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653.O1.6 Myeloma Therapy: Newly Diagnosed Myeloma

Sunday, December 7, 2008: 4:30 PM-6:00 PM
Halls B and C (Moscone Center)
Moderators:
Antonio Palumbo, MD and Sundar Jagannath, MD
4:30 PM
Phase II Trial of Lenalidomide (RevlimidTM) with Cyclophosphamide and Dexamethasone (RCd) for Newly Diagnosed Myeloma

Shaji Kumar, MD1, Suzanne Hayman1*, Francis Buadi1*, Martha Lacy1*, Keith Stewart2*, Jacob Allred1*, Kristina Lauman1*, Tammy McCarty1*, Leif Bergsagel2*, David Dingli1*, Rafael Fonseca, MD2, Morie Gertz1*, Philip Greipp1*, John Lust1*, Stephen Russell1*, Craig Reeder2*, Thomas Witzig1*, Steven Zeldenrust1*, Robert Kyle1*, S. Vincent Rajkumar1* and Angela Dispenzieri1*

1Hematology, Mayo Clinic, Rochester, MN
2Mayo Clinic Scottsdale, Scottsdale, AZ

4:45 PM
Lenalidomide, Bortezomib, and Dexamethasone in Patients with Newly Diagnosed Multiple Myeloma: Encouraging Efficacy in High Risk Groups with Updated Results of a Phase I/II Study

Paul Richardson, MD1, Sagar Lonial, MD2, Andrzej Jakubowiak, MD, PhD3, Sundar Jagannath, MD4, Noopur S Raje, MD5*, David Avigan, MD6*, Irene M Ghobrial, MD1*, Robert L Schlossman, MD1, Amitabha Mazumder, MD4, Nikhil C Munshi, MD1, David H Vesole, MD, PhD4, Robin Joyce, MD6*, Deborah Doss, RN, OCN1*, Diane L Warren, BS1*, Stephen W Hayes1*, Sarah Kaster, BS5*, Carol Delaney, BSN6*, Marisa Lauria, BA6*, Constantine Mitsiades, MD, PhD1, Teru Hideshima, MD, PhD1, Robert D. Knight, MD7, Dixie-Lee Esseltine, MD8 and Kenneth C Anderson, MD1

1Dana-Farber Cancer Institute, Boston, MA
2Hematology and Medical Oncology, Emory Univesity, Atlanta, GA
3Univ. of Michigan Comprehensive Cancer Center, Ann Arbor, MI
4St. Vincent's Comprehensive Cancer Center, New York, NY
5Massachusetts General Hospital, Boston, MA
6Beth Israel Deaconess Medical Center, Boston, MA
7Celgene Corporation, Summit, NJ
8Millennium Pharmaceuticals: The Takeda Oncology Company, Cambridge, MA

5:00 PM
Safety and Efficacy of Novel Combination Therapy with Bortezomib, Dexamethasone, Cyclophosphamide, and Lenalidomide in Newly Diagnosed Multiple Myeloma: Initial Results from the Phase I/II Multi-Center EVOLUTION Study

Shaji Kumar, MD1, Ian W Flinn, MD, PhD2, Stephen J. Noga, MD, PhD3, Parameswaran Hari, MD, MS4, Robert M. Rifkin, MD5, Natalie Scott Callander, MD6, Manish Bhandari, MD7*, Jeffrey Lee Wolf, MD8*, Cristina Gasparetto, MD9, Amrita Krishnan, MD, FACP10, Daren D Grosman, MD, PhD11*, Jonathan Glass, MD12*, Entezam Asim Sahovic, MD13*, Hongliang Shi, MS14*, Iain J. Webb, MD15, Paul Richardson, MD16 and S. Vincent Rajkumar, MD17

1Hematology, Mayo Clinic, Rochester, MN
2Sarah Cannon Research Institute, TN
3Medical Oncology/Hematology, Alvin & Lois Lapidus Cancer Institute, Baltimore, MD
4Medical College of Wisconsin, Center for International Blood and Marrow Transplant Research, Milwaukee, WI
5Rocky Mountain Cancer Center, Denver, CO
6University of Wisconsin, Madison, WI
7Research, The Christ Hospital, Cincinnati, OH
8University of California, SF, San Francisco, CA
9Cellular Therapy, Duke Univ. Medical Center, Durham, NC
10City of Hope National Medical Center, Duarte, CA
11Memorial Healthcare Cancer Center, Hollywood, FL
12Feist-Weiller Cancer Center/Department of Medicine, LSUHSC- Shreveport, Shreveport, LA
13Western Pennsylvania Hospital, Pittsburgh, PA
14Clinical Biostatistics, Millennium Pharmaceuticals: The Takeda Oncology Company, Cambridge, MA
15Millennium Pharmaceuticals: The Takeda Oncology Company, Cambridge, MA
16Dana-Farber Cancer Institute, Boston, MA
17Mayo Clinic College of Medicine, Rochester, MN

5:15 PM
A Phase II Study of Bortezomib (Velcade ®), Cyclophosphamide (Cytoxan®), Thalidomide (Thalomid®) and Dexamethasone as First-Line Therapy for Multiple Myeloma

William Bensinger1*, Sundar Jagannath, MD2, Robert Vescio, MD3, Elber S. Camacho, MD4, Jeffrey Lee Wolf5*, David H Irwin, MD6*, Gerardo Capo III, MD7*, Marti McKinley8*, Phyllis Potts8*, David H. Vesole, MD, PhD2, Amitabha Mazumder, MD2, Dixie-Lee Esseltine, MD9, Pamela Becker1*, John Crowley, PhD10 and Brian GM Durie, MD3

1Research Center, Fred Hutchinson Cancer, Seattle, WA
2St. Vincent's Comprehensive Cancer Center, New York, NY
3Cedars-Sinai Outpatient Cancer Center at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA
4Comprehensive Cancer Center of the Desert, Palm Springs, CA
5University of California San Francisco, San Francisco, CA
6Alta Bates Summit Comprehensive Cancer Center, Berkeley, CA
7Trinitas Comprehensive Cancer Center, Elizabeth, NJ
8Research Network, Aptium Oncology, Inc., Los Angeles, CA
9Millennium Pharmaceuticals: The Takeda Oncology Company, Cambridge, MA
10Cancer Research & Biostatistics, Seattle, WA

5:30 PM
Survival in Patients with Newly Diagnosed Myeloma Undergoing Therapy with Lenalidomide and Dexamethasone: Impact of High-Risk Cytogenetic Risk Status on Outcome

Prashant Kapoor, MD1*, Shaji Kumar, MD1, Rafael Fonseca, MD2, Martha Q. Lacy, MD3, Thomas E Witzig, MD1*, Suzanne R. Hayman, MD1, Angela Dispenzieri, MD4, Francis Buadi, MBChB5*, P. Leif Bergsagel, MD6, Morie Gertz, MD1*, Robert Dalton, MD7, Joseph Mikhael, MD8, David Dingli, MD, PhD4, Craig B. Reeder, MD9, John A. Lust, MD, PhD1, Stephen Russell, MD, PhD1*, Vivek Roy, MD, FACP10, Steven R. Zeldenrust, M.D., Ph.D.1, Keith Stewart, MBChB, MBA6, Robert A Kyle, MD11, Philip R. Greipp, MD1* and S. Vincent Rajkumar, MD11*

1Hematology, Mayo Clinic, Rochester, MN
2Mayo Clinic Scottsdale, Scottsdale, AZ
3Internal Medicine/Hematology, Mayo Clinic, Rochester, MN
4Mayo Clinic, Rochester, MN
5Mayo clinic college of medicine, Rochester, MN
6Mayo Clinic, Scottsdale, AZ
7ISJ-Mayo Health System, Mankato, MN
8Division of Hematology, Mayo Clinic, Scottsdale Campus, Scottsdale, AZ
9Hematology, Mayo Clinic Arizona, Scottsdale, AZ
10Mayo Clinic, Jacksonville, FL
11Hematology, College of Medicine, Mayo Clinic, Rochester, MN

5:45 PM
Microrna Expression Profile Identifies Distinct Clinically Relevant Sub-Groups in Multiple Myeloma: Novel Prognostic Markers and Potential Targets for Therapy

Sophia Adamia, Ph.D1*, Herve AvetLoiseau, MD2*, Samirkumar B Amin, MBBS3*, Yu-Tzu Tai, PhD4, Steven P. Treon, MD, PhD5*, Philippe Moreau, MD6*, Stephane Minvielle, Ph.D2*, Cheng Li, Ph.D7*, Kenneth C Anderson, MD3 and Nikhil C. Munshi, MD8

1Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
2Hematology Department, Hopital de Nantes, Nantes, France
3Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
4Medical Oncology, Dana-Farber Cancer Inst., Boston, MA
5Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
6Hematology Department, Hopital de Nantes, Nantes, 44093, France, France
7Biostatistics & Computational Biology, Dana-Farber Cancer Istitute & HArvard Medical School, Boston, MA
8Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston VA Cancer Healthcare System, Boston, MA

*signifies non-member of ASH