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731.O1.6 Clinical Results - Allogeneic Matched Related Donor Transplantation I

Monday, December 8, 2008: 11:00 AM-12:30 PM
120-121-122-123-124-125 - North (Moscone Center)
Moderators:
Jeffrey Szer and Brandon Hayes-Lattin, MD
11:00 AM
Lower Relapse Incidence and Relapse Mortality in Patients Transplanted from a Younger Sibling in HLA-Identical Stem Cell Transplantation: Does Microchimerism Matter?

Christiane Dobbelstein, MD*, Haytham Kamal, MD*, Elke Dammann*, Eva Mischak-Weissinger, MD, PhD*, Michael Stadler, MD, PhD*, Juergen Krauter, MD, PhD*, Arnold Ganser, MD, PhD and Matthias Eder, MD, PhD*

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

11:15 AM
Prognostic Factors in Patients Receiving An Allogeneic Stem Cell Transplantation for Relapsed AML. Results of the Prospective AML 295 and 01/99 Studies

Jürgen Krauter1*, Gerhard Heil2*, Dieter Hoelzer, MD, PhD3, Hans Martin3*, Oliver G. Ottmann3*, Jürgen Finke4*, Michael Lübbert, MD, PhD5*, Wolfgang Heit6*, Walter Fiedler7, Lothar Kanz, MD8, Günter Schlimok9*, Hartmut Kirchner10*, Aruna Raghavachar11*, Wolfram Brugger12*, Hartmut Döhner13* and Arnold Ganser, MD, PhD1

1Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
2Krankenhaus Lüdenscheid, Lüdenscheid, Germany
3J.W. Goethe University Hospital, Frankfurt/M, Germany
4University Medical Center Freiburg, Freiburg, Germany
5University of Freiburg Medical Center, Freiburg, Germany
6Hämatologie/Onkologie, Kliniken Essen Süd,, Essen, Germany
7Department of Hematology and Oncology, University Hospital Eppendorf, Hamburg, Germany
8Hematology and Oncology, Eberhard Karls University, Tuebingen, Germany
9II. Med. Klinik, Klinikum Augsburg, Augsburg, Germany
10Hematology/Oncology, Klinikum Hannover, Hannover, Germany
11Medizinische Klinik I, Schwerpunkt Hämatologie/Onkologie, HELIOS Klinikum Wuppertal, Wuppertal, Germany
12Hospital Villingen-Schwenningen, Germany
13Internal Medicine III, University of Ulm, Ulm, Germany

11:30 AM
Impact of Cytogenetics Risk on Outcome after Reduced Intensity Conditioning (RIC) Allogeneic Stem Cell Transplantation (allo-SCT) from An HLA Identical Sibling for Patients with Acute Myeloid Leukemia (AML) in First Complete Remission (CR1)

Mohamad Mohty, MD, PhD1, Myriam Labopin2*, Noel-Jean Milpied, PhD3, Jan J. Cornelissen, MD, PhD4, Didier Blaise, MD5, Eefke Petersen, MD6*, Niklas Theorin, MD7*, Hakan Goker8*, Gerard Socie9* and Vanderson Rocha10

1Hematology Dept., CHU and University of Nantes, Nantes, France
2EBMT Paris Office, Paris, France
3Hopital Haut Leveque - Pessac, Pessac, France
4Hematology, Erasmus MC/Daniel Den Hoed, Rotterdam, Netherlands
5Institut Paoli Calmettes, Marseille, France
6University Medical Centre Utrecht, Utrecht, Netherlands
7Dept. of Hematology, University Hospital, Linköping, Sweden
8Hematology, Hacettepe University, Ankara, Turkey
9Hematology / Transplantation, Hopital Saint-Louis, Paris, France
10BMT unit, Hopital Saint Louis APHP and Université Paris VII, Paris, France

11:45 AM
Non-Myeloablative Hematopoietic Stem Cell Transplantation in Older Patients with AML and MDS: Results from the Center for International Blood and Marrow Transplant Research (CIBMTR)Clinically Relevant Abstract

Brian McClune, DO1, Daniel J. Weisdorf, MD1, John F. DiPersio, MD, PhD2, Armand Keating, MD3, Tanya L. Pedersen4*, Gisela Tunes da Silva, PhD.5*, J. Sierra, MD6, Martin S. Tallman, MD7 and Sergio A. Giralt8*

1University of Minnesota, Minneapolis, MN
2School of Medicine, Washington University, Saint Louis, MO
3Princess Margaret Hospital, Toronto, ON, Canada
4CIBMTR, Milwaukee, WI
5Medical College of Wisconsin, Milwaukee, WI
6Clinical Hematology, Hospital De Sant Pau, Barcelona, Spain
7Northwestern University Feinberg School of Medicine, Chicago, IL
8Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Houston, TX

12:00 PM
Allogeneic Stem Cell Transplantation (Allo-SCT) in Adults with Acute Myelogenous Leukemia (AML). Final Analysis of JALSG AML97 Study

Hisashi Sakamaki, M.D.1, Shuichi Miyawaki, M.D.2, Shigeki Ohtake, M.D.3*, Nobuhiko Emi, M.D.4*, Fumiharu Yagasaki, MD5*, Kinuko Mitani, M.D.6*, Shin Matsuda, M.D.7*, Yuuji Kishimoto, M.D.8*, Yasushi Miyazaki, MD, PhD9, Norio Asou, M.D.10*, Masatomo Takahashi, M.D.11*, Yoshiaki Ogawa12*, Sumihisa Honda, Ph.D.13* and Ryuzo Ohno14*

1Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
2Hematology, Saiseikai Maebashi Hospital, Maebashi, Japan
3Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
4Hematology and Oncology, Fujita Health University Hospital, Toyoake, Japan
5Japan Adult Leukemia Study Group, Japan
6Hematology, Dokkyo University School of Medicine, Tochigi, Japan
7Center for hematopoietic disorders, Ohtanisinouchi Hospital, Kohriyama, Japan
8The First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
9Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasakishi, Japan
10Hematology, Kumamoto University School of Medicine, Kumamoto, Japan
11Hematology and Oncology, St. Marianna University School of Medicine, Kawasaki, Japan
12Hematology and Oncology, Tokai University, Isehara, Japan
13Radiation Epidemiology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan
14Aichi Cancer Center, Nagoya, Japan

12:15 PM
Similar Outcomes Using Myeloablative Versus Reduced Intensity and Non-Myeloablative Allogeneic Transplant Preparative Regimens for AML or MDS: From the Center for International Blood and Marrow Transplant Research

Selina Luger, MD1, Olle Ringden, MD2*, Waleska S. Peréz, MPH3*, Mei-Jie Zhang, PhD3*, John F. DiPersio, MD, PhD4, Jorge Sierra, MD5*, Martin Tallman, MD6, Daniel J. Weisdorf, MD7 and Michael Pulsipher, MD8

1Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
2Karolinska Institutet University Hospital Huddinge, Stockholm, Sweden
3Medical College of Wisconsin, Center for International Blood and Marrow Transplant Research, Milwaukee, WI
4Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO
5Hospital de Sant Pau, Barcelona, Spain
6Northwestern University, Chicago, IL
7University of Minnesota, Minneapolis, MN
8University of Utah Medical Center, Salt Lake City, UT

*signifies non-member of ASH