50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Clinical Transplantation: Chronic GVHD and Immune Reconstitution

Monday, December 8, 2008: 1:30 PM-3:00 PM

3014-3016-3018 - West (Moscone Center)

Moderators:

Madan Jagasia, MD, MS and Catherine J Wu, MD

1:30 PM

Macrophage Colony-Stimulating Factor Attenuated the Severity of Chronic Graft-Versus-Host Disease after Unrelated Bone Marrow Transplantation

Fumihiko Kimura¹, Ken Sato¹, Hideki Akiyama², Hiroshi Sao³^*, Shin-ichiro Okamoto, MD, PhD⁴, Naoki Kobayashi⁵^*, Masamichi Hara⁶^*, Keisei Kawa⁷^* and Kazuo Motoyoshi¹^*

¹Division of Hematology, National Defense Medical College, Tokorozawa, Japan
²Hematology Division, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
³Department of Hematology, Meitetsu Hospital, Nagoya, Japan
⁴Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
⁵Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
⁶Division of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan
⁷Osaka Medical Centre and Research Institute for Maternal and Child Health, Osaka, Japan

1:45 PM

464

Diverse Patterns of T Cell Reactivity Directed against Multiple Y Chromosome-Derived, HLA a*0201 Restricted, Peptides in Patients with chronic Gvhd

Yishay Ofran, M.D¹^*, Vladimir Brusic, Ph.D.²^*, H. T Kim³^*, Robert J. Soiffer, MD⁴, J. H Antin⁵^* and Jerome Ritz, MD⁶

¹Medical oncology, Dana Farber Cancer Institute, Boston, MA
²Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA
³Computational Biology and Biostatistics, Dana-Farber Cancer Inst., Boston, MA
⁴Dana-Farber Cancer Institute, Boston, MA
⁵Dana-Farber Cancer Inst., Boston, MA
⁶Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

2:00 PM

465

Elevated BAFF Is Correlated with Inflammatory Processes in Chronic Graft Versus Host Disease and Supports Increases in Transitional B Cells

Frances T. Hakim, PhD¹^*, Najibah Rehman¹^*, John Dickinson, MD¹^*, Sivasubramanian Baskar, PhD¹^*, Christoph M. Rader, PhD¹^*, Edward W. Cowen, MD²^*, Steven Z. Pavletic, MD¹ and Ronald E. Gress, MD¹^*

¹Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD
²Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD

2:15 PM

466

Prophylactic Rituximab after Reduced Intensity Conditioning Transplantation Results in Low Chronic Gvhd

Sally Arai, MD¹, Bita Sahaf²^*, Carol Jones³^*, James Zhender²^*, Robert Lowsky²^*, Samuel Strober²^*, Judith Shizuru²^*, Robert Negrin²^*, Laura Johnston²^*, Ginna Laport²^*, Joanna Schaenman²^*, Janice Brown²^*, Wen-Kai Weng²^*, Renee Letsinger²^*, Ruby Wong²^*, Philip Lavori²^* and David Miklos²^*

¹Bone Marrow Transplant, Stanford University Medical Center, Stanford, CA
²Stanford University, Stanford, CA
³Pathology, Stanford University, School of Medicine, Palo Alto, CA

2:30 PM

467

Monitoring of B Cell Subpopulations in Patients with Chronic Graft-Versus-Host Disease May Predict Response to Extracorporeal Photopheresis

Zoya Kuzmina¹^*, Winfried Pickl²^*, Robert Knobler³^*, Michal Kouba¹^*, Nina Worel⁴^*, Georg Stary⁵^*, Margit Mitterbauer¹^*, Peter Kalhs¹^* and Hildegard Greinix¹

¹Internal Medicine I, BMT, Medical University of Vienna, Vienna, Austria
²Institute of Immunology, Medical University of Vienna, Vienna, Austria
³Special and Environmental Dermatology, Medical University of Vienna, Vienna, Austria
⁴Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria
⁵Immunodermatology and Infectious Skin Diseases, Medical University of Vienna, Vienna, Austria

2:45 PM

468

First Report of the Prophylactic Administration of Ex Vivo Co-Stimulated Donor Lymphocyte Infusion (DLI) from Related and Unrelated Donors after Reduced Intensity Conditioning for High Risk Hematologic Malignancies

Steven C Goldstein, MD¹, Bruce Levine, PhD¹^*, Jacqueline Smith, MSN, CRNP¹^*, Joanne Hinkle, RN, BSN, OCN¹^*, Selina Luger, MD¹, Alexander Perl, MD¹^*, Alison Loren, MD¹^*, Noelle Frey, MD¹^*, Edward Stadtmauer, MD¹^*, Daniel Schullery, PhD¹^*, Jean Boyer, PhD¹^*, Dennis L. Confer, MD², David Porter, MD¹ and Carl H. June, MD¹

¹Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
²National Marrow Donor Program, Minneapolis, MN

See more of: Oral and Poster Abstracts

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^*signifies non-member of ASH

722.O3.6 Clinical Transplantation: Chronic GVHD and Immune Reconstitution