50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Clinical Transplantation: Acute GVHD Prevention and Risk Assessment

Sunday, December 7, 2008: 4:30 PM-6:00 PM

3001-3003-3005 - West (Moscone Center)

Moderators:

Corey S Cutler and David Miklos, MD, PhD

4:30 PM

BMT CTN 0302: A Phase II Randomized Trial Evaluating Etanercept, Mycophenolate Mofetil (MMF), Denileukin Diftitox, and Pentostatin in Combination with Corticosteroids in 180 Patients (pts) with Newly Diagnosed Acute Graft Vs. Host Disease (aGVHD)

Amin Alousi, MD¹, Daniel J. Weisdorf, MD², Brent R. Logan, PhD³^*, Javier Bolanos-Meade, MD⁴, Steven C. Goldstein, MD⁵, Vincent T Ho, MD⁶, Brandon Hayes-Lattin, MD⁷, John R. Wingard, MD⁸, Mary M. Horowitz, MD, MS⁹ and John E. Levine, MD, MS¹⁰

¹Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Houston, TX
²University of Minnesota, Minneapolis, MN
³Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI
⁴Hematologic Malignancies, Johns Hopkins University, Baltimore, MD
⁵University of Pennsylvania, Philadelphia, PA
⁶Hematologic Oncology, Dana-Farber Cancer Institute, Boston, MA
⁷Oregon Health and Science University, Portland, OR
⁸Shands Cancer Center, University of Florida, Gainesville, FL
⁹Clinical Cancer Center, Center for International Blood and Marrow Transplant Research, Froedtert and the Medical College of Wisconsin, Milwaukee, WI
¹⁰Blood and Marrow Transplantation Program, Univ. of Michigan, Ann Arbor, MI

4:45 PM

Post-Transplantation High Dose Cyclophosphamide (Cy) Is Effective Single Agent for Prevention of Acute and Chronic Graft Versus Host Disease after Myeloablative HLA Matched Related and Unrelated Bone Marrow Transplantation (BMT)

Leo Luznik^*, Javier Bolanos-Meade^*, Robert Brodsky^*, B. Douglas Smith, Carol A. Huff, Michele Kaup^*, Allen Chen^*, Richard F. Ambinder, Richard J. Jones and Ephraim J. Fuchs

Johns Hopkins University, Baltimore, MD

5:00 PM

A Randomized Prospective Multicenter Phase III Trial Comparing Standard GvHD Prophylaxis with Cyclosporine and Methotrexate with Additional Pretransplant ATG Fresenius (ATG-F) in Allogeneic Stem Cell Transplantation from Matched Unrelated Donors

Jürgen Finke¹^*, Wolfgang Andreas Bethge²^*, Claudia Schmoor³^*, Hellmut Ottinger⁴^*, Matthias Stelljes⁵^*, Axel Zander⁶^*, Liisa Volin⁷^*, Dominik Heim⁸, Rainer Schwerdtfeger⁹, Karin Kolbe¹⁰^*, Jiri Mayer¹¹^*, Johan Maertens¹²^*, Werner Linkesch¹³^*, Ernst Holler¹⁴^*, Vladimir Koza¹⁵^*, Martin Bornhaeuser¹⁶^*, Hermann Einsele¹⁷, Hans-Jochem Kolb¹⁸^*, Hartmut Bertz¹^*, Matthias Egger¹^*, Olga Grichina³^* and Gerard Socie¹⁹^*

¹University Medical Center Freiburg, Freiburg, Germany
²University of Tübingen Medical Center, Tübingen, Germany
³Clinical Trial Center, Freiburg, Germany
⁴University Hospital Essen, Essen, Germany
⁵University of Münster, Münster, Germany
⁶University Hospital Eppendorf, Hamburg, Germany
⁷Helsinki University Central Hospital, Helsinki, Finland
⁸University Hospital Basel, Basel, Switzerland
⁹DKD Wiesbaden, Wiesbaden, Germany
¹⁰University Mainz, Mainz, Germany
¹¹Masaryk University Hospital, Brno, Czech Republic
¹²UZ Gasthuisberg, Leuven, Belgium
¹³Med. Univ. Graz, Graz, Austria
¹⁴Klinikum der Universität Regensburg, Regensburg, Germany
¹⁵Charles University Hospital, Plzen, Czech Republic
¹⁶University Hospital, Dresden, Germany
¹⁷Medizinische Klinik II, Würzburg, Germany
¹⁸Klinikum Großhadern, Ludwig-Maximilians-University Munich, Munich, Germany
¹⁹Serv. de Greffe de Moelle, Paris, France

5:15 PM

Donor-Recipient Mismatches in MHC Class I Chain-Related Gene a (MICA) in Unrelated Donor (UD) Transplantation

Marcos De Lima¹, Morgani Rodrigues¹^*, Pedro Cano¹^*, Peter Stastny²^*, Ping Liu¹^*, Wei Wei¹^*, Susana Pesoa¹^*, Poliana Patah¹^*, Elizabeth Shpall¹^*, Sergio Giralt¹^*, Gabriela Rondon¹^*, Martin Korbling¹^*, Leandro De Padua Silva¹^*, Richard Champlin¹^* and Marcelo Fernandez-Vina¹^*

¹Department of Stem Cell Transplantation & Cell Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Internal Medicine, U.T. Southwestern Medical Center

5:30 PM

Impact of Highly Conserved HLA Haplotype on Acute Graft-Versus-Host Disease in Unrelated Bone Marrow Transplantation

Satoko Morishima¹^*, Seishi Ogawa², Takakazu Kawase¹^*, Aiko Matsubara²^*, Yasuhito Nanya²^*, Koichi Kashiwase³^*, Hiroo Saji⁴^*, Hidetoshi Inoko⁵^*, Shunichi Kato⁵^*, Yoshihisa Kodera⁶^*, Takehiko Sasazuki⁷^* and Yasuo Morishima¹

¹Aichi Cancer Center, Nagoya, Japan
²University of Tokyo, Tokyo, Japan
³Tokyo Metroporitan Red Cross Blood Center, Tokyo, Japan
⁴NPO HLA laboratory, Kyoto, Japan
⁵Tokai University, Isehara, Japan
⁶Aichi Medical University, Aichi, Japan
⁷International Medical Center of Japan, Tokyo, Japan

5:45 PM

Minor Histocompatibility Antigen Mismatches and Graft Versus Host and Relapse in High-Resolution HLA-Matched Allogeneic Hematopoietic Stem Cell Transplantation

Manuel Cliquennois¹^*, Pascale Cracco²^*, Dominique Becuwe²^*, Julia Salleron³^*, Françoise Dufossé²^*, Alain Duhamel³^*, Jean-Pierre Jouet¹^*, Jean-Paul Dessaint²^*, Myriam Labalette²^* and Ibrahim Yakoub-Agha¹

¹Maladies du Sang, UAM allo-CSH -EA2686, Lille, France
²Immunologie, EA2686, Lille, France
³CERIM, Lille, France

See more of: Oral and Poster Abstracts

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^*signifies non-member of ASH

722.O1.6 Clinical Transplantation: Acute GVHD Prevention and Risk Assessment