50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Clinical Transplantation: Immune Reconstitution and Infectious Complications

Monday, December 8, 2008: 11:00 AM-12:30 PM

2002-2004 - West (Moscone Center)

Moderators:

Michael Boeckh, MD and Katarina Le Blanc, MD, PhD

11:00 AM

IgG Allotypes Reveal That Antimicrobial Humoral Immunity Persists after Reduced-Intensity Hematopoietic Cell Transplantation

Julie R. Boiko¹^*, Bita Sahaf, PhD¹^*, Antonia M.S. Mueller, MD¹^*, George L. Chen, MD¹^*, Dolly Tyan, PhD²^* and David B. Miklos, MD, PhD¹

¹Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA
²Pathology, Stanford University School of Medicine, Palo Alto, CA

11:15 AM

350

Immune Response to the 23-Valent Polysaccharide Pneumococcal Vaccine (PPV23) after the 7-Valent Conjugate Vaccine (PCV7) in Allogeneic Stem Cell Transplant (SCT) Recipients: Results of the EBMT IDWP01 Trial

Catherine Cordonnier, MD¹, Myriam Labopin²^*, Virginie Chesnel²^*, Patricia Ribaud³^*, Rafael De La Camara, MD⁴, Rodrigo Martino⁵^*, Andrew Ullmann⁶^*, Terttu Parkkali⁷^*, Anna Locasciulli⁸^*, Karima Yakouben⁹^*, Karlis Pauksens¹⁰^*, Hermann Einsele¹¹^*, Dietger Niederwieser, MD¹²^*, Jane Apperley¹³^* and Per T. Ljungman, MD, PhD¹⁴

¹Hematologie Clinique, Hopital Henri Mondor, Creteil, France
²EBMT Paris Office, Paris, France
³Saint-Louis Hospital, Bone Marrow Transplant Department, Paris, France
⁴Hematology, Hospital Universitario De La Princesa, Madrid, Spain
⁵Sant Pau Hospital, Hematology Department, Barcelona, Spain
⁶Johannes Gütenberg Universität, Mainz, Germany
⁷Helsinki University Hospital, Helsinki, Finland
⁸San Camillo Hospital, Roma, Italy
⁹Robert Debré Hospital, Paris, France
¹⁰University Hospital, Uppsala, Sweden
¹¹Internal Medicine, University Hospital, Wursburg, Germany
¹²University of Leipzig, Leipzig, Germany
¹³Haematology, Hammersmith Teaching Hospital, London, United Kingdom
¹⁴Karolinska University Hospital, Stockholm, Sweden

11:30 AM

351

Decreased Infections in Recipients of Unrelated Donor (URD) Hematopoietic Cell Transplantation (HCT) from Donors with An Activating KIR B Genotype (B/x)

Marcie Tomblyn, MD, MS¹, Jo-Anne Young, MD¹^*, Michael D Haagenson, MS²^*, John P. Klein, PhD³^*, Jan Storek, MD, PhD⁴^*, Stephen Spellman⁵^*, Sarah Cooley, MD¹, Daniel J. Weisdorf, MD¹ and Jeffrey S. Miller, MD¹

¹University of Minnesota, Minneapolis, MN
²CIBMTR-Minneapolis, Minneapolis, MN
³Medical College of Wisconsin, CIBMTR, Milwaukee, WI
⁴University of Calgary, Calgary, Canada
⁵National Marrow Donor Program, Minneapolis, MN

11:45 AM

352

CMV-Specific T Cell Immunotherapy Promotes Restoration of Durable Functional Immunity in High Risk Patients Following Allogeneic Stem Cell Transplantation

Karl S Peggs, MD¹^*, Stephanie Verfuerth, PhD²^*, Arnold Pizzey¹^*, Christine Chow¹^*, Kirsty Thomson, MD¹^* and Stephen Mackinnon, MD²

¹Haematology, University College London Cancer Institute, London, United Kingdom
²Haematology, Royal Free and University College, London, United Kingdom

12:00 PM

353

Early and Effective Immune-Recovery by Gene-Engineered Lymphocytes after Haploidentical Transplantation for Leukemia Abate Late Transplant Mortality

Maria Teresa Lupo Stanghellini¹^*, Fabio Ciceri¹^*, Chiara Bonini², Attilio Bondanza²^*, Catia Traversari³^*, Monica Salomoni³^*, Lucia Turchetto³^*, Scialini Colombi³^*, Massimo Bernardi¹^*, Jacopo Peccatori¹^*, Alessandra Pescarollo¹^*, Paolo Servida¹^*, Zulma Magnani²^*, Serena Kimi Perna²^*, Veronica Valtolina²^*, Fulvio Crippa⁴^*, Luciano Callegaro¹^*, Elena Spoldi³^*, Roberto Crocchiolo¹^*, Katharina Fleischhauer⁵^*, Maurilio Ponzoni⁶^*, Luca Vago⁵^*, Armando Santoro⁷^*, Elisabetta Todisco⁷^*, Jane Apperley⁸^*, Eduardo Olavarria⁸^*, Shimon Slavin⁹^*, Eva Maria Weissinger¹⁰^*, Bernd Hertenstein¹⁰^*, Michael Stadler¹⁰^*, Evangelia Yannaki¹¹^*, Athanasios Fassas¹¹^*, Achilles Anagnostopoulos¹¹^*, Corrado Gallo Stampino³^*, Marco Bregni¹^*, Paolo Bruzzi¹²^* and Claudio Bordignon³^*

¹Hematology and Bone Marrow Transplantation Unit, IRCCS H San Raffaele, Milano, Italy
²Cancer Immunotherapy and Gene Therapy Program, IRCCS H San Raffaele, Milano, Italy
³MolMed S.p.A., Milan, Italy
⁴Department of Infectious Disease, San Raffaele Scientific Institute, Milan
⁵Unit of Molecular Immunology of Transplantation, Immunohematology and Transfusion Medicine Service, San Raffaele Scientific Institute, Milan
⁶Unit of Lymphoid Malignancies, Department of Oncology, Istituto Scientifico San Raffaele, Milano, Italy
⁷Oncology - Hematology, Istituto Clinico Humanitas, Rozzano, Italy
⁸Haematology, Hammersmith Teaching Hospital, London, United Kingdom
⁹Hematology, Hadassah Hospital, Jerusalem, Israel
¹⁰Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹¹Hematology Department-Bone Marrow Transplantation Unit, George Papanicolaou Hospital, Thessaloniki, Greece
¹²Epidemiologia Clinica, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy

12:15 PM

354

CD8-Depleted Donor Lymphocyte Infusions Can Improve Both T- and B-Cell Reconstitution after Allogeneic Stem Cell Transplantation from Haploidentical Family Donors

Anna Dodero, MD¹^*, Cristiana Carniti, PhD¹^*, Anna Raganato, PhD¹^*, Antonio Vendramin, PhD¹^*, Simona Di Terlizzi, PhD¹^*, Lucia Farina, MD¹^*, Francesco Spina, MD¹^*, Franca Fossati Bellani, MD²^*, Marco Milanesi, PhD³^*, Paolo Longoni, PhD³^*, Lorenza Gandola, MD⁴^*, Claudia Lombardo, MD⁵^* and Paolo Corradini, MD⁶

¹Hematology, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
²Pediatrics, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
³Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
⁴Radiotherapy, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
⁵HLA Laboratory, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
⁶Hematology - BMT, Fondazione IRCCS Istituto Nazionale Tumori and University of Milano, Milano, Italy

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^*signifies non-member of ASH

722.O2.6 Clinical Transplantation: Immune Reconstitution and Infectious Complications