50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): DLBCL and Other NHL: Novel Therapeutic Targets and Approaches

Monday, December 8, 2008: 3:30 PM-5:30 PM

3006-3008 - West (Moscone Center)

Moderators:

Izidore Lossos and Miles Prince

3:30 PM

Interleukin-21 Induces Cell Cycle Arrest and Apoptosis of Diffuse Large B-Cell Lymphomas (DLBCL) Via Activation of STAT3 and Upregulation of C-Myc

Kristopher A Sarosiek¹^*, Hovav Nechushtan, MD, PhD²^*, Eli Avisar, MD³^* and Izidore S Lossos, MD⁴

¹Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL
²Department of Medicine, Division of Hematology, University of Miami, Miami, FL, United States
³Department of Surgery, University of Miami, Miami, FL
⁴Department of Medicine, Division of Hematology, University of Miami, Miami, FL

3:45 PM

602

Antitumor Efficacy of the Purine-Scaffold Hsp90 Inhibitor PU-H71 in Diffuse Large-B Cell Lymphoma

Eloisi Caldas Lopes¹^*, Leandro Cerchietti²^*, Shao Ning Yang²^*, Ari Melnick² and Gabriela Chiosis¹^*

¹Molecular Pharmacology & Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY
²Hematology and Oncology Division, Weill Cornell Medical College, New York, NY

4:00 PM

603

Histone Deacetylase Inhibition with LBH589 Inhibits the Rapamycin Insensitive Rictor-mTOR (mTORC2) Complex and Translation Initiation Factor eIF4E Activation in Diffuse Large B-Cell Lymphoma

Mamta Gupta, PhD, Stephen M. Ansell^*, Anne J. Novak^* and Thomas E. Witzig^*

Division of Hematology, Mayo Clinic, Rochester, MN

4:15 PM

604

Onco-Mir-155 Targets SHIP to Regulate TNF-Dependent B-Cell Lymphoma Growth

Irene Munk Pedersen¹, Dennis C Otero¹^*, Elaine Kao¹^*, Ana Sedy²^*, Christoffer Hother³^*, Elisabeth Ralfkiaer⁴^*, Robert C Rickert²^*, Kirsten Gronbaek³^* and Michael David¹^*

¹Univ. of Calif.-San Diego, La Jolla, CA
²Burnham Institute for Mediacal Reseach, La Jolla, CA
³Hematology, Copenhagen University Hospital, Copenhagen, Denmark
⁴Pathology, Copenhagen University Hospital, Copenhagen, Denmark

4:30 PM

605

The BH3-Mimetic Obatoclax (GX15-070) Posses a Dual-Mechanism of Action and Induces Both Apoptosis and Autophagy-Dependent Cell Death of B Cell Non-Hodgkin’s Lymphoma (B-NHL) Cells

Francisco J. Hernandez-Ilizaliturri, MD¹, Sapna Khubchandani, MD²^*, Scott H. Olejniczak, PhD²^*, Paul Hosking, MD²^*, Elizabeth Gruber, MS²^* and Myron Czuczman, MD¹

¹Medical Oncology and Immunology, Roswell Park Cancer Institute, Buffalo, NY
²Medical Oncology, Roswell Park Cancer Institute, Buffalo, NY

4:45 PM

606

MLN4924, a Novel Small Molecule Inhibitor of Nedd8-Activating Enzyme, Demonstrates Potent Anti-Tumor Activity in Diffuse Large B-Cell Lymphoma

Michael Milhollen, MSc^*, Usha Narayanan^*, Allison J Berger, PhD^*, Michael Thomas^*, Tary Traore^*, Jie Yu^*, Julie Zhang^*, Erik Koenig^*, James J. Garnsey^*, Steven P. Langston^*, Teresa A Soucy, PhD^* and Peter G Smith, PhD^*

Oncology, Millennium Pharmaceuticals, the Takeda Oncology Company, Cambridge, MA

5:00 PM

607

Epigenetic Silencing of BIM Mediates Chemotherapy Resistance of Patients with Burkitt Lymphoma That Can Be Overcome by Therapeutic Reactivation of BIM in Mouse and Human Lymphoma Models

Jose A. Richter, MSc¹^*, Antonio Rullan¹^*, Elena Beltran, MSc¹^*, Xabier Agirre, PhD¹^*, M.ª José Calasanz, PhD²^*, Jose Roman-Gomez, MD³^*, Carlos Panizo, MD⁴^*, Jesus M Hernandez, MD, PhD⁵^*, Felipe Prosper, MD⁴, Vicente Fresquet, PhD¹^* and Jose A. Martinez-Climent, MD, PhD¹

¹Oncology Division, Center for Applied Medical Research, CIMA, University of Navarra, Pamplona, Spain
²Department of Genetics, University of Navarra, Pamplona, Spain
³Department of Hematology, Reina Sofia Hospital, Cordoba, Spain
⁴Hematology & Cell Therapy Prog., Clinica Universitaria de Navarra, Pamplona, Spain
⁵Department of Hematology, Hospital Univeristario, Salamanca, Spain

5:15 PM

608

Gene Expression and Proteomic Profiling Predict Therapeutic Response to ABT-737 in Human and Mouse Models of Mantle Cell Lymphoma

Elena Beltran, MSc¹^*, Vicente Fresquet, PhD¹^*, Jose A Richter, MSc¹^*, Miguel A. Piris, MD²^*, Reiner Siebert, MD³^* and Jose A. Martinez-Climent, MD, PhD¹

¹Oncology Division, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
²Molecular Pathology Program, CNIO, Madrid, Spain
³Department of Human Genetics, Christian-Albrechts-University, Kiel, Germany

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^*signifies non-member of ASH

625.O1.8 DLBCL and Other NHL: Novel Therapeutic Targets and Approaches