50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Signaling Diversity in Hematopoietic Cells Poster I

Sunday, December 7, 2008: 6:00 PM-8:00 PM

Hall A (Moscone Center)

Liar, a Novel Lyn-Binding Nuclear/Cytoplasmic Shuttling Protein That Influences Erythropoietin-Induced Differentiation

Amy L Samuels, PhD¹^*, Svend Peter Klinken, PhD² and Evan Ingley, PhD, BSc³

¹Laboratory for Cancer Medicine, WA Institute for Medical Research, Perth, Australia
²Western Australian, Perth, WEA, Australia
³Laboratory for Cancer Medicine, WA Institute for Medical Research, Perth, WEA, Australia

2885

Caspase Activated Rock-1 Allows Erythroblasts Enucleation Independently of Cytokine Signaling

Genevieve Courtois¹^*, Julie Vandekerckhove¹^*, Yunhua Chang²^*, jean-Antoine Ribeil¹^*, Joelle Kersual¹^*, Najet Debili²^*, William Vainchenker³, Bruno R. Varet, MD⁴ and Olivier Hermine⁵^*

¹Hôpital Necker, université René Descartes, CNRS UMR8147, Paris, France
²Institut Gustave Roussy, INSERM U790, Villejuif, France
³INSERM U790, Institut Gustave Roussy, Villejuif, France
⁴Hematology Dept., Paris Descartes Univ. Necker Hospital, Paris, France
⁵Hopital Necker, Paris, France

2886

Ectopic Expression of the Extracellular Domain of Mpl Is Sufficient to Induce a Hematopoietic Population Crisis

Daniel C. Wicke¹^*, Johann Meyer¹^*, Guntram Büsche, MD²^*, Hans Kreipe, MD²^*, Zhixiong Li, MD¹, Karl Welte³, Matthias Ballmaier³^*, Christopher Baum¹ and Ute Modlich¹^*

¹Experimental Hematology, Hannover Medical School, Hannover, Germany
²Institute of Pathology, Hannover Medical School, Hannover, Germany
³Department of Pediatric Hematology, Hannover Medical School, Hannover, Germany

2887

M-CSF Preferentially Induces C-Fos Via ERK to Specify Monopoiesis Whereas G-CSF Directs Granulopoiesis Via SHP2

Graham D. Jack, PhD^* and Alan D. Friedman, M.D.

Pediatric Oncology, Johns Hopkins University, Baltimore, MD

2888

Differential Effects of a Novel Non-Peptidic Thrombopoietin Mimetic on Proliferation and Differentiation of Human CD34⁺ Progenitor Cells

Juha Punnonen, MD, PhD¹^*, Marcus O. Muench, PhD²^* and Jeffrey R. Spencer, PhD¹^*

¹STATegics, Inc., Sunnyvale, CA
²Blood Systems Research Institute, San Francisco, CA

2889

Thrombopoietin-Mediated Ubiquitination and Degradation of C-Mpl

Sebastian J Saur¹^*, Amy Geddis, MD, PhD², Kenneth Kaushansky, MD³ and Ian Hitchcock, PhD⁴

¹School of Medicine, University of California San Diego, La Jolla, CA
²School of Medicine, University of California San Diego, San Diego, CA
³Chair, Dept. of Medicine, President, American Society of Hematology, University of California - San Diego, La Jolla, CA
⁴Dept. of Medicine, UCSD, La Jolla, CA

2891

Ligand-Independent MPL^W515L Activity Requires Cell Surface Localization

Caroline Marty¹^*, Ronan Chaligné¹^*, Catherine Lacout¹^*, Stefan N. Constantinescu², William Vainchenker¹ and Jean-Luc Villeval¹^*

¹INSERM U790, Institut Gustave Roussy, Villejuif, France
²Ludwig Institute for Cancer Research, Brussels, Belgium

2892

Influence of PI-3K/Akt Pathway on Wnt Signalling in Myeloid Progenitor Cells. Evidence for a Role of Autocrine/Paracrine Wnt Regulation in CFU-GM Proliferation

Georgios Nteliopoulos, MSc^*, Stephen B Marley, PhD^* and Myrtle Y Gordon, PhD, DSc^*

Haematology, Imperial College London, London, United Kingdom

2893

A Molecular Signature for a Cytokine Receptor Survival Pathway in AML Identifies Unique Prognostic Indicators and Therapeutic Targets

Daniel Thomas, MD¹^*, Jason A Powell, PhD¹^*, Emma F Barry¹^*, Luen Bik To, MD², Angel Lopez¹ and Mark A Guthridge¹^*

¹Human Immunology, IMVS, Adelaide, Australia
²Haematology, IMVS, Adelaide, Australia

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^*signifies non-member of ASH