50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Environmental and Extracellular Factors

Monday, December 8, 2008: 11:00 AM-12:30 PM

2001-2003-2014-2016 - West (Moscone Center)

Moderators:

Tait Shanafelt, MD and Ronald Taylor, PhD

11:00 AM

Platelet-Derived Growth Factor (PDGF) Secreted by Chronic Lymphocytic Leukemic B-Cells Is Capable of Regulating the Activation and Function of Mesenchymal Stem Cells: Implications for Leukemic Cell/Stromal Cell Crosstalk

Wei Ding, MD, PhD¹, Traci R. Knox²^*, Justin C. Boysen²^* and Neil E. Kay²^*

¹Division Hematology/Oncology, Mayo Clinic, Rochester, MN
²Hematology/Oncology division, Mayo Clinic, Rochester, MN

11:15 AM

356

The Role of the Microenvironment for CLL Proliferation and Survival: Gene Expression Profiling of Leukemic Cells Derived from Blood, Bone Marrow and Lymph Nodes Reveals the B-Cell Receptor and NF-κB as Dominant Signaling Pathways

Yair Herishanu, MD¹^*, Berengere Vire, PhD¹^*, Delong Liu, PhD²^*, Federica Gibellini, PhD¹^*, Gerald E Marti, MD, PhD³^*, Therese White, RN⁴^*, Ndegwa Njuguna, MD¹^*, Nalini Raghavachari, PhD⁵^*, Poching Liu, PhD⁵^*, Stefania Pittaluga, MD, PhD⁶, Peter J Munson, PhD²^*, Wyndham H. Wilson, MD, PhD⁴^* and Adrian Wiestner, MD, PhD¹

¹Hematology Branch, NHLBI, NIH, Bethesda, MD
²Mathematical and Statistical Computing Laboratory, DCB, CIT, NIH, Bethesda, MD
³CBER, FDA, Bethesda, MD
⁴CCR, NCI, NIH, Bethesda, MD
⁵Genomics Core Facility, NHLBI, NIH, Bethesda, MD
⁶Laboratory of Pathology, NCI, NIH, Bethesda, MD

11:30 AM

357

Vascular Endothelial Cells Promote the Viability of CLL Cells Via the up-Regulation of Bcl-2 and Bcl-X_L

Andrea G.S. Buggins, Ph.D.¹^*, Piers EM Patten, BSc, MRCP, MRCPath², Satyen H Gohil, MBBS, B.Sc.¹^*, Ghulam J Mufti, FRCP, FRCPath, M.D.³, Nicholas Shaun B. Thomas, PhD⁴^* and Stephen Devereux, FRCP, FRCPath, Ph.D.⁵

¹Haematological Medicine, King's College London, London, United Kingdom
²Dept. of Haemat. Med., King's College London, London, United Kingdom
³Department of Haematological Medicine, Kings College Hospital, London, United Kingdom
⁴Dept. of Haematological Med., King's College London, London
⁵Hematological Medicine, Kings College Hospital, London

11:45 AM

358

In Vivo Labeling of Dividing Chronic Lymphocytic Leukemia B Cells Suggests That CXCR4 and CD5 Define the Clonal Subfraction That Recently Proliferated and Emigrated from a Solid Tissue

Carlo Calissano, MD¹^*, Rajendra Damle, PhD¹, Gregory Hayes, PhD²^*, Elisabeth J Murphy, MD, PhD³^*, Marc Hellerstein, MD, PhD²^*, Barbara Sherry, PhD⁴, Matthew S Kaufman, MD⁵^*, Steven L Allen, MD⁶^*, Kanti Rai, MD⁷^* and Nicholas Chiorazzi, MD¹

¹Experimental Immunology, The Feinstein Institute for Medical Research, North Shore - LIJ Health System, Manhasset, NY
²KineMed, Inc., Emeryville, CA
³Department of Medicine, San Francisco General Hospital, University of California,, San Francisco, CA
⁴Center for Immunology and Inflammation, The Feinstein Inst. for Medical Research, Manhasset, NY
⁵OP SVC - Hematology/Oncology, Long Island Jewish Medical Center, New Hyde Park, NY
⁶Department of Medicine, North Shore Long Island Jewish Health System, New Hyde Park, NY
⁷OP Svc-Hematology/Oncology, Long Island Jewish Medical Center, New Hyde Park, NY

12:00 PM

359

Apolipoprotein E-Mimetic Therapeutic Peptides Mediate CLL Cell Cytotoxicity

Dale J. Christensen, PhD¹^*, Karen M. Bond, BS²^*, Alicia D. Volkheimer, MS²^*, Jessica Oddo, BS¹^*, Youwei Chen, MD²^*, Jon P. Gockerman, MD²^*, Joseph O. Moore, MD²^*, Louis F. Diehl, MD²^*, Carlos M. de Castro, MD²^*, Michael P. Vitek, PhD¹^* and J. Brice Weinberg, MD²

¹Cognosci, Incorporated, Research Triangle, NC
²Medicine, Duke and V.A. Medical Centers, Durham, NC

12:15 PM

360

Expression and Prognostic Significance of the Inhibitor of Apoptosis Protein (IAPs) Family and Its Antagonists in Chronic Lymphocytic Leukemia

Olga Grzybowska-Izydorczyk^*, Barbara Cebula^*, Tadeusz Robak, MD, PhD and Piotr Smolewski^*

Department of Hematology, Medical University of Lodz, Lodz, Poland

See more of: Oral and Poster Abstracts

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^*signifies non-member of ASH

641.O2.6 Environmental and Extracellular Factors