Before you can access ASH's online program, you must agree to the following:
Last updated January 16, 2009. Please note that this site represents the latest program changes
and differs from the print version in some details.

732.O1.8 Alternative Donor Transplantation - Stem Cell Source

Monday, December 8, 2008: 7:00 AM-9:00 AM
Gateway Ballroom 104 - South (Moscone Center)
Moderators:
Vanderson Rocha, MD, PhD and Claudio Brunstein, MD, PhD
7:00 AM
Nonmyeloablative Allogeneic Hematopoietic Cell Transplantation in Patients with De Novo and Secondary Acute Myeloid LeukemiaClinically Relevant Abstract

Boglarka Gyurkocza, MD1, Rainer F. Storb, MD1, Barry Storer, PhD1*, Thomas Chauncey, MD2*, Dietger Niederwieser, MD3*, Judith Shizuru, MD, PhD4*, Amelia Langston, MD5, Michael Pulsipher, MD6, Christopher Bredeson, MD7, Richard T. Maziarz, MD8, Benedetto Bruno9*, Finn Petersen, MD10, Michael Maris, MD11, Edward Agura, MD12, Andrew M. Yeager, MD13, Wolfgang A. Bethge, MD14*, Firoozeh Sahebi15*, Lars Vindelov, MD16, Peter A. McSweeney, MD11, Frederick R. Appelbaum, MD1*, David G. Maloney, MD, PhD1* and Brenda M. Sandmaier1*

1Fred Hutchinson Cancer Research Center/ University of Washington, Seattle, WA
2VA Puget Sound Health Care System/ Fred Hutchinson Cancer Research Center/ University of Washington, Seattle, WA
3University of Leipzig, Leipzig, Germany
4Stanford University Medical Center, Stanford, CA
5Emory University, Atlanta, GA
6University of Utah Medical Center, Salt Lake City, UT
7Medical College of Wisconsin, Milwaukee, WI
8Oregon Health & Science University, Portland, OR
9University of Torino, Torino, Italy
10LDS Hospital, Salt Lake City, UT
11Rocky Mountain Cancer Center, Denver, CO
12Baylor University Medical Center, Dallas, TX
13University of Arizona, Tucson, AZ
14University of Tuebingen Medical Center, Tuebingen, Germany
15City of Hope, Duarte, CA
16Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

7:15 AM
Greater HLA Disparity Is Associated with Reduced Risk of Relapse and Improved Event-Free Survival after Nonmyeloablative, HLA-Haploidentical BMT with Post-Transplantation High-Dose Cyclophosphamide

Yvette L. Kasamon1, Mary S. Leffell1*, Jeanne Kowalski1*, Hua-Ling Tsai1*, Nancy Rossiter1*, Lawrence E. Morris2, Pamela A. Crilley3, Leo Luznik1*, Javier Bolaños-Meade1, Paul V. O'Donnell4*, Richard F. Ambinder1, Richard J. Jones1 and Ephraim J. Fuchs1

1Johns Hopkins University, Baltimore, MD
2BMT Group of Georgia, Atlanta, GA
3Hahnemann University Hospital, Philadelphia, PA
4Fred Hutchinson Cancer Research Center, Seattle, WA

7:30 AM
Effect of Stem Cell Source on Transplant Outcomes in Adults with Acute Leukemia: A Comparison of Unrelated Bone Marrow (BM), Peripheral Blood (PB) and Cord Blood (CB)Clinically Relevant Abstract

Mary Eapen, MBBS1, Vanderson Rocha, MD, PhD2*, Andromachi Scaradavou, MD3, Eliane Gluckman, MD4, Mary Laughlin5*, Cladd Stevens, MD6*, Mary M. Horowitz, MD, MS7 and John E. Wagner, MD8

1Medical College of Wisconsin, Milwaukee, WI
2BMT unit, Hopital Saint Louis APHP and University of Paris VII, Paris, France
3New York Blood Center, New York, NY
4Hopital Saint-Louis, Paris, France
5Ireland Cancer Center, University Hospitals Case Medical Center, Cleveland, OH
6New York Blood Center, New York
7Medical College of Wisconsin, Center for International Blood and Marrow Transplant Research, Milwaukee, WI
8Pediatric Hematology, Oncology, University of Minnesota

7:45 AM
Negative Effect of KIR Alloreactivity in Recipients of Umbilical Cord Blood Transplantation Depends on Transplantation Conditioning Intensity

Claudio Brunstein, MD, PhD1, John E. Wagner, MD2, Daniel Weisdorf, MD1, Sarah Cooley, MD1, Harriet Noreen1*, Juliet Barker, MBBS3, Todd DeFor1*, Michael Verneris, MD1, Philip B. McGlave1*, Bruce R. Blazar, MD1 and Jeffrey S. Miller, MD1

1University of Minnesota, Minneapolis, MN
2Pediatric Hematology, Oncology, University of Minnesota, Minneapolis, MN
3Memorial Sloan-Kettering Cancer Center, New York, NY

8:00 AM
Donor-Recipient Matching at the HLA-C Locus and Early Outcomes after Unrelated Umbilical Cord Blood Transplant (UCBT)Clinically Relevant Abstract

Mary Eapen, MBBS1, John Klein, PhD1*, Guillermo Sanz, MD, PhD2, Claudio Anasetti, MD3, Joan Garcia, MD4*, Eliane Gluckman, MD5, Mary M. Horowitz, MD, MS6, Gesine Koegler, MD7*, Mary Laughlin, MD8*, Gerard Michel, MD9*, Stephen R Spellman, MS10*, Franklin O. Smith, MD11 and Vanderson Rocha, MD, PhD12

1Medical College of Wisconsin, Milwaukee, WI
2Dept. of Hematology, Hospital Universitario La Fe, Valencia, Spain
3H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
4Centre de Transfusio I Banc de Teixitis, L Hospilet de Llobregat, Barcelona, Spain
5Hopital Saint-Louis, Paris, France
6Medical College of Wisconsin, Center for International Blood and Marrow Transplant Research, Milwaukee, WI
7University of Dusseldorf, Dusseldorf, Germany
8Ireland Cancer Center, University Hospitals Case Medical Center, Cleveland, OH
9Hopital D'Enfants de la Timone, Marseille, France
10National Marrow Donor Program, Minneapolis, MN
11Children's Hosp. Med. Ctr., Cincinnati, OH
12BMT unit, Hopital Saint Louis APHP and University of Paris VII, Paris, France

8:15 AM
Double Cord Blood Transplantation (CBT) with and without Ex-Vivo Expansion (EXP): A Randomized, Controlled StudyClinically Relevant Abstract

Marcos De Lima1, Jonh D. McMannis1*, Rima Saliba1*, Laura Worth1*, Partow Kebriaei1*, Uday Popat1*, Muzaffar Qazilbash1*, Roy Jones1*, Sergio Giralt1*, Leandro de Padua Silva1, Lawrence Cooper1*, Demetrios Petropoulos1*, Dean Lee1*, Susan Kelly1*, Peter Thall2*, Simon Robinson1*, Issa Khouri1*, Chitra Hosing1*, Martin Korbling1*, Amin Alousi1*, Gabriela Rondon1*, Borje S. Andersson1*, Yago Nieto1*, Stefan Ciurea1*, Krishna Komanduri1*, Richard E Champlin1* and Elizabeth Shpall1*

1Department of Stem Cell Transplantation, M.D. Anderson Cancer Ctr., Houston, TX
2Department of Biostatistics, M.D. Anderson Cancer Ctr., Houston, TX

8:30 AM
Influence of Myeloablative Conditioning Regimens on Outcomes after Single Unrelated Cord Blood Transplantation for Adults with Leukemia : An Analysis on Behalf of Eurocord-EBMT-NetcordClinically Relevant Abstract

Samir Kanaan Nabhan, MD1*, Vanderson Rocha, MD1*, William Arcese, MD2, Anne Sirvent, MD3*, Irina Ionescu, MD1*, Renata Bizzetto, MD1*, Karim Boudjedir, MD1*, Wagnara Chaves, MD1*, Andrée-Laure Herr, MD1*, Eliane Gluckman, MD1 and Guillermo Sanz, MD, PhD4

1Eurocord, Paris, France
2Dept. of Hematology and Transplant, University of Rome 'Tor Vergata', Rome, Italy
3Hôpital de l'Archet 1, Nice, France
4Dept. of Hematology, Hospital Universitario La Fe, Valencia, Spain

8:45 AM
KIR-Ligand Incompatibility in the Graft-Versus-Host Direction Is Associated with Better Outcomes after Unrelated Cord Blood Stem Cell Transplantation for Acute Leukemia in Complete RemissionClinically Relevant Abstract

Roelof Willemze, MD, PhD1, Celso arrais Rodrigues2*, Myriam Labopin, MD3*, Guillermo Sanz, MD, PhD4, Gerard Michel, MD5*, Gerard Socié, MD, PhD6*, Bernard Rio7*, Anne Sirvent8*, Marc Renaud9*, Luis Madero10*, Mohamad Mohty, MD, PhD11, Christelle Ferra, MD, PhD12*, Federico Garnier13*, Juan Garcia14*, Lucilla Lecchi15*, Gesine Koegler16*, Yves Beguin17, Cristina Navarrete18*, Timothy Devos19*, Irina Ionescu20*, Karim Boudjedir20*, Andrée-Laure Herr, MD21*, Eliane Gluckman, MD22 and Vanderson Rocha20*

1Dept. of Hematology, Leiden Univ. Med. Ctr., Leiden, Netherlands
2Eurocord, France
3Hopital Saint-Antoine, Université Pierre et Marie Curie Paris 6, Paris 75571, France
4Dept. of Hematology, Hospital Universitario La Fe, Valencia, Spain
5Hopital D'Enfants de la Timone, Marseille, France
6Hematology / Transplantation, Hopital Saint-Louis, Paris, France
7Département d'Hématologie et d'Oncologie Médicale, Hôtel Dieu, Paris, France
8Hôpital de l'Archet 1, Nice, France
9Hôpital La Miletrie, Poitiers, France
10MD, Nino Jesus Children's Hospital, Madrid, Spain
11Hematology Dept., CHU de Nantes, Nantes, France
12GETH (Grupo Español de Trasplante Hematopoyético), PETHEMA (Programa Español de Tratamiento de Hemopatías Malignas), Barcelona, Spain
13French Network of Cord Blood Banks, Paris, France
14Cttc, Cord Blood Bank, Barcelona, Spain
15Cord Blood Bank & GRACE, Milano, Italy
16Institut für Transplantationsdiagnostik und Zelltherapeutika, Duesseldorf, Germany
17ULg, Liege, Belgium
18Cord Blood Bank, London, United Kingdom
19De Leuvense Navelstrengbloedbank, Leuven, Belgium
20Eurocord, Paris, France
21Bone Marrow Transplantation, Saint-Louis Hospital, Paris, France
22Hopital Saint-Louis, Paris, France

*signifies non-member of ASH