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652.P1.58 Myeloma - Pathophysiology and Preclinical Studies Excluding Therapy Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM
Hall A (Moscone Center)
The Parthenolide Derivative LC-1 Is An Effective Single Agent and Is Highly Synergistic with Existing Therapies in Multiple Myeloma

Elisabeth J Walsby1*, Saman Hewamana1*, Alan Burnett1*, Steven Knapper1, Chris Fegan2* and Chris Pepper1*

1Department of Haematology, School of Medicine, Cardiff University, Cardiff, United Kingdom
2Cardiff and Vale NHS Trust, Cardiff, United Kingdom

Therapeutic Antimyeloma Effect of Dendritic-Tumor Cells Hybrids Transduced with Adenovirus Encoding CD40L

Eva Alvarez*, Esther Moga*, Jorge Sierra and Javier Briones*

Clinical Hematology, Hospital Santa Creu i Sant Pau, Barcelona, Spain

Cooperation Between IL-7 and TNF-Alpha Results in Suppression of Runx2/Cbfa1 Expression and Inhibition of Osteoblast Differentiation in Myeloma

Davide Del Prete1*, Shibing Yu, PhD1*, Guozhi Xiao, PhD1*, David Roodman, MD, PhD1 and Sonia D'Souza, PhD2*

1Medicine/Hem-Onc., University of Pittsburgh, Pittsburgh, PA
2Medicine, University of Pittsburgh, Pittsburgh, PA

A Novel Non-Competitive Chemical Proteasome Inhibitor Displays Preclinical Activity in Myeloma and Leukemia

Xiaoming Li, PhD1*, Tabitha E Wood, PhD1*, Remco Sprangers, PhD2*, Xinliang Mao, PhD1*, Xiaoming Wang, PhD1*, Yi Zhang, BSc1*, David Rose, PhD1*, Robert A. Batey, PhD3*, Lewis E. Kay, PhD2* and Aaron D. Schimmer, MD, PhD1

1Princess Margaret Hospital, Toronto, ON, Canada
2Departments of Medical Genetics, Biochemistry, and Chemistry, University of Toronto, Toronto, ON, Canada
3Department of Chemistry, University of Toronto, Toronto, ON

Combined Treatment with the Mek Inhibitor PD0325901 and Arsenic Trioxide Has Potent Antitumor Activity in Vivo against Human Multiple Myeloma Xenograft Model

Paolo Lunghi1*, Laura Mazzera1*, Guerino Lombardi2*, Micaela Ricca2*, Attilio Corradi3*, Anna Maria Cantoni3*, Nicola Giuliani4, Luigi Salvatore1*, Roberta Riccioni5*, Antonio Costanzo6*, Ugo Testa5*, Massimo Levrero7*, Vittorio Rizzoli4* and Antonio Bonati8

1Clinical Sciences, University of Parma, Parma, Italy
2Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia, Italy
3Animal Health, University of Parma, Parma, Italy
4Hematology, University of Parma, Parma, Italy
5Italian Institute of Public Health, Rome, Italy
6Dermatology, University of Rome "Tor Vergata", Rome, Italy
7Internal Medicine, University of Rome "La Sapienza", Rome, Italy
8Clinical Sciences and Hematology, University of Parma, Parma, Italy

Agonist Anti-TRAILR1 Human Mab, Hgs-ETR1, Induces Myeloma Cell Death Mainly through the Intrinsic Pathway of Apoptosis

Emmanuelle Ménoret*, Sylvanie Surget*, Patricia Gomez-Bougie*, Régis Bataille*, Martine Amiot* and Catherine Pellat-Deceunynck

Nantes Angers Cancer Center, INSERM U892, Nantes, France

siRNA, a Potential Therapy for AL Amyloidosis

Beth M. Hovey*, Jennifer Ward* and David C. Seldin*

Hematology Oncology, Boston University School of Medicine, Boston, MA

The Novel NFkB Inhibitor V1810 Induces Apoptosis and Cell Cycle Arrest in Multiple Myeloma Cells and Overcomes NFkB Mediated Drug Resistance

Felix Meinel1*, Sonja Mandl-Weber1*, Philipp Baumann1*, Johann Leban2* and Ralf Schmidmaier1*

1Department of Hematology and Oncology, Medizinische Klinik Innenstadt der Universität München (LMU), Munich, Germany
24SC AG, Martinsried, Germany

The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Potent and Selective Cytotoxicity against CD138 Positive Multiple Myeloma Cells in Vitro and in Vivo

Hiroshi Ikeda, MD, PhD1, Teru Hideshima, MD, PhD1*, Robert J. Lutz2*, Sonia Vallet1*, Samantha Pozzi, MD3*, Loredana Santo1*, Elisabetta Calabrese1*, Benjamin Dälken4*, Christoph Uherek4*, Silke Aigner4*, Frank Osterroth4*, Mariateresa Fultiniti1*, Yutaka Okawa1*, Giulia Perrone1*, Gullu Gorgun1*, Hiroshi Yasui5*, Diana Cristia1*, Noopur Raje, MD1*, Nikhil Munshi, MD1*, Paul Richardson, MD1* and Kenneth C. Anderson, MD1*

1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
2ImmunoGen Inc., Waltham, MA
3Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
4Biotest AG, Dreieich,, Germany
5First department of internal medisine, Sapporo medical university, Sapporo, Japan

Hepatocyte Growth Factor-Producing Multiple Myeloma (HGF myeloma) Is a Distinct Clinical Entity and Needs for Molecular Targeted Therapy

Yutaka Hattori1, Shin-ichiro Okamoto, MD, PhD2, Wenlin Du3*, Taketo Yamada3*, Naoki Shimada4*, Kunio Matsumoto5*, Morihiko Sagawa2* and Yasuo Ikeda2*

1Clinical physiology and therapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan
2Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
3Pathology, Keio University School of Medicine, Tokyo, Japan
4Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan
5Cancer Research Institute, Kanazawa University, Kanazawa, Japan

A Humanized Anti-Ganglioside GM2 Antibody, BIW-8962, Exhibits ADCC/CDC Activity against Multiple Myeloma Cells and Potent Anti-Tumor Activity in Mouse Xenograft Models

Toshihiko Ishii1*, Asher Alban Chanan-Khan, MD2, Jazur Jafferjee, MD2*, Noreen Ersing2*, Takeshi Takahashi, PhD1*, Masato Mizutani, PhD1*, Yukimasa Shiotsu, PhD1 and Nobuo Hanai, PhD1*

1Oncology Group, Fuji Research Park, Kyowa Hakko Kirin Co., Ltd, Shizuoka, Japan
2Roswell Park Cancer Inst., Buffalo, NY

A Novel Aurora-a Kinase Inhibitor MLN8237 Induces Cytotoxicity and Cell Cycle Arrest in Experimental Multiple Myeloma Models

Gullu Gorgun, PhD1, Elisabetta Calabrese, MD1*, Mala Mani, PhD1*, Teru Hideshima, M.D., Ph.D.2, Hiroshi Ikeda, MD, PhD1, Giulia Perrone, MD1*, Loredana Santo, MD1*, Diana Cirstea, MD1*, Simona Blotta1, Paul G. Richardson, MD1*, Jeffrey Ecsedy3* and Kenneth C. Anderson, MD1

1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
2Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
3Millenium Pharmaceuticals, Cambridge, MA

Antitumor Activity in a Human Multiple Myeloma (MM) Model Using Sorafenib, Bortezomib, and Dexamethasone Treatment

Julia Schüler1*, Dagmar Wider2*, Dietmar Pfeifer2*, Martin Wagner1*, Heinz-Herbert Fiebig1* and Monika Engelhardt2

1Oncotest GmbH, Freiburg, Germany
2Hematology and Oncology, University of Freiburg Medical Center, Freiburg, Germany

Short-Term Culture of Umbilical Cord Blood-Derived Stem Cells Enhances the Engraftment into NOD/SCID Mice through the Increased Expression of CXCR4

Norioki Ohno, MD1*, Teruyuki Kajiume, MD, PhD2*, Yoshihiko Sera, MD, PhD1*, Takashi Sato, MD, PhD3* and Masao Kobayashi, MD, PhD4

1Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
2Pediatrics, Hiroshima University Graduate School of Biomedical Sciencies, Hiroshima, Japan
3Pediatrics, Hiroshima University Graduate School of Biomedical, Hiroshima, Japan
4Hiroshima University, Hiroshima, Japan

Expression of Cancer Testis Antigens as Potential Targets for Immunotherapy Is Retained Following Treatment in Multiple Myeloma

Mark van Duin1*, Surinder S. Sahota2*, Yvonne de Knegt1*, Annemiek Broyl1*, Debora Joseph-Pietras2*, George Mulligan3*, Barb Bryant3* and Pieter Sonneveld1

1Hematology, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands
2Molecular Immunology group, Tenovus Laboratory, Southampton University Hospital, Southampton, United Kingdom
3Millennium Pharmaceuticals, Cambridge

*signifies non-member of ASH