50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Low Grade B-cell Lymphoma: Biology

Monday, December 8, 2008: 3:30 PM-5:30 PM

3001-3003-3005 - West (Moscone Center)

Moderators:

Peter McLaughlin, MD and Barbara Pro

3:30 PM

Gene Expression Profiling of Post-Follicular B-Cell Lymphoma

Wee-Joo Chng¹, Gaofeng Huang¹^*, Paul J. Kurtin²^*, Ahmet Dogan, M.D., Ph.D.² and Ellen Remstein²^*

¹Haematology-Oncology, National University Hospital, Singapore, Singapore
²Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

3:45 PM

618

Comprehensive Analysis of the Waldenström Macroglobulinemia “Cytokine Milieu” Reveals a Novel Role of Rantes Signaling in the Regulation of Immunoglobulin Production

Sherine F. Elsawa, PhD¹, Anne J. Novak, Ph.D.¹^*, Steven C Ziesmer¹^*, Luciana L Almada, Ph.D.²^*, Martin E Fernandez-Zapico, M.D.²^*, Thomas E Witzig, M.D.¹^* and Stephen M. Ansell, M.D./Ph.D.¹^*

¹Hematology, Mayo Clinic, Rochester, MN
²Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN

4:00 PM

619

TRAF3 and TNFAIP3, Two Negative Regulators of NF-Kb Signaling Pathways, Are Mutated in Waldenström’s Macroglobulinemia

Esteban Braggio¹^*, J. Jonathan Keats, PhD²^*, Xavier Leleu, MD, PhD³^*, Ellen Remstein⁴^*, Scott Van Wier⁵^*, Victor H Jimenez-Zepeda¹^*, Riccardo Valdez, MD⁶, Roelandt Schop⁷^*, Tammy Price-Troska⁸^*, Antonio Sacco⁹^*, Feda Azab⁹^*, Philip R. Greipp, MD¹⁰^*, Morie Gertz¹⁰^*, S. Vincent Rajkumar, MD¹¹^*, Marta Chesi²^*, Keith Stewart, MBChB, MBA², Ahmet Dogan¹²^*, Peter Leif Bergsagel, MD², Irene Ghobrial³^* and Rafael Fonseca, MD¹³

¹Hematological Malignancies, Mayo Clinic, Scottsdale, AZ
²Mayo Clinic, Scottsdale, AZ
³Dana-Farber Cancer Institute, Boston, MA
⁴Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁵Hematology and oncology, Mayo Clinic Arizona, Scottsdale, AZ
⁶Mayo Clinic Arizona, Scottsdale, AZ
⁷Mayo Clinic Arizona, Scottsdale
⁸Hematology-Oncology, Mayo Clinic, Scottsdale, AZ
⁹Biostatistics and Computational Biology, Dana Farber Cancer Institute
¹⁰Hematology, Mayo Clinic, Rochester, MN
¹¹Hematology, College of Medicine, Mayo Clinic, Rochester, MN
¹²Mayo Clinic, Rochester, MN
¹³Mayo Clinic Scottsdale, Scottsdale, AZ

4:15 PM

620

miRNA Analysis Identifies a Unique Expression in Waldenström Macroglobulinemia B Cells and Plasma Cells

Sherine F. Elsawa, PhD, Anne J Novak, Ph.D.^*, Deanna Grote^*, Thomas E Witzig, M.D.^* and Stephen M. Ansell, M.D., Ph.D.^*

Hematology, Mayo Clinic, Rochester, MN

4:30 PM

621

High Resolution Array-Based Analysis in Marginal Zone Lymphomas and Lymphoplasmacytic Lymphomas Identified Disease-Specific Patterns of Chromosome Abnormalities

Esteban Braggio¹^*, Ellen Remstein²^*, Wee Joo J Chng³, Gaofeng Huang³^*, Michael Barrett, PhD⁴^*, Thomas E. Witzig, MD⁵^*, Ahmet Dogan⁵^* and Rafael Fonseca, MD⁶

¹Hematology and Oncology, Mayo Clinic Arizona, Scottsdale, AZ
²Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
³Haematology-Oncology, National University Hospital, Singapore, Singapore
⁴TGEN, Scottsdale
⁵Mayo Clinic, Rochester, MN
⁶Mayo Clinic Scottsdale, Scottsdale, AZ

4:45 PM

622

Array-CGH Identifies Both Common and Subtype-Specific Genomic Aberrations in Marginal Zone Lymphomas

Andrea Rinaldi¹^*, Paola MV Rancoita¹^*, Govind Bhagat²^*, Urban Novak, MD²^*, Subhadra Nandula²^*, Vundavalli V. Murty³^*, Maurilio Ponzoni⁴^*, Silvia Govi⁴^*, Andres JM Ferreri, MD⁵, Luca Baldini, MD⁶^*, Randy Gascoyne⁷^*, Jean Soulier, MD, PhD⁸, Catherine Thieblemont⁹, Roberto Marasca¹⁰^*, Silvia Franceschetti¹¹^*, Gianluca Gaidano¹¹^*, Vincenzo Canzonieri¹²^*, Valter Gattei¹²^*, Fabio Facchetti¹³^*, Alessandra Tucci¹³^*, Manuela Mollejo¹⁴^*, Miguel A. Piris¹⁴^*, Silvia Uccella¹⁵^*, Maria Grazia Tibiletti¹⁵^*, Stephan Dirnhofer¹⁶^*, Francesco Forconi¹⁷^*, Ekaterina Chigrinova¹^*, Claudio Doglioni¹⁸^*, Riccardo Dalla-Favera, MD¹⁹, Emanuele Zucca¹^*, Ivo Kwee¹^* and Francesco Bertoni, MD¹

¹Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland
²Institute of Cancer Genetics, Columbia University, New York, NY
³Institute for Cancer Genetics, Department of Pathology and Genetics & Development, Columbia University, New York, NY
⁴HSR, Milan, Italy
⁵Unit of Lymphoid Malignancies, Department of Oncology, Istituto Scientifico San Raffaele, Milano, Italy
⁶Department of Medical Science - O.U. Hematology 1, University of Milan - Fondazione IRCCS Policlinico, Milan, Italy
⁷BCCA, Vancouver, Canada
⁸Hematology Laboratory, Hopital Saint-Louis, Paris, France
⁹Hemato-Oncology, Hopital Saint-Louis, APHP - INSERM U 728 - Institut Universitaire d'Hematologie, Paris, France
¹⁰Modena University Hospital, Division of Hematology, Modena, Italy
¹¹Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
¹²Centro di Riferimento Oncologico, Aviano (PN), Italy
¹³Spedali Civili, Brescia, Italy
¹⁴CNIO, Madrid, Spain
¹⁵Insubria University, Varese, Italy
¹⁶Patholog, University Hospital, Basel, Switzerland
¹⁷Ematologia e Trapianti, Università di Siena - AOUS, Siena, Italy
¹⁸Pathology Unit, Istituto Scientifico San Raffaele, Milano, Italy
¹⁹Institute for Cancer Genetics, New York, NY

5:00 PM

623

Immunoglobulin Gene Repertoire in Ocular Adnexa Lymphomas (OAL): Hints on the Nature of the Antigenic Stimulation

Antonis Dagklis¹^*, Maurilio Ponzoni, MD²^*, Andres JM Ferreri, MD³, Maria Giulia Cangi²^*, Lorenza Pecciarini²^*, Riccardo Dolcetti⁴^*, Kostas Stamatopoulos, MD⁵^*, Claudio Doglioni, MD²^* and Paolo Ghia, MD, PhD⁶

¹Unit and laboratory of Lymphoid Malignancies, Department of Oncology, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Milano, Italy
²Pathology Unit, Istituto Scientifico San Raffaele, Milano, Italy
³Unit of Lymphoid Malignancies, Department of Oncology, Istituto Scientifico San Raffaele, Milano, Italy
⁴Cancer Bio-Immunotherapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano
⁵Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
⁶Unit and laboratory of Lymphoid Malignancies, Department of Oncology, Università Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milano, Italy

5:15 PM

624

Mir-21 Is Over Expressed in Aggressive SMZL

Marie Bouteloup¹^*, Aurélie Verney²^*, Lucile Baseggio, PhD³^*, Evelyne Callet-Bauchu, MD, PhD⁴^*, Pascale Felman, MD⁵^*, Martine Ffrench, MD, PhD³^*, Bertrand Coiffier, MD⁶, jean-Pierre Magaud, MD, PhD⁷^*, Francoise Berger, MD, PhD⁸^*, Gilles Andre Salles, MD, PhD⁹ and Alexandra Traverse-Glehen, MD, PhD¹⁰^*

¹Hematologie, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre-Benite, France
²Umr Cnrs 5239, Université Claude Bernard Lyon 1, Pierre Bénite, France
³Hématologie Biologique and UMR CNRS 5239, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud and Université Lyon I, Pierre Bénite, France
⁴Cytogenetic Laboratory and UMR CNRS 5239, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud and Université Lyon I, Pierre Bénite, France
⁵Hematologie biologique and UMR CNRS 5239, Hospices Civils de Lyon, Centre hospitalier Lyon Sud and Université Lyon I, Pierre-Benite, France
⁶Hématologie and UMR CNRS 5239, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud and Université Lyon I, Pierre-Benite
⁷Hematology (Biology) and UMR5239 CNRS, Hospices civils de Lyon Centre Hospitalier Lyon Sud, Pierre Benite, France
⁸Pathology and UMR CNRS 5239, Hospices Civils de Lyon, Centre hospitalier Lyon Sud and Université Lyon 1,, Pierre-Bénite, France
⁹Hematologie, Centre Hospitalier Lyon-Sud, Pierre-Benite, France
¹⁰Pathology and UMR CNRS 5239, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud and Université Lyon I, Pierre Bénite, France

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^*signifies non-member of ASH

622.O4.8 Low Grade B-cell Lymphoma: Biology