50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Ex Vivo Cellular Therapies and Mobilization

Monday, December 8, 2008: 7:00 AM-9:00 AM

Gateway Ballroom 103 - South (Moscone Center)

Moderators:

Colleen Delaney, MD, MSC and Adrian P. Gee, PhD

7:00 AM

Immune and Cytogenetic Perturbations after G-CSF Mobilization in Normal Peripheral Blood Stem Cell Donors

Caroline Marmier-Savet¹^*, Eric Deconinck², Fabrice Larosa²^*, Suzanne Mathieu-Nafissi³^*, Faezeh Legrand²^*, Brigitte Witz⁴^*, Caroline Bonmati⁴^*, Dana Ranta⁴^*, Maribel Tavernier⁵^*, Mauricette Michallet⁶, Pascale Louvat⁷^*, Marc Puyraveau⁸^*, Nicole Raus⁹^*, Olivier Hequet¹⁰^*, Francis Witz⁴^*, Marie-Agnes Collonge Rame¹¹^*, Fabienne Pouthier¹²^*, Jean-Luc Bresson¹¹^*, Pierre Tiberghien¹ and Eric Robinet¹³^*

¹UMR U645 Inserm Université de Franche-Comté Etablissement Francais du Sang, Besancon, France
²Hematology, INSERM UMR645 - CHU Jean Minjoz, Besancon
³Hemapheresis Department, EFS Lorraine/Champagne, Vandoeuvre les Nancy, France
⁴CHU Nancy, Nancy, France
⁵Hemapheresis Department, EFS Bourgogne/Franche-Comte, Besancon, France
⁶Hematology, Hopital Edouard Herriot, Lyon, France
⁷CIC Biothérapie, UMR U645 Inserm Université de Franche-Comté Etablissement Francais du Sang, Besancon, France
⁸Centre d'Investigation Clinique en Biothérapies, University Hospital Besancon, Besancon, France
⁹Hematology, Hopital Edouard Herriot, Lyon, Cedex 03, France
¹⁰Hemapheresis Department, EFS Rhone-Alpes, Lyon, France
¹¹Cytogenetic Department, University Hospital Besancon, Besancon, France
¹²Hemapheresis Department, Etablissement Francais du Sang, Besancon, France
¹³UMR 645 INSERM UFC EFS Besancon and INSERM UMR 748, Strasbourg

7:15 AM

206

Adoptive T Cell Therapy of Human CMV Infection in Immunocompromised Hosts: In Vitro Generation of CMV-Specific T Cells from Naïve Precursors

Sonja Schmucker^*, Mario Assenmacher^*, Jurgen Schmitz and Anne Richter^*

Department of Research & Development, Miltenyi Biotec GmbH, Bergisch Gladbach, Germany

7:30 AM

207

Alloanergization of HLA-Mismatched Human Donor T Cells Results in the Generation of Allosuppressive CD4⁺ T Regulatory Cells Both in Vitro and in Vivo

Jeff Davies, Dongin Yuk^*, Lee Nadler and Eva Guinan

Dana-Farber Cancer Institute, Boston, MA

7:45 AM

208

Rapid Generation of Antigen-Specific T Cells for Pre-Clinical and Clinical Applications Using a Novel Mini Cell Bioreactor

Juan F Vera, MD¹^*, Lara Brenner¹^*, Ann M. Leen¹, Helen E. Heslop¹^*, Gianpietro Dotti²^*, John Wilson³^* and Cliona M. Rooney⁴^*

¹Pediatrics, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX
²Medicine, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX
³Wilson Wolf Manufacturing Corporation, New Brighton, MN
⁴Pediatrics, Molecular Virology and Microbiology, Immunology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX

8:00 AM

209

Genetic Engineering and Significant Ex-Vivo Expansion of Cord Blood Natural Killer Cells: Implications for Post-Transplant Adoptive Cellular Immunotherapy

Jessica Hochberg, MD¹^*, Brenton Mar, MD¹^*, Janet Ayello, MS, MT¹, Nancy Day¹^*, Carmella van de Ven¹^*, Angela Ricci¹^*, Lalit Gurnani¹^*, Evan Cairo¹^*, Dario Campana, MD., PhD² and Mitchell S. Cairo³^*

¹Pediatrics, Columbia University Morgan Stanley Children's Hospital of New York Presbyterian, New York, NY
²Oncology, St. Jude Children's Rsrch Hosp., Memphis, TN
³Pediatrics, Medicine & Pathology, Columbia University Morgan Stanley Children's Hospital of New York Presbyterian, New York, NY

8:15 AM

210

Self-Renewal of Hematopoietic Stem Cells by a Small Molecule

Anthony E Boitano, Ph.D.^*, Peter G Schultz, Ph.D.^* and Michael Cooke, PhD

Genomics Institute of the Novartis Research Foundation, San Diego, CA

8:30 AM

211

Mesenchymal Stromal Cell Co-Culture Enhances Insulin-Like Growth Factor Binding Protein 2 - Augmented Ex Vivo Cultures of Human Cord Blood in a Viability Supporting, Contact-Dependent Process Involving the Rescue of Cells from Early Apoptosis

Pat PY Chu, PhD¹^*, Arun Prasath, M.Sc., M.Phil²^*, Zhihong Li, B.Sc.¹^*, Sudipto Bari³^*, Justina ML Ang³^*, Xiubo Fan, PhD²^*, Chengcheng Zhang, PhD⁴, Harvey F. Lodish, PhD⁵ and William YK Hwang, MBBS, MRCP, FRCP²

¹Office of Research, Singapore Health Services, Singapore, Singapore
²Department of Haematology, Singapore General Hospital, Singapore, Singapore
³Duke-NUS Graduate Medical School Singapore, Singapore, Singapore
⁴UT Southwestern, Dallas, TX
⁵Whitehead Institute for Biomedical Research, Cambridge, MA

8:45 AM

212

Notch-Mediated Expansion of Human Cord Blood Progenitor Cells Results in Rapid Myeloid Reconstitution in Vivo Following Myeloablative Cord Blood Transplantation

Colleen Delaney, MD, MSC, Carolyn Brashem-Stein^*, Howard Voorhies^*, Jonathan Gutman, Mari Dallas^*, Shelly Heimfeld^* and Irwin D Bernstein^*

Fred Hutchinson Cancer Research Center, Seattle, WA

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

711.O1.8 Ex Vivo Cellular Therapies and Mobilization