Before you can access ASH's online program, you must agree to the following:
Last updated January 16, 2009. Please note that this site represents the latest program changes
and differs from the print version in some details.

621.O1.6 Hodgkin’s Lymphoma - Biology, Excluding Therapy

Monday, December 8, 2008: 1:30 PM-3:00 PM
Golden Gate Hall (San Francisco Marriott)
Moderators:
Diponkar Banerjee and Sven De Vos, MD, PhD
1:30 PM
Dysregulation of Pax5 Activity Contributes to the Extinction of the B-Cell Phenotype in Reed-Sternberg Cells

Graham P Collins, MD1*, Jennifer C Paterson1*, Gillian E May, PhD2*, Rajeev Gupta, MD, PhD2*, Teresa Marafioti, MD1*, David Y Mason, MD, PhD1* and Tariq Enver, PhD2

1Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom
2Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford

1:45 PM
Regulation of Jak2 Kinase Gene by the Mir-135 Family in Classical Hodgkin Lymphoma

Alfons Navarro, PhD1*, Tania Diaz1*, Antonio Martinez, MD, PhD2*, Anna Gaya, MD3*, Aina Pons3*, Carmen Martinez, MD3*, Emili Montserrat, MD, PhD3 and Mariano Monzo, MD, PhD1*

1Human Anatomy, University of Barcelona, Medical School, IDIBAPS, Barcelona, Spain
2Hematopathology Section, Laboratory of Pathology, Hospital Clinic, IDIBAPS, Barcelona, Spain
3Institute of hematology and Oncology., Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain

2:00 PM
Cytokine Gene Polymorphisms and Outcome of Patients with Hodgkin Lymphoma: A Prospective Study of the Groupe D'Etude Des Lymphomes De L'Adulte

Herve Ghesquieres, MD1*, Olivier Casasnovas, MD2*, Marion Fournier3*, David Cox, MS, PhD4*, Pauline Brice, MD5, Franck Morschhauser, MD6*, Anne-Laure Borrel7*, Catherine Sebban, MD8*, Vincent Ribrag, MD9, Corinne Haioun, MD, PhD10*, Pierre Feugier, MD11*, Herve Tilly, MD, PhD12, Christophe Ferme, MD13* and Gilles Andre Salles, MD, PhD14

1Hematology, UMR CNRS 5239 - Centre Leon Berard, Lyon, France
2CHU Dijon, Dijon, France
3Biostatistic department, Gelarc, Lyon, France
4Genetic Epidemiology, UMR CNRS 5201 - Centre Leon Berard, Lyon
5Hematology, Hopital Saint Louis APHP, Paris
6Hematology, Centre Hospitalier Universitaire, Lille, France
7UMR CNRS 5239 - Université Lyon 1, Lyon
8Hematology, Centre Leon Berard, Lyon, France
9Dpt. of Medicine, Institut Gustave Roussy, Villejuif, France
10Hematology, Hopital Henri Mondor, Creteil, France
11CHU de Nancy - Hopital Brabois, Vandoeuvre les Nancy, France
12Hematology, Centre Henri Becquerel, Rouen, France
13Dept. of Medicine, Institut Gustave Roussy, Villejuif, France
14Hematology, UMR CNRS 5239 - Université Lyon 1 - HCL, Pierre-Benite, France

2:15 PM
Genome-Wide Expression Profiling Predicts Treatment Outcome in Classical Hodgkin Lymphoma

Christian Steidl1, Tang Lee1*, Sohrab P. Shah1*, Guangming Han1*, Tarun Nayar2*, Allen Delaney2*, Steven Jones2*, Wing C. Chan3, Andreas Rosenwald4*, Lisa M. Rimsza5, Elias Campo6*, Elaine S. Jaffe7*, Louis M. Staudt8, Georg Lenz8, Joseph M. Connors9 and Randy D. Gascoyne1

1Pathology, British Columbia Cancer Agency, Vancouver, BC, Canada
2Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada
3Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
4Pathology, University of Wuerzburg, Wuerzburg, Germany
5Pathology, University of Arizona, Tucson, AZ
6Pathology, Hospital Clínic, Barcelona, Spain
7Center for Cancer Research, National Cancer Institute, Bethesda, MD
8Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Health Institutes, Bethesda, MD
9Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada

2:30 PM
Coordinate Regulation of NF-κB Subunit Expression in EBV Negative, but Not EBV Positive, Pediatric Hodgkin’s Lymphoma

Terzah M. Horton, MD, PhD1, Andrea N Sheehan, MD1*, Dolores Lopez-Terrada, MD2*, Robert Edward Hutchison, MD3, Sonia Narendra, MD3*, Meghan A. Higman, MD, PhD4, Meng-Fen Wu, PhD5* and Hao Liu, PhD5*

1Baylor College of Medicine, Houston, TX
2Pathology, Baylor College of Medicine, Houston, TX
3SUNY Upstate Med. Univ., Syracuse, NY
4WCHOB/RPCI, Buffalo, NY
5Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX

2:45 PM
Genetic Alterations Detected by High-Resolution Array Comparative Genomic Hybridization in Microdissected HRS Cells Correlate with Treatment Outcome in Classical Hodgkin Lymphoma

Christian Steidl1, Adele Telenius1*, Sohrab P. Shah1*, K-John Cheung1*, Lorena Barclay2*, Joseph M. Connors3, Douglas E. Horsman1* and Randy D. Gascoyne1

1Pathology, British Columbia Cancer Agency, Vancouver, BC, Canada
2Cancer Imaging, British Columbia Cancer Agency, Vancouver, BC, Canada
3Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada

*signifies non-member of ASH