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651.P1.93 Myeloma - Biology and Pathophysiology, Excluding Therapy Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM
Hall A (Moscone Center)
Superior Rate of Complete Response with up-Front Velcade-Thalidomide-Dexamethasone Versus Thalidomide-Dexamethasone in Newly Diagnosed Multiple Myeloma Is Not Affected by Adverse Prognostic Factors, Including High-Risk Cytogenetic AbnormalitiesClinically Relevant Abstract

Michele Cavo, M.D.1*, Nicoletta Testoni, B.S.1*, Carolina Terragna, B.S.1*, Giulia Marzocchi, B.S.1*, Sandra Durante, B.S.1*, Renato Zambello, M.D.2*, Chiara Nozzoli, M.D.2*, Lucia Pantani, M.D.1*, Paola Tacchetti, M.D.1*, Luciano Masini, M.D.2*, Michela Ceccolini, M.D.1*, Paola Agostini, M.D.2*, Elena Zamagni, M.D.1*, Valerio De Stefano, M.D.2*, Patrizia Tosi, M.D.1*, Daniele Derudas, M.D.2*, Laura Dessanti, M.D.2*, Stelvio Ballanti, M.D.2*, Salvatore Palmieri, M.D.2*, Andrea Nozza, M.D.2*, Gioacchino Catania, M.D.2*, Jacopo Peccatori, M.D.2*, Alfonso D'Arco, M.D.2*, Pellegrino Musto, M.D.2*, Mariella Grasso, M.D.2*, Maria Caterina Pallotti, M.D.1*, Silvana Pasini, M.D.2*, Pier Paolo Fattori, M.D.2*, Anna Baraldi, M.D.2*, Delia Cangini, M.D.2*, Filippo Ballerini, M.D.2*, Alessandro Petrucci, M.D.1* and Michele Baccarani, M.D.3

1Seragnoli Institute of Hematology and Medical Oncology, Bologna University School of Medicine, Bologna, Italy
2Italian Myeloma Network GIMEMA, Italy
3Dept. Hematology and Medical Oncology, University of Bologna, Bologna, Italy

Loss of p53 Is a Marker of Progression in Plasma Cell Neoplasias and Is a Negative Prognostic Factor in Relapsed Disease

Soledad Molnar, MD1*, Victor J Jimenez Zepeda1*, Scott Van Wier1*, Esteban Braggio1*, Jonathan Keats1*, Michael Kuehl2*, Tammy Price-Troska3*, Greg Ahmann1*, Rachel Rempel1*, Kim Henderson, MD2*, S. Vincent Rajkumar, MD4*, Philip . R Greipp, MD3*, Daniel Auclair5*, John Carpten6*, Angela Baker6*, Keith Stewart, MD1, P. Leif Bergsagel, MD1, Wee Joo Chng, MD7* and Rafael Fonseca, MD1

1Hematology and Oncology, Mayo Clinic Arizona, Scottsdale, AZ
2Genetic Branchs, National Cancer Institute, Bethesda
3Mayo Clinic Rochester, Rochester, MN
4Hematology, College of Medicine, Mayo Clinic, Rochester, MN
5Multiple Myeloma Research Cancer
6Translational Genomics Research Institution, Phoenix, AZ
7Hematology and Oncology, National University Hospital of Singapure

Survival Signals, Growth Cytokines, Immunosuppressive Factors and Their Cellular Perpetrators in the Myeloma Tumor Microenvironment

Jayakumar R Nair, PhD1*, Louise M Carlson, PhD1*, Noreen Ersing, MS2*, Asher Alban Chanan-Khan, MD3 and Kelvin P. Lee, MD4

1Dept. of Immunology, Roswell Park Cancer Institute, Buffalo, NY
2Medicine, Roswell Park Cancer Institute, Buffalo, NY
3Medicine, Roswell Park Cancer Inst., Buffalo, NY
4Immunology, Roswell Park Cancer Institute, Buffalo, NY

Bortezomib Targets Stroma-Mediated APO2L/TRAIL Apoptosis Resistance in Multiple Myeloma

Lia Perez, MD, Nancy Parquet*, Claudio Anasetti* and William Dalton*

H. Lee Moffitt Cancer Ctr., Tampa, FL

Rho-a and Rac-1 GTPases Play Major and Differential Roles in SDF1α-Induced Cell Adhesion and Chemotaxis in Multiple Myeloma

Abdel kareem Azab1*, Feda Azab1*, Costas M Pitsillides2*, Hai T. Ngo1*, Xiaoying Jia1*, Molly R. Melhem1*, Judith Runnels1*, Aldo M. Roccaro, MD, PhD1, Antonio Sacco1*, Nicholas Burwick1*, Charles P Lin2*, Kenneth C Anderson, MD3 and Irene M. Ghobrial1*

1Dana-Farber Cancer Inst., Boston, MA
2Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA
3Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

A Gene Expression Based Proliferation Index as Independent Prognostic Factor in Multiple Myeloma

Dirk Hose1, Thierry Rème2*, Thomas Hielscher3*, Jérôme Moreaux2*, Tobias Meißner1*, Anja Seckinger1*, Axel Benner3*, Michael Hundemer1*, John Shaughnessy Jr.4, Bart Barlogie4*, Jens Hillengass1*, Uta Bertsch1*, Anna Jauch5*, Jean François Rossi2*, Thomas Möhler1*, Bernard Klein6* and Hartmut Goldschmidt1*

1Medizinische Klinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany
2CHU Montpellier and INSERM U475, Montpellier, France
3Abteilung für Biostatistik, Deutsches Krebsforschungszentrum, Heidelberg, Germany
4Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR
5Universitätsklinikum Heidelberg, Institut für Humangenetik, Heidelberg, Germany
6INSERM U847, Montpellier, France

A Functional Promoter Polymorphism (-8C>G) of the Proteasome Subunit α6 Gene Is Associated with Multiple Myeloma and Poor Outcome Independent of Circulating Proteasome Serum Levels

Hagen S Bachmann, MD1*, Juergen Novotny, MD2*, Stephan Sixt, MD3*, Peter Liebisch, MD4*, Ulrich Frey, MD3*, Juergen Peters, MD3*, Ulrich Duehrsen, MD5, Winfried Siffert, MD1* and Holger Nückel, MD2*

1Institute of Pharmacogenetics, University Hospital of Essen, Essen, Germany
2Department of Haematology, University Hospital of Essen, Essen, Germany
3Department of Anaesthesia and Intensive care, University Hospital of Essen, Essen, Germany
4Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
5University Hospital Essen, Essen, Germany

KRN5500, a Spicamycin Derivative, Exerts Anti-Myeloma Effects through Impairing Both Myeloma Cells and Osteoclasts

Hirokazu Miki1*, Shuji Ozaki2, Osamu Tanaka1*, Shingen Nakamura1*, Ayako Nakano1*, Kumiko Kagawa1*, Kyoko Takeuchi1*, Kenichiro Yata1*, Masahiro Abe1* and Toshio Matsumoto1*

1Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
2Division of Transfusion Medicine, Tokushima University Hospital, Tokushima, Japan

Prognostic Factors Influencing Survival in Solitary Plasmacytoma: A SEER Database AnalysisClinically Relevant Abstract

Paul Mehan, MD1*, Giridharan Ramsingh, MD2, Jingqin Luo, Ph.D.3*, Daniel Morgansztern, MD2* and Ravi Vij, MD2*

1Internal Medicine, Washington University School of Medicine, St. Louis, MO
2Oncology, Washington University School of Medicine, Saint Louis, MO
3Biostatistics, Washington University School of Medicine, Saint Louis, MO

Validation of a Novel Tissue Array Based Classification of Multiple Myeloma (MM)

Nizar J Bahlis, MD1, Alex Klimowicz, Ph.D.2*, Paola Neri, M.D.2*, Anthony Magliocco, M.D.3*, Douglas A. Stewart, MD, FRCPC1 and Adnan Mansoor, MD, FRCPC4

1Hematology and Bone Marrow Transplantation, University of Calgary, Tom Baker Cancer Centre, Calgary, AB, Canada
2Medicine, University of Calgary, Calgary, AB, Canada
3Department of Oncology, Pathology and Laboratory Medicine, University of Calgary, University of Calgary, Calgary, AB, Canada
4Hematology and Transfusion Medicine, Calgary Laboratory services, University of Calgary, Calgary, AB, Canada

Increased Risk of Monoclonal Gammopathy in First-Degree Relatives of Patients with Multiple Myeloma or Monoclonal Gammopathy of Undetermined Significance

Celine M Vachon, PhD1*, Robert Kyle, MD2, Terry Therneau, PhD1*, Dirk R Larson1*, Colin Colby1*, Barbara J Foreman1*, Angela Dispenzieri, MD3*, Shaji Kumar, MD3, Jerry Katzmann, MD3* and S. Vincent Rajkumar, MD3

1Health Sciences Research, Mayo Clinic, Rochester, MN
2Hematology, College of Medicine, Mayo Clinic, Rochester, MN
3Hematology, Mayo Clinic, Rochester, MN

Identification of Cellular Pathways Mediating Progression of Monoclonal Gammopathy (MGUS) to Multiple Myeloma (MM) Using Gene Expression Profiling (GEP)

Wee-Joo Chng1, Gaofeng Huang1*, Peter Leif Bergsagel, MD2 and Rafael Fonseca, MD3

1Haematology-Oncology, National University Hospital, Singapore, Singapore
2Mayo Clinic, Scottsdale, AZ
3Mayo Clinic Scottsdale, Scottsdale, AZ

CXCR7 Regulates SDF-1 Induced Adhesion and Homing in Multiple Myeloma

Nicholas Burwick, MD1*, Anne-Sophie Moreau, MD1*, Xiaoying Jia1*, Xavier Leleu, MD, PhD1*, Judith Runnels2*, Hai T. Ngo1*, Molly R. Melhem1*, Aldo M. Roccaro, MD, PhD1, Abdel kareem Azab, PhD1* and Irene M. Ghobrial, M.D.1

1Dana-Farber Cancer Institute, Boston, MA
2Dana-Farber Cancer Institute, Boston

Genetic Variation in ADME Genes Is Associated with Thalidomide Related Peripheral Neuropathy in Multiple Myeloma Patients

David C Johnson1*, Christine Ramos2*, Alex J. Szubert3*, Walter M Gregory3*, J. Anthony Child3*, Faith E Davies, MD1, Brian GM Durie, MD4, Brian G. Van Ness, PhD2 and Gareth J Morgan, MD, PhD1

1Section of Haemato-oncology, Institute of Cancer Research, London, United Kingdom
2University of Minnesota, Minneapolis, MN
3University of Leeds, Leeds, United Kingdom
4Hematology-Oncology Cedars-Sinai Outpatient Cancer Center at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA

Conditionally Expressed PU.1 Transactivates TRAIL Gene and Induces Apoptosis in Myeloma Cell Lines

Shikiko Ueno1*, Hiro Tatetsu1*, Hiroyuki Hata, MD, PhD1, Tadafumi IIno2*, Hiroaki Niiro2*, Koichi Akashi, MD, PhD2*, Daniel G. Tenen, MD3, Hiroaki Mitsuya1* and Yutaka Okuno1

1Dept. of Hematology, Kumamoto Univ., Kumamoto, Japan
2Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan
3Harvard Inst. of Med., Boston, MA

Association of High Levels of Free Light Chain and the Presence of Igh Translocations in Multiple Myeloma and Prognostic Implications

Shaji Kumar1, Lijun Zhang2*, Angela Dispenzieri1*, Scott Van Wier3*, Jerry Katzmann1*, Melissa Snyder1*, Emily Blood4*, Roberta DeGoey1*, Kim Henderson1*, Arthur Bradwell5, Robert Kyle1*, Philip Greipp1*, S.Vincent Rajkumar1* and Rafael Fonseca3*

1Mayo Clinic, Rochester, MN
2Dana-Farber Cancer Institute, Boston, MA
3Hematology and oncology, Mayo Clinic Arizona, Scottsdale, AZ
4Dartmouth Medical School, Lebanon, NH
5Dept. of Immunology, Med. School, Univ. of Birmingham, Birmingham

Familial Aggregation of Multiple Myeloma and Its Precursor Monoclonal Gammopathy of Undetermined Significance (MGUS): A Population-Based Study in Sweden

Sigurdur Y Kristinsson, M.D.1*, Magnus Bjorkholm, MD, PhD1, Lynn R. Goldin, Ph.D.2*, Cecilie Blimark, M.D.3*, Ulf-Henrik Mellqvist, MD, PhD3*, Anders Wahlin, MD, PhD4*, Ingemar Turesson, MD, PhD5* and Ola Landgren, M.D., Ph.D.2

1Department of Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
2National Cancer Institute, National Institutes of Health, Bethesda, MD
3Department of Medicine, Section of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg, Sweden
4Hematology, Umeå University Hospital, Umeå, Sweden
5Department of Medicine, Malmo University Hospital, Malmo, Sweden

Large Scale Evaluation of Genetic Variation and the Risk of Multiple Myeloma

Sonja I Berndt1*, David C Johnson2*, John Crowley3, Brian G Durie, MD4, Robert Hoover1*, Michael Katz5*, Nathaniel Rothman1*, Brian G. Van Ness, PhD6, Dalsu Baris, MD, PhD1* and Gareth J Morgan, MD, PhD7

1Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD
2Section of Haemato-Oncology, Institute of Cancer Research, London, United Kingdom
3Southwest Oncology Group (SWOG) Statistical Center, Seattle, WA
4Hematology-Oncology Cedars-Sinai Outpatient Cancer Center at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA
5International Myeloma Foundation, North Hollywood, CA
6University of Minnesota, Minneapolis, MN
7Section of Haemato-Oncology, The Institute of Cancer Research, London, United Kingdom

Indoleamine 2,3-Dioxygenase (IDO) Is Expressed by Multiple Myeloma Plasma Cells and Promotes the Differentiation of Regulatory T Cells: Investigations into the Role of Hepatocyte Growth Factor

Giuseppina Bonanno, BSc1*, Maria Corallo, BSc1*, Andrea Mariotti, BSc1*, Anna Di Maggio, BSc2*, Annabella Procoli, BSc1*, Luca De Rosa, MD3*, Luca Pierelli, MD3*, Ignazio Majolino, MD3, Giuseppe Leone, MD4*, Raimondo De Cristofaro, MD2* and Sergio Rutella, MD, PhD4

1Gynecology, Catholic University Medical School, Rome, Italy
2Medicine, Catholic University Medical School, Rome, Italy
3Ematologia, Ospedale S. Camillo, Rome, Italy
4Hematology, Catholic University Medical School, Rome, Italy

Trogocytosis in Multiple Myeloma

Ross D. Brown, PhD, MBA, Karieshma Kabani, BSc*, Shihong Yang, MSc*, Aklilu Esther, BSc*, Phoebe Joy Ho, MBBS, DPhil, John Gibson, MBBS, PhD and Douglas E. Joshua, MBBS, DPhil

Haematology, Royal Prince Alfred Hospital, Camperdown, Australia

Genomic Complexity and Recurrent Aberration in Multiple Myeloma: Analysis of a Compendium of aCGH and Gene Expression Profiles

Wee-Joo Chng1, Ian Lee1*, Victor Jimenez-zepeda2*, Esteban Braggio2*, Jonathan Keats2*, Peter Leif Bergsagel, MD2 and Rafael Fonseca, MD2

1Haematology-Oncology, National University Hospital, Singapore, Singapore
2Comprehensive Cancer Center, Mayo Clinic, Scottsdale, AZ

Gene Expression Profiles for Molecular Classification of Multiple Myeloma in Newly Diagnosed Patients Included in a Prospective, Multicenter, Phase 3 Trial

A. Broyl1*, J. Peeters2*, D. Hose3, Y. de Knegt2*, B. Beverloo4*, H. Lokhorst5, H. Goldschmidt6*, M. van Duin2* and P. Sonneveld2

1Erasmus MC, Rotterdam, Netherlands
2Hematology, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands
3Medizinische Klinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany
4Clinical Genetics, Erasmus MC, Rotterdam, Netherlands
5Hematology, University Medical Center Utrecht, Utrecht, Netherlands
6Hematology, Oncology, Rheumatology, University of Heidelberg, Heidelberg, Germany

Integrative Genomic Approach Identifies Deregulated MicroRNAs in Human Myeloma Cell Lines

Marta Lionetti, PhD*, Luca Agnelli*, Laura Mosca, PhD*, Katia Todoerti, PhD*, Domenica Ronchetti, PhD*, Sonia Fabris, PhD*, Adrian Andronache, PhD*, Donata Verdelli, PhD*, Paola Ponzo, PhD*, Giorgio Lambertenghi Deliliers, MD and Antonino Neri, MD*

Department of Medical Science, Leukemia Study Center - Hematology 1, C.T.M.O., University of Milan - Fondazione IRCCS Policlinico, Milan, Italy

Anti-Myeloma Effects of γδ T Cells Are Hampered by Bone Marrow Stromal Cells but Resumed by Stromal Cell-Derived Osteoblasts

Kenichiro Yata1*, Masahiro Abe1*, Asuka Oda1*, Hiroe Amou1*, Masahiro Hiasa2*, Kyoko Takeuchi1*, Shingen Nakamura1*, Osamu Tanaka1*, Hirokazu Miki1*, Ayako Nakano1*, Kumiko Kagawa1*, Shuji Ozaki3 and Toshio Matsumoto1*

1Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
2Department of Biomaterials and Bioengineerings, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
3Division of Transfusion Medicine, Tokushima University Hospital, Tokushima, Japan

XBP1 Expression Is An Important Prognostic Factor for Newly Diagnosed Myeloma Patients

Tina Bagratuni*, Ping Wu*, David Gonzalez de Castro*, Emma L Davenport*, Brian A Walker*, Matthew W Jenner*, David C Johnson*, Gareth J. Morgan and Faith E Davies*

Section of Haemato-oncology, Institute of Cancer Research, London, United Kingdom

Hypoxia and Hypoxia Inducible Factor (HIF)-1α in Multiple Myeloma: Effect on the  Pro-Angiogenic Signature of Myeloma Cells and the Bone Marrow Microenvironment

Simona Colla1*, Paola Storti1*, Gaetano Donofrio2*, Mirca Lazzaretti3*, Sabrina Bonomini1*, Paolo Lunghi4*, Monica Crugnola1*, Marina Bolzoni1*, Luisa Galla1*, Luigi Ippolito5*, Eugenia Martella6*, Gabriella Sammarelli1*, Luisa Craviotto1*, Cecilia Caramatti1*, Marcellina Mangoni1*, Antonio Bonati7*, Vittorio Rizzoli1* and Nicola Giuliani1

1Unit of Hematology and BMT, University of Parma, Parma, Italy
2Dipartimento di Salute Animale, University of Parma, Parma, Italy
3Genetica, University of Parma, Parma, Italy
4Department of Clinical Sciences, University of Parma, Parma, Italy
5Laboratorio di Diagnostica Ematochimica, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
6Pathology, University of Parma, Parma, Italy
7Department of Clinical Sciences and Unit of Hematology and BMT, University of Parma, Italy

HLA Specificities and Predisposition to the Development of Multiple Myeloma (MM)

Meral Beksac, MD1*, Martin Maiers2*, Loren Gragert2*, Stephen Spellman2*, Smriti Shrestha, MS, MA3*, Mei-Jie Zhang, PhD3*, Angela Dispenzieri, MD4, Donna E. Reece, MD5, David H. Vesole, MD, PhD6* and Parameswaran Hari, MD, MS3

1Hematology, Ankara University School of Medicine, Ankara, Turkey
2National Marrow Donor Program, Minneapolis, MN
3Medical College of Wisconsin, Center for International Blood and Marrow Transplant Research, Milwaukee, WI
4Mayo Clinic, Rochester, MN
5Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, ON, Canada
6St. Vincent's Comprehensive Cancer Center, New York, NY

Role of NT-ProBNP to Assess the Adequacy of Treatment Response in AL Amyloidosis

Ashutosh Wechalekar1, Giampaolo Merlini2*, Julian D Gillmore1*, P. Russo3*, Helen J Lachmann1*, Laura Obici3*, Philip N Hawkins1* and Giovanni Palladini2*

1National Amyloidosis Center, University College London Medical School, London, United Kingdom
2Center for Amyloidosis, Fondazione IRCCS Policlinico San Matteo and Department of Biochemistry, University of Pavia, Italy
3Center for Amyloidosis, Fondazione IRCCS Policlinico San Matteo and Department of Biochemistry, Italy

Immunomodulatory Effects of Lenalidomide and Bortezomib on Bone Marrow Stroma Cell and CD4 T Cell Interaction in Multiple Myeloma

Gullu Gorgun, PhD, Elisabetta Calabrese, MD*, Teru Hideshima*, Hiroshi Ikeda*, Giulia Perrone*, Loredana Santo*, Diana Cirstea*, Paul G Richardson* and Kenneth C Anderson*

Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Only Concomitant Presence of Cytogenetic Abnormalities in Randomly Sampled Bone Marrow and in MRI-Defined Focal Lesions Imparts Poor Prognosis and Is Associated with Gene Expression Profiling (GEP)-Based High-Risk Myeloma

Bijay Nair, PhD1*, Yiming Zhou, PhD1*, Bart Barlogie, MD, PhD1, Jeffrey Sawyer, PhD2*, Jackie Szymonifka3*, John Crowley, PhD3 and John D. Shaughnessy Jr., PhD1

1Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR
2Pathology, University of Arkansas for Medical Sciences, Little Rock, AR
3Cancer Research & Biostatistics, Seattle, WA

A Pre-Existing Plasma Cell Disorder Occurs in Most Patients with Multiple Myeloma

Brendan M Weiss, MD1, Pramvir Verma, MD2*, Jude Abadie, PhD3*, Robin Howard, MA4* and Michael Kuehl, MD5*

1Hematology-Oncology Service, Walter Reed Army Medical Center, Washington, DC
2Hematology-Oncology Service, Womack Army Medical Center, Fort Bragg, NC
3Pathology and Area Laboratory Services, Walter Reed Army Medical Center, Washington, DC
4Department of Clinical Investigation, Walter Reed Army Medical Center, Washington, DC
5Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD

Molecular Characterization of Human Multiple Myeloma Cell Lines by Genome-Wide Profiling Identifies Kinase Pathway Alterations

Carolina Elosua1*, Purificacion Catalina1*, Brian A Walker2*, Nicholas J Dickens2*, Athanasia Avramidou2*, Luis Brito2*, Emma Davenport, PhD2*, Matthew W Jenner2*, David Gonzalez, PhD2*, Faith Davies, MD2, Gareth J Morgan, MD, PhD2 and Paola E Leone, PhD1*

1Multiple Myeloma Group, Andalusian Stem Cell Bank, Granada, Spain
2Section of Haemato-Oncology, The Institute of Cancer Research, London, United Kingdom

Myeloma and Osteolytic Bone Disease: Is DKK1 All It Takes?

Bangzheng Chen, PhD, Hong Wu*, Yuxin Zeng*, John E Freeman III*, Damir Herman*, John D. Shaughnessy Jr., Bart Barlogie and Joshua Epstein

Myeloma Institute for Research and Therapy, Little Rock, AR

Regulatory T Cells (Treg) Are Depressed in Patients with Relapsed/ Refractory Multiple Myeloma (MM) and Increases towards Normal Range in Responding Patients Treated with Lenalidomide (LEN)

Hang Quach, MB, BS, FRACP, FRCPA1*, David Ritchie, MBChB, FRACP, FRCPA, PhD2*, Paul Neeson, PhD3*, Simon Harrison, MB, BS, MRCP, MRCPath, PhD2*, Tsin Tai, MSc4*, Kellie Tainton, BSc4*, Kevin Lynch, MB, BS, FFPM5* and Miles Prince, MB, BS, FRACP, FRCPA, MRACMA, MD6

1Dept. of Haematology and Clinical Oncology., Peter MacCallum Cancer Centre, Melbourne, Australia
2Dept. of Haematology and Clinical Oncology, Peter MacCallum Cancer Center, Melbourne, Australia
3Haematology Immunology Translational Research Laboratory, Immunology Program, Peter MacCallum Cancer Center, Melbourne, Australia
4Haematology Immunology Translational Research Laboratory, Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Australia
5Celgene Pty Ltd, Melbourne, Australia
6Dept. of Haematology and Clinical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia

Brain-Derived Neurotrophic Factor Induces Proliferation, Migration and VEGF Secretion in Human Multiple Myeloma Cells Via Activation of MEK-ERK and PI3K/Akt Signaling

Yu Hu1*, Chun-yan Sun1*, Jing Huang1*, Lu Zhang1*, Zhang-bo Chu1* and Shiang Huang, MD2

1Institute of Hematology, Union Hospital, Tongji medical college, Huazhong University of Science and Technology, Wuhan, China
2Institute of Hematology, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China

Wnt3 Signaling Augments integrinβ1-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma in Autocrine and Paracrine Manner

Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD*, Satoshi Iyama, MD, PhD*, Tsutomu Sato, MD, PhD*, Yutaka Kawano, MD, PhD*, Shohei Kikuchi, MD, PhD*, Koji Miyanishi, MD, PhD*, Rishu Takimoto, MD, PhD* and Junji Kato, MD, PhD*

Fourth Dept. of Internal Med., Sapporo Medical University, Sapporo, Japan

Analysis of Protein Biology to Increase Efficacy of Aurora Kinase Inhibitors for Multiple Myeloma Therapy

Robert P. Evans, Ph.D.1*, Kim Laginha1*, Linda M. Pilarski, PhD2, Andrew Belch, MD3 and Tony Reiman, MD3

1Oncology, Cross Cancer Institute & University of Alberta, Edmonton, AB, Canada
2University of Alberta & Cross Cancer Institute, Edmonton, AB, Canada
3Cross Cancer Institute, Edmonton, AB, Canada

Glucocorticoid Receptor Expression Correlates with Clinical Outcome in Myeloma Patients Treated with Glucocorticoid-Containing Regimens

Shuo Ma, MD, PhD1*, Fenghuang Zhan, MD, PhD2*, Chunguang Ma1*, Michael Tessel1*, Lijun Zhang3*, S. Vincent Rajkumar, MD4*, Seema Singhal5, Bart Barlogie, MD6*, John Shaughnessy, PhD7, Steven T. Rosen, MD8 and Nancy Krett, PhD1*

1Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
2Blood/Marrow Transplant and Myeloma Program, University of Utah School of Medicine, Salt Lake City, UT
3Dana-Farber Cancer Institute, Boston, MA
4Hematology, Mayo Clinic, Rochester, MN
5Hem./Onc., Northwestern Univ. Med. School, Chicago, IL
6Myeloma Institute for Research and Therapy, University of Arkansas for Medical Science, Little Rock, AR
7Dept. of Medicine, Univ. of AR for Med. Sciences, Little Rock, AR
8Northwestern University, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL

The CXCR4 Antagonist AMD3100 Stimulates the Proliferation of Myeloma Cells

Ha-Yon Kim*, Seong-Woo Kim*, Hyo-Jin Lee, MD, PhD*, Hwan-Jung Yun, MD*, Samyong Kim, MD, PhD* and Deog-Yeon Jo, MD, PhD

Department of Internal Medicine and Cancer Research Institute, College of Medicine, Chungnam National University, Daejeon, South Korea

Loss of Chromosome 1p21 Band Is Associated with Disease Progression and Poor Survival in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation

Hong Chang, MD1, Connie Qi, MD2*, Allan Jiang1*, Wei Xu, PhD3*, Young Trieu, MSc4* and Donna E. Reece, MD4

1University Health Network, Toronto, ON, Canada
2UNIVERSITY HEALTH NETWORK, Toronto, ON, Canada
3Biostatistics, Princess Margaret Hospital, Toronto, ON, Canada
4Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, ON, Canada

Decreased Thymosin Beta 4 Expression Results in Poor Prognosis and Decreased Survival in Multiple Myeloma

Jo Caers1*, Dirk Hose2, Ine Kuipers1*, Tomas Jan Bos1*, Els Van Valckenborgh1*, Eline Menu1*, Elke De Bruyne1*, Hartmut Goldschmidt2*, Ben Van Camp1*, Bernard Klein3* and Karin Vanderkerken1

1Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium
2GMMG and University of Heidelberg, Heidelberg, Germany
3INSERM U847, Montpellier, France

High-Throughput Microrna Profiling in Patients with Waldenstrom’s Macroglobulinemia

Sophia Adamia, Ph.D1*, Samir B Amin, MBBS2*, Cheng Li, Ph.D3*, Christopher J Patterson4*, Herve AvetLoiseau, MD5*, Stephane Minvielle, Ph.D5*, Philippe Moreau, MD5*, Kenneth C Anderson, MD6, Nikhil C. Munshi, MD7 and Steven Treon, MD, PhD8

1Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
2Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
3Department of Biostatistics and Department of Biostatistics and Computational Biology, Harvard School of Public Health and Dana-Farber Cancer Institute, Boston
4Waldenstrom's macroglubulinemia center, Dana-Farber Cancer Institute, Boston, MA
5Hematology Department, Hopital de Nantes, Nantes, France
6Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
7Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston VA Cancer Healthcare System, Boston, MA
8Dana-Farber Cancer Institute, Boston, MA

Proteomic Profiling of Multiple Myeloma: Correlation of Protein and Gene Expression Data

Ricky D Edmondson, PhD*, Sheeno P Thyparambil, Ph.D.*, Veronica MacLeod*, Bart Barlogie, MD, PhD and John D. Shaughnessy Jr., PhD

Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR

β1 Integrin Adhesion Enhances IL-6 Mediated STAT3 Signaling in Multiple Myeloma Cells: Implications for Microenvironment Influence on Tumor Cell Survival and Proliferation

Kenneth H Shain, M.D., Ph.D.1, Danielle Yarde2*, Mark Mead, Ph.D.2*, Lori Hazlehurst, Ph.D.2* and William S Dalton, M.D., Ph.D1*

1Hematology Oncology and Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
2Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Mechanisms of the Formation of Multinuclear Malignant Plasma Cells in the Novel AL/MM Human Cell Lines, ALMC-1 and ALMC-2: Implications for Tumor Cell Growth Control

Bonnie K Arendt1*, Xiaosheng Wu, MD1*, Philip R Greipp, MD2*, S. Vincent Rajkumar, MD2*, Robert Kyle, MD2, Rhett P Ketterling, MD3*, Ryan A Knudson3* and Diane F Jelinek1*

1Immunology, College of Medicine, Mayo Clinic, Rochester, MN
2Hematology, College of Medicine, Mayo Clinic, Rochester, MN
3Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, MN

*signifies non-member of ASH