Before you can access ASH's online program, you must agree to the following:
Last updated January 16, 2009. Please note that this site represents the latest program changes
and differs from the print version in some details.

623.O1.8 Targeted Therapies and New Agents in Lymphoma

Monday, December 8, 2008: 7:00 AM-9:00 AM
2005-2007-2018-2020 - West (Moscone Center)
Moderators:
Michael Crump, MD and Silvia Montoto, MD
7:00 AM
PROPEL: A Multi-Center Phase 2 Open-Label Study of Pralatrexate (PDX) with Vitamin B12 and Folic Acid Supplementation in Patients with Replapsed or Refractory Peripheral T-Cell Lymphoma

Owen A. O'Connor, MD, PhD1*, Barbara Pro, M.D.2, Lauren Pinter-Brown, MD3*, Leslie Popplewell, MD4, Nancy Barlett, MD5*, Andrei Shustov, MD6, Mary Jo Lechowicz, MD7, Kerry J Savage, MD, MSc8, Bertrand Coiffier, MD9, Eric Jacobsen, MD10*, Pier Luigi Zinzani, MD11*, Andre Goy, MD12, Jasmine Zain, MD1*, Shannon Wilroy13*, Molly Patterson1*, Adam Boyd13*, Michael E. Saunders, MD13*, Pablo Cagnoni, MD13* and Steven M. Horwitz, MD14

1CUMC, New York, NY
2Department of Lymphoma/Myeloma, University of Texas M.D. Anderson Cancer Center, Houston, TX
3Dept of Internal Medicine, Division of Oncology, University of California at Los Angeles, Los Angeles, CA
4City of Hope, Duarte, CA
5Department of Internal Medicine, Division of Oncology, Washington University of Medicine, St Louis, MO
6University of Washington, Seattle, WA
7Emory University, Atlanta, GA
8British Columbia Cancer Agency, Vancouver, BC, Canada
9Centre Hospitalier Lyon-Sud, Pierre-Benite
10Dana Farber, Boston, ME
11Department of Hematology/Oncology, University of Bologna, Bologna, Italy
12Cancer Center at HUMC, Hackensack, NJ
13Allos Therapeutics, Inc., Westminster, CO
14Memorial Sloan-Kettering Cancer Center, New York, NY

7:15 AM
Confirmation of the Efficacy and Safety of Lenalidomide Oral Monotherapy in Patients with Relapsed or Refractory Mantle-Cell Lymphoma: Results of An International Study (NHL-003)

Pier Luigi Zinzani, MD1*, Thomas E. Witzig, MD2*, Julie M. Vose, MD3, Craig B. Reeder, MD4, Rena Buckstein, MD, FRCPC5, Corinne Haioun6, Reda Bouabdallah, MD7, Jonathan Polikoff, MD8*, Pingshan Guo9*, Annette Ervin-Hayes9*, Dennis Pietronigro9*, Jerome B. Zeldis, MD9 and Myron S. Czuczman, MD10

1Department of Hematology/Oncology, University of Bologna, Bologna, Italy
2Mayo Clinic, Rochester, MN
3Univ. of NE Med. Ctr., Omaha, NE
4Hematology, Mayo Clinic Arizona, Scottsdale, AZ
5Dept. of Hematology/Oncology, Sunnybrook Odette Cancer Center, Toronto, ON, Canada
6Service d'Hématologie Clinique, Hôpital Henri Mondor, Créteil, France
7Institut Paoli-Calmettes, Marseille, France
8Kaiser Permanente Medical Group, San Diego, CA
9Celgene Corporation, Summit, NJ
10Roswell Park Cancer Institute, Buffalo, NY

7:30 AM
Clinically Significant Responses Achieved with Romidepsin in Treatment-Refractory Cutaneous T-Cell Lymphoma: Final Results from a Phase 2B, International, Multicenter, Registration Study

Youn Kim, MD1, Sean Whittaker, MD, FRCP2*, Marie France Demierre, MD3*, Alain H Rook, MD4*, Adam Lerner, MD5, Madeleine Duvic, MD6, Sunil Reddy, MD1*, Ellen J Kim, MD4*, Tadeusz Robak, MD7*, Jürgen C Becker, MD8*, Alexey Samtsov, MD9*, William McCulloch, MB, FRCP10* and Archibald G Prentice, MBChB, FRCP, FRCPath11

1Dematology, Stanford Comphrehensive Cancer Center, Stanford, CA
2St. John's Institution of Dermatology, St. Thomas' Hospital, London, United Kingdom
3Dematology, University of Texas MD Anderson Cancer Center, Houston, TX
4Dematology, University of Pennsylvania, Philadelphia, PA
5Boston Medical Center, Boston, MA
6M.D. Anderson Cancer Center, The University of Texas, Houston, TX
7Klinika Hematologii Uniwersyteu Medycznego, Łódź, Poland
8Universität Würzburg, Universität Würzburg, Würzburg, Germany
9Dermatovenerology Department, State Educational Institution for Higher Professional Education Military Medical Academy, Saint-Petersburg, Russia
10Gloucester Pharmaceuticals, Cambridge, MA
11Department of Haematology, Royal Free Hospital, London

7:45 AM
Cdk4/6 Inhibitor PD 0332991 Demonstrates Cell Cycle Inhibition Via FLT-PET Imaging and Tissue Analysis in Patients with Recurrent Mantle Cell Lymphoma

John P. Leonard, MD1, Ann LaCasce, MD2, Mitchell R Smith, MD, PhD3, Ariela Noy, MD4, Jeffrey T Yap, PhD2*, Annick D Van den Abbeele, MD2*, Jian Q Yu, MD, FRCPC5*, Selina Chen-Kiang, PhD6, Scott A Ely, MD, PhD6*, Shankar Vallabhajosula, PhD7*, Lucian R Chirieac, MD2*, Steven M Larson, MD4*, Geoffrey I Shapiro, MD, PhD2* and Heiko Schoder8*

1Division of Hem./Onc., Weill Cornell Medical College, New York, NY
2Dana-Farber Cancer Inst., Boston, MA
3Fox Chase Cancer Center, Philadelphia, PA
4Memorial Sloan-Kettering Cancer Ctr., New York, NY
5Fox Chase Cancer Ctr., Philadelphia, PA
6Weill-Cornell Medical College, New York, NY
7Radiochemistry and Radiopharmacy, Weill-Cornell Medical Center, New York, NY
8Radiology/Nuclear Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

8:00 AM
VcR-CVAD Produces a High Complete Response Rate in Untreated Mantle Cell Lymphoma: A Phase II Study from the Wisconsin Oncology Network

Brad Kahl1, Julie Chang1*, Jens Eickhoff2*, Leslie Gilbert1*, Eric Rogers1*, Jae Werndli1*, Michael Huie3*, Thomas McFarland3*, Michael Volk4, Jules H. Blank4, Natalie Callander1*, Walter Longo1* and Christopher Peterson5

1Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI
2Biostatistics and Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI
3University of Wisconsin Medical Foundation, Madison, WI
4Green Bay Oncology, Ltd., Green Bay, WI
5Aspirus Cancer Center, Wausau, WI

8:15 AM
Safety and Clinical Activity of the Anti-CD22 Immunoconjugate Inotuzumab Ozogamicin (CMC-544) in Combination with Rituximab in Follicular Lymphoma or Diffuse Large B-Cell Lymphoma: Preliminary Report of a Phase 1/2 Study

Luis Fayad1, Hemant Patel, PhD2, Gregor Verhoef3*, Mitchell R. Smith4*, Peter W.M. Johnson, MD, FRCP5, Myron S. Czuczman, MD6, Bertrand Coiffier7*, Georg Hess8*, Eva Gine9*, Anjali Advani, MD10, Fritz Offner, MD11, Erik R. Vandendries, MD, PhD12, Mark Shapiro, MD, PhD, FACP12 and Nam H. Dang, MD, PhD13

1MD Anderson Cancer Center, Houston, TX
2Oncology, Wyeth Pharmaceuticals, Cambridge, MA
3University Hospital, Leuven, Belgium
4Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA
5Cancer Research UK Clinical Centre, University of Southampton, Southampton, United Kingdom
6Roswell Park Cancer Institute, Buffalo, NY
7Centre Hospitalier Lyon-Sud, Pierre-Benite, France
8Johannes Gutenberg-Universität, Mainz, Germany
9Hematology, Hospital Clinic de Barcelona, Barcelona, Spain
10Hematologic Oncology and Blood Disorders, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH
11University Hospital Ghent, Gent, Belgium
12Wyeth Research, Cambridge, MA
13Nevada Cancer Institute, Las Vegas, NV

8:30 AM
Sustained Response Duration Seen after Treatment with Single Agent Blinatumomab (MT103/MEDI-538) in the Ongoing Phase I Study MT103-104 in Patients with Relapsed NHL

Ralf C Bargou, MD1*, Max Topp, MD2*, Peter Kufer, MD3*, Mariele Goebeler, MD4*, Stefan Knop, MD2*, Hermann Einsele, MD5, Richard Noppeney, MD6*, Andreas Viardot, MD7*, Patrick A Baeuerle, PhD3*, Carsten Reinhardt, MD3*, Margit Schmidt, PhD3*, Petra Klappers3*, Dirk Nagorsen, MD3* and Gerhard Zugmaier, MD3*

1Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
2Hematology & Oncology, Medical Center University of Wuerzburg, Wuerzburg, Germany
3Micromet AG, Munich, Germany
4Department of Internal Medicine II, Division of Hematology, University Hospital Würzburg
5Medizinische Klinik II, Wurzburg, Germany
6Center for Internal Medicine , Hematology, University Hospital Essen, Essen, Germany
7Internal Medicine III, Hematology, University Hospital Ulm, Ulm, Germany

8:45 AM
Confirmation of the Efficacy and Safety of Lenalidomide Oral Monotherapy in Patients with Relapsed or Refractory Diffuse Large-B-Cell Lymphoma: Results of An International Study (NHL-003)

Myron S. Czuczman, MD1, Julie M. Vose, MD2, Pier Luigi Zinzani, MD3*, Craig B. Reeder, MD4, Rena Buckstein, MD, FRCPC5, Corinne Haioun6*, Reda Bouabdallah, MD7, Jonathan Polikoff, MD8*, Pingshan Guo9*, Annette Ervin-Haynes9*, Dennis Pietronigro9*, Jerome B. Zeldis, MD9 and Thomas E. Witzig10*

1Roswell Park Cancer Institute, Buffalo, NY
2Univ. of NE Med. Ctr., Omaha, NE
3Department of Hematology/Oncology, University of Bologna, Bologna, Italy
4Hematology, Mayo Clinic Arizona, Scottsdale, AZ
5Dept. of Hematology/Oncology, Sunnybrook Odette Cancer Center, Toronto, ON, Canada
6Hopital Henri Mondor, Creteil, France
7Institut Paoli-Calmettes, Marseille, France
8Kaiser Permanente Medical Group, San Diego, CA
9Celgene Corporation, Summit, NJ
10Mayo Clinic, Rochester, MN

*signifies non-member of ASH