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614.O2.6 Acute Lymphoblastic Leukemia Therapy: New Trends

Monday, December 8, 2008: 11:00 AM-12:30 PM
Yerba Buena Ballroom Salon 9 (San Francisco Marriott)
Moderators:
Andre Baruchel, MD and Elizabeth Raetz, MD
11:00 AM
Augmented Therapy Based on PCR-MRD Levels of Children with Acute Lymphoblastic Leukemia: A Report from the Japanese Children's Cancer and Leukemia Study Group ALL 2000 MRD Pilot Study

Toshinori Hori*, Kazutaka Yamaji*, Shohei Yokota*, Tomoko Okamoto*, Arata Watanabe*, Atsushi Kikuta*, Keiko Asami*, Yasuo Horikoshi*, Nobuyuki Hyakuna*, Takashi Taga*, Keiko Nomura*, Asayuki Iwai*, Tsutomu Watanabe*, Takuya Yanase*, Yutaka Saikawa*, Akira Kamitamari*, Takeji Matsushita*, Yasuto Shimomura* and Masahito Tsurusawa

Japanese Children's Cancer and Leukemia Study Group, Aichi, Japan

11:15 AM
PEG-Asparaginase in Adult Acute Lymphoblastic Leukemia (ALL): Efficacy and Feasibility Analysis with Increasing Dose Levels

Nicola Goekbuget, MD1, Anja Baumann, MD2*, Joachim Beck, MD3*, Joachim Boos, MD, PhD4*, Monika Brueggemann, MD, PhD5*, Helmut Diedrich, MD6*, Andreas Hüttmann, MD7*, Lothar Leimer, MD8*, Thomas Lipp, MD9*, Ralph Naumann, MD, PhD10*, Martin Mohren, MD11*, Albrecht Reichle, MD, PhD12*, Kerstin Schäfer-Eckart, MD13*, Marc Schmalzing, MD14*, Mathias Schmid, MD, PhD15*, Norbert Schmitz, MD, PhD16, Theis Therwey, MD17* and Dieter Hoelzer, MD, PhD18*

1Medical Department II, J.W.Goethe University, Frankfurt, Germany
2University Hospital München-Großhadern, München, Germany
3University Hospital, Mainz, Germany
4University Hospital, Münster, Germany
5University Hospital, Kiel, Germany
6Medizinische Hochschule, Hannover, Germany
7University Hospital, Essen, Germany
8Robert Bosch Krankenhaus, Stuttgart, Germany
9Klinikum München-Schwabing, München, Germany
10University of Dresden, Dresden, Germany
11University Hospital, Magdeburg, Germany
12University of Regensburg, Regensburg, Germany
13Klinikum Nürnberg-Nord, Nürnberg, Germany
14University Hospital, Tuebingen, Germany
15University Hospital Ulm, Ulm, Germany
16Hematology and Stem Cell Transplantation, ASKLEPIOS Klinik St. Georg, Hamburg, Germany
17Charite University Hospital, Berlin, Germany
18J.W. Goethe University Hospital, Frankfurt/M, Germany

11:30 AM
Prognostic Significance of Central Nervous System (CNS) Status of Children with Acute Lymphoblastic Leukemia (ALL) Treated without Cranial Irradiation: Results of European Organization for Research and Treatment of Cancer (EORTC) Children Leukemia Group Study 58951

Nicolas Sirvent1*, Stefan Suciu2, Yves Benoit3*, Yves Bertrand4*, Brigitte Nelken5*, Alain Robert6*, Anne Uyttebroeck7*, Patrick Lutz, MD8*, Alina Ferster, MD, PhD9, Karima Yacouben10*, Lucilia Norton11*, Geneviève Margueritte12*, Martine Munzer13*, Dominique Plantaz14*, Frédéric Millot15*, Patrick Boutard16*, Pierre Philippet17*, Claire Hoyoux18*, Liliana Baila19* and Jacques Otten20*

1CHU Nice, Nice, France
2EORTC Leukemia Group, Brussels, Belgium
3Ghent University Hospital, Ghent, Belgium
4CHU Lyon, Lyon, France
5Pediatrics Hematology, CHU Lille, Lille
6CHU Toulouse, Toulouse, France
7University Hospital, Leuven, Belgium
8Service Oncologie hématologie pédiatrique, Strasbourg, France
9Hémato-oncologie pédiatrique, Children's University Hospital Reine Fabiola, Brussels, Belgium
10Hôpital Robert Debre, Paris, France
11Hospital escolar San Joao, Porto, Portugal
12CHU Montpellier, Montpellier
13CHU Reims, Reims, France
14CHU Grenoble, Grenoble, France
15CHU Poitiers, Poitiers, France
16CHU Caen, Caen, France
17Clinique de l'espérance, Montegnée, Belgium
18Centre Hospitalier Liège, Brussels, Belgium
19EORTC Headquarters, Brussels, Belgium
20University Hospital Brussels, Brussels, Belgium

11:45 AM
First European Chemotherapy Schedule for Elderly Patients with Acute Lymphoblastic Leukemia: Promising Remission Rate and Feasible Moderate Dose Intensity Consolidation

Nicola Goekbuget, MD1, Thibaut Leguay, MD2*, Mathilde Hunault, MD3*, Chadi Al-Nawakil, MD4*, Patrice Chevallier, MD5*, Herve Dombret, MD6, Gisela Fritsch, MD7*, Albert Oriol, MD8*, Josep Maria Ribera, MD9*, Philippe Rousselot, MD10*, Juan Manuel Sancho, MD11* and Dieter Hoelzer, MD, PhD12*

1Medical Department II, J.W.Goethe University, Frankfurt, Germany
2Hematology, CHU de Bordeaux, Bordeaux, France
3CHU d'Angers, Angers, France
4Hopital Cochin, Paris, France
5Hematology, CHU Hotel-Dieu, Nantes, France
6Hopital Saint Louis, Paris, France
7Städt.Kliniken, Braunschweig, Germany
8Hospital Universitari Germans Trias i Pujol, Badalona, Spain
9Hospital Germans Trials i Pujol, Badalona, Spain
10Centre André Mignot, Versaille, France
11Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
12J.W. Goethe University Hospital, Frankfurt/M, Germany

12:00 PM
Line Treatment of Adult Ph+ Acute Lymphoblastic Leukemia (ALL) Patients. Final Results of the GIMEMA LAL1205 Study

Robert Foà1, Antonella Vitale1*, Anna Guarini1*, Maria Sefania De Propris1*, Loredana Elia1*, Giuseppe Cimino1*, Mario Luppi2*, Carlo Castagnola3*, Simona Sica4*, Rosa Nieddu5*, Maria-Novella Piersantelli6*, Felicetto Ferrara7, Francesco Nobile8*, Renato Fanin9*, Francesco Fabbiano10, Marco Vignetti1*, Paola Fazi1*, Simona Soverini11*, Franco Mandelli12*, Giovanni Martinelli11, Giovanna Meloni1* and Michele Baccarani11

1Division of Hematology, Department of Cellular Biotechonologies and Hematology, "Sapienza" University, Rome, Italy
2Department of Oncology and Hematology, University of Modena, Italy
3Department of Hematology, University of Pavia, Italy
4Department of Hematology, Catholic University, Rome, Italy
5Institute of Hematology, University of Sassari, Italy
6Department of Hematology, University of Ancona, Italy
7Department of Hematology, Cardarelli Hospital, Naples, Italy
8Division of Hematology, Ospedali Riuniti, Reggio Calabria, Italy
9Clinica Ematologica AOUD, Udine, Italy
10Hematology I, Ospedale V. Cervello, Palermo, Italy
11Department of Hematology/Oncology “L. and A. Seràgnoli”, University of Bologna, Italy
12GIMEMA, Rome, Italy

12:15 PM
GRASPALL 2005.01 Clinical Study:  L-Asparaginase Loaded into Red Blood Cells Is Effective at Depleting Serum Asparagine in Children and Adults with Relapsed Acute Lymphoblastic Leukaemia (ALL)

Yves Bertrand1*, Xavier Thomas2, Andre Baruchel3, Françoise Mazingue4*, Anne Auvrignon5*, Selim Corm4*, Herve Dombret3, Patrice Chevallier6*, Claire Galambrun7*, Françoise Huguet8*, Faezeh Legrand9*, Françoise Mechinaud6*, Norbert Vey10, Sylvie Chabaud11*, Florence Noel Baron12*, Irène Philip11*, David Liens13* and Yann Godfrin13*

1Institut d'Hemato-Oncologie pédiatrique et Université Claude Bernard, Lyon, France
2Hopital Edouard Herriot, Lyon, France
3Hopital Saint Louis, Paris, France
4CHRU Lille, Lille, France
5Hopital Trousseau, Paris, France
6CHU Hotel-Dieu, Nantes, France
7Hopital La Timone, Marseille, France
8CHU de Toulouse, Toulouse, France
9CHU Jean Minjoz, Besancon, France
10Institut Paoli Calmettes, Marseille, France
11centre Léon Bérard, Lyon, France
12CIC 201 INSERM CHU Lyon, Lyon, France
13ERYtech Pharma, Lyon, France

*signifies non-member of ASH