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633.P1.81 Myelodysplastic Syndromes Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM
Hall A (Moscone Center)
Comparison of Fluorescence In Situ Hybridization for EGR1 Vs CSF1R for the Detection of Del(5q) in Myelodysplasia and Acute Myeloid Leukemia

Yang Sun1* and James R. Cook, MD, PhD2

1Clinical Pathology, Cleveland Clinic, Cleveland, OH
2Cleveland Clinic Foundation, Cleveland, OH

Somatic Expansion of the Frataxin Gene GAA Repeats in MDS Patients

Drorit Merkel, MD1*, H. Joachim Deeg2, Amos Simon, B.A.3*, Ninette Amariglio, PhD4, Arnon Nagler, M.D.5 and Gideon Rechavi, MD, PhD6*

1Dept. of Hematology, Sheba Medical Center, Tel Hashomer, Israel
2Fred Hutchinson Cancer Research Center, Seattle, WA
3Laboratory of Hematology, Sheba Medical Center, Tel Hashomer, Israel
4Institute of Hematology, Tel-Hashomer, Israel
5Division of Hematology, BMT and CBB, Chaim Sheba Medical Center, Tel Hashomer, Israel
6Cancer Research Center, Sheba Medical Center, Tel-Hashomer, Israel

Acquired 1p Uniparental Disomy Is Associated with Biallelic MPL W515L Mutation in RARS-T

Hadrian Szpurka, MSc, PhD1, Lukasz P Gondek, MD1*, Sanjay R Mohan, MD1*, Eric D Hsi, MD2, Karl S Theil, MD2, Mikkael A Sekeres, MD, MS3 and Jaroslaw P Maciejewski, MD, PhD1

1CHOMT, Experimental Hematology and Hematopoiesis Section, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
2Clinical Pathology, Cleveland Clinic, Cleveland, OH
3Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

The Heterogeneous Prognosis of Patients with Myelodysplastic Syndrome (MDS) and Chromosome 5 Abnormalities: How Does It Relate to the Original Lenalidomide Experience in MDS?

Hagop M Kantarjian1, Susan O'Brien2*, Farhad Ravandi2*, Gautam Borthakur2*, Stefan Faderl2*, Carlos Bueso-Ramos2*, Lynne Abruzzo2*, Sherry Pierce2*, Jianqin Shan2*, Jean-Pierre Issa2* and Guillermo Garcia-Manero2*

1The University of Texas M. D. Anderson Cancer Center, Houston, TX
2M.D. Anderson Cancer Center, Houston, TX

European Leukemianet (ELN) Project Diagnostic Platform (WP10): Final Results of the First Study of the European Morphology Consensus Panel

Gina Zini, MD, Prof.1*, Barbara Bain, MD, Prof.2*, Gianluigi Castoldi, MD, Prof.3*, José Cortez, PhD, Prof.4*, Judit Csomor, MD5*, Edgar Faber, MD, Prof.6*, Aristoteles Giagounidis7*, Torsten Haferlach8, Petra Kacirkova, MD9*, Krzysztof Lewandowski, MD, Prof.10*, Vincenzo Liso11*, Estella Matutes, MD, PhD12*, Marc Maynadie, MD, PhD13, John Meletis, MD.Prof.14*, Anna Porwit15*, M.Leticia Ribeiro, MD16*, Lydia Sreter, MD., Prof.5*, Andre Tichelli17*, Teresa Vallespì, MD.PhD..18*, Mars B. van 't Veer, MD19*, Soledad Woessner, MD20* and Marie-Christine Bene21*

1Hematology Laboratory, Università Cattolica Sacro Cuore - Policlinico Gemelli, Rome, Italy
2Department of Haematology, St Mary's Hospital Campus of Imperial College, London, United Kingdom
3Department of Biomedical Sciences, University of Ferrara /S.Anna Hospital, Ferrara, Italy
4Faculty of Medical Sciences, New University of Lisbon, Lisboa, Portugal
5Department of Pathology and Experimental Cancer Research, 1st Semmelweis University, Budapest, Hungary
6Hemato-Oncology, University Hospital Olomouc, Olomuc, Czech Republic
7Medizinische Klink II, St. Johannes Hospital, Duisburg, Germany
8MLL Munich Leukemia Laboratory GmbH, Munich, Germany
9Laboratory of Morphology and Cytochemistry, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
10Medical University of Gdansk, Poland, Gdansk, Poland
11Hematology, Università degli Studi di Bari, Bari, Italy
12Section of Haemato-Oncology, The Institute of Cancer Research, London, United Kingdom
13Service d'Hématologie Biologique, Plateau Technique de Biologie, Dijon cedex, France
14First Department of Internal Medicine, University of Athens School of Medicine, Athen, Greece
15Department of Pathology, Stockholm, Sweden
16Departamento de Hematologia, Centro Hospitalar de Coimbra, Coimbra, Portugal
17Hematology, University Hospital of Basel, Switzerland
18Dpt. Hematology, Vall d'Hebron Hospital, Barcelona, Spain
19Dpt. Hematology, Erasmus Medical Center, Rotterdam, Netherlands
20Cytological School of Haematology, Hospital del Mar, Barcelona, Spain
21GRAALL Group, Lyon, France

Treatment of Patients with Low-Risk Myelodysplastic Syndromes Receiving Azacitidine Who Are Enrolled in AVIDA, a Longitudinal Patient Registry

David L. Grinblatt, MD1, Mohit Narang, MD2*, James M. Malone III, MD3, David A. Sweet4*, Tim S. Dunne4* and Kristen A. Sullivan5*

1Evanston Northwestern Healthcare, Evanston, IL
2Alliance Hematology Oncology, Westminster, MD
3Oncology-Hematology Medical Associates of the Central Coast, San Luis Obispo, CA
4Celgene Corporation, Summit, NJ
5Celgene Corporation, Overland Park, KS

Long-Term Cytogenetic Follow-up of MDS Patients with 5q- Treated within the MDS-003 (CC-5013-MDS-003) Study: Evolution to Complex Clones and Progression to AML

Gudrun Göhring, MD1*, Aristoteles Giagounidis2, Carlo Aul3*, Guntram Büsche, MD4*, Hans Kreipe, MD4*, Eva Hellström-Lindberg, MD, PhD5, Robert D. Knight, MD6 and Brigitte Schlegelberger, MD1

1Institute of Cell & Molecular Pathology, Hannover Medical School, Hannover, Germany
2Medizinische Klinik II, St Johannes Hospital, Duisburg, Germany, Duisburg, Germany
3Medical Clinic II, St. Johannes Hospital, Duisburg, Germany
4Institute of Pathology, Hannover Medical School, Hannover, Germany
5Dept. of Med., Div. of Hem, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
6Celgene Corporation, Summit, NJ

Comorbidity as Prognostic Variable in MDS: Comparative Evaluation of the HCT-CI and CCI in a Core Data Set of 582 Patients of the Austrian MDS Platform

Wolfgang R Sperr1*, Friedrich Wimazal1*, Michael Kundi2*, Christian Baumgartner1*, Thomas Noesslinger3, Anabel Makrai3*, Reinhard Stauder, MD4*, Otto Krieger5*, Michael Pfeilstocker, MD3 and Peter Valent, MD1

1Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
2Institute of Environmental Hygiene, Medical University of Vienna, Vienna, Austria
33rd Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna, Austria
4University Hospital, Innsbruck, Austria
5Department of Internal Medicine I, Hospital Elisabethinen, Linz, Austria

Prognostic Impact of Additional Chromosomal Aberrations (ACA) to 5q- in Patients with primary Myelodysplastic Syndrome

Maria del Mar Mallo1*, José Cervera, MD, PhD2*, Julie Schanz3*, Blanca Espinet, PhD1*, Esperanza Such2*, Elisa Luño, MD, PhD4*, Christian Steidl, MD3*, María Luisa Martín5*, Ulrich Germing6*, Javier Grau, MD7*, Michael Pfeilstoecker, MD8*, Jesús M Hernández, MD, PhD9*, Thomas Noesslinger10, M.ª José Calasanz, PhD11*, Peter Valent, MD12, Rosa Collado, MD, PhD13*, Christa Fonatsch14*, Encarna Bureo, MD15*, Michael Lübbert, MD, PhD16*, Rafael Ríos, MD, PhD17*, Reinhard Stauder, MD18*, Eva Arranz19*, Barbara Hildebrandt20*, Marilyn L. Slovak, PhD21, Juan Cigudosa, PhD22, Virginie Eclache23*, Otto Krieger24*, Carmen Pedro, MD25*, Marta Salido1*, Leonor Arenillas, MD1*, Guillermo Sanz, MD, PhD26, Miguel A. Sanz, MD, PhD27, Ana Valencia2*, Lourdes Florensa, MD, PhD1*, Detlef Haase, MD, PhD3* and Francesc Solé, PhD1

1Pathology, Hospital del Mar, Barcelona, Spain
2Servicio de Hematologia, Hospital Univ. La Fe, Valencia, Spain
3Hematology and Oncology, University of Göttingen, Göttingen, Germany
4Hematology, Hospital Universitario Central de Asturias, Oviedo, Spain
5Genetics, Hospital Universitario 12 de Octubre, Madrid, Spain
6Universitatsklinik Dusseldorf, Dusseldorf, Germany
7Hematology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
83rd Med. Dept. Hanusch-Hosp., Vienna, Austria
9Hematology, Hospital Universitario de Salamanca, Salamanca, Spain
103rd Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna, Austria
11Genetics, Universidad de Navarra, Pamplona, Spain
12Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
13Hematology, Consorcio Hospital General Universitario, Valencia, Spain
14Medical Genetics, Medical University of Vienna, Vienna, Austria
15Hematology, Hospital Universitario Marqués de Valdecilla, Santander, Spain
16Medical Center, University of Freiburg, Freiburg, Germany
17Hematology, Hospital Universitario Virgen de las Nieves, Granada, Spain
18University Hospital, Innsbruck, Austria
19Genetics, Hospital Universitario La Princesa, Madrid, Spain
20Human Genetics, University of Düsseldorf, Düsseldorf, Germany
21City of Hope Nat'l Med. Ctr., Duarte, CA
22Cytogenetics Unit, CNIO, Madrid, Spain
23Hôpital Avicenne/Université Paris, Bobigny, France
24Department of Internal Medicine I, Hospital Elisabethinen, Linz, Austria
25Hematology, Hospital del Mar, Barcelona, Spain
26Dept. of Hematology, Hospital Universitario La Fe, Valencia, Spain
27On behalf of the PETHEMA, HOVON, PALG, and GATLA cooperative groups, Valencia, Spain

Both Expanded and Uncultured Mesenchymal Stem Cells from MDS Patients Are Genomically Abnormal, Showing a Specific Genetic Profile for the 5q- Syndrome

Olga López Villar, MD1*, Juan LuíS. García, PhD2*, Fermín. M Sánchez Guijo, MD, PhD1*, Cristina Robledo2*, Pilar Hernandez Campo, PhD3*, Maria Diez Campelo, MD, PhD1*, Sandra Muntion3*, Jose Antonio Pérez Simón, MD, PhD1*, J.F. San Miguel, MD, PhD1 and MaríA. Consuelo Del Cañizo, MD, PhD1*

1Hematology, Hospital Universitario de Salamanca, Salamanca, Spain
2Centro de Investigación del Cancer, Universidad de Salamanca, Salamanca, Spain
3Centro en Red de Terapia Celular de Castilla y León, Salamanca, Spain

Suppression of Cyclin D 1 (CD1) by on 01910.Na Is Associated with Decreased Survival or Trisomy 8 Myelodysplastic Bone Marrow: A Potential Targetted Therapy for Trisomy 8 MDS

Aarthi Shenoy, MD1, Loretta Pfannes1*, Francois Wilhelm, MD, Ph.D2*, Manoj Maniar, Ph.D2*, Neal Young, MD1 and Elaine M Sloand, MD1

1Nhlbi, NIH, Bethesda, MD
2Onconova Therapeutics, Newtown, PA

Epigenetic Dysregulation of GATA1 but Not Downstream Notch Effectors is Involved in MDS Dyserythropoiesis

Olaf Joachim Hopfer, MD1*, Martina Komor, PhD2*, Claudia Freitag1*, Maximilian Mossner3*, Dieter Hoelzer, MD, PhD4, Eckhard Thiel, MD, PhD5 and Wolf-Karsten Hofmann, MD, PhD6*

1Hematology and Oncology, Charite Medical School, Berlin, Germany
2Hematology and Oncology, J.W. Goethe University Hospital, Frankfurt/M, Germany
3Charité, Campus Benjamin Franklin, Berlin, Germany
4J.W. Goethe University Hospital, Frankfurt/M, Germany
5Medizinische Klinik III (Haematologie, Onkologie und Transfusionsmedizin), Charite Campus Benjamin Franklin (Charite Centrum 14), Berlin, Germany
6MILE Study Group, on Behalf of European LeukemiaNet (ELN, WP13), Munich, Germany

Management and Supportive Care Measures of Adverse Events (AEs) in Higher-Risk MDS Patients (Pts) Treated with Azacitidine (AZA)

Valeria Santini, MD1*, Pierre Fenaux, MD, PhD2, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath3, Eva Hellström-Lindberg, MD, PhD4*, Lewis B. Silverman, MD5, Alan List, MD6*, Steven D. Gore, MD7, John F Seymour, MBBS, PhD, FRACP8*, Jay Backstrom, MD, MPH9*, David McKenzie, MS9* and C. L Beach, PharmD9*

1Hematology, Azienda Ospedaliera Careggi, Firenze, Italy
2Hématologie Clinique, Assistance Publique - Hôpitaux de Paris, Hôpital Avicenne; Paris 13 University, Bobigny, France
3Department of Haematological Medicine, Kings College London, London, United Kingdom
4Karolinska University Hospital, Stockholm, Sweden
5Pediatric Oncology, Dana-Farber Cancer Inst., Boston, MA
6H Lee Moffitt Cancer Center, Tampa, FL
7The Sidney Kimmel Comprehensive Cancer Ctr. at Johns Hopkins, Baltimore, MD
8Dept of Haematology, Peter MacCallum Cancer Institute, Australia
9Celgene, Overland Park, KS

Modification of WPSS for the Time of Diagnosis Retains Its Prognostic Impact and Confirms Transfusion Dependency as An Important Parameter Affecting Survival in Early MDS Patients with Isolated Erythroid Dysplasia

Jaroslav Cermak, M.D., Ph.D.1, Dana Mikulenkova, M.D.2*, Petra Kacirkova, M.D.2* and Kyra Michalova, Prof., Ph.D.3*

1Clinical Hematology, Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic
2Clinical Hematology, Institute of Hematology and Blood Transfusion, Praha, Czech Republic
3Center of Oncocytogenetics, Institute of Clinical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic

The Capacity of the Hypomethylating Agents Azacytidine and Decitabine to Induce Apoptosis and Cell Cycle Arrest Depends on the Activation of the DNA-Damage Response Pathway

Simone Boehrer1*, Lionel Ades2, Nicolas Tajeddine3*, Lorenzo Galluzzi1*, Stephane de Botton4*, Pierre Fenaux5 and Guido Kroemer1*

1Institut Gustave Roussy, INSERM U848, Villejuif, France
2Hematologie Clinique, Hopital Avicenne, Bobigny, France
3INSERM U848
4institut Gustave Roussy, Villejuif, France
5Hematologie Clinique, Assistance Publique - Hopitaux de Paris, Hopital Avicenne; Paris 13 University, Bobigny, France

Selective Suppression of the DNA Damage Response in Acute Myeloid Leukemia Versus Myelodysplastic Syndrome

Simone Boehrer1*, Lionel Ades2, Nicolas Tajeddine3*, Lorenzo Galluzzi1*, Wolf-Karsten Hofmann4*, Pierre Fenaux5 and Guido Kroemer1*

1Institut Gustave Roussy, INSERM U848, Villejuif, France
2Hematologie Clinique, Hopital Avicenne, Bobigny, France
3iNSERM U848
4Charite, Campus Benjamin Franklin, Berlin, Germany
5Hematologie Clinique, Assistance Publique - Hopitaux de Paris, Hopital Avicenne; Paris 13 University, Bobigny, France

Characteristics and Outcome of MDS with Isolated Del 20q: The GFM Experience in 64 Cases

Thorsten Braun*, Stephane de Botton*, Anne-Laure Taksin*, Sophie Park*, Odile Beyne-Rauzy*, Sylvie Chevret*, Michaela Fontenay*, Bruno Cassinat*, Anne Lazareth*, Virginie Eclache*, Chrisitine Terre*, Norbert Vey*, Agnes Guerci*, Francois Dreyfus*, Dominique Bordessoule*, Aspasia Stamatoullas*, Sylvie Castaigne*, Pierre Fenaux* and Lionel Ades

Groupe Francophone des Myelodysplasies (GFM), Bobigny, France

Hematological Characteristics of Patients with Myelodysplastic Syndromes in the Light of WHO 2008 Proposals

Kathrin Nachtkamp1*, Andrea Kuendgen1*, Barbara Hildebrandt2*, Norbert Gattermann3, Rainer Haas4* and Ulrich Germing4*

1Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
2Human Genetics, University of Düsseldorf, Düsseldorf, Germany
3Heinrich-Heine-University, Düsseldorf, Germany
4Hematology, Oncology, Heinrich Heine University, Duesseldorf, Germany

Outcome of Patients (pts) with Myelodysplastic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML) Post Decitabine Failure

Elias Jabbour1*, Guillermo Garcia-Manero2*, Jianqin Shan1*, Susan O'Brien1*, Jorge Cortes, MD1, Farhad Ravandi1*, Jean-Pierre J Issa3 and Hagop M Kantarjian3

1M.D. Anderson Cancer Center, Houston, TX
2Leukemia, M.D. Anderson Cancer Center, Houston, TX
3The University of Texas M. D. Anderson Cancer Center, Houston, TX

Aberrant Phenotype of blasts in Low and Intermediate-1 Risk Myelodysplastic syndromes Predicts Response of Growth Factor Treatment. a Prospective clinical Phase-II Study

Maurice JDL van der Vorst, MD*, Theresia M Westers, PhD*, Martine ED Chamuleau, MD*, Corien Eeltink*, Gert J Ossenkoppele, MD, PhD and Arjan A van de Loosdrecht, MD, PhD

Department of Hematology, VU University Medical Center, Amsterdam, Netherlands

Quantitative Dynamics of Flow Cytometric Aberrancies during Treatment with Erythropoietin/G-CSF Are Predictive for Responses in LOW/INT-I Risk Myelodysplastic Syndromes

Theresia M Westers, PhD*, Canan Alhan, MD*, Claudia Cali*, Gert J Ossenkoppele, MD, PhD and Arjan A van de Loosdrecht, MD, PhD

Department of Hematology, VU University Medical Center, Amsterdam, Netherlands

*signifies non-member of ASH