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634.O1.6 Myeloproliferative Disorders-Experimental Therapeutics

Sunday, December 7, 2008: 4:30 PM-6:00 PM
304-306-308 - South (Moscone Center)
Moderators:
Mario Cazzola, MD and Alessandro M. Vannucchi
4:30 PM
A Phase I Study of TG101348, An Orally Bioavailable JAK2-Selective Inhibitor, in Patients with Myelofibrosis

Animesh D. Pardanani, MBBS, PhD1, Jason Gotlib, MD, MS2*, Catriona Jamieson, MD, PhD3, Jorge Cortes, MD4, Moshe Talpaz, MD5*, Richard M. Stone, MD6, Michael H Silverman, MD, FACP7*, Jolene Shorr8*, D. Gary Gilliland9 and Ayalew Tefferi, MD10

1Mayo Clinic, Rochester, MN
2Stanford University School of Medicine, Stanford, CA
3Deapartment of Medicine and Moores Cancer Center, University of California San Diego, La Jolla, CA
4M.D. Anderson Cancer Center, Houston, TX
5Comprehensive Cancer Ctr., Univ. of Michigan, Ann Arbor, MI
6Dana-Farber Cancer Institute, Boston, MA
7Biostrategics Consulting Ltd., Marblehead, MA
8TargeGen Inc., San Diego, CA
9Brigham and Women's Hospital, Boston, MA
10Medicine, Division of Hematology, Mayo Clinic Graduate School of Medicine, Rochester, MN

4:45 PM
A Phase I Study of XL019, a Selective JAK2 Inhibitor, in Patients with Primary Myelofibrosis, Post-Polycythemia Vera, or Post-Essential Thrombocythemia Myelofibrosis

Neil P. Shah, MD, PhD1, Patrycja Olszynski1*, Lubomir Sokol, MD, PhD2, Srdan Verstovsek3, Ronald Hoffman, MD4, Alan F. List, MD5, Jorge Cortes, MD3, Hagop M Kantarjian6, D. Gary Gilliland7, Douglas O Clary, PhD8*, Lynne A. Bui, MD8 and Martha Wadleigh, MD9

1University of California - San Francisco, San Francisco, CA
2H. Lee Moffitt Cancer Center, Tampa, FL
3M.D. Anderson Cancer Center, Houston, TX
4Hematology, Mount Sinai School of Medicine, New York, NY
5H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
6The University of Texas M. D. Anderson Cancer Center, Houston, TX
7Brigham and Women's Hospital, Boston, MA
8Exelixis, Inc., South San Francisco, CA
9Dana-Farber Cancer Inst., Boston, MA

5:00 PM
An Open-Label Study of CEP-701 in Patients with JAK2 V617F-Positive Polycythemia Vera and Essential Thrombocytosis

Alison R Moliterno, MD1, Gail J. Roboz, MD2, Martin Carroll3*, Selina Luger, MD4, Elizabeth Hexner, MD5 and Debra M. Bensen-Kennedy, MD6

1Medicine, Johns Hopkins University School of Medicince, Baltimore, MD
2Medicine, Weill Cornell Medical College, New York, NY
3Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA
4Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
5University of Pennsylvania, Philadelphia, PA
6Cephalon, Frazer, PA

5:15 PM
A Phase 2A study of the Histone-Deacetylase Inhibitor ITF2357 in Patients with Jak2V617F Positive Chronic Myeloproliferative Neoplasms

Alessandro Rambaldi1, Chiara Maria Dellacasa2*, Silvia Salmoiraghi2*, Orietta Spinelli2*, Maria Luisa Ferrari2*, Elisabetta Gattoni, MD3*, Paola Guglielmelli4*, Alessandro M. Vannucchi4, Giovanni Barosi5* and Tiziano Barbui2*

1Clinical Hematology Division, Hospital de Sant Pau, Barcelona, Spain
2USC Hematology, Ospedali Riuniti di Bergamo, Bergamo, Italy
3Laboratorio Epidemiologia Clinica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
4Hematology, Universitą  degli Studi di Firenze, Firenze, Italy
5Unit of Clinical Epidemiology, Center for the Study of Myelofibrosis, Istituto Policlinico San Matteo, Pavia, Italy

5:30 PM
Correction of the Abnormal Trafficking of Primary Myelofibrosis CD34+ Cells by Treatment with Chromatin Modifying Agents

Xiaoli Wang, MD, PhD, Wei Zhang*, Takefumi Ishii*, Selcuk Sozer*, Jiapeng Wang*, Mingjiang Xu* and Ronald Hoffman, MD*

Division of Hematology/Oncology, Mount Sinai Cancer Institute, Departments of Medicine and Cell & Gene Medicine, Mount Sinai School of Medicine, New York, NY

5:45 PM
Activity of the BH3 Mimetic ABT-737 on Polycythemia Vera  (PV) Erythroid Precursor Cells

Agostino Tafuri, MD1, Francesca Pedini2*, Federica Francescangeli2*, Michele Signore2*, Robert Foa3, Gabriella Girelli4*, De Maria Ruggero2* and Zeuner Ann2*

1Division of Hematology-Dept. of Cellular Biotechnologies and Hematology, University of Rome, Rome, Italy
2Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanitą, Roma, Italy
3Dept. of Cellular Biotechnologies & Hematology, University 'Sapienza', Rome, Italy
4Division of Hematology-Dept. of Cellular Biotechnologies and Hematology, University of Rome,, Roma, Italy

*signifies non-member of ASH