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622.O3.8 Diffuse Large B-cell Lymphoma: Molecular Biology

Tuesday, December 9, 2008: 7:00 AM-9:00 AM
3001-3003-3005 - West (Moscone Center)
Moderators:
Timothy C. Greiner, MS, MD and Eric Hsi
7:00 AM
Mutations in Multiple Genes Cause Deregulation of the NFkB Pathway in Diffuse Large B-Cell Lymphoma

Laura Pasqualucci, MD1*, Mara Compagno, PhD1*, Wei Keat Lim2*, Adina Grunn1*, Subhadra V Nandula, PhD1*, Marta Scandurra3*, Francesco Bertoni, MD3, Maurilio Ponzoni, MD4*, Andrea Califano, PhD2*, Govind Bhagat, MD5*, Amy Chadburn, MD6 and Riccardo Dalla-Favera, MD1

1Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY
2Joint Centers for Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY
3Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
4Pathology Unit, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
5Department of Pathology, Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY
6Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

7:15 AM
BCL6 Regulates Tonic BCR Signaling in Diffuse Large B-Cell Lymphomas by Repressing the SYK Phosphatase, PTPROt

Przemyslaw Juszczynski1, Linfeng Chen1*, Jose M. Polo2*, Stella M. Ranuncolo2*, Riccardo Dalla-Favera3, Ari Melnick2 and Margaret A. Shipp1

1Dana-Farber Cancer Institute, Boston, MA
2Albert Einstein College of Medicine, Bronx, NY
3Institute for Cancer Genetics, Department of Pathology and Genetics & Development, Columbia University, New York, NY

7:30 AM
Gene Expression Profile Analysis According to Recurrent Gene Copy Number Abnormalities Defines a Diffuse Large B-Cell Lymphoma Subgroup Characterized by 9p21 Locus Deletion, Ribosome Machinery Deregulation and Poor Prognosis. A GELA Study

Fabrice Jardin1*, Jean-Philippe Jais2*, Thierry Jo Molina3*, Francoise Parmentier1*, Jean-Michel Picquenot1*, Philippe Ruminy1*, Herve Tilly4, Christian Bastard1*, Gilles Andre Salles5, Bertrand Coiffier6, Corinne Haioun7 and Karen Leroy8*

1Hematology, INSERM U918, Centre Henri Becquerel, Rouen, France
2Biostatistics, Hôpital Necker, EA 4067 université Paris-Descartes, Paris, France
3Pathology, Université Paris Descarte and Hôtel Dieu Hospital, Paris, France
4Centre Henri Becquerel, Rouen, France
5Hematologie, Centre Hospitalier Lyon-Sud, Pierre-Benite, France
6Centre Hospitalier Lyon-Sud, Pierre-Benite
7Service d'Hématologie Clinique, Hôpital Henri Mondor, Créteil, France
8Inserm U841, Henri Mondor Hospital, Creteil, France

7:45 AM
Lymphomas with Concurrent T(14;18) and 8q24 Translocations Are Under-Reported and Clinical Outcome Depends on the MYC Partner

Nathalie A Johnson, MD1*, Kerry J. Savage, MD1*, Susanna Ben-Neriah1*, Christian Steidl, MD1*, Richard Klasa, MD1*, Joseph M. Connors, MD1*, Randy D. Gascoyne, MD2 and Douglas E. Horsman, MD1*

1Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada
2Pathology, British Columbia Cancer Agency, Vancouver, BC, Canada

8:00 AM
Differentiation-Stage-Specific Expression of MicroRNAs in B-Lymphocytes and Diffuse Large B-Cell Lymphomas (DLBCL)

Raquel Malumbres, PhD.1*, Robert Tibshirani, PhD.2*, Elena Cubedo, PhD.1*, Kristopher A Sarosiek, BS3*, Xiaoyu Jiang, PhD.1*, Jose Ruiz, MD1* and Izidore Lossos, MD4

1Hematology/Oncology, University of Miami, Miami, FL
2Department of Health Research and Policy, and Statistics, Stanford University, Stanford, CA
3Pharmacology, University of Miami, Miami, FL
4School of Medicine, University of Miami, Miami, FL

8:15 AM
MicroRNA Is Prognostic Indicator in Patients with Diffuse Large B Cell Lymphoma

Meir Lahav, MD1, Ron Ram1*, Michal Kushnir, Rosetta, Genomics, Israel2*, Ofer Spilberg1*, Gila Lithwick Yanai2*, Osnat Beeri1*, Moshe Hoshen2* and Maora Feinmesser1*

1Medicine A, Rabin Medical Center, Petah Tikva, Israel
2Rosetta Genomics, Israel, Israel

8:30 AM
Genome-Wide Analysis of B Cell Non-Hodgkin’s Lymphoma Disclosed Frequent Involvement of Genes in NFkB Pathway

Motohiro Kato, MD1*, Kumi Nakazaki2*, Yasuharu Sato3*, Kengo Takeuchi, MD4*, Masashi Sanada5*, Yoshitaka Asakura6*, Satsuki Muto7*, Yuyan Chen1*, Junko Takita1*, Yasuhide Hayashi8*, Takashi Igarashi1*, Toshiki Watanabe7*, Kensei Tobinai, MD6, Yuichi Ishikawa4*, Shigeo Mori, MD9*, Mineo Kurokawa, MD, PhD2, Tadashi Yoshino, MD3*, Yukio Kobayashi6* and Seishi Ogawa, MD, PhD5

1Department of Pediatrics, The University of Tokyo, Tokyo, Japan
2Hematology and Oncology, Graduate School of Med., Tokyo, Japan
3Department of Pathology, Okayama University Graduate School of Medicine, Okayama, Japan
4Department of Pathology, The Cancer Institute of Japanese Foundation for Cancer Research,, Tokyo, Japan
5Cncer Genomics Project, University of Tokyo, Tokyo, Japan
6National Cancer Center Hospital, Tokyo, Japan
7The institute of Medical Science, Unviersity of Tokyo, Tokyo, Japan
8Hematology/Oncology, Gunma Children's Medical Center, Shibukawa, Japan
9Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan

8:45 AM
A Population of Suppressive Monocytes Inhibiting T Cell Proliferation and Dendritic Cell Differentiation in Relapsed Non-Hodgkin's Lymphoma

Yi Lin, MD, PhD1, Peggy A Bulur, B.S.2*, Michael P. Gustafson, Ph.D.2*, Thomas E. Witzig, M.D.1* and Allan B. Dietz, Ph.D.2*

1Hematology, Mayo Clinic, Rochester, MN
2Transfusion Medicine, Mayo Clinic, Rochester, MN

*signifies non-member of ASH