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613.O1.6 Acute Myeloid Leukemia- New Molecular Mechanisms

Monday, December 8, 2008: 11:00 AM-12:30 PM
Golden Gate Hall (San Francisco Marriott)
Moderators:
Marc Loriaux, MD, PhD and Torsten Haferlach, MD
11:00 AM
Evidence for CD34+ Hematopoietic Progenitor Cell Involvement in Acute Myeloid Leukemia with NPM1 Gene Mutation: Implications for the Cell of Origin  

Maria Paola Martelli1*, Valentina Pettirossi1*, Elisabetta Bonifacio1*, Federica Mezzasoma1*, Nicla Manes1*, Debora Cecchini1*, Maruska Capanni1*, Ilaria Gionfriddo1*, Arcangelo Liso2*, Roberta Pacini1*, Manola Carini1*, Giorgina Specchia3, Massimo F Martelli1* and Brunangelo Falini1*

1Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
2Hematology, University of Foggia, Foggia, Italy
3Chair of Hematology, University of Bari

11:15 AM
Human Nucleophosmin (NPM1) Perturbs Myeloid Development in Zebrafish in Vivo

Niccolò Bolli, MD*, Elspeth Payne, MB, BSc, MRCP*, Clemens Grabher, PhD*, Adam Johnston, AB*, John Kanki, PhD* and A. Thomas Look, MD

Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA

11:30 AM
Blocking the Autophagy Gene 5 (ATG5) Impairs ATRA-Induced Myeloid Differentiation, and ATG5 Is Downregulated in AML

Adrian Britschgi, MSc1*, Shida Yousefi, PhD2*, Judith Laedrach1*, Deborah Shan1*, Hans-Uwe Simon, MD, PhD2*, Andreas Tobler, MD3, Martin F. Fey, MD4 and Mario P. Tschan, PhD1

1Department of Clinical Research, University of Bern, Bern, Switzerland
2Department of Pharmacology, University of Bern, Bern, Switzerland
3Department of Hematology, Inselspital, Bern, Switzerland
4Medical Oncology, Inselspital, Bern, Switzerland

11:45 AM
MLF1 Is a Candidate Susceptibility Factor for T-AML That Induces Apoptosis in Normal Hematopoietic Cells

Megan R Janke1*, Fola Babatunde1*, Patrick Cahan1*, James M Cheverud2* and Timothy A Graubert1

1Internal Medicine - Stem Cell Biology, Washington University in Saint Louis, School of Medicine, Saint Louis, MO
2Anatomy & Neurobiology, Washington University in St. Louis, School of Medicine, St. Louis, MO

12:00 PM
HDAC Inhibition by SNDX-275 (Entinostat) Restores Expression of Silenced Leukemia-Associated Transcription Factors Nur77 and Nor1 and of Key Pro-Apoptotic Proteins in AML

Liran Zhou, PhD1*, Marina Konopleva, MD, PhD2 and Michael Andreeff, MD, PhD1

1Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX
2Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX

12:15 PM
Hypermethylation of HOX Genes Is Associated with Longer Survival in Acute Myeloid Leukemia

Jaroslav Jelinek, Heike Kroeger, Rong He*, Amanda Saraf*, Samantha F Lau*, Tuong-Van Nguyen*, Michael W Thomas*, Elizabeth J Shpall*, Steven Kornblau*, Carlos Bueso-Ramos*, Hagop M Kantarjian and Jean-Pierre J Issa

The University of Texas M. D. Anderson Cancer Center, Houston, TX

*signifies non-member of ASH