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653.O3.8 Novel Therapies for Myeloma and Related Disorders

Tuesday, December 9, 2008: 7:00 AM-9:00 AM
Gateway Ballroom 103 - South (Moscone Center)
Moderators:
Nikhil C. Munshi, MD and Evangelos Terpos
7:00 AM
Initial Results of PX-171-003, An Open-Label, Single-Arm, Phase II Study of Carfilzomib (CFZ) in Patients with Relapsed and Refractory Multiple Myeloma (MM)

Sundar Jagannath, MD1, Ravi Vij, MD2*, A. Keith Stewart, MBChB3, George Somlo, MD4*, Andrzej Jakubowiak, MD, PhD5, Tony Reiman, MD6, Suzanne Trudel, MD7*, Jessica Taylor, BA8*, Diana Fuhrman, BSN8*, Scott Cruickshank, MS8*, Richard Schwartz, MD8*, Lori Kunkel, MD8*, David Siegel, MD, PhD9 and The Multiple Myeloma Research Consortium (MMRC)10*

1St. Vincent's Comp. Cancer Ctr., New York, NY
2Washington University School of Medicine, Saint Louis, MO
3Mayo Clinic, Scottsdale, AZ
4City of Hope, Duarte, CA
5Univ. of Michigan Comprehensive Cancer Center, Ann Arbor, MI
6Cross Cancer Institute, Edmonton, AB, Canada
7Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, ON, Canada
8Clinical Operations, Proteolix, Inc., South San Francisco, CA
9Hackensack University Medical Center, Hackensack, NJ
10The Multiple Myeloma Research Consortium (MMRC), Norwalk, CT

7:15 AM
Initial Results of PX-171-004, An Open-Label, Single-Arm, Phase II Study of Carfilzomib (CFZ) in Patients with Relapsed Myeloma (MM)

Ravi Vij, MD1*, Michael Wang, MD2*, Robert Orlowski, MD, PhD2*, A. Keith Stewart, MBChB3, Sundar Jagannath, MD4, Vishal Kukreti, MD, FRCPC5, Jessica Taylor, BA6*, Diana Fuhrman, BSN6*, Scott Cruickshank, MS6*, Richard Schwartz, MD6*, Lori Kunkel, MD6*, David Siegel, MD, PhD7 and The Multiple Myeloma Research Consortium (MMRC)8*

1Washington University School of Medicine, Saint Louis, MO
2Lymphoma and Myeloma, University of Texas M.D. Anderson Cancer Center, Houston, TX
3Mayo Clinic, Scottsdale, AZ
4St. Vincent's Comp. Cancer Ctr., New York, NY
5Princess Margaret Hospital, Toronto, ON, Canada
6Clinical Operations, Proteolix, Inc., South San Francisco, CA
7Hackensack University Medical Center, Hackensack, NJ
8The Multiple Myeloma Research Consortium (MMRC), Norwalk, CT

7:30 AM
Pomalidomide (CC4047) Plus Low-Dose Dexamethasone (Pom/dex) Is Highly Effective Therapy in Relapsed Multiple Myeloma

Martha Q. Lacy, MD1, Suzanne R. Hayman1*, Morie A. Gertz1*, Jacob B. Allred1*, Sumithra J. Mandrekar1*, Angela Dispenzieri1*, Stephen R. Zeldenrust1*, Shaji Kumar1*, Philip R. Greipp1*, John A. Lust1*, Stephen J Russell1*, Francis Buadi1*, Robert A. Kyle1*, Peter Leif Bergsagel, MD2, Rafael Fonseca, MD3, Vivek Roy, MD, FACP4, Joseph Mikhael, MD5, A. Keith Stewart, MBChB, MBA6 and S. Vincent Rajkumar1*

1Mayo Clinic, Rochester, MN
2Mayo Clinic, Scottsdale, AZ
3Mayo Clinic Scottsdale, Scottsdale, AZ
4Mayo Clinic, Jacksonville, FL
5Division of Hematology, Mayo Clinic, Scottsdale Campus, Scottsdale, AZ
6Research, Mayo Clinic Scottsdale, Scottsdale, AZ

7:45 AM
Preliminary Results of CNTO 328, An Anti-Interleukin-6 Monoclonal Antibody, in Combination with Bortezomib in the Treatment of Relapsed or Refractory Multiple Myeloma

Jean-François Rossi, MD, PhD1*, Robert F. Manges, MD2*, Heather J. Sutherland, MD, PhD3, Sundar Jagannath, MD4, Peter Voorhees, MD5*, Pieter Sonneveld, MD6, Michel Delforge, MD, PhD7*, Brigitte Pegourie, MD8*, Adrian Alegre, MD9*, Javier de la Rubia, MD10*, David La Police, BS11*, Rajesh Bandekar, PhD11*, Hong Xie, MD11* and Robert Z. Orlowski, MD, PhD12*

1CHU Montpellier, CIC BT509 and INSERM U475, Montpellier, France
2Investigative Clinical Research, L.L.C., Indianapolis, IN
3Vancouver General Hospital, Vancouver, BC, Canada
4St. Vincent's Comprehensive Cancer Center, New York, NY
5The University of North Carolina at Chapel Hill, Chapel Hill, NC
6Erasmus Medical Center, Rotterdam, Netherlands
7University Hospital Gasthuisberg, Leuven, Belgium
8CHU de Grenoble, Hôpital Michallon, Grenoble, France
9Hospital de La Princesa, Madrid, Spain
10Hospital La Fe de Valencia, Valencia, Spain
11Centocor Research & Development, Malvern, PA
12The University of Texas, M. D. Anderson Cancer Center, Houston, TX

8:00 AM
Combination of Lenalidomide, Melphalan, Prednisone and Thalidomide (RMPT) in Relapsed/Refractory Multiple Myeloma: Results of a Multicenter Phase II Clinical Trial

Antonio Palumbo, MD1, Patrizia Falco, MD1*, Grazia Sanpaolo, MD2*, Antonietta Falcone, MD2*, Vincenzo Ferderico, MD3*, Letizia Canepa, MD4*, Monica Crugnola, MD5*, Luca Baldini, MD6*, Alessandra Larocca, MD1*, Valeria Magarotto, MD1*, Maria Teresa Petrucci, MD3* and Mario Boccadoro, MD1*

1Divisione di Ematologia dell'Università di Torino, A.O.U. San Giovanni Battista, Torino, Italy
2UO Ematologia e Trapianto di Cellule Staminali, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy
3Dipartimento di Bioteconologie e Ematologia, Policlinico Umberto I - Università La Sapienza, Roma, Italy
4Clinica Ematologica, Ospedale San Martino Università di Genova, Genova, Italy
5Cattedra e UO Ematologia e Trapianti Midollo, Università degli Studi di Parma, Parma, Italy
6Unità Operativa Ematologia 1, Dipartimento di Ematologia e Oncologia, Ospedale Maggiore IRCCS, Milano, Italy

8:15 AM
Significant Activity of Bortezomib-Based Therapy in Patients with Primary Systemic (AL) Amyloidosis

Efstathios Kastritis1*, Ashutosh D Wechalekar2*, Meletios A. Dimopoulos1, Giampaolo Merlini3*, Philip N Hawkins2*, Vittorio Perfetti4*, Julian D Gillmore2* and Giovanni Palladini3*

1Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece
2National Amyloidosis Center, University College London Medical School, United Kingdom
3Center for Amyloidosis, Fondazione IRCCS Policlinico San Matteo and Department of Biochemistry, University of Pavia, Italy
4Center for Amyloidosis and Department of Internal Medicine , Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

8:30 AM
Phase I/II Results of a Multicenter Trial of Perifosine (KRX-0401) + Bortezomib in Patients with Relapsed or Relapsed / Refractory Multiple Myeloma Who Were Previously Relapsed from or Refractory to Bortezomib

Paul Richardson, MD1, Jeffrey Wolf, MD2*, Andrzej Jakubowiak, MD, PhD3, Jeffrey Zonder, MD4, Sagar Lonial, MD5, David H Irwin, MD6*, John Densmore, MD, PhD7, Amrita Krishnan, MD, FACP8, Noopur Raje, MD9*, Michael H. Bar, MD10, Jeffrey P. Allerton, MD11, Robert Schlossman1*, Irene M. Ghobrial, M.D.1, Nikhil C. Munshi, MD1, Thomas Martin, MD2, Jacob Laubach, MD1*, Kathy Colson, RN1*, Sarah Dean1*, Deanna Tocco1*, Elizabeth Steinfield, RN2*, Tara Kendall, PA3*, Kimberly O'Riley, RN4*, Teru Hideshima, MD, PhD1, Peter Sportelli12*, Lesa Gardner, RN12* and Kenneth C. Anderson, MD1

1Dana-Farber Cancer Institute, Boston, MA
2University of California, SF, San Francisco, CA
3Univ. of Michigan Comprehensive Cancer Center, Ann Arbor, MI
4Wayne State University, Karmanos Cancer Institute, Detroit, MI
5Hematology and Medical Oncology, Emory Univesity, Atlanta, GA
6Alta Bates Comprehensive Cancer Center, Berkeley, CA
7Health Sciences Center, University of Virginia, Charlottesville, VA
8City of Hope National Medical Center, Duarte, CA
9Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
10Bennett Cancer Ctr., Stamford, CT
11Guthrie Clinic, Sayre, PA
12Keryx Biopharmaceuticals, Inc., New York, NY

8:45 AM
Vorinostat Plus Bortezomib for the Treatment of Relapsed/Refractory Multiple Myeloma: Early Clinical Experience

Donna Weber1, Ashraf Z. Badros2, Sundar Jagannath3, David Siegel4, Victoria Richon5*, Syed Rizvi5, Jose Garcia-Vargas5*, David Reiser5* and Kenneth C. Anderson6*

1Department of Lymphona and Myeloma M.D., Anderson Cancer Center, Houston, TX
2University of Maryland, Baltimore, MD
3St. Vincent's Comp. Cancer Ctr., New York, NY
4Hackensack University Medical Center, Hackensack, NJ
5Merck & Co Inc., Upper Gwynedd, PA
6Medical Oncology, Dana Farber Cancer Institute, Brookline, MA

*signifies non-member of ASH