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633.O2.8 Myelodysplastic Syndromes: Basic Biology: Ribosomal Proteins, MicroRNAs and Animal Models

Tuesday, December 9, 2008: 7:00 AM-9:00 AM
303-305-307 - South (Moscone Center)
Moderators:
David Bowen, MD, MA, MB, CHB, FRCP, MRCPath and Jean-Pierre J Issa
7:00 AM
ABT-737 Targets Intrinsic Apoptosis during Cooperation of BCL-2 and Oncogenic NRAS in An in Vivo Progression Model of Myelodysplasia/Acute Myeloid Leukaemia

Nader Omidvar1*, Stephanie Beurlet2*, Carole Le Pogam2*, Anne Janin3, Christophe Leboeuf3*, Annie Soulie2*, Niclas Setterblad4*, Maria-Elena Noguera5*, Laure Sarda-Mantel6*, Pascal Merlet6*, Marika Pla2*, Scott C. Kogan, MD7, Irving L Weissman8, Marina Konopleva9, William Bormann9*, Michael Andreeff9, Christine Chomienne2 and Rose Ann Padua1

1Institut Universitaire d'Hématologie, Inserm U718, Paris, France & Cardiff University, Cardiff, United Kingdom
2Inserm U718, Institut Universitaire d'Hématologie, Paris, France
3Inserm U728, Institut Universitaire d'Hématologie, Paris, France
4Departement d'Imagerie, Hopital Saint-Louis, Paris, France
5Departement d'Hématologie, Hopital Saint-Louis, Paris, France
6Inserm U773, Hôpital Bichat, Paris, France
7Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California - San Francisco, San Francisco, CA
8Stanford University, CA
9M.D. Anderson Cancer Center, TX

7:15 AM
Defective Telomerase in Familial Myelodysplasia and Leukemia

Michael Kirwan1*, Tom Vulliamy1*, Amanda J. Walne1*, Richard Beswick1*, Peter Hillmen2, Richard Kelly2*, Andrew Stewart3*, David Bowen2*, Stefan Schonland4*, Annika Maria Whittle2*, Tony McVerry2*, Maria Gilleece2* and Inderjeet Dokal1

1Centre for Paediatrics, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
2Leeds Institute of Oncology, Leeds, United Kingdom
3Central Pathology Laboratory, University Hospital of North Staffordshire, Stoke-on-Trent, United Kingdom
4Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany

7:30 AM
Establishment of Myelodysplastic Syndrome-Specific Methylome: Implications for the Pathogenesis of Clonal Evolution and Association with Survival

Rebecca D Ganetzky, B.A.1*, Ying Jiang, M.D., Ph.D.2*, Courtney Prince, B.S.3*, Mikkael A. Sekeres, MD, MS4, Yogen Saunthararajah, M.D.3 and Jaroslaw P. Maciejewski, MD, PhD5

1Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, OH
2Hematologic Oncology and Blood Disorders/Experimental Hematology and Hematopoiesis Section, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
3Experimental Hematology and Hematopoiesis Section, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH
4Hematologic Oncology and Blood Disorders, Cleveland Clinic, Cleveland, OH
5Experimental Hematology and Hematopoiesis Section, Taussig Cancer Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

7:45 AM
Frequent Detection of C-Cbl Homozygous Mutation in Secondary Myelogeneous Leukemia Transformed from MDS/MPD with Chromosome 11q Uniparental Disomy

Hideki Makishima, MD, PhD1, Andrew J Dunbar1*, Anna M Jankowska1*, Lukasz P. Gondek, MD1*, Eric D Hsi, MD2, Michael A McDevitt, MD, PhD3, Alan F. List, MD, PhD4* and Jaroslaw P. Maciejewski, MD, PhD5

1Exp. Hem. & Hematopoiesis, Taussig Cancer Center, Cleveland, OH
2Clinical Pathology, Cleveland Clinic, Cleveland, OH
3Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
4Risk Assessment, Detectio and Intervention Program, Moffitt Cancer Center, Tampa, FL
5Experimental Hematology and Hematopoiesis Section, Taussig Cancer Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

8:00 AM
Generation of a Factor Dependent Myeloid Cell Line from Nucleophosmin-1 Heterozygous (NPM-1+/-) Mouse Bone Marrow as a Model for 5q- MDS

Arati Khanna-Gupta, PhD1, Hong Sun1*, Jian Chen1*, Stephanie Halene, MD2, Paolo Sportoletti, MD3*, Pier Paolo Pandolfi, MD, PhD3* and Nancy Berliner1*

1Brigham and Women's Hospital, Boston, MA
2Yale Univ. School of Med., New Haven, CT
3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

8:15 AM
Identification of Mir-145 and Mir-146a as Micrornas Involved in the Pathogenesis of 5q- Syndrome

Daniel T. Starczynowski, PhD1, Florian Kuchenbauer, MD2*, Bob Argiropoulos, PhD2*, Sandy Sung1*, Ryan Morin, PhD3*, Andrew L Muranyi, MSc4*, Martin Hirst, PhD3*, Donna E. Hogge, MD, PhD5, Marco Marra, PhD6, Richard A. Wells, MD, DPhil7, Wan Lam, PhD8*, R. Keith Humphries, MD, PhD9 and Aly Karsan, MD10

1Dept. of Medical Biophysics, BC Cancer Research Ctr., Vancouver, BC, Canada
2Terry Fox Laboratory, BC Cancer Research Agency, Vancouver, BC, Canada
3Genome Sciences Centre, BC Cancer Research Centre, Vancouver, BC, Canada
4Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
5B.C. Cancer Research Center, Vancouver, BC, Canada
6Genome Sciences Center, British Columbia Cancer Agency, Vancouver, BC, Canada
7Sunnybrook Health Sciences Centre, Toronto, ON, Canada
8Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
9Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
10British Columbia Cancer Rsch. Ctr., Vancouver, BC, Canada

8:30 AM
Downregulation of Ribosomal Proteins Is Seen in Non 5q- MDS

Davendra P. Sohal1*, Andrea Pellagati2*, Li Zhou1*, Yongkai Mo1, Joanna B. Opalinska1, Christina Alencar1*, Christoph Heuck1*, Amittha Wickrema3, Ellen Friedman4*, John Greally1*, Benjamin L. Ebert5*, Jonathan Warner1*, Jacqueline Boultwood2 and Amit Verma1

1Albert Einstein College of Medicine, Bronx, NY
2John Radcliffe Hospital, United Kingdom
3University of Chicago, Chicago, IL
4Montefiore Med. Center, Bronx, NY
5Brigham and Women's Hospital, Boston, MA

8:45 AM
Genome-Wide Analysis of MDS/MPD Disclosed Frequent Homozygous C-Cbl mutations Tightly Associated with 11q-UPD

Sanada Masashi, MD1*, Shih Lee Yung, MD, PhD2*, Takahiro Suzuki, MD, PhD3*, Motohiro Kato, MD1*, Mamiko Yanagimoto Sakata, MD, PhD4*, Keiki Kumano, MD, PhD5*, Norihiko Kawamata, MD, PhD6*, Junko Takita, MD, PhD5*, Hiraku Mori, MD, PhD7*, Mineo Kurokawa, MD, PhD8, Shigeru Chiba, MD, PhD9*, Mitsuhiro Omine, MD, PhD7*, H. Phillip Koeffler, MD, PhD6 and Seishi Ogawa, MD, PhD1

1Cancer Genomics Project, University of Tokyo Hospital, Tokyo, Japan
2Department of Hematology/Oncology, Chungun Memorial Hospital, Taoyuan, Taiwan
3Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsukeshi, Japan
4University of Tokyo Hospital, Tokyo, Japan
5Department of Cell Therapy & Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
6Division of Hematology and Oncology, Cedars Sinai Medical Center, Los Angeles, CA
7Showa University Fujigaoka Hospital, Yokohama, Japan
8Department of Hematology and Oncology, Graduate School of Med., Tokyo, Japan
9Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan

*signifies non-member of ASH