50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Mantle Cell Lymphoma, Follicular Lymphoma, Tumor Microenvironment

Monday, December 8, 2008: 11:00 AM-12:30 PM

3001-3003-3005 - West (Moscone Center)

Moderators:

Timothy C. Greiner, MS, MD and Patricia Aoun

11:00 AM

The Mir-17~92 Cluster Enhances Cell Growth and Resistance to Chemotherapy in Mantle Cell Lymphoma by Down-Regulating PTEN, PHLPP2 and BIM

Enyu Rao¹^*, Timothy McKeithan, MD., Ph.D.²^*, Chunsun Jiang, MD.¹^*, Ming Ji¹^*, Javeed Iqbal, Ph.D.¹^*, George Wright, Ph.D.³^*, Louis M. Staudt, MD., Ph.D.³, Yong Zhao, Ph.D.⁴^*, Wing C. Chan, MD.¹ and Kai Fu, MD., Ph.D.¹

¹Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
²Internal Medicine, University of Nebraska Medical Center, Omaha, NE
³Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Health Institutes, Bethesda, MD
⁴Institute of Zoology, Chinese Academy of Sciences, Beijing, China

11:15 AM

374

Protein Profiling of Plasma Membranes and Lipid Rafts Defines Aberrant Signaling Pathways in Mantle Cell Lymphoma

Robert S Boyd, PhD¹^*, Rebekah Jukes-Jones, PhD¹^*, Renata Walewska, FRCP¹^*, David Brown, PhD¹^*, Martin J.S. Dyer, MA, DPhil, FRCP¹ and Kelvin Cain, PhD²^*

¹MRC Toxicology Unit, Leicester, United Kingdom
²Medical Research Council, Leicester

11:30 AM

375

Agricultural Pesticide Use Ă‚Â and the T(14;18) Connection to Lymphomagenesis

Sandrine Roulland, PhD, PharmD¹, Julie Agopian¹^*, Yannick Lecluse²^*, Jean-Marc Navarro¹^*, Anne-claire Gac²^*, Mélanie Briand²^*, Pierre Grenot¹^*, Pascal Gauduchon²^*, Philippe Ruminy³^*, Pierre Lebailly²^* and Bertrand Nadel¹

¹Centre d' Immunologie de Marseille - Luminy, Marseille, France
²GRECAN, Caen, France
³Hematology, INSERM U918, Centre Henri Becquerel, Rouen, France

11:45 AM

376

MUM1 Expression in Follicular Lymphoma Is a Poor Prognostic Marker in Patients Treated with Immunochemotherapy (SWOG 9800/9911) but Not Chemotherapy Alone (SWOG 8809): A Southwest Oncology Group Correlative Science Study

Eric D Hsi, MD¹, Lisa Rimsza, MD²^*, Bryan H Goldman, MS³^*, James R. Cook, MD, PhD¹^*, Raymond R. Tubbs, DO¹^*, Oliver W. Press, MD, PhD³, David G. Maloney, MD, PhD⁴, Richard I Fisher, MD⁵^* and John Sweetenham, MD⁶^*

¹Pathology, Cleveland Clinic, Cleveland, OH
²University of Arizona, Tucson, AZ
³Fred Hutchinson Cancer Research Center, Seattle, WA
⁴Fred Hutchinson Cancer Rsch. Ctr., Seattle, WA
⁵Wilmot Cancer Center, Rochester, NY
⁶Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH

12:00 PM

377

Signaling Diversity in Human Lymphoma B Cells and in Tumor Infiltrating T Cells Correlates with Follicular Lymphoma Patient Clinical Outcomes

Jonathan M. Irish, PhD, Roch Houot, MD^*, June H. Myklebust, PhD^*, Debra K. Czerwinski^*, Garry P. Nolan, PhD^* and Ronald Levy, MD

Stanford University, Stanford, CA

12:15 PM

378

Monocytes Promote Survival of Malignant T Cells in Cutaneous T-Cell Lymphoma and Are Recruited to the Tumor Microenvironment by CCL5 (RANTES)

Ryan A Wilcox, MD, PhD¹, Wada A David, MD²^*, Andrew L. Feldman³^*, Sherine F Elsawa¹^*, Deanna M Grote¹^*, Steven C Ziesmer¹^*, Anne J Novak¹^*, Mark R. Pittelkow²^*, Thomas E. Witzig¹^* and Stephen M Ansell¹^*

¹Hematology, Mayo Clinic, Rochester, MN
²Dermatology, Mayo Clinic, Rochester, MN
³Anatomic Pathology, Mayo Clinic, Rochester, MN

See more of: Oral and Poster Abstracts

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^*signifies non-member of ASH

622.O1.6 Mantle Cell Lymphoma, Follicular Lymphoma, Tumor Microenvironment