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623.P1.71 Lymphoma: Chemotherapy and Clinical Trials Poster I

Saturday, December 6, 2008: 5:30 PM-7:30 PM
Hall A (Moscone Center)
Human Herpesvirus 8 Protein K1 Interference with Fas-Mediated Apoptosis Induces Clonal Growth Which Leads to Lymphoid Hyperplasia

Ronghua Tao, Ph.D.1*, Zuzana Berkova2*, Shu Wang, M.D.2*, Suizhao Wang, M.D., Ph.D.2*, Jillian Wise, BS1* and Hoyoung Maeng, M.D.1*

1Lymphoma/Myeloma, M.D. Anderson Cancer Center, Houston, TX
2Lymphoma/Myeloma, M. D. Anderson Cancer Center, Houston, TX

Eight Cycles of BEACOPP Escalated Compared with 4 Cycles of BEACOPP Escalated Followed by 4 Cycles of BEACOPP Baseline with Our without Radiotherapy in Patients in Advanced Stage Hodgkin Lymphoma (HL): Final Analysis of the Randomised HD12 Trial of the German Hodgkin Study Group (GHSG)

Volker Diehl1, Heinz Haverkamp2*, Rolf Peter Mueller3*, Hans Theodor Eich4*, Hans Konrad Mueller-Hermelink5*, Thomas Cerny6*, Jana Markova7*, Anthony Ho8, Lothar Kanz9, Richard Greil10*, Wolfgang Hiddemann11* and Andreas Engert2

1University of Cologne, Cologne/Germany, Germany
2First department of Internal Medicine / German Hodgkin Study Group (GHSG), University of Cologne, Cologne, Germany
3Department of Radiotherapy, University of Cologne, Cologne, Germany
4Department of Radiotherapy, University of Cologne, Cologne/Germany, Germany
5Department of Pathology, University of Wuerzburg, Wuerzburg, Germany
6Department of Oncology, Kantonsspital St. Gallen, St. Gallen, Switzerland
7Clinic Hematologia, Fakultne Nemocnice Kralovska Vinohrady, Prague, Czech Republic
8Department of Hematology and Oncology, University of Heidelberg, Heidelberg, Germany
9Hematology and Oncology, Eberhard Karls University, Tuebingen, Germany
10Third Department of Internal Medicine, University of Salzburg, Salzburg, Austria
11Third Department of Internal Medicine, University of Munic, Munic, Germany

Supportive Efficacy Analyses for the Phase 3 Study of Temsirolimus Versus Investigator's Choice Therapy for the Treatment of Patients with Relapsed or Refractory Mantle Cell Lymphoma

Jorge Romaguera1, Bertrand Coiffier2, Michael Crump3, Raoul Herbrecht4, Gregor Verhoef5, Orysia Hanushevsky6*, Andrew Strahs6*, Becker Hewes6, Anna Berkenblit6* and Georg Hess7*

1MD Anderson Cancer Center, Houston, TX
2Centre Hospitalier Lyon-Sud, Pierre-Benite, France
3Princess Margaret Hospital, Toronto, ON, Canada
4Hopital de Hautepierre, Strasbourg, France
5University Hospital, Leuven, Belgium
6Wyeth Research, Cambridge, MA
7Johannes Gutenberg-Universität, Mainz, Germany

The Efficacy and Safety of Lenalidomide Oral Monotherapy in Patients with Mantle Cell Lymphoma Previously Treated with Bortezomib: Pooled Data from Two Phase II Studies (NHL-002 and NHL-003)

Craig B. Reeder, MD1, T.E. Witzig2*, Julie M. Vose3*, Pier Luigi Zinzani, MD4*, Rena Buckstein, MD, FRCPC5, Corinne Haioun6, Reda Bouabdallah, MD7, Jonathan Polikoff, MD8*, Pingshan Guo9*, Annette Ervin-Haynes9, Dennis Pietronigro9*, Jerome B. Zeldis, MD9 and Myron S. Czuczman, MD10

1Hematology, Mayo Clinic Arizona, Scottsdale, AZ
2Health Sciences Research, Mayo Clinic, Rochester, MN
3Genetics, Cell Biology and Anatomy, University Of Nebraska Medical Center, Omaha, NE
4Department of Hematology/Oncology, University of Bologna, Bologna, Italy
5Dept. of Hematology/Oncology, Sunnybrook Odette Cancer Center, Toronto, ON, Canada
6Service d'Hématologie Clinique, Hôpital Henri Mondor, Créteil, France
7Institut Paoli-Calmettes, Marseille, France
8Kaiser Permanente Medical Group, San Diego, CA
9Celgene Corporation, Summit, NJ
10Roswell Park Cancer Institute, Buffalo, NY

Farnesyltransferase Inhibitor Tipifarnib (Zarnestra) in Refractory Mantle Cell Lymphoma (MCL): A Therapeutic Target Only for Specific Patients Categorized by the 2-Gene Classifier for Predictive Response to Tipifarnib

Delphine Rolland1*, Vincent Ribrag2*, Corinne Haioun3*, Herve Ghesquieres, MD4*, Fabrice Jardin5*, Reda Bouabdallah6*, Patricia Franchi7*, Josette Briere8*, Eric De Kerviler9*, Catherine Chassagne-Clement10*, Mitch Raponi, PhD11, Remi Houlgatte12*, Jean-Philippe Jais13* and Catherine Thieblemont14

1INSERM U836 Equipe 7 - Faculte de Medecine, Universite J. Fourier, Grenoble, France
2Medecine, Institut Gustave Roussy, Villejuif, France
3Hematology, Henri Mondor Hospital, Creteil, France
4Hematology, Centre Léon Berard, Lyon, France
5Hematology, INSERM U918, Centre Henri Becquerel, Rouen, France
6Hematology, Cancer Centre Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France
7Hemato-oncologie, Hôpital Saint-Louis APHP, Paris, France
8Anatomo-pathologie, Hôpital Saint-Louis APHP - INSERM U728 - IUH, Paris, France
9Radiologie, Hopital Saint-Louis APHP, Paris, France
10Anatomie pathologique, Centre Léon Bérard, Lyon, France
11Veridex, LLC, San Diego, CA
12INSERM U533 - Institut du thorax - Faculté de Médecine, Université de Nantes, Nantes, France
13Biostatistics, Hôpital Necker, EA 4067 université Paris-Descartes, Paris, France
14Hemato-Oncology, Hopital Saint-Louis, APHP - INSERM U 728 - Institut Universitaire d'Hematologie, Paris, France

A Phase II Trial of Darinaparsin in Advanced Lymphomas: Report on Safety and Activity

Michael Craig1*, Sandip Shah2*, Martin Tallman3*, Poonam Patil4*, Jose Easow5*, Jill Buck6*, Sachin Shah6*, Jonathan Lewis6 and Izidore S. Lossos7

1West Virginia University Hospitals, Morgantown, WV
2Vendanta Institute of Medical Sciences, Ahmedabad, India
3Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL
4Manipal Comprehensive Cancer Centre, Bangalore, India
5Apollo Hospital, Chennai, India
6ZIOPHARM Oncology, Inc., Boston, MA
7Sylvester Comprehensive Cancer Center, Miami, FL

A Phase I/II Trial of the Kinesin Spindle Protein (KSP) Inhibitor SB-743921 Administered on Days 1 and 15 Every 28 Days without and with Prophylactic G-CSF in Non-Hodgkin or Hodgkin Lymphoma

John Gerecitano1, O. O'Connor2, H. Van Deventer3*, J. Hainsworth4, J. Leonard5, A. Goy6, B. Afanasyev7*, M. Chen8*, K. Saikali8*, M. G Conlan8*, R Escandon8* and A Wolff8*

1Memorial Sloan-Kettering Cancer Ctr., New York, NY
2Columbia Univ. Med. Ctr., New York, NY
3Univ. North Carolina, Chapel Hill, NC
4Sarah Cannon Cancer Ctr., Nashville, TN
5Cornell Med. College, New York, NY
6Hackensack Univ. Med. Ctr., Hackensack, NJ
7St. Petersburg State Med. Univ., St. Petersburg, Russia
8Cytokinetics, Inc., S. San Francisco, CA

A Phase 2 Study of Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) in  Relapsed or Refractory Indolent Non-Hodgkin’s Lymphoma. A California Cancer Consortium Study

Mark Kirschbaum, MD1, Leslie Popplewell2, Auayporn P. Nademanee3, Vinod Pullarkat4, Maria Delioukina2*, Jasmine M. Zain5*, Deron Matsuoka3*, Bernadette Pulone3*, Paul Frankel3*, Igor Espinoza-Delgado, MD6*, Stephen J. Forman7*, David Gandara8* and Edward Newman3*

1Division of Hematology, City of Hope National Medical Center, Duarte, CA
2City of Hope, Duarte, CA
3City of Hope National Medical Center, Duarte, CA
4Division of Hematology/HCT, City of Hope National Medical Center, Duarte, CA
5Division of Medical Oncology, Columbia University College of Physicians and Surgeons, New York, NY
6Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD
7Hematology/HCT, City of Hope, Duarte, CA
8University of California-Davis, Sacramento, CA

Phase I and Pharmacokinetic Study of Inotuzumab Ozogamicin (CMC-544) as a Single Agent in Japanese Patients with Follicular Lymphoma Pretreated with Rituximab

Kensei Tobinai, MD, PhD1, Michinori Ogura, MD, PhD2, Kiyohiko Hatake, MD, PhD3, Yukio Kobayashi, MD, PhD1*, Takashi Watanabe, MD, PhD1*, Toshiki Uchida, MD, PhD2*, Masanobu Kasai, MD2*, Masahiro Yokoyama, MD3*, Yasuhito Terui, MD, PhD3, Chiho Ono4*, Masanao Akiyama4* and Junko Ohata, MD, PhD4*

1Hematology and Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan
2Hematology & Oncology, Nagoya Daini Red Cross Hospital, Nagoya, Japan
3Oncology and Hematology, Cancer Institute Hospital, Tokyo, Japan
4Medical Research, Wyeth Research, Tokyo, Japan

Plitidepsin Is Active in Peripheral T-Cell Lymphoma (PTCL): A Subset Analysis from An Ongoing Multicenter Phase II Trial

Christophe Ferme, MD1*, Maria Victoria Mateos, MD, PhD2*, Sergio Szyldergemajn, MD3*, Emanuele Zucca, MD4*, Jose Espinoza, MD3*, Javier Briones, MD5*, Franck Morschhauser, MD6*, Christian Gisselbrecht, MD7* and Vincent Ribrag, MD1

1Dpt. of Medicine, Institut Gustave Roussy, Villejuif, France
2Dpt of Hematology, Hospital Universitario de Salamanca, Salamanca, Spain
3Clinical Oncology, PharmaMar, Colmenar Viejo (Madrid), Spain
4Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland
5Dpt of Hematology, Hospital Sant Pau, Barcelona, Spain
6Hematology, Centre Hospitalier Universitaire, Lille, France
7Institut Hematologie, Hopital Saint Louis, Paris, France

Results of a Phase 2 NCI Multicenter Study of Romidepsin in Patients with Relapsed Peripheral T-Cell Lymphoma (PTCL)

Richard Piekarz, MD, PhD1*, John Wright, MD, PhD2*, Robin Frye, RN1*, Steven L. Allen, MD3, Michael Craig, MD4*, Larisa Geskin, MD, FAAD5*, Laura Hutchins, MD6, David Joske, MBBS, FRCPA, FRACP7, Mark Kirschbaum, MD8, John P Leonard, MD9*, Miles Prince, MD10, Craig B. Reeder, MD11, Elaine Jaffe, MD1* and Susan Bates, MD1*

1National Cancer Institute, Bethesda, MD
2IDB CTEP NCI, Rockville, MD
3Medicine, North Shore University Hospital - LIJ, Lake Success, NY
4Mary Babb Randolph Cancer Center, Morgantown, WV
5Dermatology, University of Pittsburgh, Pittsburgh
6Univ. of AR for Med. Sciences, Little Rock, AR
7Haematology Care Center, Sir Charles Gairdner Hospital, Perth, WEA, Australia
8Division of Hematology, City of Hope National Medical Center, Duarte, CA
9Weill Medical College of Cornell, New York, NY
10Peter MacCallum Cancer Institute, East Melbourne, Australia
11Hematology, Mayo Clinic Arizona, Scottsdale, AZ

Final Clinical Results of a Phase 2 NCI Multicenter Study of Romidepsin in Recurrent Cutaneous T-Cell Lymphoma  (Molecular Analyses Included)

Susan Bates, MD1*, Richard Piekarz, MD, PhD1*, John Wright, MD, PhD2*, Robin Frye, RN1*, William Douglas Figg Sr., PharmD1*, Steven L. Allen, MD3, Michael Craig, MD4*, Larisa Geskin, MD, FAAD5*, Laura Hutchins, MD6*, David Joske, MBBS, FRCPA, FRAPC7*, Mark Kirschbaum, MD8, John P. Leonard, MD9, Miles Prince, MD10, Craig B. Reeder, MD11, Maryalice Stetler-Stevenson, MD, PhD1*, Alex Ling, MD1* and Jean Nichols, PhD12*

1National Cancer Institute, Bethesda, MD
2IDB CTEP NCI, Rockville, MD
3Medicine, North Shore University Hospital - LIJ, Lake Success, NY
4West Virginia University Hospitals, Morgantown, WV
5Dermatology, University of Pittsburgh, Pittsburgh
6Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, AR
7Sir Charles Gairdner Hospital, Nedlands, Australia
8Division of Hematology, City of Hope National Medical Center, Duarte, CA
9Division of Hem./Onc., Weill Cornell Medical College, New York, NY
10Peter MacCallum Cancer Institute, East Melbourne, Australia
11Mayo Clinic, Scottsdale, AZ
12Gloucester Pharmaceuticals, Cambridge, MA

Pralatrexate (PDX) IS Active in Cutaneous T-Cell Lymphoma: Preliminary Results of a Multi-Center Dose-Finding Trial

Steven M. Horwitz, MD1, Madeleine Duvic, MD2, Youn Kim, MD3, Jasmine M. Zain, MD4, Mary Jo Lechowicz, MD5, Patricia Myskowski, MD1*, Hanna Weissbrot1*, Danielle Wright4*, Lacey Chance6*, Tony Koutsoukos6*, Pablo Cagnoni, MD6*, Michael Saunders, MD6* and Owen A. O'Connor, MD, PhD4*

1Memorial Sloan-Kettering Cancer Center, New York, NY
2M.D. Anderson Cancer Center, The University of Texas, Houston, TX
3Stanford, Stanford, CA
4CUMC, New York, NY
5Emory University, Atlanta, GA
6Allos Therapeutics, Inc., Westminster, CO

A Phase 1/2A Open-Label Study of Pralatrexate and Gemcitabine in Patients with Relapsed or Refractory Lymphoproliferative Malignancies

Steven M. Horwitz, MD1, Julie M. Vose, MD2, Ranjana Advani, MD3, Kamalesh Sankhala, MD4*, Swaminathan Padmanabhan, M.D.5*, Paul A. Hamlin Jr., MD1, Andy Chen, MD, PhD6, Shannon Wilroy7*, Jasmine M. Zain, MD8, Danielle Wright8*, Hanna Weissbrot1*, Maribeth Hohenstein2*, Pablo J Cagnoni, MD7*, Michael E Saunders, MD7* and Owen A. O'Connor, MD, PhD8*

1Memorial Sloan-Kettering Cancer Center, New York, NY
2Univ. of NE Med. Ctr., Omaha, NE
3Stanford University, Stanford, CA
4University of Texas Health Science Center at San Antonio, San Antonio, TX
5Institute for Drug Development, Cancer Therapy and Research Center, San Antonio, TX
6Stanford Cancer Center, Palo Alto, CA
7Allos Therapeutics, Inc., Westminster, CO
8CUMC, New York, NY

Flavopiridol, Fludarabine and Rituximab (FFR): An Active Regimen in Indolent B-Cell Lymphoproliferative Disorders and Mantle Cell Lymphoma

Thomas S. Lin, MD, PhD, Beth Fischer, BSN, RN*, Kristie A. Blum, MD, Pierluigi Porcu, MD*, Eric H. Kraut, MD, Robert A. Baiocchi, MD, PhD, Mollie E. Moran, MSN, CNP*, Sarah Mitchell*, Michael R. Grever, MD and John C. Byrd, MD

Division of Hematology and Oncology, The Ohio State University, Columbus, OH

Results of a Phase II Study of Bortezomib in Patients with Relapsed or Refractory Indolent Lymphoma

Nicholas Di Bella, MD1, Raymond Taetle, MD2*, Kathryn S. Kolibaba, MD3, Thomas E Boyd, MD4*, Robert N Raju, MD5*, David N Barrera, DO6, Ernest Cochran, MD7*, Philip Dien, MD8*, David Hakimian, MD9, Roger M. Lyons, MD10, Peter J Schlegel, MD11*, Svetislava J Vukelja, MD12*, Julie Boston, RN13*, Kristi A Boehm, MS13*, Yunfei Wang, MS13* and Lina Asmar, PhD13*

1Research, US Oncology Research, Inc., Houston, TX and Rocky Mountain Cancer Centers, Aurora, CO
2Research, US Oncology Research, Inc., Houston, TX and Hematology and Oncology Physicians, Tucson, AZ
3Research, US Oncology Research, Inc., Houston, TX and Northwest Cancer Specialists, Vancouver, WA
4Research, US Oncology Research, Inc., Houston, TX and Yakima Valley Memorial Hospital, Yakima, WA
5Research, US Oncology Research, Inc., Houston, TX and Dayton Oncology and Hematology, Kettering, OH
6Research, US Oncology Research, Inc., Houston, TX and Texas Oncology, Fort Worth, TX
7Research, US Oncology Research, Inc., Houston, TX and Texas Oncology, Paris, TX
8Research, US Oncology Research, Inc., Houston, TX and Minnesota Onc. Hem., Burnsville, MN
9Research, US Oncology Research, Inc., Houston, TX and Cancer Care and Hematology Associates, Niles, IL
10Research, US Oncology Research, Inc., Houston, TX Cancer Care Centers of South Texas, San Antonio, TX
11Research, US Oncology Research, Inc., Houston, TX and Cancer Care Northwest, Spokane, WA
12Research, US Oncology Research, Inc., Houston, TX and Texas Oncology, Tyler, TX
13Research, US Oncology Research, Inc., Houston, TX

Phase I Trial of Bortezomib (NSC 681239) and Flavopiridol (NSC 649890) in Patients with Recurrent or Refractory Indolent B-Cell Neoplasms

Steven Grant, MD1, Daniel Sullivan2*, David Roodman, MD, PhD3, Robert K Stuart, MD4, Edward Perkins1*, Sarah Kolla1*, Viswanathan Ramakrishnan1*, John Wright, MD, PhD5*, Alexander Dimitri Colevas6*, M B Tombes1* and John D Roberts1*

1Massey Cancer Center, Virginia Commonwealth University, Richmond, VA
2H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL
3Medicine/Hem-Onc., University of Pittsburgh, Pittsburgh, PA
4Medical Univ. of South Carolina, Charleston, SC
5IDB CTEP NCI, Rockville, MD
6School of Medicine, Stanford University, Stanford, CA

Weekly Treatment with a Combination of Bendamustine and Bortezomib in Relapsed or Refractory Indolent Non-Hodgkin’s Lymphoma: A Single-Center Phase 1/2 Study

Peter R Moosmann, MD, PhD*, Marc Heizmann, MD, Nina Kotrubczik, MD*, Mario Bargetzi, MD and Martin Wernli, MD

Center of Oncology, Hematology, & Transfusion Medicine, Cantonal Hospital of Aarau, Aarau, Switzerland

Interim Results of the RiPAD+C Regimen Including Velcade in Front Line Therapy for Elderly Patients with Mantle Cell Lymphoma. A Phase II Prospective Study of the GOELAMS Group

Remy Gressin, MD1, Sylvie caulet Maugendre, MD2*, Steven Le Gouill, MD3*, Mario ojeda Uribe, MD4*, Magda Alexis Vigier, MD5*, Krimo Bouabdallah6*, Christiane Mounier7*, Olivier Tournilhac, MD8*, Philippe Rodon, MD9, Abderrazak El Yamani10*, Laurent Sutton11*, Delphine Senecal, MD12*, Bruno Lioure, MD13*, David Assouline, MD14*, Annie Le Mevel, MD15*, Bruno Villemagne, MD16*, Charles Dauriac, MD17*, Martine Gardembas, MD18*, Sophie Park, MD19* and Thierry Lamy, PhD17*

1Dept. of Onc.-Haem., CHU Michallon, Grenoble, France
2Pathology, CHU Rennes, Rennes, France
3Haematology, CHU Nantes, Nantes, France
4Haematology, CH, Mulhouse, France
5Oncology, CH Orleans, Orleans, France
6Haematology, CHU Bordeaux, Pessac, France
7Haematology, CHU Saint Etienne, St Priest en Jarez, France
8Haematology, CHU Clermont Ferrand, Clermont Ferrand, France
9Haematology, CH Blois, Blois, France
10Haematology, CH Le Mans, Le Mans, France
11CH Argenteuil, Argenteuil, France
12Haematology, CHU Tours, Tours, France
13Département d'Hématologie et d'Oncologie, CHU Hautepierre, Strasbourg, France
14Oncology, Clinique du Mail, Grenoble, France
15Haematology, Centre Anticancereux, Saint Herblain, France
16Haematology, CH La Roche sur Yon, La Roche sur Yon, France
17Haematology, CHU Rennes, Rennes, France
18Haematology, CHU Angers, Angers, France
19Haematology, CH Cochin, Paris, France

Tolerability and Efficacy of Bortezomib Added to CVP-R for Previously Untreated Advanced Stage Follicular Lymphoma: Interim Analysis of a Phase II Study by the NCIC Clinical Trials Group

Laurie H Sehn, MD, MPH1*, David A Macdonald, MD2, Sheldon H. Rubin, MD3, Morel Rubinger, MD, FRCPC4, Kevin R Imrie, MD5, Judy-Anne W Chapman, PhD6*, Marina Djurfeldt7*, Lois Shepherd, MD6, Stephen Couban, MD8 and Michael Crump, MD9

1British Columbia Cancer Agency, Vancouver, BC, Canada
2QEII Health Sciences Centre, Halifax, NS, Canada
3The Moncton Hospital, Moncton, NB, Canada
4Cancercare Manitoba, Winnipeg, MB, Canada
5Sunnybrook Hospital, Toronto, ON, Canada
6Queen's University, Kingston, ON, Canada
7National Cancer Institute of Canada Clinical Trials Group, Kingston, ON, Canada
8Sciences Centre, Queen Elizabeth II Health, Halifax, NS, Canada
9Princess Margaret Hospital, Toronto, ON, Canada

*signifies non-member of ASH