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701.O2.6 Experimental Transplantation - Basic Biology, Immune Function, and Engraftment

Monday, December 8, 2008: 11:00 AM-12:30 PM
303-305-307 - South (Moscone Center)
Moderators:
Aaron P. Rapoport, MD and James E Talmadge
11:00 AM
CD26 Inhibitor Treated and CD26-/- Recipient Mice Exhibit Improved Transplant Efficiency as Quantitated by Increased Short-Term Homing and Long-Term Engraftment

Laura A. Paganessi*, Stephanie A. Gregory, MD, Henry C. Fung and Kent W. Christopherson II, PhD

Section of Hematology & Stem Cell Transplantation, Rush University Medical Center, Chicago, IL

11:15 AM
Breast Milk Transmission of Maternal Alloantibodies Activates a Postnatal Immune Response That Limits Allogeneic Engraftment after in Utero Hematopoietic Stem Cell Transplantation in the Murine Model

Demetri J. Merianos, MD1*, Eleonor Tiblad, MD1*, Pablo Laje, MD1*, Masayuki Endo2*, Philip W. Zoltick2* and Alan W. Flake, MD1

1Children's Hosp. of Philadelphia, Philadelphia, PA
2Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA

11:30 AM
TAA/ecdCD40L VPP Vaccination Induces Robust Adaptive Immune Response Even in Individuals with Post Transplantation Lymphopenia

Tae Hae Han, MD, PhD*, Yucheng Tang, MD, PhD*, Yeon Hee Park, MD*, Jonathan Maynard*, Pingchuan Li, PhD*, Hakan Akbulut, MD*, Line Petersen* and Albert B. Deisseroth, MD, PhD

Genetic Therapy, Sidney Kimmel Cancer Center, San Diego, CA

11:45 AM
Direct Fluorescent Visualization of HSC Competitive Repopulation in Transparent Adult Zebrafish

Pulin Li, BS* and Leonard I Zon, MD

Hematology/Oncology, Harvard Medical School/Children's Hospital Boston, Boston, MA

12:00 PM
Prevention of Rat Cardiac Allograft Rejection by Host Th2 Cell Adoptive Transfer

Shoba Amarnath, PhD1*, Hao Chen, MD, PhD2*, Carliann M Costanzo1*, Joanna M Swerczek, LVT, LATg2*, Michael A Solomon, MD2* and Daniel H Fowler, MD3*

1Experimental Transplantation Immunology Branch, National Cancer Institute, Bethesda, MD
2Critical Care Medicine, cinical center, National Institute of Health, Bethesda, MD
3Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD

12:15 PM
HLA-E up-Regulation on IFN-γ Activated AML Blasts Impaired CD94/NKG2A-Dependent NK Cytolysis Following Haplo-Mismatched Haematopoietic Stem-Cell Transplantation

Stéphanie Nguyen1*, Vivien Beziat2*, Nathalie Dhedin3*, Mathieu Kuentz, MD4*, Madalina Uzunov3*, Jean-Paul Vernant3*, Patrice Debre5* and Vincent Vieillard5*

1Hôpital Pitié-Salpêtrière, Service d'Hématologie Clinique, Paris, France
2Immunology, Hopital Pitie Salpetriere, Paris, France
3Service d'Hématologie Clinique, Hôpital Pitié-Salpêtrière, Paris, France
4Hopital Henri-Mondor - SFGMTC, Paris, France
5INSERM U543, Paris, France

*signifies non-member of ASH