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641.O3.6 Signaling Pathways

Monday, December 8, 2008: 1:30 PM-3:00 PM
2005-2007-2018-2020 - West (Moscone Center)
Moderators:
Diane F. Jelinek, PhD and Steven A. Schichman, MD, PhD
1:30 PM
541
CD44 Signaling Via PI3K/AKT and MAPK/ERK Pathways Protects CLL Cells from Spontaneous and Drug Induced ApoptosisClinically Relevant Abstract

Yair Herishanu, MD1*, Federica Gibellini, PhD2*, Ndegwa Njuguna, MD2*, Keyvan Keyvanfar, BS2* and Adrian Wiestner, MD, PhD2

1Hematology Branch, NHLBI, NIH and Tel-Aviv Sourasky Medical Center, Bethesda, MD
2Hematology Branch, NHLBI, NIH, Bethesda, MD
1:45 PM
542
Dichotomy in NF-κb Signaling and Chemoresistance in IgVH Mutated Versus Unmutated CLL Cells Revealed by CD40Ligand/CpG Stimulation

Jacqueline Tromp1*, Sanne H. Tonino2*, Marinus H.J. Van Oers, MD, PhD3 and Eric Eldering1*

1Department of Hematology and Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands
2Department of Hematology, Academic Medical Center, Amsterdam, the Netherlands, Amsterdam, Netherlands
3Hematology, Academic Medical Center Amsterdam, Amsterdam, Netherlands
2:00 PM
543
Spleen Tyrosine Kinase (SYK) Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic LeukemiaClinically Relevant Abstract

Maike Buchner, PhD1*, Simon Fuchs, MS1*, Gabriele Prinz, BA1*, Dietmar Pfeifer, PhD1*, Kilian Bartholomé, PhD2*, Nina Chevalier, MD1*, Laurent Vallat, MD3*, Jens Timmer, PhD2*, John G Gribben, MD, DSc4*, Hassan Jumaa, PhD5*, Hendrik Veelken, MD1, Christine Dierks, MD1* and Katja Zirlik, MD1

1Hematology and Oncology, University Hospital Freiburg, Freiburg, Germany
2Institute of Physics, University of Freiburg, Freiburg, Germany
3Department of Hematology, Pitie-Salpetriere Hospital, Paris, France
4Institute of Cancer, Barts and The London School of Medicine, London, United Kingdom
5Department of Molecular Immunology, Max-Planck-Institute of Immunobiology, Freiburg, Germany
2:15 PM
544
Overexpression of the LEF-1 and TCF4 Transcription Factors in B-CLL: Further Evidence for a Role of the Wnt Signaling Pathway in B-CLL Biology and Leukemogenesis

Albert Gutierrez, BS1*, Renee Tschumper1*, Jeanette Eckel-Passow, PhD2*, Neil E. Kay, MD3 and Diane F. Jelinek, PhD1

1Immunology, College of Medicine, Mayo Clinic, Rochester, MN
2Biostatistics, College of Medicine, Mayo Clinic, Rochester, MN
3Hematology, College of Medicine, Mayo Clinic, Rochester, MN
2:30 PM
545
Interactome-Based Molecular Prognosis of Chronic Lymphocytic LeukemiaClinically Relevant Abstract

Han-Yu Chuang1*, Laura Rassenti, PhD2, Trey Ideker, PhD3* and Thomas J. Kipps, MD, PhD2

1Bioinformatics, UCSD, La Jolla, CA
2Moores UCSD Cancer Center, CLL Research Consortium, La Jolla, CA
3Bioengineering, UCSD, La Jolla, CA
2:45 PM
546
Molecular Basis of Proliferation/Survival and Migration of CLL in Peripheral Blood, Bone Marrow and Lymph Nodes

Amit K Mittal, DVM, MS1*, Javeed Iqbal, PhD2*, Tara Marie Nordgren, BS1*, Margaret Moragues, RN3*, R. Gregory Bociek, MD3, Patricia Aoun, MD2, Dennis D. Weisenburger, MD2 and Shantaram Joshi, PhD1

1Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE
2Pathology/Microbiology, University of Nebraska Medical Center, Omaha, NE
3Internal Medicine-Section of Oncology/Hematology, University of Nebraska Medical Center, Omaha, NE
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