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701.O1.6 Experimental Transplantation - Basic Biology, Immune Function, and Engraftment

Sunday, December 7, 2008: 4:30 PM-6:00 PM
303-305-307 - South (Moscone Center)
Moderators:
Geoff Hill and Yair Reisner
4:30 PM
67
Novel Observation That Mice Lacking the Fifth Complement Cascade Protein Component (C5) Are Very Poor Stem Cell Mobilizers Explained by Defective Egress of Granulocytes: A Novel Role for Bone Marrow Granulocytes to Act as "ice Breaker" Cells in Facilitating Egress of Hematopoietic Stem/Progenitor Cells

Wan Wu, MS*, Hakmoo Lee, Ph.D.*, Marcin Wysoczynski, MS*, Magdalena Kucia, Ph.D., Janina Ratajczak, M.D., Ph.D. and Mariusz Z Ratajczak, M.D., Ph.D.

James Graham Brown Cancer Center, Stem Cell Institute University of Louisville, Louisville, KY
4:45 PM
68
Mobilization of Hematopoitic Stem/Progenitor Cells by a Cdc42 Activity-Specific Inhibitor

Wei Liu, MD, MS1*, Lei Wang, PhD2*, Xun Shang, PhD3*, Fukun Guo, PhD3*, Marnie A. Ryan, PhD3*, Hartmut Geiger, PhD4* and Yi Zheng, PhD3

1Division of Experimental Hematology and Cancer Biology, Molecular and Developmental Biology Program, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH
2Beijing Novo Nordisk Pharmaceuticals Sci & Tech Co. Ltd, Beijing, China
3Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
4Division of Experimental hematology and cancer biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
5:00 PM
69
Human Embryonic Stem Cell-Derived CD34+ Cells Preferentially Develop into Endothelial Cells When Transplanted into Neonatal Immunodeficient Mice

Xinghui Tian, PhD1*, Melinda K. Hexum1*, Vesselin R. Penchev1*, Russell J. Taylor1*, Leonard Shultz, PhD2 and Dan S. Kaufman, MD, PhD3

1Medicine, University of Minnesota, Minneapolis,, MN
2The Jackson Laboratory, Bar Harbor, ME
3Medicine, University of Minnesota, Minneapolis, MN
5:15 PM
70
Administration of IL-2-Anti-IL2mAb Complex Post-Allogeneic HCT:  a New Approach to Facilitate Rapid and Stable Hematopoietic Chimerism Following Reduced Intensity Conditioning and Experimental HCT

Alwi Shatry, Ph.D* and Robert B Levy, Ph.D

Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL
5:30 PM
71
The Combination of AMD3100 Plus GROβ Rapidly Mobilizes Hematopoietic Stem Cells with Enhanced Homing, Adhesion and Survival Properties

Louis M. Pelus, PhD and Pratibha Singh, Ph.D.*

Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN
5:45 PM
72
Tyrosine Kinase Inhibition with Sunitinib Facilitates Thymic Engraftment by Modulating Thymic Niche Accessibility

Aviva C Krauss, M.D.1*, Martin Guimond, PhD2*, Stefania Dobre2* and Crystal L. Mackall, M.D.3

1Children's National Medical Center, Washington, DC 20010 and Pediatric Oncology Branch, CCR/National Cancer Institute, Bethesda, MD
2Pediatric Oncology Branch, Center for Cancer Research/National Cancer Institute, Bethesda, MD 20892
3Pediatric Oncology Branch, Center for Cancer Research/National Cancer Institute, Bethesda, MD
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