Francesco Zaja^1*, Michele Baccarani², Patrizio Mazza^3*, Nicola Vianelli^4*, Monica Bocchia^5*, Luigi Gugliotta, MD⁶, Marzia Defina^7*, Alessia Tieghi^6*, Sergio Amadori⁸, Selenia Campagna^8*, Felicetto Ferrara⁹, Maria Carla De Simone^10*, Alfonso Zaccaria^11*, Anna Lia Molinari^11*, Emanuele Angelucci¹², Emilio Usala^12*, Silvia Cantoni^13*, Antonella Fornaro^14*, Giuseppe Visani^15*, Rita Rizzi^16*, Valerio De Stefano^17*, Francesco Casulli^3*, Marta Lisa Battista^1*, Miriam Isola^18*, Franca Soldano^18*, Mario Regazzi^19*, Enrica Gamba^20* and Renato Fanin^1*

¹Clinica Ematologica DIRM AOUD, Udine, Italy
²Department of Hematology/Oncology "L. and A. Seragnoli", University of Bologna, Italy
³Ematologia-Taranto, Italy
⁴Istituto L.A. Seràgnoli-Bologna, Italy
⁵Clinica Ematologica-Siena, Siena, Italy
⁶Ematologia-Reggio Emilia, Italy
⁷Clinica Ematologica-Siena, Italy
⁸Ematologia Tor Vergata-Roma, Italy
⁹Department of Hematology, Ospedale Cardarelli, Naples, Italy
¹⁰Ematologia Cardarelli-Napoli, Italy
¹¹Ematologia-Ravenna, Italy
¹²Ematologia-Cagliari, Italy
¹³Ematologia Niguarda-Milano, Italy
¹⁴Ematologia-Pescara, Italy
¹⁵Ematologia-Pesaro, Italy
¹⁶Clinica Ematologica-Bari, Italy
¹⁷Ematologia Cattolica-Roma, Italy
¹⁸Istituto Statistica DIRM-Udine, Italy
¹⁹Istituto di Farmacologia-Pavia, Italy
²⁰Roche-Monza, Italy

Caroline M Bateman, MBBS, MRCP^1*, Sharon W Horsley^1*, Tracy Chaplin^2*, Bryan D Young^2*, Anthony M Ford¹, Lyndal Kearney¹ and Mel Greaves^1*

¹Section of Haemato-Oncology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom
²Medical Oncology Unit, Cancer Research UK, London

Jonathan W. Friedberg, MD¹, Jeff Sharman^2*, Julia Schaefer-Cutillo^1*, Patrick B. Johnston^3*, Sven De Vos, MD, PhD^4*, Ann LaCasce, MD⁵, John P. Leonard, MD⁶, Larry D. Cripe, MD⁷, Rajni Sinha, MD^8*, Stephanie A. Gregory^9*, John Sweetenham^10*, Julie M. Vose, MD¹¹, Ann M Lowe, MD¹², R. Levy¹³ and Margaret A. Shipp, MD¹⁴

¹James P. Wilmot Cancer Center, University of Rochester, Rochester, NY
²Stanford University
³Mayo Clinic Graduate School of Medicine, Rochester, MN
⁴David Geffen School of Med. at UCLA, Los Angeles, CA
⁵Dana-Farber Cancer Inst., Boston, MA
⁶Division of Hem./Onc., Weill Cornell Medical College, New York, NY
⁷Indiana University Simon Cancer Center, Indianapolis, IN
⁸Heme/Onc, Emory University
⁹Section of Hematology & Stem Cell Transplantation, Rush University Medical Center, Chicago, IL
¹⁰Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
¹¹Univ. of NE Med. Ctr., Omaha, NE
¹²Rigel Pharmaceuticals, South San Francisco, CA
¹³Oncology, Stanford University, Stanford, CA
¹⁴Dana-Farber Cancer Institute, Boston, MA

Simon Mendez-Ferrer, Ph.D.^1*, Grigori N. Enikolopov, Ph.D.^2*, Sergio Lira, M.D., Ph.D.^3* and Paul S. Frenette, M.D.⁴

¹Mount Sinai School of Medicine, New York, NY
²Cold Spring Harbor Laboratory, New York, NY
³Mount Sinai School of Medicine
⁴Department of Medicine and Immunology Institute, Mount Sinai School of Medicine, New York, NY

Kaan Boztug^1*, Giridharan Appaswamy^1*, Angel Ashikov^2*, Alejandro A Schäffer^3*, Ulrich Salzer^4*, Jana Diestelhorst^1*, Manuela Germeshausen^1*, Gudrun Brandes^5*, Jacqueline Lee-Gossler^5*, Fatih Noyan^1*, Anna-Katherina Gatzke^1*, Milen Minkov^6*, Johann Greil^7*, Christian Kratz⁸, Theoni Petropoulou^9*, Isabelle Pellier^10*, Christine Bellanne-Chantelot^11*, Nima Rezaei^12*, Kirsten Mönkemöller^13*, Noha Irani-Hakimeh^14*, Hans Bakker^2*, Rita Gerardy-Schahn^5*, Cornelia Zeidler^1*, Bodo Grimbacher^15*, Karl Welte¹ and Christoph Klein¹⁶

¹Department of Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany
²Department of Cellular Chemistry, Hannover Medical School, Hannover, Germany
³National Center for Biotechnology Information, National Institutes of Health, Bethesda
⁴Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany
⁵Department of Cell Biology, Hannover Medical School, Hannover, Germany
⁶Department of Pediatric Hematology/Oncology, St. Anna Children's Hospital, Vienna, Austria
⁷Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Heidelberg, Germany
⁸Department of Pediatric Hematology/Oncology, University of Freiburg, Freiburg, Germany
⁹Aghia Sophia Children's Hospital, Athens
¹⁰Unité Immuno-Hémato-Oncologie Pédiatrique, CHU Angers, Angers, France
¹¹Department of Genetics, AP-HP Pitié-Salpétriére, Paris, France
¹²Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
¹³Department of General Pediatrics, Children's Hospital Amsterdamer Straße, Cologne, Germany
¹⁴Department of Laboratory Medicine and Blood Bank, Saint George University Hospital, Beirut, Lebanon
¹⁵Department of Immunology, Royal Free Hospital and University College London, London, United Kingdom
¹⁶Department of Pediatric Hematology/Oncology, Medical School Hannover, Hannover, Germany

Giancarlo Agnelli, M.D.^1*, Gualberto Gussoni, M.D.^2*, Carlo Bianchini, M.D.^3*, Melina Verso, M.D.^1* and Maurizio Tonato, M.D.^4*

¹Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy
²Protecht Clinical Project Leader, Milan, Italy
³Scientific Department, Italfarmaco, Milan, Italy
⁴Regional Cancer Center, Perugia, Italy