50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Experimental GVHD: Regulation of Systemic and Organ-Specific GVHD

Sunday, December 7, 2008: 4:30 PM-6:00 PM

3020-3022-3024 - West (Moscone Center)

Moderators:

Lisbeth A. Welniak, PhD and Robert B. Levy, PhD

4:30 PM

NK Cells Suppress Gvhd by Directly Inhibiting Activated Alloreactive T Cells through An NKG2D-Mediated Mechanism

Janelle A Olson¹^*, Dennis B Leveson-Gower, PhD¹^*, Jeanette Baker¹^*, Andreas Beilhack, MD²^* and Robert Negrin, MD¹

¹Medicine/BMT, Stanford University, Stanford, CA
²Department of Medicine II, Wuerzburg University, Germany

4:45 PM

Radiation-Free Anti-CD3-Conditioning Regimen Maintains Tissue Protection Mechanisms and Prevents GVHD: Role of Tissue Expression of B7H1

Ying Chen¹^*, Chia-Lei Lin¹^*, Nainong Li¹^*, Gong Du¹^*, Lieping Chen²^*, Stephen Forman¹^* and Defu Zeng, MD¹

¹Division of Hematology & Hematopoietic Cell Transplantation, The Beckman Rsch. Inst.of the City of Hope, Duarte, CA
²Department of Dermatology/Oncology, Johns Hopkins University School of Medicine, Baltimore, MD

5:00 PM

T Cell Toll-Like Receptors Play a Critical Role in Graft-Versus-Host Disease and Graft-Versus-Leukemia

Masanori Kadowaki¹^*, Kazutoshi Aoyama¹^*, Motoko Koyama¹^*, Yukimi Sakoda¹^*, Kiyoshi Takeda²^*, Chen Liu³^*, Koichi Akashi¹^*, Mitsune Tanimoto⁴ and Takanori Teshima⁵

¹Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan
²Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Japan
³Department of Pathology, University of Florida School of Medicine, Gainesville, FL
⁴Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
⁵Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan

5:15 PM

Interleukin 23 Secretion by Donor Antigen Presenting Cells Is Critical for Organ-Specific Pathology in Graft Versus Host Disease

Rupali Das, Ph.D.^*, Xiao Chen, Ph.D.^*, Richard Komorowski, M.D.^*, Martin Hessner, Ph.D.^* and William R. Drobyski, MD

Medical College of Wisconsin, Milwaukee, WI

5:30 PM

The T Cell Cytolytic Molecules Fas Ligand and TRAIL, the Trafficking Molecules CCR9, β7 Integrin and PSGL-1, and the Immune Modulating Molecules OX40, CEACAM1, and CTLA4 Are Required for Thymic Graft-Versus-Host Disease

Il-Kang Na, MD^*, Sydney X. Lu^*, Gabrielle L. Goldberg, PhD^*, Daniel Daniel Hirschhorn-Cymerman, PhD^*, Christopher G. King^*, Odette M. Smith^*, David Suh^*, Uttam Rao^*, Nury Yim^*, Amanda M. Holland^*, Olaf Penack, MD^*, Robert R. Jenq, MD^*, Arnab Ghosh, MD, PhD^*, Laura Teisch^*, Simon Meykler^*, Janine Lin^*, Alejandro Sepulveda, PhD^*, Taha Merghoub, PhD^*, Alan Houghton, MD^* and Marcel R.M. van den Brink, MD, PhD

Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY

5:45 PM

Protection of the Intestinal Epithelium from Conditioning with R-spondin1 Ameliorates Graft-Versus-Host Disease

Shuichiro Takashima¹^*, Kazutoshi Aoyama¹^*, Motoko Koyama¹^*, Daigo Hashimoto²^*, Takeshi Oshima³^*, Kazuma Tomizuka³^*, Koichi Akashi¹^* and Takanori Teshima²

¹Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan
²Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
³Chromosome Engineering, Discovery Research Section, Discovery Research, Kirin Pharma Co., Ltd., Gunma, Japan

See more of: Oral and Poster Abstracts

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^*signifies non-member of ASH

702.O1.6 Experimental GVHD: Regulation of Systemic and Organ-Specific GVHD