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652.O2.8 Myeloma - Pathophysiology and Animal Models: Bone Disease

Monday, December 8, 2008: 3:30 PM-5:30 PM
2009-2011-2022-2024 - West (Moscone Center)
Moderators:
Noopur Raje, MD and John Gibson, MBBS, FRACP, FRCPA
3:30 PM
Human-Like Mouse Models for Testing the Efficacy and Safety of Anti-β2-Microglobulin Monoclonal Antibodies to Treat Myeloma

Jing Yang, PhD, Yabing Cao*, Sungyongl Hong*, Haiyan Li*, Larry W. Kwak* and Qing Yi*

M.D. Anderson Cancer Center, Houston, TX

3:45 PM
Increased Signaling through p62 in the Marrow Microenvironment Increases Myeloma Cell Growth and Osteoclast Formation

Yuko Hiruma, PhD, DDS1*, Noriyoshi Kurihara, PhD, DDS1*, Diane F. Jelinek, PhD2 and David Roodman, MD, PhD1

1Medicine/Hem-Onc., University of Pittsburgh, Pittsburgh, PA
2Mayo Clinic/Foundation, Rochester, MN

4:00 PM
Proteomic Analysis of Multiple Myeloma Identifies Upregulation of CRIK Protein, a Novel Protein Regulating Migration and Adhesion

Hai T. Ngo1*, Evdoxia Hatjiharissi, MD1, Alexey A. Leontovich, PhD2*, Wee Chng, PhD3*, Mena Farag1*, Xavier Leleu, MD, PhD1*, Xiaoying Jia1*, Judith Runnels, PhD1*, Aldo Roccaro, MD, PhD1*, Abdel Kareem Azab, PhD1*, Feda Azab1*, Antonio Sacco1*, Nicholas Burwick, MD1*, Molly R. Melhem1*, Kenneth C. Anderson, MD1*, Rafael Fonseca, MD3, Thomas E. Witzig, MD4* and Irene M. Ghobrial, MD1*

1Dana-Farber Cancer Institute, Boston, MA
2Mayo Clinic College of Medicine, Rochester, MN
3Mayo Clinic College of Medicine, Scottsdale, AZ
4Mayo Clinic, Rochester, MN

4:15 PM
Restoration of Bone Balance Via Activin a Inhibition Results in Anti-Myeloma Activity

Sonia Vallet, MD1*, Siddhartha Mukherjee, MD2*, Nileshwari Vaghela, MS1*, Samantha Pozzi, MD3*, Loredana Santo, MD3*, Diana Cirstea, MD3*, Mariateresa Fulciniti, PhD3*, Aliyah Rahemtullah, MD4*, Eyal Attar, MD2, Alexander R Guimaraes5*, Wanling Xie6*, Chirayu Patel2*, Jesse Schoonmaker2*, Edie Weller, PhD6*, Teru Hideshima, M.D., Ph.D.3, Nikhil C. Munshi, MD3, Jas Seehra7*, David T. Scadden, MD2, Kenneth C Anderson, MD3 and Noopur Raje, MD1*

1Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
2Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA
3Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
4Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
5Center for Molecular Imaging Research and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
6Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
7Acceleron Pharma, Inc, Cambridge, MA

4:30 PM
Human Placenta-Derived Adherent Stem Cells Prevent Bone Loss and Stimulate Bone Formation in Myelomatous Bones, and Suppress Growth of Primary Multiple Myeloma

Xin Li1*, Wen Ling1*, Angela Pennisi1*, Jianmei Chen1*, Sharmin Khan1*, Mohammad Heidaran2*, Herbert Faleck2*, Robert Hariri2*, John Shaughnessy1*, Frits van Rhee1*, Joshua Epstein1*, Bart Barlogie1* and Shmuel Yaccoby1

1Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR
2Celgene Inc, Warren, NJ

4:45 PM
In Vivo Imaging Model of Multiple Myeloma and Its Cellular Interaction with the Bone Marrow Microenvironment

Judith Runnels, PhD1*, Alicia Carlson, PhD2*, Costas Pitsillides, PhD2*, Joel Spencer, PhD2*, Juwell Wu2*, Abdel kareem Azab, PhD1*, Aldo M. Roccaro, MD, PhD1, Anne-Sophie Moreau, MD1*, Xavier Leleu, MD, PhD1*, Andrew Kung, MD, PhD3, Scott J. Rodig, MD, PhD4*, Kenneth C Anderson, MD1, Charles P. Lin, PhD2* and Irene M. Ghobrial, M.D1

1Dana-Farber Cancer Institute, Boston, MA
2Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA
3Dana-Farber Cancer Inst., Boston, MA
4Department of Pathology, Brigham and Women Hospital, Boston, MA

5:00 PM
The BCL9 Oncogene Promotes Tumor Progression by Conferring Enhanced Proliferative, Metastatic and Angiogenic Properties to Myeloma Cells

Mala Mani, Ph.D.1*, Jui Dutta1*, Yunyu Zhang1*, Daniel E Carrasco1*, Yiming Zhou2*, Moshe Gatt1*, Bart Barlogie2*, John D. Shaughnessy Jr., PhD3, Kenneth C Anderson, MD4 and Daniel Ruben Carrasco, M.D., Ph.D.1*

1Medical Oncology, Dana Farber Cancer Institute, Boston, MA
2Myeloma Institute for Research and Therapy, University of Arkansas for Medical Science, Little Rock, AR
3Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR
4Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

*signifies non-member of ASH