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651.O2.8 Molecular Profiling of Myeloma

Monday, December 8, 2008: 3:30 PM-5:30 PM
2005-2007-2018-2020 - West (Moscone Center)
Moderators:
Irene Ghobrial, MD and Jonathan D. Licht, MD
3:30 PM
High Resolution Genomic Profiling Using Single Nucleotide Polymorphism Microarrays Identifies Multiple Novel Genomic Minimally Deleted Regions in Multiple Myeloma

Brian A Walker, PhD1*, Paola E Leone, PhD1*, Nicholas J Dickens, DPhil1*, Matthew W Jenner, MD1*, Laura Chiecchio2*, GianPaolo Dagrada2*, Fiona M Ross, DPhil2*, Faith E Davies, MD1* and Gareth J Morgan, MD, PhD1

1Section of Haemato-Oncology, Institute of Cancer Research, London, United Kingdom
2LRF UK Myeloma Forum Cytogenetics Group, Wessex Regional Genetics Laboratory, Salisbury, United Kingdom

3:45 PM
Genome-Wide Profiling of Endothelial Progenitor Cells in Multiple Myeloma: Disease-Relevant Pathways and Overlaps with Common Cancer Biomarkers

Marc J. Braunstein1*, Fabien Campagne, PhD2*, Piali Mukherjee2*, Daniel Ruben Carrasco, M.D., Ph.D.3*, Kumar Sukhdeo3*, Alexei Protopopov3*, Kenneth C Anderson, MD4 and Olcay Batuman, MD1

1Medicine, Hematology/Oncology, SUNY Downstate Medical Center, Brooklyn, NY
2Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, NY
3Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
4Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

4:00 PM
Genome-Wide Chromatin Immunopreciptiation and Gene Expression Analysis Indicates That MMSET Is a Transcriptional Repressor in Vivo

Dong-Joon Min, PhD1*, Julia Meyer, BS1*, Eva Martinez-Garcia, PhD1*, Josh Lauring, MD, PhD2 and Jonathan D. Licht, MD1

1Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
2Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD

4:15 PM
Gene Transcriptional Activity Analysis in the 6q Region in Waldenstrom Macroglobulinemia (WM) Using ChIP-on-Chip Technology

Xavier Leleu, MD, PhD1, Fangxin Hong, PhD2*, Aldo M. Roccaro, MD, PhD3, Xiaoying Jia3*, Antonio Sacco3*, Anne-Sophie Moreau, MD1*, Hai Ngo3*, Abdel kareem Azab, PhD3*, Feda Azab3*, Molly Melhem3*, Kenneth C. Anderson, MD3* and Irene M. Ghobrial, MD3*

1Service des Maladies du Sang, Hopital Huriez, CHRU Lille, Lille, France
2Biostatistics and Computational Biology, Dana-Farber Cancer Institute
3Dana-Farber Cancer Institute, Boston, MA

4:30 PM
MicroRNA Expression Profiling in Multiple Myeloma: Correlation with Genetic Abnormalities

Norma C. Gutiérrez*, Maria Eugenia Sarasquete*, Manuel Delgado*, Patricia Martín-Jiménez*, Carmen Chillón*, Isabel M. Isidro*, Teresa Prieto*, Ramon García-Sanz*, Jesus M. Hernández*, Marcos González* and Jesus F San Miguel

Hematology, Hospital Universitario de Salamanca; Centro de Investigación del Cáncer (CIC, IBMCC USAL-CSIC), Salamanca, Spain

4:45 PM
MicroRNA Signature in Waldenstrom Macroglobulinemia

Aldo M Roccaro1, Antonio Sacco1*, Changzhong Chen1*, Xavier Leleu1*, Judith Runnels1*, Feda Azab1*, Abdel Kareem Azab1*, Xiaoying Jia1*, Hai T Ngo1*, Molly R. Melhem1*, Nicholas Burwick1*, Phong Quang1*, Lyuba Varticovski2*, Carl D Novina1*, Barrett J. Rollins1*, Kenneth C. Anderson1* and Irene M. Ghobrial1*

1Dana-Farber Cancer Institute, Boston, MA
2National Cancer Center, Bethesda, MD

5:00 PM
MicroRNA 15a and 16-1 Target Identification in Deletion 13 Multiple Myeloma

Travis J. Henry, PhD and Rafael Fonseca, MD*

Hematology, Mayo Clinic Scottsdale, Scottsdale, AZ

5:15 PM
In Myeloma, the Prognostic Impact of Hyperdiploidy Is Mainly Related to the Gain of Chromosome 5

Herve Avet Loiseau, MD, PhD1, Cheng Li2*, Florence Magrangeas1*, Catherine Guerin1*, Wilfried Gouraud1*, Jean-Luc Harousseau1*, Michel Attal, MD3, Gerald Marit4*, Claire Mathiot5*, Thierry Facon6, Philippe Moreau1*, Kenneth C Anderson, MD7, Loic Campion, MD8*, Nikhil C. Munshi, MD9 and Stephane Minvielle1*

1Hematology Department, Hopital de Nantes, Nantes, France
2Department of Biostatistics and Department of Biostatistics and Computational Biology, Harvard School of Public Health and Dana-Farber Cancer Institute, Boston
3Hopital Purpan, Toulouse, France
4Hematology, CHU de Bordeaux, Bordeaux, France
5Department of Hematology, Institut Curie, France
6Service d'Hématologie, CHRU Lille, Lille, France
7Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
8Statistics, Centre Gauducheau, Saint-Herblain, France
9Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston VA Cancer Healthcare System, Boston, MA

*signifies non-member of ASH