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632.O2.6 Chronic Myeloid Leukemia - Response and Prognosis

Monday, December 8, 2008: 11:00 AM-12:30 PM
2009-2011-2022-2024 - West (Moscone Center)
Moderators:
Henrik Hjorth-Hansen, MD, PhD and Jorge Cortes, MD
11:00 AM
The Initial Molecular Response of Chronic Phase CML Patients Treated with Second Generation ABL Inhibitor Therapy after Imatinib Failure Can Predict Inadequate Response and Provide Indications for Rational Mutation Screening

Susan Branford, Rebecca Lawrence*, Linda Fletcher*, Chani Field*, Zbigniew Rudzki* and Timothy Hughes

Institute of Medical & Veterinary Science, Adelaide, Australia

11:15 AM
Prediction of Cytogenetic Response to Second Generation TKI Therapy in CML Chronic Phase Patients Who Have Failed Imatinib Therapy and Early Identification of Factors That Influence Survival

Dragana Milojkovic*, Marco Bua*, Jane F Apperley*, Kasia Kozlowski*, Jamshid Sorori*, Letizia Foroni*, Alistair Reid*, Jiri Pavlu*, Katy Rezvani*, Francesco Dazzi*, Eduardo Olavarria*, Matthias Klammer*, John M Goldman* and David Marin

Department of Hematology, Imperial College London, Hammersmith Hospital, London, United Kingdom

11:30 AM
Molecular Response to First Line Imatinib Therapy Is Predictive for Long Term Event Free Survival in Patients with Chronic Phase Chronic Myelogenous Leukemia – An Interim Analysis of the Randomized German CML Study IV

Martin C. Müller, MD1*, Benjamin Hanfstein, MD1*, Philipp Erben, MD1*, Susanne Schnittger, PhD2, Susanne Saussele, MD1*, Armin Leitner, MD1*, Ulrike Proetel, MD1*, Michael Lauseker3*, Markus Pfirrmann, PhD3*, Gerhard Ehninger, MD4, Thomas Fischer, MD5*, Joerg Hasford, MD3*, Dieter K. Hossfeld, MD, PhD6*, Hans Jochem Kolb, MD7, Stefan W Krause, MD8*, Christoph Nerl, MD9*, Hans Pralle, MD10*, Alois Gratwohl, MD11, Andreas Tobler, MD12, Ruediger Hehlmann, MD1, Andreas Hochhaus, MD1 and The German CML Study Group1*

1Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany
2MLL, München, Germany
3IBE, München, Germany
41. Medizinische Klinik, Universitätsklinikum Carl Gustav Carus, Dresden, Germany
53. Medizinische Klinik, Universitätsklinikum, Mainz, Germany
6Onkologische Schwerpunktpraxis Lerchenfeld, Hamburg, Germany
73. Medizinische Klinik, Transplantationseinheit, München, Germany
8Medizinische Klinik 5, Universitätsklinikum, Erlangen, Germany
9Krankenhaus Schwabing, München, Germany
10Medizinische Klinik IV, Giessen, Germany
11Universitätsspital, Basel, Switzerland
12Department of Hematology, Inselspital, Bern, Switzerland

11:45 AM
Reduction of BCR-ABL Transcript Levels at 6, 12, and 18 Months (mo) Correlates with Long-Term Outcomes on Imatinib (IM) at 72 Mo: An Analysis from the International Randomized Study of Interferon versus STI571 (IRIS) in Patients (pts) with Chronic Phase Chronic Myeloid Leukemia (CML-CP)

Timothy P Hughes, MD1*, Andreas Hochhaus, MD2, Susan Branford, PhD3, Martin C Müller, MD4*, Letizia Foroni, MD, PhD, FRCPath5*, Brian J. Druker, MD6, François Guilhot, MD7, Richard A. Larson, MD8, Stephen G O'Brien, MD, PhD9*, Roger J. Waltzman, MD10, Manisha Mone, PhD11*, Elisabeth Wehrle, PhD12*, Jerald P. Radich, MD13* and John M. Goldman, MD14*

1Haematology, Institute of Medical and Veterinary Science, Adelaide, Australia
2Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany
3Institute of Medical & Veterinary Science, Adelaide, Australia
4Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
5Department of Haematology, Imperial College, London, United Kingdom
6Oregon Health & Science University Cancer Institute, Portland, OR
7Clinical Investigational Centre INSERM 802, CHU de Poitiers, Poitiers, France
8University of Chicago, Chicago, IL
9University of Newcastle, Newcastle, United Kingdom
10Global Medical Affairs, Novartis Pharma. Corporation, Florham Park, NJ
11Novartis Pharmaceuticals, Florham Park, NJ
12Novartis Pharma AG, Basel, Switzerland
13Fred Hutchinson Cancer Research Ctr., Seattle, WA
14Department of Haematology, Hammersmith Hospital, London, United Kingdom

12:00 PM
A Phase III, Randomized, Open-Label Study of 400 Mg Versus 800 Mg of Imatinib Mesylate (IM) in Patients (pts) with Newly Diagnosed, Previously Untreated Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Using Molecular Endpoints: 1-Year Results of TOPS (Tyrosine Kinase Inhibitor Optimization and Selectivity) Study

Jorge Cortes, MD1, Michele Baccarani, MD2*, François Guilhot, MD3, Brian J. Druker, MD4, Susan Branford, PhD5*, Dong-Wook Kim, MD, PhD6, Fabrizio Pane, MD7*, Marc Rudoltz, MD8, Richard Yu9*, LaTonya Collins, RN, BSN8*, Tillmann Krahnke, PhD10*, Jerald P. Radich, MD11* and Timothy P Hughes, MD12*

1The University of Texas MD Anderson Cancer Center, Houston, TX
2Institute of Hematology and Medical OncologySeragnoli, Bologna, Italy
3Clinical Investigational Centre INSERM 802, CHU de Poitiers, Poitiers, France
4Oregon Health & Science University, Portland, OR
5Division of Molecular Pathology, Institute of Medical & Veterinary Science, Adelaide, Australia
6Division of Hematology, St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
7CEINGE- Biotecnologie Avanzate, University of Naples Federico II, Naples, Italy
8Novartis Pharmaceutical, Inc., Florham Park, NJ
9Novartis, East Hanover, NJ
10B&sr, Novartis Pharmaceuticals
11Fred Hutchinson Cancer Research Ctr., Seattle, WA
12Haematology, Institute of Medical and Veterinary Science, Adelaide, Australia

12:15 PM
Identification of Novel Biomarkers for Prediction of Response to Tyrosine Kinase Inhibitors (TKIs) by Proteomic Profiling of Imatinib as Well as 2nd and 3rd Generation TKIs in Vitro

Stefan Balabanov, MD/PhD1*, Thoma Wilhelm, PhD1*, Simone Venz, PhD2*, Christine Barret1*, Gunhild Keller, MD1*, Mirja Bernhardt1*, Artur Gontarewicz, MD1*, Melanie Braig, PhD1*, Reinhard Walther, PhD2* and Tim H. Brummendorf, MD1

1Klinik für Onkologie und Hämatologie, Hubertus-Wald-Tumorzentrum-Universitäres Cancer Center Hamburg (UCCH), University Hospital Hamburg-Eppendorf (UKE), Hamburg, Germany
2Institut für Medizinische Biochemie und Molekularbiologie, Ernst-Moritz-Arndt Universität Greifswald, Greifswald

*signifies non-member of ASH