Before you can access ASH's online program, you must agree to the following:
Last updated January 16, 2009. Please note that this site represents the latest program changes
and differs from the print version in some details.

625.O2.8 Preclinical Studies in NHL: Novel Antibodies and Immunotherapeutic Approaches

Tuesday, December 9, 2008: 7:00 AM-9:00 AM
3006-3008 - West (Moscone Center)
Moderators:
John Timmerman, MD and John Kuruvilla, MD
7:00 AM
I-131-Anti-CD45 Radioimmunotherapy Effectively Targets and Treats T-Cell Non-Hodgkin's Lymphoma

Ajay K Gopal, MD1, Oliver W. Press, MD, PhD2, Jonathan R Fromm, MD, PhD3*, Shani Wilbur, BS4* and John M. Pagel, MD, PhD5

1University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA
2Fred Hutchinson Cancer Research Center, Seattle, WA
3Laboratory Medicine, University of Washington, Seattle
4Fred Hutchinson Cancer Research Center, Seattle
5Division of Oncology, Fred Hutchinson Cancer Research Ctr., Seattle, WA

7:15 AM
An Fc-Engineered Humanized Anti-CD40 Monoclonal Antibody, XmAb5485, Exhibits Potent Activity in Vitro and in Vivo against Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia and Multiple Myeloma

Eugene A. Zhukovsky, PhD1, Holly Horton, Ph.D1*, Matthias Peipp, PhD2*, Erik Pong, BS1*, Matthew Bernett, PhD1*, Sher Karki, PhD1*, John Richards, PhD1*, Seung Chu, PhD1*, Roland Repp, MD2 and John Desjarlais, PhD1*

1Xencor, Monrovia, CA
2Div. of Stem Cell Transp. and Immunoth., 2nd Medical Department, Christian-Albrechts-University; Kiel, Kiel, Germany

7:30 AM
Cyclin D1 as a Universally-Expressed Mantle Cell Lymphoma-Associated Tumor Antigen for Immunotherapy

Michael Wang, MD1, Luhong Sun, PhD1*, Jianfei Qian, PhD1, Xiaohong Han, PhD1*, Liang Zhang, PhD1*, Pei Lin, MD2* and Qing Yi, MD, PhD1*

1Department of Lymphoma and Myeloma, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston, TX
2Department of Hematopathology, Division of Pathology and Laboratory Medicine, University of Texas M.D. Anderson Cancer Center, Houston, TX

7:45 AM
Novel Mechanisms of Non-Apoptotic Cell Death Evoked by Type II Anti-CD20 (Tositumomab) and HLA-DR Monoclonal Antibodies

Tim Illidge, MD, PhD1, Andrei Ivanov, PhD1*, Stephen A Beers, PhD2*, Claire Walshe, PhD2*, Claude Chan, PhD2*, Waleed Alduaij1*, Martin J. Glennie, PhD2* and Mark S Cragg2*

1Paterson Institute for Cancer Research, School of Cancer and Imaging Sciences, University of Manchester, Manchester, United Kingdom
2Tenovus Laboratory, Cancer Sciences Division, Southampton, United Kingdom

8:00 AM
Cancer Stem Cell Activity in Mantle Cell Lymphoma Is Inhibited by TLR9 Activation

Sarah Brennan, BS1*, Brooke Meade, BA1*, Qiuju Wang, MA1*, George Weiner, MD2 and William Matsui, MD1

1Johns Hopkins University, Baltimore, MD
2University of Iowa, Holden Comprehensive Cancer Ctr., Iowa City, IA

8:15 AM
Lenalidomide Repairs Suppressed T Cell Immunological Synapse Formation in Follicular Lymphoma

Alan G. Ramsay, PhD, Andrew J. Clear, BSc*, Rewa Fatah, BSc* and John G. Gribben, MD, DSc*

Centre. for Medical Oncology, Institute of Cancer, Barts & The London School of Medicine, London, United Kingdom

8:30 AM
Combination Anti-CD74 (Milatuzumab) and CD20 (Rituximab) Monoclonal Antibody Therapy Has in Vitro and in Vivo Activity in Mantle Cell Lymphoma

Lapo Alinari, MD1, Erin Hertlein, PhD1*, David M. Goldenberg, ScD, MD2*, Rosa Lapalombella, PhD1*, Fengting Yan, MD, PhD1*, Xiaoli Zhang, PhD3*, David M. Lucas, PhD1, Natarajan Muthusamy, PhD1*, John C. Byrd, MD1* and Robert A. Baiocchi, MD, PhD1*

1Comprehensive Cancer Center, The Ohio State University, Columbus, OH
2Immunomedics, Inc., Morris Plains, NJ
3Center for Biostatistics, The Ohio State University, Columbus, OH

8:45 AM
Co-Treatment with Panobinostat Enhances Bortezomib-Induced Unfolded Protein Response, Endoplasmic Reticulum Stress and Apoptosis of Human Mantle Cell Lymphoma Cells

Rekha Rao1*, Warren Fiskus1*, Yonghua Yang1*, Rajeshree Joshi1*, Pravina Fernandez1*, Pearl Lee1*, Anand Jillella1*, Jianguo Tao2*, Peter Atadja3*, Eduardo Sotomayor2* and Kapil N. Bhalla1

1MCG Cancer Center, Medical College of Georgia, Augusta, GA
2H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
3Novartis Institute for Biomedical Research, Cambridge, MA

*signifies non-member of ASH