarbine, Cytarabine, G-CSF and Gemtuzumab Ozogamicin

Gautam Borthakur, MD1, Stefan Faderl2*, Srdan Verstovsek2*, Dan Jones, MD, PhD3*, Zeev Estrov2*, Susan O'Brien2*, Joyce Bass2* and Hagop Kantarjian2

1Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX
2M.D. Anderson Cancer Ctr., Houston, TX
3Department of Hematopathology, M.D. Anderson Cancer Ctr., Houston, TX

Multi-Targeted Receptor Tyrosine Kinase Inhibitor, ABT-869, Induces Apoptosis and Suppresses Proliferation of Ba/F3 FLT-3 ITD Mutant Cells in Vitro and in Vivo through Inhibition of FLT3 and AKT

Jenny E Hernandez, BSc1*, Joan Zape2*, Keith Glaser, Ph.D.3*, Elliot Landaw, M.D., Ph.D.4*, Cecilia Fu, M.D.5 and Kathleen M. Sakamoto, M.D., Ph.D.2

1David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA
2Pediatrics, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA
3Cancer Research, Abbott Laboratories, Abbott Park, IL
4Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, Los, CA
5Pediatrics A2-412 MDCC, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA

Efficacy and Safety of Micafungin as An Empirical Antifungal Therapy for Suspected Fungal Infection in Patients with Hematological Disorders

Minoru Yoshida1*, Kazuo Tamura2*, Masahiro Imamura, MD3, Yoshiro Niitsu4*, Takeshi Sasaki5*, Akio Urabe6*, Kazuma Ohyashiki7*, Tomoki Naoe8, Akihisa Kanamaru9*, Mitsune Tanimoto10* and Tohru Masaoka11*

1Dept of IM, Teikyo Univ Sch of Med, Kawasaki, Japan
2Fukuoka Univ., Fukuoka, Japan
3Dept of Hematol, Hokkaido Univ Sch of Med
4Dept of IM, Sapporo Medical Univ
5Dept of Hematol, Tohoku Univ Sch of Med
6Div of Hematol, NTT Kanto Medical Ctr
7Dept of IM, Tokyo Medical Univ
8Dept of Hematol, Nagoya Univ Sch of Med
9Dept of IM, Kinki Univ Sch of Med
10Dept of Hematol Oncol, Okayama Univ Sch of Med
11Dept of IM, Osaka Med Ctr for Cancer and Cardiovascular Dis Hosp, Japan

Liposomal Daunorubicin Causes Only Low Cardiotoxicity in Pediatric AML Patients

Ursula Creutzig, MD1, Martin Zimmermann2*, Gertjan Kaspers, MD, PhD3 and Dirk Reinhardt, MD, PhD4

1Universitats-Kindeklinik, Munster, Germany
2Department of Pediatric Hematology-Oncology, Medical School Hanover, Hannover, Germany
3VU University Medical Center, Amsterdam, Netherlands
4Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany

Simultaneous Activation of p53 and Inhibition of XIAP Enhance the Activation of Apoptosis Signaling Pathways in AML

Bing Z. Carter, PhD1, Duncan H. Mak1*, Wendy D. Schober1*, Erich Koller, PhD2*, Clemencia Pinilla, PhD3*, Lyubomir T. Vassilev, PhD4*, John C. Reed, MD, PhD5 and Michael Andreeff, MD, PhD1

1Stem Cell Transplantation & Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX
2Isis Pharmaceuticals, Inc., Carlsbad, CA
3Torrey Pines Institute for Molecular Studies, San Diego, CA
4Hoffman La-Roche Inc., Nutley, NJ
5Burnham Institute for Medical Research, La Jolla, CA

Impact of Weekend Admissions on Quality of Care and Outcomes in Patients with Acute Myeloid Leukemia (AML)

Nelli Bejanyan, MD1*, Alex Z Fu, PhD2*, Rao Fu3*, Matt Kalaycio, MD4, Anjali Advani, MD5, Ronald Sobecks, MD6, Edward A. Copelan7 and Mikkael A. Sekeres, MD, MS8

1Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
2Quantitative Health Sciences, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
3Cleveland Clinic Lerner College of Medicine, Cleveland, OH
4Cleveland Clinic Foundation, Cleveland, OH
5Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Center
6Cleveland Clinic, Cleveland, OH
7Hematologic Oncology and Blood Disorders, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH
8Hematologic Oncology and Blood Disorders R35, Cleveland Clinic, Cleveland, OH

Pharmacodynamic Study of Phase 1/2 Trial of the XIAP Antisense Oligonucleotide (AEG35156) in Combination with Chemotherapy in Patients with Relapsed/Refractory AML

Bing Z. Carter, PhD1, Duncan H. Mak1*, Stephen Morris2*, Gautam Borthakur, MD3*, Elihu Estey, MD4*, Anna L. Byrd, RN3*, Marina Konopleva, MD, PhD3, Hagop M. Kantarjian, MD3* and Michael Andreeff, MD, PhD1

1Stem Cell Transplantation & Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX
2Aegera Therapeutics, Inc., Montreal, QC, Canada
3Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
4University of Washington, Seattle, WA

Mobilization and Chemosensitization of AML with the CXCR4 Antagonist Plerixafor (AMD3100): A Phase I/II Study of AMD3100+MEC in Patients with Relapsed or Refractory Disease

Geoffrey L. Uy, MD, Michael P. Rettig, PhD, Kyle M. McFarland*, Lindsay M. Hladnik, PharmD*, Shashikant Kulkarni, PhD*, Camille N. Abboud, MD, Amanda F. Cashen, MD, Keith Stockerl-Goldstein, MD, Ravi Vij, MBBS, Peter Westervelt, MD, PhD and John F. DiPersio, MD, PhD

Washington University School of Medicine, Saint Louis, MO

A Phase 1 Clinical-Pharmacodynamic Study of the Farnesyltransferase Inhibitor Tipifarnib in Combination with the Proteasome Inhibitor Bortezomib in Advanced Acute Leukemias

Jeffrey E. Lancet, MD1, Elliott F. Winton, MD2, Robert K. Stuart, MD3, Michelle Burton, RN1*, Christopher Cubitt, PhD1*, Michelle Blaskovich1*, John Wright, MD, PhD4*, Said Sebti, PhD1* and Daniel Sullivan, MD, MS1

1H. Lee Moffitt Cancer Ctr. & Rsrch. Institute, Tampa, FL
2Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA
3Medical Univ. of S. Carolina, Charleston, SC
4IDB CTEP NCI, Rockville, MD

A Homoharringtonine-Based Protocol Is Superior to Daunorubicin and Idarubicin-Based Protocols in Elderly Patients with Newly-Diagnosed Acute Myeloid Leukemia with Comparable Effects and Low Toxicities: Experience in a Chinese Center

Jianmin Wang, MD, Shuqing Lü*, Jianmin Yang*, Xianmin Song*, Li Chen*, Jun Hou*, Weiping Zhang*, Chongmei Huan*, Xiong Ni* and Huiying Qiu*

Department of Hematology, Changhai Hospital,, Second Military Medical University, Shanghai, China

5-Azacytidine for the Treatment of Acute Myeloid Leukemia: A Retrospective, Multicenter Study of 55 Patients

Luca Maurillo*, Alessandra Spagnoli*, Mariella Genuardi*, Monia Lunghi*, Nicola Di Renzo*, Alfonso Maria D'Arco*, Giuseppe Mele*, Alessandro Levis*, Antonella Gozzini*, Mario Petrini*, Manuela Mianulli*, Grazia Sanpaolo*, Alberto Santagostino*, Giuseppe Pietrantuono*, Fiorella D'Auria*, Dario Ferrero*, Gianluca Gaidano*, Felicetto Ferrara*, Adriano Venditti*, Giuseppe Leone*, Valeria Santini* and Pellegrino Musto

Italian Cooperative Group on Azacytidine in Myelodysplastic Syndromes and Acute Myeloid Leukemias, Rionero in Vulture and Rome, Italy

Post-Consolidation Immunotherapy with Histamine Dihydrochloride and Interleukin-2 in AML: Assessment of Consistency and Robustness of Treatment Benefit for Patients in First Complete Remission

Marc E Buyse, ScD1*, Pierre Squifflet, MSc2*, Jacob M Rowe, MD3, John K Whisnant, MD4*, Dileep Bhagwat, PhD, MBA4*, Stephane E Allard, MD4*, Kristoffer Hellstrand, MD, PhD5* and Mats L Brune, MD6

1International Drug Development Institute and Hasselt University, Diepenbeek, Louvain-la-Neuve, Belgium
2International Drug Development Institute, Louvain-la-Neuve, Belgium
3Hematology and BMT, Rambam Medical Center and Technion, Haifa, Israel
4EpiCept Corporation, Tarrytown, NY
5Infectious Diseases, University of Gothenburg, Gothenburg, Sweden
6Hematology, Sahlgrenska University Hospital, Gothenburg, Sweden

Quality of Life Scores Have a Prognostic Significance  In Elderly AML Patients

Esther Natalie Oliva, MD1, Roberto Latagliata2*, Giorgina Specchia3, Francesca Ronco1*, Giuliana Alimena4, Domenico Pastore3*, Stella Impera5*, Patrizia Guglielmo5*, Ida Carmosino6*, Iolanda Vincelli1*, Caterina Alati1*, Massimo Breccia4*, Laura Napoleone2* and Francesco Nobile7*

1Hematology, A.O. Bianchi-Melacrino-Morelli, Reggio Calabria, Italy
2Dipartimento di Biotecnologie Cellulari ed Ematologia, Universitŕ "La Sapienza", Rome, Italy
3Chair of Hematology, University of Bari, Italy
4Division of Hematology-Dept. of Cellular Biotechnologies and Hematology, University of Rome,, Rome, Italy
5Hematology, Presidio Ospedaliero Garibaldi-Nesima, Catania, Italy
6Division of Hematology-Dept. of Cellular Biotechnologies and Hematology, University La Sapienza of Rome, Rome, Italy
7Hematology Unit, Azienda Ospedaliera " Bianchi-Melacrino-Morelli", Reggio Calabria, Italy

The Reduction of Leukemic Blasts  In Bone Marrow Aspirate on Day 6 of Remission Induction Treatment Is Predictive for Complete Remission  Rate and Survival in Adult Acute Myeloid Leukemia: The Results of Multicenter, Prospective Polish Adult Leukemia Group Study

Jerzy Holowiecki1, Sebastian Grosicki1*, Slawomira Kyrcz-Krzemien1*, Kazimierz Kuliczkowski2*, Marek Kielbinski2*, Aleksander B. Skotnicki3*, Beata Piatkowska-Jakubas3*, Andrzej Hellmann, MD, PhD4*, Agnieszka Wierzbowska5*, Marek Seweryn1*, Beata Stella-Holowiecka1* and Maria Sadus-Wojciechowska1*

1Dept. of Hematology and BMT, Silesian Medical University Hospital SPSKM, Katowice, Poland
2Dep.of Hematology, Wroclaw Medical University, Wroclaw, Poland
3Collegium Medicum, Jagiellonian University, Cracow, Poland
4Department of Hematology, Medical University of Gdansk, Gdansk, Poland
5Medical University,Lodz,Poland, Lodz, Poland

Phase 2 Study of Voreloxin (Formerly Known as SNS-595) as Single Agent Therapy for Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia (AML): Preliminary Safety and Clinical Responses (The REVEAL-1 Study)

Michael Maris, MD1*, Larry D. Cripe, MD2, Robert K Stuart, MD3, Farhad Ravandi, MBBS4, Glenn C Michelson, MD5*, Rachel E. Hawtin, PhD5*, Lyra E Ericson5* and Craig J. Berman, MD5*

1Bone Marrow Transplantation, Rocky Mountain Cancer Center, Denver, CO
2Indiana University Simon Cancer Center, Indianapolis, IN
3Medical Univ. of S. Caroline, Charleston, SC
4Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX
5Clinical Science, Sunesis Pharmaceuticals, South San Francisco, CA

The Pitfalls of Early Publication of Data in Acute Myeloid Leukemia: A Report from the Eastern Cooperative Oncology Group (ECOG)

Jacob M. Rowe, MD1, Xiaopan Yao, Ph.D2*, Peter A. Cassileth, MD3, Frederick R. Appelbaum, MD4, Peter H. Wiernik, MD5, Charles Schiffer, MD6, Mark R. Litzow, MD7, Selina Luger, MD8, John M. Bennett, MD9, Hillard M Lazarus, MD10* and Martin S Tallman11

1Hematology and Bone Marrow Transplantation, Rambam Health Care Campus and Technion, Israel Institute of Technology, Haifa, Israel., Haifa, Israel
2Biostatistics & Computational Biology, Dana-Farber Cancer Institute, Boston, MA
3Univ. of Miami Sylvester Cancer Ctr., Miami, FL
4Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA
5New York Medical College, Our Lady of Mercy Cancer Center, Bronx, NY
6Wayne State University, Detroit
7Mayo Clinic, Rochester, MN
8Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
9University of Rochester, Rochester, NY
10Ireland Cancer Center, University Hospitals of Cleveland, Cleveland, OH
11Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL

Interim Results of a Phase I/II Clinical Trial of Belinostat in Combination with Idarubicin in Patients with AML Not Suitable for Standard Intensive Therapy

Richard Schlenk1, Kristina Sohlbach2*, Marie-Luise Hütter3*, Patrice Ceballos4*, Nathalie Fegueux, MD5*, Emmanuel Raffoux6*, Herve Dombret, MD7, Mike Dennis8*, Jo Tomlins8*, Jette Tjřrnelund9* and Andreas Neubauer2*

1Internal Medicine III, University of Ulm, Ulm, Germany
2Dept. Hematology, Oncology, Immunology, Philipps University Marburg, Marburg, Germany
3University of Ulm, Ulm, Germany
4CHU Montpellier and INSERM U475, Montpellier, France
5Haematology-Oncology, CHU Montpellier, Montpellier Cedex 5, France
6Dept. of Hematology, Hopital Saint Louis, Paris, France
7Hopital Saint Louis, Paris, France
8Department of Haematology, Christie Hospital NHS Trust, Manchester, United Kingdom
9Drug Metabolism and Pharmacokinetics, Topotarget, Copenhagen, Denmark

Lenalidomide Enhances Leukaemia Specific T Cell Responses to Dendritic Cell Based Immunotherapy for Myeloid Leukaemias

Caroline J Duncan, MBBS, MRCP(Ed)1*, Peter R. E. Johnson, MD2 and Huw Roddie, MBChB, PhD3*

1Centre for Regenerative Medicine, Adult Cell Therapy Group, Edinburgh, United Kingdom
2Haematology, Western General Hospital, Edinburgh, ARRAY(0xc41f4f0)
3Department of Haematology, Western General Hospital, Edinburgh, United Kingdom

Voreloxin (formerly known as SNS-595) in Combination with Cytarabine Demonstrates Preliminary Clinical Responses in a Phase 1 Study in Relapsed/Refractory Acute Myeloid Leukemia

Jeffrey Lancet, MD1, Judith E. Karp, MD2, Larry D. Cripe, MD3, Gail J. Roboz, MD4, Matt Suster5*, Nguyen Tan5*, Rachael Hawtin5*, Judith Fox5*, Craig Berman5* and Glenn Michelson5*

1H. Lee Moffitt Cancer Ctr. & Rsrch. Institute, Tampa, FL
2Johns Hopkins University, The Sidney Kimmel Cancer Center at, Baltimore, MD
3Indiana University Simon Cancer Center, Indianapolis, IN
4Cornell University, New York, NY
5Sunesis Pharmaceuticals Inc, South San Francisco, CA

Approach to Establish Long Term Anti-Acute Myeloid Leukemia (AML) Immune Responses by Inducing Central Memory AML Specific CD4 T Cells

Ruikun Zhong, MD1*, Thomas A. Lane, MD2 and Edward D Ball, MD3

1Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA
2Moores UCSD Cancer Center, La Jolla, CA
3Medicine, Division of Blood and Marrow Transplantation, UCSD, La Jolla, CA

*signifies non-member of ASH