50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Genetic Events and Myeloma Pathogenesis

Monday, December 8, 2008: 1:30 PM-3:00 PM

Halls B and C (Moscone Center)

Moderators:

Selina Chen-Kiang, PhD and Ralph D. Sanderson

1:30 PM

A Novel Mechanism for Intrachromosomal Gene Amplification in Multiple Myeloma: 1q12 Pericentromeric Heterochromatin Mediates Breakage-Fusion-Bridge Cycles of the 1q12~23 Amplicon

Jeffrey Sawyer¹^*, Erming Tian²^*, Edward Thomas¹^*, Mark Koller¹^*, Collin Stangeby¹^*, Gael Sammartino¹^*, Linda Goosen¹^*, Charles Swanson¹^*, Regina Lichti Binz¹^*, Bart Barlogie²^* and John Shaughnessy²

¹Pathology, University of Arkansas for Medical Sciences, Little Rock, AR
²Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR

1:45 PM

494

A Comparative Oncogenomic Analysis Identifies Genetic Events Associated with Myeloma Progression and Drug Resistance

Marta Chesi, PhD^*, Esteban Braggio^*, Jonathan J Keats^* and P. Leif Bergsagel, MD

Comprehensive Cancer Center, Mayo Clinic, Scottsdale, AZ

2:00 PM

495

Characterization of Cancer Stem Cells in Multiple Myeloma

Haiming Chen, MD, PhD¹^*, Mingjie Li¹^*, Eric Sanchez¹^*, Cathy S Wang¹^*, Ariana M Berenson¹^*, Jennifer Li¹^*, Jeffrey A Steinberg¹^*, James Wang¹^*, Jing Shen¹^*, Zhi-Wei Li, PhD¹, Benjamin Bonavida, PhD² and James R. Berenson, MD¹

¹Hematology/Oncology, Institute for Myeloma & Bone Cancer Research, West Hollywood, CA
²Microbiology, Immunology & Molecular Genetics, University of CA, Los Angeles, Los Angeles, CA

2:15 PM

496

The Impact of Constitutional Copy Number Variants in Myeloma

Matthew W Jenner¹^*, David C Johnson²^*, Paola E Leone²^*, Brian A Walker³^*, David Gonzalez²^*, Nicholas J Dickens²^*, Faith E Davies² and Gareth J. Morgan²

¹Section of Haemato-Oncology, Institute of Cancer Research, London, United Kingdom
²Section of Haemato-Oncology, Institute of Cancer Research, Sutton, United Kingdom
³Section of Haemato-Oncology, The Institute of Cancer Research, London, United Kingdom

2:30 PM

497

_{Interim Analyses of the MMRC Reference Collection Identifies Recurrent Genomic-Level Events in Multiple Myeloma and Demonstrates That CDKN2C/p18 Deletion Is the Pre-Eminent Copy Number Alteration in Poor Prognosis Disease}

Michael A Chapman¹^*, Jean-Philippe Brunet¹^*, Angela Baker²^*, Jonathan Keats³, Gregory Ahmann, BS³, Anna C Schinzel, PhD⁴^*, Anna Moore²^*, Vijayalakshmi Shanmugam²^*, Louise M. Perkins, PhD⁵, Daniel Auclair, PhD⁵^*, William C. Hahn, M.D., Ph.D⁴^*, P. Leif Bergsagel, MD³, Rafael Fonseca, MD³, John Carpten²^*, Jeffrey Trent⁶^* and Todd R. Golub, MD⁴

¹Cancer Program, Broad Institute, Cambridge, MA
²Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ
³Mayo Clinic Arizona, Scottsdale, AZ
⁴Dana-Farber Cancer Institute, Boston, MA
⁵Multiple Myeloma Research Foundation, Norwalk, CT
⁶Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, AZ

2:45 PM

498

Alternate Splicing Is a Frequent Event and Impacts Clinical Outcome in Myeloma: A High-Density Exon Array Analysis of Uniformly Treated Newly-Diagnosed Myeloma Patients

Nikhil C. Munshi, MD¹, Cheng Li, PhD²^*, Stephane Minvielle, PhD³^*, Samir B Amin, MBBS⁴^*, Philippe Moreau, MD³^*, Florence Magrangeas³^*, Kenneth C Anderson, MD⁴^* and Herve Avet-Loiseau, MD³^*

¹Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston VA Cancer Healthcare System, Boston, MA
²Department of Biostatistics and Department of Biostatistics and Computational Biology, Harvard School of Public Health and Dana-Farber Cancer Institute, Boston
³Hematology Department, Hopital de Nantes, Nantes, France
⁴Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

651.O1.6 Genetic Events and Myeloma Pathogenesis