50th ASH Annual Meeting and Exposition (December 6 - 9, 2008): Acute Myeloid Leukemia- New Molecular Mechanisms

Monday, December 8, 2008: 11:00 AM-12:30 PM

Golden Gate Hall (San Francisco Marriott)

Moderators:

Marc Loriaux, MD, PhD and Torsten Haferlach, MD

11:00 AM

Evidence for CD34+ Hematopoietic Progenitor Cell Involvement in Acute Myeloid Leukemia with NPM1 Gene Mutation: Implications for the Cell of Origin

Maria Paola Martelli¹^*, Valentina Pettirossi¹^*, Elisabetta Bonifacio¹^*, Federica Mezzasoma¹^*, Nicla Manes¹^*, Debora Cecchini¹^*, Maruska Capanni¹^*, Ilaria Gionfriddo¹^*, Arcangelo Liso²^*, Roberta Pacini¹^*, Manola Carini¹^*, Giorgina Specchia³, Massimo F Martelli¹^* and Brunangelo Falini¹^*

¹Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
²Hematology, University of Foggia, Foggia, Italy
³Chair of Hematology, University of Bari

11:15 AM

308

Human Nucleophosmin (NPM1) Perturbs Myeloid Development in Zebrafish in Vivo

Niccolò Bolli, MD^*, Elspeth Payne, MB, BSc, MRCP^*, Clemens Grabher, PhD^*, Adam Johnston, AB^*, John Kanki, PhD^* and A. Thomas Look, MD

Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA

11:30 AM

309

Blocking the Autophagy Gene 5 (ATG5) Impairs ATRA-Induced Myeloid Differentiation, and ATG5 Is Downregulated in AML

Adrian Britschgi, MSc¹^*, Shida Yousefi, PhD²^*, Judith Laedrach¹^*, Deborah Shan¹^*, Hans-Uwe Simon, MD, PhD²^*, Andreas Tobler, MD³, Martin F. Fey, MD⁴ and Mario P. Tschan, PhD¹

¹Department of Clinical Research, University of Bern, Bern, Switzerland
²Department of Pharmacology, University of Bern, Bern, Switzerland
³Department of Hematology, Inselspital, Bern, Switzerland
⁴Medical Oncology, Inselspital, Bern, Switzerland

11:45 AM

310

MLF1 Is a Candidate Susceptibility Factor for T-AML That Induces Apoptosis in Normal Hematopoietic Cells

Megan R Janke¹^*, Fola Babatunde¹^*, Patrick Cahan¹^*, James M Cheverud²^* and Timothy A Graubert¹

¹Internal Medicine - Stem Cell Biology, Washington University in Saint Louis, School of Medicine, Saint Louis, MO
²Anatomy & Neurobiology, Washington University in St. Louis, School of Medicine, St. Louis, MO

12:00 PM

311

HDAC Inhibition by SNDX-275 (Entinostat) Restores Expression of Silenced Leukemia-Associated Transcription Factors Nur77 and Nor1 and of Key Pro-Apoptotic Proteins in AML

Liran Zhou, PhD¹^*, Marina Konopleva, MD, PhD² and Michael Andreeff, MD, PhD¹

¹Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX
²Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX

12:15 PM

312

Hypermethylation of HOX Genes Is Associated with Longer Survival in Acute Myeloid Leukemia

Jaroslav Jelinek, Heike Kroeger, Rong He^*, Amanda Saraf^*, Samantha F Lau^*, Tuong-Van Nguyen^*, Michael W Thomas^*, Elizabeth J Shpall^*, Steven Kornblau^*, Carlos Bueso-Ramos^*, Hagop M Kantarjian and Jean-Pierre J Issa

The University of Texas M. D. Anderson Cancer Center, Houston, TX

See more of: Oral and Poster Abstracts

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^*signifies non-member of ASH

613.O1.6 Acute Myeloid Leukemia- New Molecular Mechanisms