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623.O2.6 Hogkin Lymphoma - Interim PET in Lymphoma

Monday, December 8, 2008: 11:00 AM-12:30 PM
2005-2007-2018-2020 - West (Moscone Center)
Moderators:
Philippe Armand, MD, PhD and Philip Bierman, MD
11:00 AM
Dose-Intensified Combined Modality Treatment with 2 Cycles of BEACOPP Escalated Followed by 2 Cycles of ABVD and Involved Field Radiotherapy (IF-RT) Is Superior to 4 Cycles of ABVD and IF-RT in Patients with Early Unfavourable Hodgkin Lymphoma (HL): An Analysis of the German Hodgkin Study Group (GHSG) HD14 Trial

Peter Borchmann1*, Andreas Engert2, Annette Pluetschow2*, Michael Fuchs2*, Jana Markova3*, Andreas Lohri4, Zdenek Kral5*, Richard Greil6*, Max Topp7*, Matthias Villalobos8*, Jose Zijlstra, MD9*, Martin Soekler10*, Harald Stein11*, Hans Theodor Eich12*, Rolf Peter Mueller13* and Volker Diehl14

1First Department of Internal Medicine, University of Cologne, Cologne, Germany
2First department of Internal Medicine / German Hodgkin Study Group (GHSG), University of Cologne, Cologne, Germany
3Hematologia, Fakultni Nemocnice Kralovske Vinohrady, Prague, Czech Republic
4Dept. of Oncology/Hematology, Medical University Clinic, Liestal, Switzerland
5Department of Internal Medicine and Hematology, University Hospitel of Brno, Brno, Czech Republic
6Third Department of Internal Medicine, University of Salzburg, Salzburg, Austria
7Department of Hematology and Oncology, University of Wuerzburg, Wuerzburg, Germany
8Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
9Hematology, VU University Medical Centre Amsterdam, Amsterdam, Netherlands
10Hematology and Oncology, University of Tuebingen, Tuebingen, Germany
11Institute of Pathology, University Hospitel Benjamin Franklin Berlin, Berlin, Germany
12Department of Radiotherapy, University of Cologne, Cologne/Germany, Germany
13Department of Radiotherapy, University of Cologne, Cologne, Germany
14First department of Internal Medicine / German Hodgkin Study Group (GHSG), University of Cologne, Cologne/Germany, Germany

11:15 AM
Consolidation Radiotherapy Is Associated with Improved Outcomes after Chemotherapy for Advanced Hodgkin Lymphoma: Analysis of Results from the UKLG LY09 Trial (ISRCTN97144519)

Peter W.M. Johnson, MD, FRCP1, Matthew R Sydes2*, John Radford, MD, FRCP3*, Michael Cullen, MD, FRCP4*, Sally Stenning2* and Barry Hancock, MD, FRCP5*

1Cancer Research UK Clinical Centre, University of Southampton, Southampton, United Kingdom
2MRC Cancer Trials Unit, London, United Kingdom
3Christie Hospital and The University of Manchester, Manchester, United Kingdom
4University Hospitals, Department of Medical Oncology, Birmingham, United Kingdom
5Weston Park Hospital, Department of Clinical Oncology, Sheffield, United Kingdom

11:30 AM
Results of the 2nd Planned Interim Analysis of the RAPID Trial (involved field radiotherapy versus no further treatment) in Patients with Clinical Stages 1A and 2A Hodgkin Lymphoma and a 'negative' FDG-PET Scan after 3 Cycles ABVD

John Radford1*, Michael O'Doherty2*, Sally Barrington2*, Wendi Qian3*, Philippa Patrick4*, Stewart Coltart5*, Dominic Culligan6, Jennie Wimperis7*, Eric Bessell8*, David Linch9*, Peter Johnson10, David Cunningham11*, T. Andrew Lister12, Peter Hoskin13*, Ruth Pettengell14*, Barry Hancock15* and Timothy Illidge1

1Christie Hospital and The University of Manchester, Manchester, United Kingdom
2PET Imaging Centre, St Thomas' Hospital, London, United Kingdom
3MRC Cancer Trials Unit, London, United Kingdom
4Cancer Research UK and University College London Clinical Trials Centre, London, United Kingdom
5Kent and Canterbury Hospital, Canterbury, United Kingdom
6Aberdeen Royal Infirmary, Aberdeen, United Kingdom
7Norfolk and Norwich University Hospital, Norwich, United Kingdom
8Nottingham City Hospital, Nottingham, United Kingdom
9University College London, London, United Kingdom
10Cancer Research UK Clinical Centre, University of Southampton, Southampton, United Kingdom
11Royal Marsden Hospital, London, United Kingdom
12Centre for Medical Oncology, Barts and the London School of Medicine and Dentistry, London, United Kingdom
13Mount Vernon Hospital, Northwood, United Kingdom
14St Georges University of London, London, United Kingdom
15Weston Park Hospital, Sheffield, United Kingdom

11:45 AM
Randomised Comparison of the Stanford V (SV) Regimen and ABVD in the Treatment of Advanced Hodgkin Lymphoma (HL): Results from a UK NCRI Lymphoma Group Study, ISRCTN 64141244Clinically Relevant Abstract

Peter W.M. Johnson, MD, FRCP1, Alan Horwich, PhD, FRCR, MRCP2*, Andrew Jack, MD, FRCPath3*, Graham Mead, DM, FRCP1*, Barry Hancock, MD, FRCP4*, Paul Smith5*, Wendi Qian6*, Philippa Patrick, PhD5*, Andrew Pettitt7*, David Cunningham8* and Peter Hoskin, MD, FRCR9*

1Cancer Research UK Clinical Centre, University of Southampton, Southampton, United Kingdom
2Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hosp, London, United Kingdom
3St James's Institute of Oncology, HMDS, Leeds, United Kingdom
4Weston Park Hospital, Department of Clinical Oncology, Sheffield, United Kingdom
5Lymphoma Trials Office, CR UK UCL Cancer Trials Office, London, United Kingdom
6MRC Cancer Trials Unit, London, United Kingdom
7University of Liverpool, Liverpool, United Kingdom
8Royal Marsden Hospital, London, United Kingdom
9Mount Vernon Cancer Centre, Department of Clinical Oncology, London, United Kingdom

12:00 PM
Poor Predictive Value of FDG-PET/CT Performed after 2 Cycles of R-CHOP in Patients with Diffuse Large B-Cell Lymphoma (DLCL)

Amanda Cashen, M.D., Farrokh Dehdashti, M.D.*, Jingqin Luo, Ph.D.* and Nancy L. Bartlett, MD

Washington University School of Medicine, Saint Louis, MO

12:15 PM
Interim Positron Emission Tomography (PET) in Diffuse Large B-Cell Lymphoma: Independent Expert Nuclear Medicine Evaluation of ECOG 3404

Sandra J. Horning, MD1, Malik E. Juweid, MD2*, Heiko Schoder3*, Gregory Wiseman, MD4*, Alex McMillan, Ph.D.5*, Lode J. Swinnen, MBChB6, Ranjana Advani, MD1, Randy D. Gascoyne, MD7 and Andrew Quon8*

1Stanford University, Stanford, CA
2Dept. of Radiology/Nuclear Med., Univ. of Iowa College of Med., Iowa City, IA
3Radiology/Nuclear Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
4Mayo Clinic, Rochester, MN
5Health Research and Policy, Stanford University, Stanford, CA
6Div. of Hem. Malignancy, Johns Hopkins Cancer Center, Baltimore, MD
7British Columbia Cancer Agency, Vancouver, BC, Canada
8Radiology/Nuclear Medicine, Stanford University, Stanford, CA

*signifies non-member of ASH