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642.P1.42 Chronic Lymphocytic Leukemia - Therapy, Excluding Transplantation Poster I

Sunday, December 7, 2008: 6:00 PM-8:00 PM
Hall A (Moscone Center)
Biologic and Clinical Markers for Outcome after Fludarabine (F) or F Plus Cyclophosphamide (FC) - Comprehensive Analysis of the CLL4 Trial of the GCLLSGClinically Relevant Abstract

Stephan Stilgenbauer1, Barbara F. Eichhorst2, Raymonde Busch3*, Thorsten Zenz1*, Dirk Winkler1*, Andreas Bühler1*, Valentin Goede2*, Clemens M Wendtner2*, Peter Lichter4*, Berthold Emmerich5*, Michael Hallek2 and Hartmut Döhner1*

1Internal Medicine III, University of Ulm, Ulm, Germany
2Dept. of Internal Med. I, University of Cologne, Cologne, Germany
3Technical University, Institute for Medical Statistic and Epidemiology, Munich, Germany
4Division Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
5Oncology Practice, Munich, Germany

Life after Fludarabine, Cyclophosphamide, & Rituximab (FCR) - the Clinical Outcome of Patients with Chronic Lymphocytic Leukemia Who Receive Salvage Treatment after Frontline FCR

Constantine S. Tam1, William G. Wierda, M.D., Ph.D2, Susan O'Brien3, Susan Lerner3*, Issa F Khouri4*, Hagop M. Kantarjian3* and Michael J Keating, M.D.3*

1Haematology, St Vincent's Hospital, Fitzroy, Australia
2Leukemia, UT M. D. Anderson Cancer Center, Houston, TX
3Leukemia, UT MD Anderson Cancer Center, Houston, TX
4Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX

Bendamustine Versus Chlorambucil as First-Line Treatment in B Cell Chronic Lymphocytic Leukemia: An Updated Analysis from An International Phase III StudyClinically Relevant Abstract

Wolfgang Ulrich Knauf1, Toshko Lissitchkov2*, Ali Aldaoud3*, Anna Liberati4*, Javier Loscertales5*, Roul Herbrecht6*, Gunnar Juliusson, MD7, Gerhard Postner8*, Liana Gercheva9*, Stefan Goranov, MD10, Martin Becker11*, Klaus Hoeffken12*, Francoise Huguet13*, Robert Foa, MD14, Karlheinz Merkle15 and Marco Montillo16

1Onkologische Praxis Frankfurt, Frankfurt, Germany
2Hematology & Transfusion Medicine, National Hematological Center, Sofia, Bulgaria
3Onkologische Gemeinschaftspraxis, Leipzig, Germany
4Dept. Oncology, Universita degli Studi, Perugia, Italy
5Dept. Hematology, Hopital de la Princesa, Madrid, Spain
6Dept. Hematology & Oncology, Hopital de Hautepierre, Strasbourg, France
7Dept. of Hematology, Lund Stem Cell Center, Lund, Sweden
83rd Medical Department, Kaiser Franz Josef Spital, Vienna, Austria
9Dept. Hematology, University Hospital, Varna, Bulgaria
10University Hospital for Active Treatment "St. George", Plovdiv, Bulgaria
11Onkologische Schwerpunktpraxis, Porta Westphalika, Germany
12Dept. Hematology & Oncology, University Hospital, Jena, Germany
13Dept. Hematology, Hopital de Purpan, Toulouse, France
14Dept. of Cellular Biotechnologies & Hematology, University 'La Sapienza', Rome, Italy
15Oncology Consulting, Miesbach, Germany
16Divisione Ematologia, Ospedale Niguarda, Milano, Italy

Molecular and Immunological Effects of Thalidomide in Chronic Lymphocytic Leukemia

Krzysztof Giannopoulos1*, Anna Dmoszynska2, Malgorzata Kowal2*, Ewa Wasik-Szczepanek2*, Paulina Wlasiuk2*, Agnieszka Bojarska-Junak1*, Jacek Rolinski1*, Hartmut Döhner3*, Stephan Stilgenbauer3* and Lars Bullinger3*

1Clinical Immunology, Medical University of Lublin, Lublin, Poland
2Hematooncology, Medical University of Lublin, Lublin, Poland
3Internal Medicine III, University of Ulm, Ulm, Germany

Predicting Time to Initial Treatment in Early Stage CLL - Integration of Classical and Novel Prognostic FactorsClinically Relevant Abstract

Michael J. Keating, M.B., B.S.1, Susan Lerner1*, Xuemei Wang2*, Laura Z. Rassenti, Ph.D.3, Susan O'Brien, M.D.1, Thomas J. Kipps, M.D., Ph.D.3 and William G. Wierda, M.D., Ph.D1

1Leukemia, UT M. D. Anderson Cancer Center, Houston, TX
2Quantitative Sciences Division, UT M. D. Anderson Cancer Center, Houston, TX
3Moores Cancer Center, University of California, San Diego, San Diego, CA

Integrating Newer with Traditional Prognostic Factors in Evaluating Patients with CLL Receiving Frontline ChemoimmunotherapyClinically Relevant Abstract

William G Wierda, MD, PhD1, Susan M O'Brien, MD1, Xuemei Wang, MS2*, Stefan H Faderl, MD1*, Alessandra Ferrajoli, MD1, Guillermo Garcia-Manero, MD1*, Jorge Cortes, MD1, Constantine S Tam, MBBS3, Jan A Burger, MD, PhD1, Lynne V Abruzzo, MD, PhD4, Ellen Schlette, MD4, Susan Lerner1* and Michael J Keating, MBBS1

1Leukemia, U.T.M.D. Anderson Cancer Center, Houston, TX
2Quantitative Sciences Division, U.T.M.D. Anderson Cancer Center, Houston, TX
3Haematology, St Vincent's Hospital, Fitzroy, Australia
4Hematopathology, U.T.M.D. Anderson Cancer Center, Houston, TX

CFAR, An Active Frontline Regimen for High-Risk Patients with CLL, Including Those with Del 17pClinically Relevant Abstract

William G Wierda, MD, PhD, Susan M O'Brien, MD, Stefan H Faderl, MD, Alessandra Ferrajoli, MD, Charles Koller, MD*, Zeev Estrov, MD*, Jan A Burger, MD, PhD, Susan Lerner*, Hagop M. Kantarjian, MD and Michael J Keating, MBBS

Leukemia, U.T.M.D. Anderson Cancer Center, Houston, TX

Human CD38 Is a Potential Therapeutic Target for Sekected Chronic Lymphocytic Leukemia cases

Silvia Deaglio1, Semra Aydin1*, Tiziana Vaisitti1*, Luciana Bergui2*, Giovanni D'Arena3*, Lisa Bonello4*, Ifigenia Saborit1*, Davide Rossi5, Gianluca Gaidano5*, Giovanna Chiorino6* and Fabio Malavasi1*

1Department of Genetics, Laboratory of Immunogenetics, University of Turin, Turin, Italy
2Division of Hematology, University of Turin, Turin, Italy
3IRCCS San Giovanni Rotondo, San Giovanni Rotondo (FG), Italy
4CeRMS, University of Turin, Turin, Italy
5Division of Hematology, Department of Clinical and Experimental Medicine, University of Eastern Piedmont, Novara, Italy
6Fondo Edo Tempia, Biella, Italy

Rituximab, Fludarabine, Cyclophosphamide, and Mitoxantrone (R-FCM) Is a Highly Active Chemoimmunotherapy Regimen for Chronic Lymphocytic LeukemiaClinically Relevant Abstract

Francesc Bosch, MD, PhD1, Pau Abrisqueta, MD2*, Neus Villamor, MD, PhD2*, Maria Jose Terol, MD2*, Josep-Maria Ribera, MD2*, Eva Gonzalez-Barca, MD2*, Marcos Gonzalez, MD2*, Eugenia Abella, MD2*, Julio Delgado, MD2*, Yolanda Gonzalez, MD2*, Secundino Ferrer, MD2*, Felix Carbonell, MD2*, Lourdes Escoda, MD2*, Isidro Jarque, MD2*, Encarnacion Monzo, MD2*, Ana Muntañola, MD2*, Olga Salamero, MD2* and Emili Montserrat, MD2*

1Institute of Hematology and Oncology. Departament of Hematology, Spanish CLL Group, IDIBAPS, Hospital Clinic Barcelona, Barcelona, Spain
2Spanish CLL Group, Barcelona, Spain

Alemtuzumab and Rituximab Combination Therapy for Patients with Untreated CLL – a Phase II TrialClinically Relevant Abstract

Olga Frankfurt, Elizabeth Hamilton*, Sara Duffey*, Simbi Acharya*, Adekunle Raji*, Shuo Ma*, Loann Peterson*, Charles Goolsby* and Steven T. Rosen

Robert H. Lurie CCC, Northwestern University, Chicago, IL

Lenalidomide Induced Cytokine Release Syndrome in Chronic Lymphocytic Leukemia (CLL): Clinical and Laboratory Correlates of Immune Activation

Georg Aue, MD1, Ndegwa Njuguna, MD1*, Xin Tian, PhD2*, Janet Valdez, PA1*, Susan Soto, RN1*, J. Philip McCoy Jr., PhD3*, Leigh Samsel3*, Berengere Vire, PhD1*, Keyvan Keyvanfar1*, Stefania Pittaluga, MD4 and Adrian Wiestner, MD, PhD1

1Hematology Branch, NHLBI, NIH, Bethesda, MD
2Office of Biostatistics Research, NHLBI, NIH, Bethesda, MD
3Flow Cytometry Core Facility, NHLBI, NIH, Bethesda, MD
4Laboratory of Pathology, NCI, NIH, Bethesda, MD

A Phase I Study of Immune Gene Therapy for Patients with CLL Using Intranodal Injection of ISF35, a Membrane-Stable CD40 Binding Protein

Januario Castro, MD1, Jose D. Sandoval, MD1*, Johanna Melo-Cardenas, B.Sc1*, Denise Darrah, RN1*, Mauricio Urquiza, PhD1*, Charles Prussak, PhD2 and Thomas J. Kipps, MD, PhD3

1Moores Cancer Center, University of California, San Diego, San Diego, CA
2MemGen, LLC, Solana Beach, CA
3Moores Cancer Ctr., Univ. of California, San Diego, La Jolla, CA

Long-Term Follow-up of 228 Hairy Cell Leukemia Patients Treated with Pentostatin or Cladribine with 15.4 Years Median Time from Diagnosis

Monica Else, MA, MSc1*, Claire E. Dearden, MD2, Estella Matutes, MD1*, Ama Z S Rohatiner, MD3, Steve A N Johnson, MD4*, Nigel T J O'Connor, MD5*, Andy Haynes, MD6*, Nnenna Osuji, MD1* and Daniel Catovsky, MD, DSc(Med)7

1Section of Haemato-Oncology, The Institute of Cancer Research, Sutton SM2 5NG, United Kingdom
2The Royal Marsden Hospital, Sutton, Surrey, United Kingdom
3St Bartholomew's Hospital, London, United Kingdom
4Taunton and Somerset Hospital, United Kingdom
5Royal Shrewsbury Hospital, United Kingdom
6Nottingham City Hospital, United Kingdom
7Section of Haemato-Oncology, The Institute of Cancer Research, London, United Kingdom

Platinum-Based Compounds Induce Expression of p73 and Restores Drug-Sensitivity in p53 Dysfunctional Chronic Lymphocytic Leukemia (CLL) Cells

Sanne H. Tonino, MD1*, Chantal Mulkens1*, Yoshinori Nonomura, MD2*, Guangli Suo, MD2*, Thomas J. Kipps, MD, PhD3, Marinus H.J. van Oers, MD, PhD1*, Eric Eldering, MD4* and Arnon P. Kater, MD, PhD5*

1Department of Hematology, Academic Medical Center, Amsterdam, the Netherlands, Amsterdam, Netherlands
2Moores Cancer Center, University of California San Diego, La Jolla, CA
3Moores Cancer Ctr., Univ. of California, San Diego, La Jolla, CA
4Department of Hematology and Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands
5Department of Hematology, Academic Medical Center and University of California San Diego, Amsterdam, Netherlands

Randomized Comparison of Cladribine Plus Cyclophosphamide with Fludarabine Plus Cyclophosphamde in Untreated Patients with Chronic Lymphocytic Leukemia: Report of the Polish Adult Leukemia Group (PALG-CLL3)Clinically Relevant Abstract

Tadeusz Robak, MD, PhD1, Jerzy Z Blonski1*, Krzysztof Jamroziak1*, Joanna Gora-Tybor1*, Beata Stella-Holowiecka2*, Lech Konopka3*, Bernadeta Ceglarek3*, Krzysztof Warzocha4*, Ilona Seferynska4*, Janusz Kloczko5*, Jaroslaw Piszcz5*, Malgorzata Calbecka6*, Aleksandra Kostyra6*, Jadwiga Dwilewicz-Trojaczek7*, Elzbieta Wiater7*, Anna Dmoszynska8, Malgorzata Kowal8*, Krystyna Zawilska9*, Alina Grzywacz9*, Andrzej Hellmann, MD, PhD10*, Andrzej Mital11*, Andrzej Zdunczyk12*, Jacek Dybowicz12*, Kazimierz Kuliczkowski13*, Stanislaw Potoczek13*, Aleksander Skotnicki14*, Maria Nowakowska-Domagala15*, Krzysztof Lewandowski16* and Kazimierz Sulek17*

1Department of Hematology, Medical University of Lodz, Lodz, Poland
2Dept. of Hematology and BMT, Silesian Medical University Hospital SPSKM, Katowice, Poland
3Institute of Hematology and Blood Transfusion, Warszawa, Poland
4Institute of Hematology and Blood Transfusion, Warsaw, Poland
5Dept. of Hematology, Bialystok Medical Academy, Bialystok, Poland
6Haematology, Provincial Hospital, Torun, Poland
7Department of Hematology and Oncology, Medical University of Warsaw
8Medical University of Lublin, Lublin, Poland
9Dept. of Internal Medicine, Strus Hospital, Poznan, Poland
10Department of Hematology, Medical University of Gdansk, Gdansk, Poland
11Dept. of Hematology, Medical Academy, Gdansk, Poland
12Hematology, City Hospital, Krakow, Poland
13Dept. of Hematology, Medical Academy, Wroclaw, Poland
14Collegium Medicum, Uniwersytetu Jagielonskiego, Krakow, Poland
15Haematology, Oncological Hospital, Kielce, Poland
16Dept Hematol, Med Univ, Poznan, Poland
17Dept. of Clinical Hematology, Military Medical Institute, Warsaw, Poland

Preliminary Results of a Phase 1/2, Multi-Center, Open-Label Study (CLL-001) Investigating a Stepwise Dose-Escalation Schedule of Lenalidomide in Relapsed or Refractory Chronic Lymphocytic Leukemia

Clemens M Wendtner, MD1*, Daruka Mahadevan, MD, PhD2, Stephan Stilgenbauer, MD, PhD3, Olga Frankfurt, MD4, Adrian Bloor, PhD, MRCP, FRCPath5*, Francesc Bosch, MD, PhD6, Lutz Uharek7*, Marco Gobbi8*, Richard R Furman, MD9, John G. Gribben, MD, DSc10, Eva K. Kimby, MD, PhD11, Mikkael A. Sekeres, MD, MS12, Larry D. Cripe, MD13, Elyane Lombardy14*, Sheetal Shah14*, Laure A Moutouh-de Parseval14*, Asher Alban Chanan-Khan, MD15 and Robert D. Knight, MD14

1Department I of Internal Medicine, Univeristy of Cologne, Cologne, Germany
2Arizona Cancer Center, Tucson, AZ
3Internal Medicine III, University of Ulm, Ulm, Germany
4Robert H. Lurie CCC, Northwestern Memorial Hospital, Chicago, IL
5Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
6Dept. de Hematology, Hospital Clinic Barcelona, Barcelona, Spain
7Medical Clinic III - Hematology and Oncology, Charité University Medicine Berlin, Germany
8Clinical hematology, University of Genova Italy, Genova, Italy
9Department of Hematology/Oncology, Weill Cornell Medical College, New York, NY
10Medical Oncology, Barts and the London School of Medicine, London, United Kingdom
11Hematology Center, Karolinska Institute, Stockholm, Sweden
12Hematologic Oncology and Blood Disorders R35, Cleveland Clinic, Cleveland, OH
13Indiana University Simon Cancer Center, Indianapolis, IN
14Celgene Corporation, Summit, NJ
15Roswell Park Cancer Inst., Buffalo, NY

Mcl-1 as a Possible Predictor of Progression-Free Survival in Previously Untreated Chronic Lymphocytic Leukemia Patients Treated with Pentostatin, Cyclophosphamide and Rituximab

Farrukh Awan, MD, MS1, Neil E. Kay2*, Melanie Davis1*, Wenting Wu2*, Nelson Leung3*, Diane F. Jelinek2*, Renee Tschumper2*, Charla Secreto2*, Thomas S. Lin4*, Michael R Grever, MD4*, Tait Shanafelt, MD2, Clive S. Zent2*, Timothy G. Call2*, Nyla A. Heerema, PhD5, Gerard Lozanski5*, John C. Byrd, MD4 and David Lucas, PhD6

1Hematology/Oncology, The Ohio State University, Columbus, OH
2Mayo Clinic, Rochester, MN
3Hematology, Mayo Clinic, Rochester, MN
4The Ohio State University, Columbus, OH
5Ohio State University, Columbus, OH
6OSUCCC Bldg., Rm. 455, Ohio State University, Columbus, OH

Vaccination Strategies  for Patients with B-CLL

Fatma V Okur, MD1*, Eric Yvon, MS1*, Gianpietro Dotti, MD1*, George Carrum, MD1*, Helen E. Heslop, MD1, Malcolm K Brenner, MD, PhD1*, Joseph C. Fratantoni, MD2, Madhusudan V Peshwa, PhD2* and Linhong Li, PhD2*

1Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, TX
2MaxCyte, Gaithersburg, MD

Treatment with Lenalidomide Has a Positive Immunomodulatory Effect in Patients with Chronic Lymphocytic Leukemia

Hui Gao, PhD1*, Alessandra Ferrajoli, MD2*, Evan N Cohen1*, Bang-Ning Lee, PhD3*, Sanda Tin, M.D.1*, Susan O'Brien, M.D.4, William G. Wierda, M.D., Ph.D5, Zeev Estrov, M.D.6*, Stefan Faderl, MD3, Michael J Keating, M.D.7* and James M. Reuben, PhD8

1Hematopathology, UT, M.D. Anderson Cancer Center, Houston, TX
2Department of Leukemia, M.D. Anderson Cancer Ctr., Houston, TX
3M.D. Anderson Cancer Center, Houston, TX
4Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
5Leukemia, UT M. D. Anderson Cancer Center, Houston, TX
6Leukemia, UT, M.D. Anderson Cancer Center, Houston, TX
7Leukemia, UT MD Anderson Cancer Center, Houston, TX
8M.D. Anderson Cancer Center, University of Texas, Houston, TX

Phase 1 Study of ABT-263, a Bcl-2 Family Inhibitor, in Relapsed or Refractory Lymphoid Malignancies

Wyndham H Wilson, MD, PhD1, O. O'Connor, M.D.2, Myron S. Czuczman, MD3, Ann LaCasce, MD4, J. Gerecitano, M.D., Ph.D.5, John P. Leonard, MD6, Anil Tulpule, MD7, Hao Xiong, Ph.D.8*, Yi-Lin Chiu, Ph.D.8*, Todd Busman, Ph.D.8*, Raymond A. Knight, MBA8*, Sari Enschede, M.D.8*, Andrew Krivoshik, M.D., Ph.D.8* and Rod Humerickhouse, M.D., Ph.D8*

1Center for Cancer Research, National Cancer Institute, Bethesda, MD
2Columbia Univ. Med. Ctr., New York, NY
3Roswell Park Cancer Institute, Buffalo, NY
4Dana-Farber Cancer Inst., Boston, MA
5Memorial Sloan-Kettering Cancer Ctr., New York, NY
6Division of Hem./Onc., Weill Cornell Medical College, New York, NY
7USC School of Medicine, Norris Cancer Center, Los Angeles, CA
8Abbott Laboratories, Abbott Park, IL

Plasma Alemtuzumab Levels at End of Treatment Correlate with Response and Response Duration in Patients with CLL Receiving Treatment for Residual DiseaseClinically Relevant Abstract

William G Wierda, MD, PhD1, Thomas J Kipps, MD, PhD2, Michael J Keating, MBBS1, Jennifer R Brown, MD, PhD3, John G Gribben, MD, DSc4, Laura Z Rassenti, PhD2, Andrew W Greaves2*, Donna Neuberg, ScD5 and Susan M O'Brien, MD1

1Leukemia, U.T.M.D. Anderson Cancer Center, Houston, TX
2Moores Cancer Center, University of California, San Diego, San Diego, CA
3Dana-Farber Cancer Inst., Boston, MA
4Institute of Cancer, Centre for Medical Oncology, London
5Biostatistics and Computational Biology, Dana-Farber Cancer Inst., Boston, MA

*signifies non-member of ASH