50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Experimental Transplantation - Basic Biology, Immune Function, and Engraftment Poster I

Sunday, December 7, 2008: 6:00 PM-8:00 PM

Hall A (Moscone Center)

Sensitization to Minor Histocompatibility Antigens Poses a Barrier in Transplantation and Can Be Prevented by CD154:CD40 Co-Stimulatory Blockade

Hong Xu, M.D., Yiming Huang, M.D.^*, Lala-Rukh Hussain, B.S.^* and Suzanne T Ildstad, M.D.

University of Louisville, Institute for Cellular Therapeutics, Louisville, KY

2318

CD8⁺/TCR^- Facilitating Cells Induce Generation of Regulatory T cells in Vivo: Chimeric Regulatory T Cells are Antigen-Specific and Enhance Engraftment of Allogeneic HSC in Non-Obese Diabetic (NOD) Mice

Yiming Huang, M.D.¹, Larry D Bozulic, Ph.D¹^*, Thomas Miller, B.S.¹^*, Hong Xu, M.D.¹, Lala-Rukh Hussain, B.S.¹^* and Suzanne T. Ildstad, MD²

¹University of Louisville, Institute for Cellular Therapeutics, Louisville, KY
²Institute for Cellular Therapeutics, University of Louisville, Louisville, KY

2319

Fully Functional NK Cells Promote Graft-to-Leukemia Effect, after Cord Blood Transplantation

Vivien Beziat¹^*, Stéphanie Nguyen²^*, Simona Lapusan³^*, Baptiste Hervier¹^*, Nathalie Dhedin²^*, Dominique Bories⁴^*, Madalina Uzunov²^*, Hélène Treberden-Negre⁵^*, Françoise Norol⁵^*, Zora Marjanovic³^*, Jean-Pierre Marie³, Jean-Paul Vernant²^*, Patrice Debre¹^*, Bernard Rio³^* and Vincent Vieillard¹^*

¹Laboratoire d'Immunologie Cellulaire et Tissulaire, INSERM U543, Paris, France
²Service d'Hématologie Clinique, Hôpital Pitié-Salpêtrière, Paris, France
³Département d'Hématologie et d'Oncologie Médicale, Hôtel Dieu, Paris, France
⁴Unité d'Hématologie Moléculaire, Hôpital Henri Mondor, Creteil, France
⁵Laboratoire de Thérapie Cellulaire, Hôpital Pitié-Salpêtrière, Paris, France

2320

Horizontal Gene Transfer through Apoptotic Bodies Confers a Possible Mechanism of Epithelial Chimerism after Allogeneic Hematopoietic Cell Transplantation

Miguel Waterhouse¹^*, Maria Themeli²^*, Jurgen Finke¹ and Alexandros Spyridonidis²

¹Hematology, University of Freiburg, Freiburg, Germany
²Hematology, University of Patras, Rio-Patras, Greece

2321

Co-Transplantation of MSC Improves the Engraftment of HSC after Auto-iBMT in Non-Human Primates

Shigeo Masuda¹^*, Yoko Obara²^*, Naohide Ageyama³^*, Hiroaki Shibata³^*, Tamako Ikeda¹^*, Yasuji Ueda⁴^*, Keiya Ozawa²^* and Yutaka Hanazono¹

¹Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
²Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan
³Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Ibaraki, Japan
⁴Department of Gene Therapy, Graduate School of Medicine, Chiba University, Chiba, Japan

2322

Humanized Sc(Fv)2 Minibody against C-Mpl Successfully Increased Platelet Number in Monkey and Increased Engraftment of Human Umbilical Cord Blood Cells in NOD/SCID Mouse

Takashi Yoshikubo¹, Yoshihiro Matsumoto¹^*, Masahiko Nanami¹^*, Takayuki Sakurai¹^*, Hiroyuki Tsunoda¹^*, Akihisa Kaneko¹^*, Yukiko Inagaki¹^*, Masashi Shiina¹^*, Mizuho Noguchi¹^*, Makoto Monnai²^*, Souhei Ohyama¹^*, Yukihito Miura²^*, Tetsuro Orita¹^*, Yasufumi Kikuchi¹^*, Tomoyuki Igawa¹^*, Kunihiro Hattori¹^* and Hisafumi Okabe¹^*

¹Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
²Chugai Research Institute for Medical Science, Gotemba, Japan

2323

Ex-Vivo Acquisition of Central Memory Phenotype Is Critical for Tolerance Induction by Donor Anti-3^rdparty CD8 T Cells in Allogeneic Bone Marrow Transplantation

Yaki Edelshtein^*, Eran Ophir^*, Esther Bachar-Lustig^*, Ran Afik^* and Yair Reisner

Immunology, Weizmann Institute of Science, Rehovot, Israel

2324

Ex Vivo Expansion and Long-Term Hematopoietic Reconstitution Ability of Sorted CD34+CD59+ Cells from Patients with Paroxysmal Nocturnal Hemoglobinuria

Juan Xiao, MD, PhD^*, Bing Han, MD, PhD^*, Wanling Sun, MD, PhD^*, Yuping Zhong, MD, PhD^* and Yongji Wu, MD^*

Hematology, Peking Union Medical Collegue Hospital, Chinese Academy of Medical Science, Beijing, China

2325

Interaction with Human Stromal Cells Enhances CXCR4 Expression and Engraftment of Cord Blood Lin-CD34- Cells Via Wnt Signaling

Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD^*, Satoshi Iyama, MD, PhD^*, Tsutomu Sato, MD, PhD^*, Shohei Kikuchi, MD, PhD^*, Yutaka Kawano, MD, PhD^*, Kohichi Takada, MD, PhD^*, Koji Miyanishi, MD, PhD^*, Rishu Takimoto, MD, PhD^* and Junji Kato, MD, PhD^*

Fourth Dept. of Internal Med., Sapporo Medical University, Sapporo, Japan

2326

Dose and Timing Limitations in the Use of Bone Marrow-Derived Mesenchymal Stem Cells for the Treatment of Experimental Arthritis

Evangelia Yannaki, MD¹, Anastasia Papadopoulou, PhD, student²^*, Minas Yiangou, PhD³^*, Evangelia Athanasiou, MD²^*, Argyrw Paraskeva, BS³^*, Ioannis Batsis, MD¹^*, Eleftheria Tsolaki, PhD, student²^*, Angeliki Xagorari, PhD²^*, Achilles Anagnostopoulos, MD⁴ and Athanasios Fassas, MD¹^*

¹GENE and CELL THERAPY CENTER, HEMATOLOGY-BMT UNIT, GEORGE PAPANICOLAOU HOSPITAL, Thessaloniki, Greece
²GENE and CELL THERAPY CENTER, GEORGE PAPANICOLAOU HOSPITAL, Thessaloniki, Greece
³Department of Genetics, Development & Molecular Biology, School of Biology,, ARISTOTLE UNIVERSITY, Thessaloniki, Greece
⁴GENE and CELL THERAPY CENTER, Hematology-BMT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece

2327

5-Androstene-3b,17b-Diol Administration of Mice Exposed to Total Body Irradiation Results in Rapid Reconstitution of Immature Bone Marrow Progenitor Cells and Synergizes with Thrombopoietin but Not with Granulocyte-Colony Stimulating Factor

Fatima SF Aerts Kaya, MD¹^*, Trudi P Visser, BSc¹^*, James M Frincke, PhD²^*, Dwight R. Stickney, MD², Chris L Reading, PhD²^* and Gerard Wagemaker, PhD¹^*

¹Hematology, Erasmus MC, Rotterdam, Netherlands
²Hollis-Eden Pharmaceuticals, San Diego, CA

2328

A Novel SNP-Based Method for Assessing Langerhans Cell Chimerism Following Hematopoietic Stem Cell Transplantation in Humans

A. Yasmine Kirkorian¹^*, Matthew P Collin, MD, PhD¹^*, Marco Mielcarek, MD², Wandi Zhang³^*, Donna Neuberg, ScD⁴, Catherine J Wu, MD⁵ and Miriam Merad, MD, PhD¹^*

¹Department of Gene and Cell Medicine, Mount Sinai Medical Center, New York, NY
²Fred Hutchinson Cancer Rsch. Ctr., Seattle, WA
³Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Biostatistics & Computational Biology, Dana-Farber Cancer Inst., Boston, MA
⁵Department of Medical Oncology, Dana-Farber Cancer Inst., Boston, MA

2329

siRNA-Induced Transient Silencing of PTEN Expression Enhances Human Hematopoietic Cell Engraftment in NOD/SCID/γ_c^null Mice and Increases Gene Transduction Efficiency

Inho Kim^*, Andre Larochelle, Yoo-Jin Kim^* and Cynthia E. Dunbar^*

Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD

2330

Control of the HSC Niche Signaling for the Efficient Long-Term Engraftment of Hematopoietic Stem Cells without Irradiation or High-Dose Chemotherapy

Hiroki Yoshihara, MD¹^*, Fumio Arai, DDS, PhD¹, Kentaro Hosokawa, PhD¹^*, Takao Takahashi, MD²^*, Hiroshi Miyazaki, PhD³^* and Toshio Suda, MD¹

¹Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
²Department of Pediatrics, School of Medicine, Keio University, Tokyo, Japan
³Frontier Laboratory, Kirin Pharma Co., Ltd., Gunma, Japan

2331

Cyclosporine, but Not mTOR Inhibitors, Hampers the Reconstitution of Bone Marrow-Derived Tregs in Long-Term Complete Donor chimeras

Haruko Sugiyama, MD¹^*, Yoshinobu Maeda, MD¹^*, Hisakazu Nishimori, MD¹^*, Koichiro Kobayashi, MD¹, Miyuki Nishie-Kataoka, MD¹^*, Takanori Teshima, MD² and Mitsune Tanimoto, MD¹

¹Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
²Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan

2332

Donor-Specific Tolerance Induction through Expansion of DCregs and Tregs by a Liposomal Formulation of KRN7000 (RGI-2001)

Omar Duramad, PhD¹^*, Amy Laysang¹^*, Jun Li¹^*, Yasuyuki Ishii, PhD²^* and Reiko Namikawa, MD, PhD³

¹Research and Development, Regimmune Corporation, Mountain View, CA
²Laboratory for Vaccine Design, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
³Consultant, Portola Valley, CA

2333

Compared to Adult Peripheral Blood T Cells, Cord Blood T Cells Show Enhanced Immunological Recognition of Chronic Lymphocytic Leukemia Tumor Cells

Alan G. Ramsay, PhD¹, Dong-Xia Xing, PhD²^*, William K. Decker, PhD²^*, Jared K. Burks, PhD²^*, William G. Wierda, MD²^*, John G. Gribben, MD, DSc¹^* and Elizabeth J. Shpall, MD³

¹Ctr. for Medical Oncology, Institute of Cancer, Barts & London Sch. of Med., London, United Kingdom
²M.D. Anderson Cancer Center, University of Texas, Houston, TX
³Stem Cell Transplantation and Cellular Therapy, The University of Texas M. D. Anderson Cancer Center, Houston, TX

2334

In Vivo Development of Murine NK Cells Early after Congeneic BMT: Effects of MHC Molecules, and the Administration of hIL-15

Isabel Barao-Silvestre, PhD¹^*, Doug Redelman, PhD¹^*, Erik Ames¹^*, Jonathan Weiss, PhD²^*, Kai Sun, PhD³, Lisbeth Welniak, PhD⁴, John Ortaldo, PhD²^*, Robert Wiltrout, PhD²^* and William Murphy, PhD¹

¹Microbiology and Immunology, UNR, Reno, NV
²NCI-Frederick, Frederick, MD
³Microbiology and Immunology, UNR-School of Medicine, Reno, NV
⁴University of Nevada, Reno, Reno, NV

2335

The Antioxidant Inflammation Modulator, CDDO-Me Promotes Myelopoiesis in Mice

Lisbeth A. Welniak, PhD¹, Salif Harouna¹^*, David Prosser¹^*, Erik Ames¹^*, Colin Meyer, M.D.²^* and William J. Murphy, PhD¹

¹Microbiology & Immunology, University of Nevada School of Medicine, Reno, NV
²Reata Pharmaceuticals, Inc, Irving, TX

2336

Conversion to Full Donor Chimerism without Gvhd Using High-Dose DLI in Minimally Conditioned Miniature Swine Recipients of Haploidentical HCT

Raimon Duran-Struuck, D.V.M.¹^*, Banjamin M Horner, M.D.¹^*, Bram V Lutton, PhD¹^*, Alex G.S. Teague, BS¹^*, Kelly K. Ferguson, BS¹^*, Jonathan C Summers¹^*, Thomas Spitzer², Jay Fishman, M.D.²^*, Stuart Houser, M.D.²^*, David H Sachs, M.D.¹^* and Christene A Huang, PhD¹^*

¹Surgery, Massachusetts General Hospital, Boston, MA
²Massachusetts General Hospital, Boston, MA

2337

Pharmacological Inhibition of EGFR Signaling Enhances G-CSF Induced Hematopoietic Stem Cell Mobilization

Marnie A. Ryan, PhD¹^*, Ellen Xing¹^*, David Schleimer¹^*, Kalpana Nattamai¹^*, Deidre Daria¹^*, Wei Liu, MD, MS²^*, Michael Jansen, MS, PhD³, Nancy Ratner¹^*, Timothy Le Cras⁴^*, Gary Van Zant, PhD⁵, Yi Zheng, PhD⁶ and Hartmut Geiger, PhD⁶^*

¹Division of Experimental hematology and cancer biology, Children's Hospital Medical Center, Cincinnati, OH
²Division of Experimental hematology and cancer biology, Molecular and Developmental Biology Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Cincinnati Children's Hospital, Cincinnati, OH
⁴Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵Markey Cancer Center, Lexington, KY
⁶Division of Experimental hematology and cancer biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

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^*signifies non-member of ASH

701.P1.42 Experimental Transplantation - Basic Biology, Immune Function, and Engraftment Poster I